Therapeutic Hypothermia for Neonatal Hypoxic –Ischemic Encephalopathy: Reducing Variability in Practice through a Collaborative Telemedicine Initiative
Conclusion This study shows that implementing a tele-educational program in neonatal neurocritical care is feasible and may decrease variability in the delivery of care to patients with HIE treated with TH.
Key Points
[...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - May 7, 2024 Category: Perinatology & Neonatology Authors: Leandro, Danieli M.K. Variane, Gabriel F.T. Dahlen, Alex Pietrobom, Rafaela F.R. de Castro, Jessica A.R.R. Rodrigues, Daniela P. Magalh ães, Mauricio Mimica, Marcelo J. Van Meurs, Krisa P. Chock, Valerie Y. Tags: Original Article Source Type: research
Pharmacokinetics and Pharmacodynamics of Standard Nerve Agent Medical Countermeasures in G öttingen Minipigs
Toxicol Lett. 2024 May 2:S0378-4274(24)00084-5. doi: 10.1016/j.toxlet.2024.04.014. Online ahead of print.ABSTRACTAnimal research continues to serve a critical role in the testing and development of medical countermeasures. The Göttingen minipig, developed for laboratory research, may provide many benefits for addressing research questions within chemical defense. Targeted development of the Göttingen minipig model could reduce reliance upon non-human primates, and improve study design, statistical power, and throughput to advance medical countermeasures for regulatory approval and fielding. In this vein, we completed fou...
Source: Toxicology Letters - May 4, 2024 Category: Toxicology Authors: Jeffrey L Langston Mark C Moffett M Ross Pennington Todd M Myers Source Type: research
Pharmacokinetics and Pharmacodynamics of Standard Nerve Agent Medical Countermeasures in G öttingen Minipigs
Toxicol Lett. 2024 May 2:S0378-4274(24)00084-5. doi: 10.1016/j.toxlet.2024.04.014. Online ahead of print.ABSTRACTAnimal research continues to serve a critical role in the testing and development of medical countermeasures. The Göttingen minipig, developed for laboratory research, may provide many benefits for addressing research questions within chemical defense. Targeted development of the Göttingen minipig model could reduce reliance upon non-human primates, and improve study design, statistical power, and throughput to advance medical countermeasures for regulatory approval and fielding. In this vein, we completed fou...
Source: Toxicology Letters - May 4, 2024 Category: Toxicology Authors: Jeffrey L Langston Mark C Moffett M Ross Pennington Todd M Myers Source Type: research
IJERPH, Vol. 21, Pages 595: Evaluating the Agreement between Oral, Armpit, and Ear Temperature Readings during Physical Activities in an Outdoor Setting
This study evaluated the agreement, correlation, and interchangeability of oral, axillary, and tympanic temperature measurements in outdoor exercise conditions. Systems developed for specific placements might generate different sensor readouts. Conducted as an observational field study, it involved 21 adult participants (11 males and 10 females, average age 25.14 ± 5.80 years) that underwent the Yo-Yo intermittent recovery test protocol on an outdoor court. The main outcomes measured were the agreement and correlation between temperature readings from the three methods, both before and after exercise. The re...
Source: International Journal of Environmental Research and Public Health - May 4, 2024 Category: Environmental Health Authors: Yuanzhe Zhao Leonardo de Almeida e Bueno David A. Holdsworth Jeroen H. M. Bergmann Tags: Article Source Type: research
Cool-shot Technique to Protect Spinal Cord During Thoracoabdominal Aortic Replacement
Thorac Cardiovasc Surg. 2024 May 3. doi: 10.1055/a-2318-5855. Online ahead of print.ABSTRACTDeep hypothermia helps protect the spinal cord, but is invasive. Here, we present a method to avoid reperfusion injury by selectively circulating cold blood under high pressure to the intercostal artery during reperfusion after intercostal artery reconstruction. Of the 23 patients who underwent thoracoabdominal aortic aneurysm open repair, one died. The motor evoked potential disappeared during aortic clamping in nine patients. Six patients recovered completely from aortic clamping release, two showed recovery >50% and one achiev...
