Follow-Up: Effects of a Pandemic and Isolation on Alcohol and Psychoactive Medication Use in a Population of Rehabilitation and Pain Patients
CONCLUSION: In summary, these findings demonstrate relatively consistent drug use, with decreased positivity for high-risk drugs and dangerous drug combinations. We speculate that monitoring of these patients mitigates the possibility of drug misuse and potential overdose and is in concordance with the goals of these monitoring programs.PMID:36564077 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - December 23, 2022 Category: Laboratory Medicine Authors: Amadeo Pesce Raymond T Suhandynata Dennis Ritz Richard Thomas Gregory Ackerman Katie Bollman Source Type: research
Follow-Up: Effects of a Pandemic and Isolation on Alcohol and Psychoactive Medication Use in a Population of Rehabilitation and Pain Patients
CONCLUSION: In summary, these findings demonstrate relatively consistent drug use, with decreased positivity for high-risk drugs and dangerous drug combinations. We speculate that monitoring of these patients mitigates the possibility of drug misuse and potential overdose and is in concordance with the goals of these monitoring programs.PMID:36564077 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - December 23, 2022 Category: Laboratory Medicine Authors: Amadeo Pesce Raymond T Suhandynata Dennis Ritz Richard Thomas Gregory Ackerman Katie Bollman Source Type: research
Follow-Up: Effects of a Pandemic and Isolation on Alcohol and Psychoactive Medication Use in a Population of Rehabilitation and Pain Patients
CONCLUSION: In summary, these findings demonstrate relatively consistent drug use, with decreased positivity for high-risk drugs and dangerous drug combinations. We speculate that monitoring of these patients mitigates the possibility of drug misuse and potential overdose and is in concordance with the goals of these monitoring programs.PMID:36564077 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - December 23, 2022 Category: Laboratory Medicine Authors: Amadeo Pesce Raymond T Suhandynata Dennis Ritz Richard Thomas Gregory Ackerman Katie Bollman Source Type: research
Follow-Up: Effects of a Pandemic and Isolation on Alcohol and Psychoactive Medication Use in a Population of Rehabilitation and Pain Patients
CONCLUSION: In summary, these findings demonstrate relatively consistent drug use, with decreased positivity for high-risk drugs and dangerous drug combinations. We speculate that monitoring of these patients mitigates the possibility of drug misuse and potential overdose and is in concordance with the goals of these monitoring programs.PMID:36564077 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - December 23, 2022 Category: Laboratory Medicine Authors: Amadeo Pesce Raymond T Suhandynata Dennis Ritz Richard Thomas Gregory Ackerman Katie Bollman Source Type: research
Follow-Up: Effects of a Pandemic and Isolation on Alcohol and Psychoactive Medication Use in a Population of Rehabilitation and Pain Patients
CONCLUSION: In summary, these findings demonstrate relatively consistent drug use, with decreased positivity for high-risk drugs and dangerous drug combinations. We speculate that monitoring of these patients mitigates the possibility of drug misuse and potential overdose and is in concordance with the goals of these monitoring programs.PMID:36564077 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - December 23, 2022 Category: Laboratory Medicine Authors: Amadeo Pesce Raymond T Suhandynata Dennis Ritz Richard Thomas Gregory Ackerman Katie Bollman Source Type: research
Follow-Up: Effects of a Pandemic and Isolation on Alcohol and Psychoactive Medication Use in a Population of Rehabilitation and Pain Patients
CONCLUSION: In summary, these findings demonstrate relatively consistent drug use, with decreased positivity for high-risk drugs and dangerous drug combinations. We speculate that monitoring of these patients mitigates the possibility of drug misuse and potential overdose and is in concordance with the goals of these monitoring programs.PMID:36564077 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - December 23, 2022 Category: Laboratory Medicine Authors: Amadeo Pesce Raymond T Suhandynata Dennis Ritz Richard Thomas Gregory Ackerman Katie Bollman Source Type: research
A preliminary study of hydrocodone and hydromorphone to oxycodone ratios for distinguishing impurities from independent opioid use
Clin Biochem. 2022 Dec 16:S0009-9120(22)00279-X. doi: 10.1016/j.clinbiochem.2022.12.009. Online ahead of print.NO ABSTRACTPMID:36535386 | DOI:10.1016/j.clinbiochem.2022.12.009 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - December 19, 2022 Category: Biochemistry Authors: Ibrahim Choucair Cristina Figueroa Villalba Michael A Vera Gina Cassella-Mclane Thomas J S Durant Joe M El-Khoury Source Type: research
A preliminary study of hydrocodone and hydromorphone to oxycodone ratios for distinguishing impurities from independent opioid use
Clin Biochem. 2022 Dec 16:S0009-9120(22)00279-X. doi: 10.1016/j.clinbiochem.2022.12.009. Online ahead of print.NO ABSTRACTPMID:36535386 | DOI:10.1016/j.clinbiochem.2022.12.009 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - December 19, 2022 Category: Biochemistry Authors: Ibrahim Choucair Cristina Figueroa Villalba Michael A Vera Gina Cassella-Mclane Thomas J S Durant Joe M El-Khoury Source Type: research
A preliminary study of hydrocodone and hydromorphone to oxycodone ratios for distinguishing impurities from independent opioid use
CONCLUSIONS: Hydrocodone and/or hydromorphone are detectable in patients taking only oxycodone and can likely be identified as an impurity if their calculated ratio to oxycodone is <1 %. Further validation of the ratios in a larger sample size is recommended.PMID:36535386 | DOI:10.1016/j.clinbiochem.2022.12.009 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - December 19, 2022 Category: Biochemistry Authors: Ibrahim Choucair Cristina Figueroa Villalba Michael A Vera Gina Cassella-Mclane Thomas J S Durant Joe M El-Khoury Source Type: research
Recent advances in the detection of drugs of abuse by Dried Blood Spots
Biomed Chromatogr. 2022 Nov 23:e5555. doi: 10.1002/bmc.5555. Online ahead of print.ABSTRACTPurpose of this review study is to sum up the main recent advances reported in the scientific literature about the detection of common drugs of abuse in biological samples upon their collection by Dried Blood Spot (DBS) devices. The most recent, innovative and fully validated methods for the qualitative and/or quantitative detection of common drugs of abuse are reported, including alprazolam, clonazepam, diazepam, 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA), 3,4-methyl- enedioxyethylamphetamine (MDEA...
