Dexmedetomidine for analgesia and sedation in newborn infants receiving mechanical ventilation
CONCLUSIONS: Despite the increasing use of dexmedetomidine, there is insufficient evidence supporting its routine use for analgesia and sedation in newborn infants on mechanical ventilation. Furthermore, data on dexmedetomidine safety are scarce, and there are no data available on its long-term effects. Future studies should address the efficacy, safety, and long-term effects of dexmedetomidine as a single drug therapy for sedation and analgesia in newborn infants.PMID:38695625 | DOI:10.1002/14651858.CD012361.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - May 2, 2024 Category: General Medicine Authors: Jia Yi Lim Chin Jin Ker Nai Ming Lai Olga Romantsik Michelle Fiander Kenneth Tan Source Type: research
Perioperative Hypothermia in Elderly Patients During Pelvic Floor Reconstruction Surgery: An Observational Study
ConclusionsThis observational prospective study identified several predictive factors for perioperative hypothermia in elderly patients during pelvic floor reconstruction surgery. Strategies aimed at preventing perioperative hypothermia should target these factors. Further studies are required to assess the effectiveness of these strategies, specifically in elderly patients undergoing pelvic floor reconstruction surgery. (Source: International Urogynecology Journal and Pelvic Floor Dysfunction)
Source: International Urogynecology Journal and Pelvic Floor Dysfunction - May 2, 2024 Category: OBGYN Source Type: research
Cirbp suppression compromises DHODH-mediated ferroptosis defense and attenuates hypothermic cardioprotection in an aged donor transplantation model
In this study, we examined whether hypothermic cardioprotection was attenuated in aged donor hearts during transplantation and evaluated potential therapeutic targets. Using a rat heart transplantation model, we found that hypothermic cardioprotection was impaired in aged donor hearts but preserved in young donor hearts. RNA-Seq showed that cold-inducible RNA-binding protein (Cirbp) expression was decreased in aged donor hearts, and these hearts showed severe ferroptosis after transplantation. The young donor hearts from Cirbp-KO rats exhibited attenuated hypothermic cardioprotection, but Cirbp overexpression in aged donor...
Source: Journal of Clinical Investigation - May 1, 2024 Category: Biomedical Science Authors: Yifan Zhu, Chenyu Jiang, Jian He, Chen He, Xingliang Zhou, Xu Huang, Yi Shen, Liwei Wu, Yongnan Li, Bei Feng, Yi Yan, Jun Li, Hao Zhang, Yiwei Liu Source Type: research
Trauma Diamond of Death: Adding Calcium to the Lethal Triad
In trauma patients, the triad of hypothermia, acidosis, and coagulopathy has been shown to cause an increase in morbidity and mortality. This lethal combination was first named the “bloody vicious cycle” in 1982 by the American Trauma Society when it was noted that the triad caused worsening hemorrhage and death.1 The triad is now used as the basis for damage control resuscitation in critically ill trauma patients. (Source: Journal of Emergency Nursing: JEN)
Source: Journal of Emergency Nursing: JEN - May 1, 2024 Category: Nursing Authors: Jessica Dawkins Mills Tags: Trauma Notebook Source Type: research
Cold-shock proteome of myoblasts reveals role of RBM3 in promotion of mitochondrial metabolism and myoblast differentiation
Commun Biol. 2024 Apr 30;7(1):515. doi: 10.1038/s42003-024-06196-4.ABSTRACTAdaptation to hypothermia is important for skeletal muscle cells under physiological stress and is used for therapeutic hypothermia (mild hypothermia at 32 °C). We show that hypothermic preconditioning at 32 °C for 72 hours improves the differentiation of skeletal muscle myoblasts using both C2C12 and primary myoblasts isolated from 3 month and 18-month-old mice. We analyzed the cold-shock proteome of myoblasts exposed to hypothermia (32 °C for 6 and 48 h) and identified significant changes in pathways related to RNA processing and central carbon...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Paulami Dey Srujanika Rajalaxmi Pushpita Saha Purvi Singh Thakur Maroof Athar Hashmi Heera Lal Nistha Saini Nirpendra Singh Arvind Ramanathan Source Type: research
Agreement between three noninvasive temperature monitoring devices during spinal anaesthesia for caesarean delivery: a prospective observational study
This study aimed to compare a noninvasive core temperature monitor with two readily available peripheral temperature monitors during obstetric spinal anaesthesia. We undertook a prospective observational study including elective and emergency caesarean deliveries, to determine the agreement between affordable reusable surface temperature monitors (Welch Allyn SureTemp ® Plus oral thermometer and the Braun 3-in-1 No Touch infrared thermometer) and the Dräger T-core© (using dual-sensor heat flux technology), in detecting thermoregulatory changes during obstetric spinal anaesthesia. Predetermined clinically relevant limits...
Source: Journal of Clinical Monitoring and Computing - April 30, 2024 Category: Information Technology Source Type: research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hypothermia and Hypoxia and Impact of Mother's Milk on Incidence of Disease
CONCLUSIONS The modified experimental NEC model based on formula feeding and single exposure to hypothermia and hypoxia was assessed statistically and histologically. In this model, mother's milk had a protective effect against necrotizing enterocolitis.PMID:38678319 | DOI:10.12659/MSM.943443 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 28, 2024 Category: Research Authors: Marek Wolski Source Type: research
Hypothermia protects the integrity of corticospinal tracts and alleviates mitochondria injury after intracerebral hemorrhage in mice
In this study, we employed a chemogenetics approach to selectively activate bilateral warm-sensitive neurons in the preoptic areas to induce a hypothermia-like state. We then assessed effects of HT treatment on the integrity of CST and motor functional recovery after ICH. Our results showed that HT treatment significantly alleviated axonal degeneration around the hematoma and the CST axons at remote midbrain region, ultimately promoted skilled motor function recovery. Anterograde and retrograde tracing revealed that HT treatment protected the integrity of the CST over an extended period. Mechanistically, HT treatment preve...
