Study of the metabolic stability profiles of perampanel, rufinamide and stiripentol and prediction of drug interactions using HepaRG cells as an in vitro human model
Toxicol In Vitro. 2022 May 18:105389. doi: 10.1016/j.tiv.2022.105389. Online ahead of print.ABSTRACTNew-generation antiepileptic drugs as perampanel, rufinamide and stiripentol emerged as alternatives in chronic epilepsy polytherapy. Hence, their metabolic stability and potential involvement in relevant drug-drug interactions (DDI) are of great clinical interest, being HepaRG cells herein used as an in vitro human model. To characterize their metabolic stability profiles, HepaRG cells were incubated with perampanel (1 μM), rufinamide (100 μM) or stiripentol (5 μM) for 12-h. HepaRG cells, pretreated with known CYP450 iso...
Source: Toxicology in Vitro - May 21, 2022 Category: Toxicology Authors: Sara Meirinho M árcio Rodrigues Ana Fortuna Am ílcar Falcão Gilberto Alves Source Type: research
Study of the metabolic stability profiles of perampanel, rufinamide and stiripentol and prediction of drug interactions using HepaRG cells as an in vitro human model
Toxicol In Vitro. 2022 May 18:105389. doi: 10.1016/j.tiv.2022.105389. Online ahead of print.ABSTRACTNew-generation antiepileptic drugs as perampanel, rufinamide and stiripentol emerged as alternatives in chronic epilepsy polytherapy. Hence, their metabolic stability and potential involvement in relevant drug-drug interactions (DDI) are of great clinical interest, being HepaRG cells herein used as an in vitro human model. To characterize their metabolic stability profiles, HepaRG cells were incubated with perampanel (1 μM), rufinamide (100 μM) or stiripentol (5 μM) for 12-h. HepaRG cells, pretreated with known CYP450 iso...
Source: Toxicology in Vitro - May 21, 2022 Category: Toxicology Authors: Sara Meirinho M árcio Rodrigues Ana Fortuna Am ílcar Falcão Gilberto Alves Source Type: research
Impact of Antiseizure Medications on Appetite and Weight in Children
AbstractThere are numerous potential factors that may affect growth in children with epilepsy, and these must be evaluated in any child with appetite and weight concerns. Antiseizure medications (ASMs) have potential adverse effects, and many may affect appetite, thus impacting normal growth and weight gain. The aim of this review is to focus on the impact of both epilepsy and ASMs on appetite and weight in children. We systematically reviewed studies using Medline assessing the impact of ASMs on appetite and weight in children. Eligible studies included randomized controlled trials and open-label studies (open-label exten...
Source: Pediatric Drugs - May 21, 2022 Category: Pediatrics Source Type: research
Impact of Antiseizure Medications on Appetite and Weight in Children
Paediatr Drugs. 2022 May 21. doi: 10.1007/s40272-022-00505-2. Online ahead of print.ABSTRACTThere are numerous potential factors that may affect growth in children with epilepsy, and these must be evaluated in any child with appetite and weight concerns. Antiseizure medications (ASMs) have potential adverse effects, and many may affect appetite, thus impacting normal growth and weight gain. The aim of this review is to focus on the impact of both epilepsy and ASMs on appetite and weight in children. We systematically reviewed studies using Medline assessing the impact of ASMs on appetite and weight in children. Eligible st...
Source: Paediatric Drugs - May 20, 2022 Category: Pediatrics Authors: Ersida Buraniqi Hicham Dabaja Elaine C Wirrell Source Type: research
Impact of Antiseizure Medications on Appetite and Weight in Children
Paediatr Drugs. 2022 May 21. doi: 10.1007/s40272-022-00505-2. Online ahead of print.ABSTRACTThere are numerous potential factors that may affect growth in children with epilepsy, and these must be evaluated in any child with appetite and weight concerns. Antiseizure medications (ASMs) have potential adverse effects, and many may affect appetite, thus impacting normal growth and weight gain. The aim of this review is to focus on the impact of both epilepsy and ASMs on appetite and weight in children. We systematically reviewed studies using Medline assessing the impact of ASMs on appetite and weight in children. Eligible st...
Source: Paediatric Drugs - May 20, 2022 Category: Pediatrics Authors: Ersida Buraniqi Hicham Dabaja Elaine C Wirrell Source Type: research
Impact of Antiseizure Medications on Appetite and Weight in Children
Paediatr Drugs. 2022 May 21. doi: 10.1007/s40272-022-00505-2. Online ahead of print.ABSTRACTThere are numerous potential factors that may affect growth in children with epilepsy, and these must be evaluated in any child with appetite and weight concerns. Antiseizure medications (ASMs) have potential adverse effects, and many may affect appetite, thus impacting normal growth and weight gain. The aim of this review is to focus on the impact of both epilepsy and ASMs on appetite and weight in children. We systematically reviewed studies using Medline assessing the impact of ASMs on appetite and weight in children. Eligible st...
Source: Paediatric Drugs - May 20, 2022 Category: Pediatrics Authors: Ersida Buraniqi Hicham Dabaja Elaine C Wirrell Source Type: research
Stroke and Ischemic Heart Disease With Enzyme-inducing Antiseizure Medications: Time to Change Prescribing Habits
Conclusions and Relevance: The hazard of incident cardiovascular disease is higher in those receiving eiASMs. The association is dose dependent and the absolute difference in hazard seems to reach clinical significance by approximately 10 years from first exposure.PMID:35444497 | PMC:PMC8988723 | DOI:10.1177/15357597211070392 (Source: Epilepsy Currents)
Source: Epilepsy Currents - April 21, 2022 Category: Neurology Authors: David G Vossler Source Type: research