Source: Biomedical Chromatography : BMC - November 23, 2022 Category: Biomedical Science Authors: Christina Ververi Marco Vincenti Alberto Salomone Source Type: research
Recent advances in the detection of drugs of abuse by Dried Blood Spots
Biomed Chromatogr. 2022 Nov 23:e5555. doi: 10.1002/bmc.5555. Online ahead of print.ABSTRACTPurpose of this review study is to sum up the main recent advances reported in the scientific literature about the detection of common drugs of abuse in biological samples upon their collection by Dried Blood Spot (DBS) devices. The most recent, innovative and fully validated methods for the qualitative and/or quantitative detection of common drugs of abuse are reported, including alprazolam, clonazepam, diazepam, 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA), 3,4-methyl- enedioxyethylamphetamine (MDEA...
Source: Biomedical Chromatography : BMC - November 23, 2022 Category: Biomedical Science Authors: Christina Ververi Marco Vincenti Alberto Salomone Source Type: research
Drug–drug–gene interaction risk among opioid users in the U.S. Department of Veterans Affairs
Response to analgesic therapy is influenced by several factors including genetics and drug–drug interactions. Pharmacogenetic (PGx) variants in the CYP2D6 gene modify response to opioids by altering drug metabolism. We sought to determine the potential impact of PGx testing on the care of Veterans with noncancer pain prescribed opioids metabolized by CYP2D6 (codeine, hydrocodone, or tramadol). A retrospective analysis was performed within the Veterans Health Administration evaluating prescription records for pain medications metabolized by CYP2D6 and interacting drugs from 2012 to 2017. Among 2,436,654 Veterans Health Ad...
Source: Pain - November 21, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Association of Opioid Type With Opioid Consumption After Surgery
Conclusions:
Although patients prescribed hydrocodone consumed more tablets than patients prescribed oxycodone, this difference was not clinically significant and did not result in differences in satisfaction, pain, or refills. Perioperative opioid prescribing guidelines may recommend the same number of 5 mg oxycodone and hydrocodone tablets without sacrificing patient-reported outcomes. (Source: Annals of Surgery)
Source: Annals of Surgery - November 14, 2022 Category: Surgery Tags: Original Articles Source Type: research
Heroin and fentanyl in Dallas County: A 5-year retrospective review of toxicological, seized drug, and demographical data
J Forensic Sci. 2022 Oct 27. doi: 10.1111/1556-4029.15155. Online ahead of print.ABSTRACTThe opioid epidemic resulted in an increase in identifications of fentanyl, fentanyl analogs, and heroin, among other opioids, in the toxicology and seized drug analysis fields over the past several years. The Dallas County Southwestern Institute of Forensic Sciences, comprised of the Toxicology Laboratory and Drug Analysis Laboratory, observed a rise in fentanyl-positive analyses in both laboratories. Fentanyl positivity increased from 1.1% to 3.4% in the Toxicology Laboratory over the five years of this study, whereas 6-monoacetylmor...
Source: Journal of Forensic Sciences - October 28, 2022 Category: Forensic Medicine Authors: Lindsay Glicksberg Sara K Dempsey Brittany K Casey Source Type: research
CYP2D in the brain impacts oral hydrocodone analgesia in vivo
Neuropharmacology. 2022 Oct 11:109291. doi: 10.1016/j.neuropharm.2022.109291. Online ahead of print.ABSTRACTCytochrome P450 2D (CYP2D) metabolises many centrally-acting substrates including opioids. Hydrocodone, an opioid and CYP2D substrate, is metabolised to hydromorphone, an active metabolite. CYP2D in the brain is active in vivo and can alter drug response however, it is unknown whether metabolism by CYP2D in the brain alters oral hydrocodone induced analgesia. Propranolol, a selective CYP2D mechanism-based inhibitor, or vehicle, was administered into the right cerebral ventricle of male rats, (HAN Wistars, Envigo), 24...
Source: Neuropharmacology - October 14, 2022 Category: Drugs & Pharmacology Authors: Janielle Richards Sharon Miksys Maria Novalen Rachel F Tyndale Source Type: research
