Gestational diabetes mellitus induces congenital anomalies of the kidney and urinary tract in mice by altering RET/MAPK/ERK pathway
In this study, we established a GDM mouse model to investigate the embryological alterations and molecular mechanisms underlying the development of congenital anomalies of the kidney and urinary tract (CAKUT) affected by GDM. Our study highlights that GDM could contribute to the manifestation of CAKUT, with prevalent phenotypes characterized by isolated hydronephrosis and duplex kidney complicated with hydronephrosis in mice. Ectopic ureteric buds (UBs) and extended length of common nephric ducts (CNDs) were noted in the metanephric development stage. The expression of Ret and downstream p-ERK activity were enhanced in UBs...
Source: Biochemical and Biophysical Research communications - April 24, 2024 Category: Biochemistry Authors: Haixin Ju Minghui Yu Xuanjin Du Shanshan Xue Ningli Ye Lei Sun Xiaohui Wu Hong Xu Qian Shen Source Type: research
Correspondence to - “A machine learning algorithm predicting risk of dilating VUR among infants with hydronephrosis using UTD classification”
We recently read the paper by Wang et al. with great interest, which is a single institutional study with 280 patients (540 renal units) using a machine learning-based model to differentiate which patients with prenatal hydronephrosis are most likely to “benefit” from VCUG, i.e., most likely to have high-grade reflux [1]. With the advent of better imaging techniques and greater awareness regarding routine prenatal imaging, the incidence of antenatally diagnosed cases of hydronephrosis has been increasing over the past decade. (Source: Journal of Pediatric Urology)
Source: Journal of Pediatric Urology - April 20, 2024 Category: Urology & Nephrology Authors: Somya Bhatt, Arvind Sinha, Manish Pathak, Kirti Kumar Rathod Source Type: research
Predicting the Efficacy of Repeated Shockwave Lithotripsy for Treating Patients with Upper Urinary Tract Calculi Using an Artificial Neural Network Model
CONCLUSION: Establishing an ANN model for repeated SWL of UUTC is crucial for optimizing patient care. This model will be pivotal in providing accurate treatment plans for patients with an initial unsuccessful SWL treatment. Moreover, it can significantly enhance the success rate of subsequent SWL treatments, ultimately alleviating patients' treatment burden.PMID:38629197 (Source: Urology Journal)
Source: Urology Journal - April 17, 2024 Category: Urology & Nephrology Authors: Zhongfan Peng Mingjun Wen Yunfei Li Tao He Jiao Wang Taotao Zhang Source Type: research
Predicting the Efficacy of Repeated Shockwave Lithotripsy for Treating Patients with Upper Urinary Tract Calculi Using an Artificial Neural Network Model
CONCLUSION: Establishing an ANN model for repeated SWL of UUTC is crucial for optimizing patient care. This model will be pivotal in providing accurate treatment plans for patients with an initial unsuccessful SWL treatment. Moreover, it can significantly enhance the success rate of subsequent SWL treatments, ultimately alleviating patients' treatment burden.PMID:38629197 (Source: Urology Journal)
Source: Urology Journal - April 17, 2024 Category: Urology & Nephrology Authors: Zhongfan Peng Mingjun Wen Yunfei Li Tao He Jiao Wang Taotao Zhang Source Type: research
Predicting the Efficacy of Repeated Shockwave Lithotripsy for Treating Patients with Upper Urinary Tract Calculi Using an Artificial Neural Network Model
CONCLUSION: Establishing an ANN model for repeated SWL of UUTC is crucial for optimizing patient care. This model will be pivotal in providing accurate treatment plans for patients with an initial unsuccessful SWL treatment. Moreover, it can significantly enhance the success rate of subsequent SWL treatments, ultimately alleviating patients' treatment burden.PMID:38629197 (Source: Urology Journal)
Source: Urology Journal - April 17, 2024 Category: Urology & Nephrology Authors: Zhongfan Peng Mingjun Wen Yunfei Li Tao He Jiao Wang Taotao Zhang Source Type: research
Single-port robot-assisted pyeloplasty using the da vinci SP system versus multiport pyeloplasty: Comparison of outcomes and costs
CONCLUSION: SP-pyeloplasty showed cosmetic benefits, lower blood loss, operative time, and console time compared with MP-pyeloplasty. In patients who underwent surgery for UPJO for the first time, SP surgery can show comparable outcomes when compared to MP surgery.PMID:38614849 | DOI:10.1016/j.asjsur.2024.03.175 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 13, 2024 Category: Surgery Authors: Ji Eun Heo Hyun Ho Han Jongsoo Lee Young Deuk Choi Won Sik Jang Source Type: research
Ureteral stricture rate after endoscopic treatments for urolithiasis and related risk factors: systematic review and meta-analysis
ConclusionsThe overall US rate ranges from 0.3 to 4.9%, with an increasing trend in the last few years. It is influenced by type of treatment, stone location and impaction, preoperative hydronephrosis and intraoperative perforation. Future standardized reporting and prospective and more extended follow-up studies might contribute to a better understanding of US risks related to calculi treatment. (Source: World Journal of Urology)
