Combination of acetaminophen and ibuprofen is noninferior to acetaminophen and hydrocodone for postnail procedure analgesia: A randomized controlled trial
To the Editor: Nail surgery using anesthesia with 1% lidocaine is associated with moderate-to-severe pain, peaking 6 to 12 hours postoperatively (5.7 ± 2.4) and rivaling that of Mohs micrographic surgery.1,2 Therefore, there is a need to better the nail surgery patient experience. We sought to improve immediate postnail surgery pain by incorporating the long-acting anesthetic ropivacaine, and compare efficacy of op ioids versus nonopioids for postoperative analgesia. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 22, 2023 Category: Dermatology Authors: Jonathan K. Hwang, Jose W. Ricardo, Shari R. Lipner Tags: Research letter Source Type: research
Potential drug –drug interactions among U.S. adults treated with nirmatrelvir/ritonavir: A cross‐sectional study of the National Covid Cohort Collaborative (N3C)
ConclusionsOne in six of individuals receiving nirmatrelvir/ritonavir were at risk of a potential moderate or severe DDI, underscoring the importance of clinical and pharmacy systems to mitigate such risks. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 21, 2023 Category: Drugs & Pharmacology Authors: Xuya Xiao,
Hemalkumar B. Mehta,
Jill Curran,
Brian T. Garibaldi,
G. Caleb Alexander,
National Covid Cohort Collaborative (N3C) Consortium,
Adam B. Wilcox,
Adam M. Lee,
Alexis Graves,
Alfred (Jerrod) Anzalone,
Amin Manna,
Amit Saha,
Amy Olex, Tags: RESEARCH ARTICLE Source Type: research
Potential drug ‐drug interactions among U.S. adults treated with nirmatrelvir/ritonavir: A cross‐sectional study of the national covid cohort collaborative (N3C)
Conclusions and RelevanceOne in six of individuals receiving nirmatrelvir/ritonavir were at risk of a potential moderate or severe DDI, underscoring the importance of clinical and pharmacy systems to mitigate such risks. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 9, 2023 Category: Drugs & Pharmacology Authors: Xuya Xiao,
Hemalkumar B. Mehta,
Jill Curran,
Brian T. Garibaldi,
G. Caleb Alexander,
National Covid Cohort Collaborative (N3C) Consortium Tags: RESEARCH ARTICLE Source Type: research
Efficacy of opioids for traumatic pain in the emergency department: a systematic review and Bayesian network meta-analysis
Conclusion: Sufentanil, buprenorphine and fentanyl may be superior to other opioid medications in terms of pain relief and the incidence of dizziness, hypotension and pruritus, which might be selected as opioid analgesics for traumatic pain in the emergency setting. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - July 27, 2023 Category: Drugs & Pharmacology Source Type: research
Postprocedural Opioid-Prescribing Practice in Nail Surgery
CONCLUSIONS: Podiatric physicians cannot assume that their prescribing of opioids does not affect the opioid abuse problem in the United States. The presented study serves to be an initiation for procedure-specific opioid prescription benchmarking to foster future guideline and policy development. After nail procedures, opioids should not be routinely prescribed.PMID:37467257 | DOI:10.7547/21-139 (Source: Journal of the American Podiatric Medical Association)
Source: Journal of the American Podiatric Medical Association - July 19, 2023 Category: Podiatry Authors: Brandon M Brooks Qiyang Li Adam E Fleischer Natalie A Anderson Aaron Z Handa Chia-Ding Shih Source Type: research
Postprocedural Opioid-Prescribing Practice in Nail Surgery
CONCLUSIONS: Podiatric physicians cannot assume that their prescribing of opioids does not affect the opioid abuse problem in the United States. The presented study serves to be an initiation for procedure-specific opioid prescription benchmarking to foster future guideline and policy development. After nail procedures, opioids should not be routinely prescribed.PMID:37467257 | DOI:10.7547/21-139 (Source: Journal of the American Podiatric Medical Association)
Source: Journal of the American Podiatric Medical Association - July 19, 2023 Category: Podiatry Authors: Brandon M Brooks Qiyang Li Adam E Fleischer Natalie A Anderson Aaron Z Handa Chia-Ding Shih Source Type: research
Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
