CYP2D in the brain impacts oral hydrocodone analgesia in vivo
Neuropharmacology. 2022 Oct 11:109291. doi: 10.1016/j.neuropharm.2022.109291. Online ahead of print.ABSTRACTCytochrome P450 2D (CYP2D) metabolises many centrally-acting substrates including opioids. Hydrocodone, an opioid and CYP2D substrate, is metabolised to hydromorphone, an active metabolite. CYP2D in the brain is active in vivo and can alter drug response however, it is unknown whether metabolism by CYP2D in the brain alters oral hydrocodone induced analgesia. Propranolol, a selective CYP2D mechanism-based inhibitor, or vehicle, was administered into the right cerebral ventricle of male rats, (HAN Wistars, Envigo), 24...
Source: Neuropharmacology - October 14, 2022 Category: Drugs & Pharmacology Authors: Janielle Richards Sharon Miksys Maria Novalen Rachel F Tyndale Source Type: research
A retrospective analysis of the impact of Michigan's opioid prescribing legislation on discharge opioid prescribing at a single institution
CONCLUSIONS AND RELEVANCE: Our results indicate that the legislation implemented in Michigan to regulate opioid prescriptions was associated with a reduction in opioids prescribed to patients discharged from a community-based academic teaching hospital.PMID:36226786 | DOI:10.5055/jom.2022.0740 (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - October 13, 2022 Category: Addiction Authors: Richard Sadowski Emily Hillaker Michael Chavarria Fareea Khaliq Adam Schwark Source Type: research