Source: The Thoracic and Cardiovascular Surgeon - May 3, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Taira Yamamoto Daisuke Endo Yasutaka Yokoyama Minoru Tabata Source Type: research
Cool-shot Technique to Protect Spinal Cord During Thoracoabdominal Aortic Replacement
Thorac Cardiovasc Surg. 2024 May 3. doi: 10.1055/a-2318-5855. Online ahead of print.ABSTRACTDeep hypothermia helps protect the spinal cord, but is invasive. Here, we present a method to avoid reperfusion injury by selectively circulating cold blood under high pressure to the intercostal artery during reperfusion after intercostal artery reconstruction. Of the 23 patients who underwent thoracoabdominal aortic aneurysm open repair, one died. The motor evoked potential disappeared during aortic clamping in nine patients. Six patients recovered completely from aortic clamping release, two showed recovery >50% and one achiev...
Source: The Thoracic and Cardiovascular Surgeon - May 3, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Taira Yamamoto Daisuke Endo Yasutaka Yokoyama Minoru Tabata Source Type: research
Cool-shot Technique to Protect Spinal Cord During Thoracoabdominal Aortic Replacement
Thorac Cardiovasc Surg. 2024 May 3. doi: 10.1055/a-2318-5855. Online ahead of print.ABSTRACTDeep hypothermia helps protect the spinal cord, but is invasive. Here, we present a method to avoid reperfusion injury by selectively circulating cold blood under high pressure to the intercostal artery during reperfusion after intercostal artery reconstruction. Of the 23 patients who underwent thoracoabdominal aortic aneurysm open repair, one died. The motor evoked potential disappeared during aortic clamping in nine patients. Six patients recovered completely from aortic clamping release, two showed recovery >50% and one achiev...
Source: The Thoracic and Cardiovascular Surgeon - May 3, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Taira Yamamoto Daisuke Endo Yasutaka Yokoyama Minoru Tabata Source Type: research
Growth trajectories and need for oral feeding support among infants with neonatal encephalopathy treated with therapeutic hypothermia
Journal of Perinatology, Published online: 03 May 2024; doi:10.1038/s41372-024-01983-7Growth trajectories and need for oral feeding support among infants with neonatal encephalopathy treated with therapeutic hypothermia (Source: Journal of Perinatology)
Source: Journal of Perinatology - May 3, 2024 Category: Perinatology & Neonatology Authors: Jennifer Prial Hoda El-Shibiny Mohamed El-Dib Jennifer Benjamin Carmina Erdei Pamela Dodrill Eniko Szakmar Katherine A. Bell Source Type: research
Dexmedetomidine for analgesia and sedation in newborn infants receiving mechanical ventilation
CONCLUSIONS: Despite the increasing use of dexmedetomidine, there is insufficient evidence supporting its routine use for analgesia and sedation in newborn infants on mechanical ventilation. Furthermore, data on dexmedetomidine safety are scarce, and there are no data available on its long-term effects. Future studies should address the efficacy, safety, and long-term effects of dexmedetomidine as a single drug therapy for sedation and analgesia in newborn infants.PMID:38695625 | DOI:10.1002/14651858.CD012361.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - May 2, 2024 Category: General Medicine Authors: Jia Yi Lim Chin Jin Ker Nai Ming Lai Olga Romantsik Michelle Fiander Kenneth Tan Source Type: research
Dexmedetomidine for analgesia and sedation in newborn infants receiving mechanical ventilation
CONCLUSIONS: Despite the increasing use of dexmedetomidine, there is insufficient evidence supporting its routine use for analgesia and sedation in newborn infants on mechanical ventilation. Furthermore, data on dexmedetomidine safety are scarce, and there are no data available on its long-term effects. Future studies should address the efficacy, safety, and long-term effects of dexmedetomidine as a single drug therapy for sedation and analgesia in newborn infants.PMID:38695625 | DOI:10.1002/14651858.CD012361.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - May 2, 2024 Category: General Medicine Authors: Jia Yi Lim Chin Jin Ker Nai Ming Lai Olga Romantsik Michelle Fiander Kenneth Tan Source Type: research