Source: Experimental Neurology - April 28, 2024 Category: Neurology Authors: Eryi Sun Siyuan Lu Chuanyan Yang Zheng Li Yu Qian Yue Chen Siyuan Chen Xiaodong Ma Yan Deng Xiuhong Shan Bo Chen Source Type: research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hypothermia and Hypoxia and Impact of Mother's Milk on Incidence of Disease
CONCLUSIONS The modified experimental NEC model based on formula feeding and single exposure to hypothermia and hypoxia was assessed statistically and histologically. In this model, mother's milk had a protective effect against necrotizing enterocolitis.PMID:38678319 | DOI:10.12659/MSM.943443 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 28, 2024 Category: Research Authors: Marek Wolski Source Type: research
Hypothermia protects the integrity of corticospinal tracts and alleviates mitochondria injury after intracerebral hemorrhage in mice
In this study, we employed a chemogenetics approach to selectively activate bilateral warm-sensitive neurons in the preoptic areas to induce a hypothermia-like state. We then assessed effects of HT treatment on the integrity of CST and motor functional recovery after ICH. Our results showed that HT treatment significantly alleviated axonal degeneration around the hematoma and the CST axons at remote midbrain region, ultimately promoted skilled motor function recovery. Anterograde and retrograde tracing revealed that HT treatment protected the integrity of the CST over an extended period. Mechanistically, HT treatment preve...
Source: Experimental Neurology - April 28, 2024 Category: Neurology Authors: Eryi Sun Siyuan Lu Chuanyan Yang Zheng Li Yu Qian Yue Chen Siyuan Chen Xiaodong Ma Yan Deng Xiuhong Shan Bo Chen Source Type: research
Inequalities in birth before arrival at hospital in South West England: a multimethods study of neonatal hypothermia and emergency medical services call-handler advice
Conclusions
Findings identified factors associated with BBA and neonatal hypothermia following BBA. Improvements to EMS call-handler advice could reduce the number of babies arriving at hospital hypothermic. (Source: BMJ Open)
Source: BMJ Open - April 28, 2024 Category: General Medicine Authors: Goodwin, L., Kirby, K., McClelland, G., Beach, E., Bedson, A., Benger, J. R., Deave, T., Osborne, R., McAdam, H., McKeon-Carter, R., Miller, N., Taylor, H., Voss, S. Tags: Open access, Emergency medicine Source Type: research
Hypothermia as Potential Therapeutic Approach to Attenuating Soman-Induced Seizure, Neuropathology, and Mortality with an Adenosine A < sub > 1 < /sub > Receptor Agonist and Body Cooling
Neuropharmacology. 2024 Apr 25:109966. doi: 10.1016/j.neuropharm.2024.109966. Online ahead of print.ABSTRACTOrganophosphorus nerve agents, such as soman (GD), produce excitotoxic effects resulting in sustained status epilepticus (SSE) and brain damage. Previous work shows that neuronal inhibitory effects of A1 adenosine receptor (A1AR) agonists, such as N6- Bicyclo(2.2.1)-hept-2-yl-5'-chloro-5'-deoxyadenosine (Cl-ENBA), suppresses GD-induced SSE and improves neuropathology. Some other physiologic effects of these agonists are hypothermia, hypotension, and sedation. Hypothermia may also shield the brain from injury by slowi...
Source: Neuropharmacology - April 27, 2024 Category: Drugs & Pharmacology Authors: Crystal Munoz Cindy Acon-Chen Zora-Maya Keith Tsung-Ming Shih Source Type: research
Hypothermia as Potential Therapeutic Approach to Attenuating Soman-Induced Seizure, Neuropathology, and Mortality with an Adenosine A < sub > 1 < /sub > Receptor Agonist and Body Cooling
Neuropharmacology. 2024 Apr 25:109966. doi: 10.1016/j.neuropharm.2024.109966. Online ahead of print.ABSTRACTOrganophosphorus nerve agents, such as soman (GD), produce excitotoxic effects resulting in sustained status epilepticus (SSE) and brain damage. Previous work shows that neuronal inhibitory effects of A1 adenosine receptor (A1AR) agonists, such as N6- Bicyclo(2.2.1)-hept-2-yl-5'-chloro-5'-deoxyadenosine (Cl-ENBA), suppresses GD-induced SSE and improves neuropathology. Some other physiologic effects of these agonists are hypothermia, hypotension, and sedation. Hypothermia may also shield the brain from injury by slowi...
Source: Neuropharmacology - April 27, 2024 Category: Drugs & Pharmacology Authors: Crystal Munoz Cindy Acon-Chen Zora-Maya Keith Tsung-Ming Shih Source Type: research
Therapeutic Hypothermia Compared with Normothermia in Adults with Traumatic Brain Injury; Functional Outcome, Mortality, and Adverse Effects: A Systematic Review and Meta-Analysis
ConclusionsWith the addition of several recent randomized clinical trials and a thorough quality assessment, we have provided an updated systematic review and meta-analysis that concludes that TH does not show any benefit over normothermia in terms of mortality and functional outcome. (Source: Neurocritical Care)
Source: Neurocritical Care - April 25, 2024 Category: Neurology Source Type: research
