Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Estimates of Drug Metabolism Using Drug Excretion Concentrations
Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for...
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