Perioperative Hypothermia in Elderly Patients During Pelvic Floor Reconstruction Surgery: An Observational Study
ConclusionsThis observational prospective study identified several predictive factors for perioperative hypothermia in elderly patients during pelvic floor reconstruction surgery. Strategies aimed at preventing perioperative hypothermia should target these factors. Further studies are required to assess the effectiveness of these strategies, specifically in elderly patients undergoing pelvic floor reconstruction surgery. (Source: International Urogynecology Journal and Pelvic Floor Dysfunction)
Source: International Urogynecology Journal and Pelvic Floor Dysfunction - May 2, 2024 Category: OBGYN Source Type: research
Cirbp suppression compromises DHODH-mediated ferroptosis defense and attenuates hypothermic cardioprotection in an aged donor transplantation model
In this study, we examined whether hypothermic cardioprotection was attenuated in aged donor hearts during transplantation and evaluated potential therapeutic targets. Using a rat heart transplantation model, we found that hypothermic cardioprotection was impaired in aged donor hearts but preserved in young donor hearts. RNA-Seq showed that cold-inducible RNA-binding protein (Cirbp) expression was decreased in aged donor hearts, and these hearts showed severe ferroptosis after transplantation. The young donor hearts from Cirbp-KO rats exhibited attenuated hypothermic cardioprotection, but Cirbp overexpression in aged donor...
Source: Journal of Clinical Investigation - May 1, 2024 Category: Biomedical Science Authors: Yifan Zhu, Chenyu Jiang, Jian He, Chen He, Xingliang Zhou, Xu Huang, Yi Shen, Liwei Wu, Yongnan Li, Bei Feng, Yi Yan, Jun Li, Hao Zhang, Yiwei Liu Source Type: research
Trauma Diamond of Death: Adding Calcium to the Lethal Triad
In trauma patients, the triad of hypothermia, acidosis, and coagulopathy has been shown to cause an increase in morbidity and mortality. This lethal combination was first named the “bloody vicious cycle” in 1982 by the American Trauma Society when it was noted that the triad caused worsening hemorrhage and death.1 The triad is now used as the basis for damage control resuscitation in critically ill trauma patients. (Source: Journal of Emergency Nursing: JEN)
Source: Journal of Emergency Nursing: JEN - May 1, 2024 Category: Nursing Authors: Jessica Dawkins Mills Tags: Trauma Notebook Source Type: research
Cold-shock proteome of myoblasts reveals role of RBM3 in promotion of mitochondrial metabolism and myoblast differentiation
Commun Biol. 2024 Apr 30;7(1):515. doi: 10.1038/s42003-024-06196-4.ABSTRACTAdaptation to hypothermia is important for skeletal muscle cells under physiological stress and is used for therapeutic hypothermia (mild hypothermia at 32 °C). We show that hypothermic preconditioning at 32 °C for 72 hours improves the differentiation of skeletal muscle myoblasts using both C2C12 and primary myoblasts isolated from 3 month and 18-month-old mice. We analyzed the cold-shock proteome of myoblasts exposed to hypothermia (32 °C for 6 and 48 h) and identified significant changes in pathways related to RNA processing and central carbon...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Paulami Dey Srujanika Rajalaxmi Pushpita Saha Purvi Singh Thakur Maroof Athar Hashmi Heera Lal Nistha Saini Nirpendra Singh Arvind Ramanathan Source Type: research
Agreement between three noninvasive temperature monitoring devices during spinal anaesthesia for caesarean delivery: a prospective observational study
This study aimed to compare a noninvasive core temperature monitor with two readily available peripheral temperature monitors during obstetric spinal anaesthesia. We undertook a prospective observational study including elective and emergency caesarean deliveries, to determine the agreement between affordable reusable surface temperature monitors (Welch Allyn SureTemp ® Plus oral thermometer and the Braun 3-in-1 No Touch infrared thermometer) and the Dräger T-core© (using dual-sensor heat flux technology), in detecting thermoregulatory changes during obstetric spinal anaesthesia. Predetermined clinically relevant limits...
Source: Journal of Clinical Monitoring and Computing - April 30, 2024 Category: Information Technology Source Type: research
