Comparative Risk of Injury with Concurrent Use of Opioids and Skeletal Muscle Relaxants
In conclusion, the relative injury rate associated with different SMRs used concurrently with the three most dispensed opioids appears to vary depending on the specific opioid and the order of combination initiation. If confirmed by future studies, clinicians should consider the varying injury rates when prescribing SMRs to individuals using hydrocodone, oxycodone, and tramadol.PMID:38482733 | DOI:10.1002/cpt.3248 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - March 14, 2024 Category: Drugs & Pharmacology Authors: Cheng Chen Sean Hennessy Colleen M Brensinger Todd A Miano Warren B Bilker Sascha Dublin Sophie P Chung John R Horn Anika Tiwari Charles E Leonard Source Type: research
Comparative Risk of Injury with Concurrent Use of Opioids and Skeletal Muscle Relaxants
In conclusion, the relative injury rate associated with different SMRs used concurrently with the three most dispensed opioids appears to vary depending on the specific opioid and the order of combination initiation. If confirmed by future studies, clinicians should consider the varying injury rates when prescribing SMRs to individuals using hydrocodone, oxycodone, and tramadol.PMID:38482733 | DOI:10.1002/cpt.3248 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - March 14, 2024 Category: Drugs & Pharmacology Authors: Cheng Chen Sean Hennessy Colleen M Brensinger Todd A Miano Warren B Bilker Sascha Dublin Sophie P Chung John R Horn Anika Tiwari Charles E Leonard Source Type: research
“We agreed we would both die”: Navigating Ethical Complexities in Suicide Attempts in Older Adults
Mr. Smith was an 80-year-old man admitted to the inpatient medicine service following a suicide attempt by ingestion of an unknown amount of hydrocodone-acetaminophen and alcohol. The patient was transported by ambulance, accompanied by his daughter. His daughter was also his appointed medical power of attorney and had a copy of the patient's advance directive, where he had indicated his wish not to be resuscitated (DNR) in case of a life-threatening emergency.Soon after his arrival to the hospital, a dramatic series of events unfolded. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - February 18, 2024 Category: Geriatrics Authors: Michael Ward Source Type: research
News at a glance: Mars helicopter ’s final flight, grants for U.K. diversity, and a nonopioid pain drug
PLANETARY SCIENCE
Breakdown finally grounds Mars helicopter
After 72 flights on Mars—67 more than originally planned—NASA’s Ingenuity helicopter flew its final sortie last month. The tiny helicopter (above), a technology demonstration deployed from the Perseverance rover, lasted for 3 years, covering 17 kilometers during more than 2 hours of flight, until at least one of its carbon-fiber blades fractured during a crash landing. Ingenuity served as a scout for Perseverance as it climbed toward the rim of Jezero crater, helping it avoid hazardous terrain and collect rock samples. The mission coul...
Source: Science of Aging Knowledge Environment - February 1, 2024 Category: Geriatrics Source Type: research
Hydrocodone
(Source: Reactions Weekly)
Source: Reactions Weekly - January 1, 2024 Category: Drugs & Pharmacology Source Type: research
Barriers and Best Practices on the Management of Opioid Use Disorder
This article provides an overview of the pharmacology of heroin and non-prescription fentanyl (NPF) and its synthetic analogues, and summarizes the literature related to the management of opioid use disorder, overdose, and withdrawal. This is followed by a description of barriers to treatment and best practices for management with a discussion on recent updates and their potential impact on this patient population. This is followed by a description of barriers to treatment and best practices for management with a discussion on recent updates and their potential impact on this patient population.PMID:38100521 | DOI:10.1080/...
Source: Journal of Pain and Palliative Care Pharmacotherapy - December 15, 2023 Category: Palliative Care Authors: Michelle Krichbaum Daniela Fernandez Devada Singh-Franco Source Type: research
Contextualising opioid-related risk factors before an initial opioid prescription
When asked about the similarities between the region of Valencia, Spain and the State of Oregon in the USA, an artificial-intelligence (AI)-driven chatbot poetically listed several common features, such as natural beauty, strong focus on agricultural industries including wine production, extensive outdoor activities and a shared commitment to sustainable practices. But are there similarities in healthcare delivery, considering vastly different systems and significant practice variability, particularly regarding the management of pain and the role of opioid analgesics? Here, the differences emerge. Oxycodone and hydrocodone...
Source: BMJ Quality and Safety - December 14, 2023 Category: General Medicine Authors: Weiner, S. G., Hoppe, J. A. Tags: Editorials Source Type: research
Leveraging the functionality of Research Electronic Data Capture (REDCap) to enhance data collection and quality in the Opioid Analgesic Reduction Study
CONCLUSION: Research Electronic Data Capture is an effective digital health technology that can be maximized to contribute to the success of a clinical trial. The Research Electronic Data Capture infrastructure and enhanced functionality used in Opioid Analgesic Reduction Study provides the framework and the logic that ensures complete, accurate, data while guiding an effective, efficient workflow that can be followed by team members across sites. This enhanced data reliability and comprehensive quality management processes allow for better preparedness and readiness for clinical monitoring and regulatory reporting.PMID:37...