Source: World Journal of Urology - April 13, 2024 Category: Urology & Nephrology Source Type: research
Isolated Hydronephrosis and Urinary Tract Infection by Two Years of Age: A Population-Based Study
To evaluate the risk for urinary tract infection (UTI) in infants with isolated hydronephrosis (IH). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - April 11, 2024 Category: Pediatrics Authors: Gilad Hamdani, Noga Yaniv MHI, Shoval Marton, Yael Borovitz, Shelly Levi, Daniel Landau, Amit Dagan Tags: Original Articles Source Type: research
Percutaneous Nephrostomy as a Procedure in the Treatment of Urinary Tract Obstruction - Experiences in the University Clinic of Urology in Skopje
CONCLUSION: Percutaneous nephrostomy is a safe and effective treatment option for urinary tract obstruction, especially in patients with malignancies. Continuous monitoring is essential to assess long-term complications and the longevity of PNS functionality. This procedure offers a significant benefit in preserving renal function and minimizing the need for hemodialysis in these patients.PMID:38575377 | DOI:10.2478/prilozi-2024-0004 (Source: Molecular Medicine)
Source: Molecular Medicine - April 4, 2024 Category: Molecular Biology Authors: Aleksandar Trifunovski Galina Severova Ana Atanasova Josif Janculev Viktor Stankov Sotir Stavridis Skender Saidi Aleksandra Gavrilovska Brzanov Martina Ambardjieva Sasho Dohchev Source Type: research
Comparison of safety and efficacy of tubeless vs. conventional mini percutaneous nephrolithotomy in patients with Escherichia coli bacteriuria
AbstractTo evaluate the safety and efficacy of tubeless percutaneous nephrolithotomy (PCNL) in patients with Escherichia coli (E. coli) bacteriuria. We conducted a retrospective review of 84 patients with E. coli bacteriuria who underwent PCNL. Patients were divided into two groups according to whether a nephrostomy tube is placed at the end of the procedure. Preoperative clinical data, surgical outcomes, and postoperative complications were compared. Then, regression analysis of factors predicting success rate of PCNL in patients with E. coli bacteriuria was performed. After PCNL, residual fragments ≤ 4 mm were co...
Source: Urolithiasis - April 3, 2024 Category: Urology & Nephrology Source Type: research
Variation coefficient of stone density and renal cortical thickness: the parameters evaluating non-contrast computed tomography imaging for predict extracorporeal shock wave lithotripsy success
This study demonstrated that VCSD value and RCT are predictive parameters in determining the treatment of patients with urinary calculi and selecting suitable ESWL candidates. (Source: Urolithiasis)
Source: Urolithiasis - April 2, 2024 Category: Urology & Nephrology Source Type: research
Area of hydronephrosis is a useful predictive factor of impacted ureteral stones
AbstractUreteroscopic lithotripsy for impacted stones is challenging, but it is important to predict impacted stones preoperatively. Hydronephrosis, which is evaluated by a grading system, is often apparent in impacted stones. However, the currently used grading system is a qualitative evaluation. We, therefore, focused on aquantitative evaluation: the area of hydronephrosis. The aim of this study was to investigate whether the area of hydronephrosis could predict impacted stones more accurately than Society for Fetal Urology grade. We retrospectively identified 160 patients who underwent ureteroscopic lithotripsy for uret...
Source: Urolithiasis - April 2, 2024 Category: Urology & Nephrology Source Type: research
Variation coefficient of stone density and renal cortical thickness: the parameters evaluating non-contrast computed tomography imaging for predict extracorporeal shock wave lithotripsy success
This study demonstrated that VCSD value and RCT are predictive parameters in determining the treatment of patients with urinary calculi and selecting suitable ESWL candidates. (Source: Urolithiasis)
Source: Urolithiasis - April 2, 2024 Category: Urology & Nephrology Source Type: research
Area of hydronephrosis is a useful predictive factor of impacted ureteral stones
AbstractUreteroscopic lithotripsy for impacted stones is challenging, but it is important to predict impacted stones preoperatively. Hydronephrosis, which is evaluated by a grading system, is often apparent in impacted stones. However, the currently used grading system is a qualitative evaluation. We, therefore, focused on aquantitative evaluation: the area of hydronephrosis. The aim of this study was to investigate whether the area of hydronephrosis could predict impacted stones more accurately than Society for Fetal Urology grade. We retrospectively identified 160 patients who underwent ureteroscopic lithotripsy for uret...
Source: Urolithiasis - April 2, 2024 Category: Urology & Nephrology Source Type: research