Source: Clinical Trials - November 14, 2023 Category: Research Authors: Janine Fredericks-Younger Patricia Greenberg Tracy Andrews Pamela B Matheson Paul J Desjardins Shou-En Lu Cecile A Feldman Source Type: research
Leveraging the functionality of Research Electronic Data Capture (REDCap) to enhance data collection and quality in the Opioid Analgesic Reduction Study
CONCLUSION: Research Electronic Data Capture is an effective digital health technology that can be maximized to contribute to the success of a clinical trial. The Research Electronic Data Capture infrastructure and enhanced functionality used in Opioid Analgesic Reduction Study provides the framework and the logic that ensures complete, accurate, data while guiding an effective, efficient workflow that can be followed by team members across sites. This enhanced data reliability and comprehensive quality management processes allow for better preparedness and readiness for clinical monitoring and regulatory reporting.PMID:37...
Source: Clinical Trials - November 14, 2023 Category: Research Authors: Janine Fredericks-Younger Patricia Greenberg Tracy Andrews Pamela B Matheson Paul J Desjardins Shou-En Lu Cecile A Feldman Source Type: research
Leveraging the functionality of Research Electronic Data Capture (REDCap) to enhance data collection and quality in the Opioid Analgesic Reduction Study
CONCLUSION: Research Electronic Data Capture is an effective digital health technology that can be maximized to contribute to the success of a clinical trial. The Research Electronic Data Capture infrastructure and enhanced functionality used in Opioid Analgesic Reduction Study provides the framework and the logic that ensures complete, accurate, data while guiding an effective, efficient workflow that can be followed by team members across sites. This enhanced data reliability and comprehensive quality management processes allow for better preparedness and readiness for clinical monitoring and regulatory reporting.PMID:37...
Source: Clinical Trials - November 14, 2023 Category: Research Authors: Janine Fredericks-Younger Patricia Greenberg Tracy Andrews Pamela B Matheson Paul J Desjardins Shou-En Lu Cecile A Feldman Source Type: research
Leveraging the functionality of Research Electronic Data Capture (REDCap) to enhance data collection and quality in the Opioid Analgesic Reduction Study
CONCLUSION: Research Electronic Data Capture is an effective digital health technology that can be maximized to contribute to the success of a clinical trial. The Research Electronic Data Capture infrastructure and enhanced functionality used in Opioid Analgesic Reduction Study provides the framework and the logic that ensures complete, accurate, data while guiding an effective, efficient workflow that can be followed by team members across sites. This enhanced data reliability and comprehensive quality management processes allow for better preparedness and readiness for clinical monitoring and regulatory reporting.PMID:37...
Source: Clinical Trials - November 14, 2023 Category: Research Authors: Janine Fredericks-Younger Patricia Greenberg Tracy Andrews Pamela B Matheson Paul J Desjardins Shou-En Lu Cecile A Feldman Source Type: research
Leveraging the functionality of Research Electronic Data Capture (REDCap) to enhance data collection and quality in the Opioid Analgesic Reduction Study
CONCLUSION: Research Electronic Data Capture is an effective digital health technology that can be maximized to contribute to the success of a clinical trial. The Research Electronic Data Capture infrastructure and enhanced functionality used in Opioid Analgesic Reduction Study provides the framework and the logic that ensures complete, accurate, data while guiding an effective, efficient workflow that can be followed by team members across sites. This enhanced data reliability and comprehensive quality management processes allow for better preparedness and readiness for clinical monitoring and regulatory reporting.PMID:37...
Source: Clinical Trials - November 14, 2023 Category: Research Authors: Janine Fredericks-Younger Patricia Greenberg Tracy Andrews Pamela B Matheson Paul J Desjardins Shou-En Lu Cecile A Feldman Source Type: research
Report Finds VA ’s Prescribing of Benzodiazepines to Homeless ‘Risky,’ ‘Inappropriate’
Homeless veterans with mental illness who use Veterans Affairs (VA) health services are less likely to receive prescriptions for benzodiazepines than those with mental illness who are not homeless, according to areport published this week inPsychiatric Services. When homeless veterans are prescribed benzodiazepines, however, they appear more likely than their peers to receive prescriptions that put them at risk for substance use disorder, overdose, and death, the study found.Drug overdose is a leading cause of death among homeless people, and benzodiazepines are often implicated in such overdose deaths, wrote Katherine Koh...
Source: Psychiatr News - November 2, 2023 Category: Psychiatry Tags: alcohol use benzodiazepines death drug use homeless overdose prescribing substance use disorder VA veterans Source Type: research
