Intraplacental Gestational Neoplasms: A Review of Clinically Relevant Diagnostically Challenging Lesions
CONCLUSIONS.—: Intraplacental gestational tumors exist along the spectrum of benign (chorangioma) to aggressive malignant (choriocarcinoma) neoplasms with a high potential for metastasis. Although most gestational choriocarcinomas follow complete hydatidiform mole, 20% to 25% occur in association with normal intrauterine gestations, including rare cases in which they are detected within the placenta (IPC). IPCs range from asymptomatic to widely metastatic, with metastases possible even when only microscopic IPCs are present. A second, even less common lesion, variably called "chorangiocarcinoma" and chorangioma with atyp...
Source: Archives of Pathology and Laboratory Medicine - November 17, 2023 Category: Laboratory Medicine Authors: Julia Dahl Source Type: research
Intraplacental Gestational Neoplasms: A Review of Clinically Relevant Diagnostically Challenging Lesions
CONCLUSIONS.—: Intraplacental gestational tumors exist along the spectrum of benign (chorangioma) to aggressive malignant (choriocarcinoma) neoplasms with a high potential for metastasis. Although most gestational choriocarcinomas follow complete hydatidiform mole, 20% to 25% occur in association with normal intrauterine gestations, including rare cases in which they are detected within the placenta (IPC). IPCs range from asymptomatic to widely metastatic, with metastases possible even when only microscopic IPCs are present. A second, even less common lesion, variably called "chorangiocarcinoma" and chorangioma with atyp...
Source: Archives of Pathology and Laboratory Medicine - November 17, 2023 Category: Laboratory Medicine Authors: Julia Dahl Source Type: research
Intraplacental Gestational Neoplasms: A Review of Clinically Relevant Diagnostically Challenging Lesions
CONCLUSIONS.—: Intraplacental gestational tumors exist along the spectrum of benign (chorangioma) to aggressive malignant (choriocarcinoma) neoplasms with a high potential for metastasis. Although most gestational choriocarcinomas follow complete hydatidiform mole, 20% to 25% occur in association with normal intrauterine gestations, including rare cases in which they are detected within the placenta (IPC). IPCs range from asymptomatic to widely metastatic, with metastases possible even when only microscopic IPCs are present. A second, even less common lesion, variably called "chorangiocarcinoma" and chorangioma with atyp...
Source: Archives of Pathology and Laboratory Medicine - November 17, 2023 Category: Laboratory Medicine Authors: Julia Dahl Source Type: research
Intraplacental Gestational Neoplasms: A Review of Clinically Relevant Diagnostically Challenging Lesions
CONCLUSIONS.—: Intraplacental gestational tumors exist along the spectrum of benign (chorangioma) to aggressive malignant (choriocarcinoma) neoplasms with a high potential for metastasis. Although most gestational choriocarcinomas follow complete hydatidiform mole, 20% to 25% occur in association with normal intrauterine gestations, including rare cases in which they are detected within the placenta (IPC). IPCs range from asymptomatic to widely metastatic, with metastases possible even when only microscopic IPCs are present. A second, even less common lesion, variably called "chorangiocarcinoma" and chorangioma with atyp...
Source: Archives of Pathology and Laboratory Medicine - November 17, 2023 Category: Laboratory Medicine Authors: Julia Dahl Source Type: research
Cornual invasive hydatidiform mole: a rare case report and literature review
The cornual pregnancy is a rare condition of ectopic pregnancies. Invasive hydatidiform mole is a rare form of gestational trophoblastic diseases. Cornual invasive hydatidiform mole is extremely rare. (Source: BMC Women's Health)
Source: BMC Women's Health - November 2, 2023 Category: OBGYN Authors: Jing Qian, Song Xu and Li Chen Tags: Case Report Source Type: research
Double Trisomy 16 and 22 Clinically Mimic Partial Hydatidiform Mole in a Case of Subsequent Pregnancy Loss
In conclusion, aneuploidies can mimic partial hydatidiform mole. Genetic analysis is helpful on the one hand to rule out partial hydatidiform mole and on the other hand to identify aneuploidies and in this way to determine the cause of miscarriage.PMID:37888974 (Source: Physiological Research)
Source: Physiological Research - October 27, 2023 Category: Physiology Authors: L Gergely M Korbe ľ A Adamec V Repisk á P Bab ál K Meli šová P Pri ščáková Source Type: research
Double Trisomy 16 and 22 Clinically Mimic Partial Hydatidiform Mole in a Case of Subsequent Pregnancy Loss
In conclusion, aneuploidies can mimic partial hydatidiform mole. Genetic analysis is helpful on the one hand to rule out partial hydatidiform mole and on the other hand to identify aneuploidies and in this way to determine the cause of miscarriage.PMID:37888974 (Source: Physiological Research)
Source: Physiological Research - October 27, 2023 Category: Physiology Authors: L Gergely M Korbe ľ A Adamec V Repisk á P Bab ál K Meli šová P Pri ščáková Source Type: research
Double Trisomy 16 and 22 Clinically Mimic Partial Hydatidiform Mole in a Case of Subsequent Pregnancy Loss
In conclusion, aneuploidies can mimic partial hydatidiform mole. Genetic analysis is helpful on the one hand to rule out partial hydatidiform mole and on the other hand to identify aneuploidies and in this way to determine the cause of miscarriage.PMID:37888974 (Source: Physiological Research)
Source: Physiological Research - October 27, 2023 Category: Physiology Authors: L Gergely M Korbe ľ A Adamec V Repisk á P Bab ál K Meli šová P Pri ščáková Source Type: research
Double Trisomy 16 and 22 Clinically Mimic Partial Hydatidiform Mole in a Case of Subsequent Pregnancy Loss
In conclusion, aneuploidies can mimic partial hydatidiform mole. Genetic analysis is helpful on the one hand to rule out partial hydatidiform mole and on the other hand to identify aneuploidies and in this way to determine the cause of miscarriage.PMID:37888974 (Source: Physiological Research)
Source: Physiological Research - October 27, 2023 Category: Physiology Authors: L Gergely M Korbe ľ A Adamec V Repisk á P Bab ál K Meli šová P Pri ščáková Source Type: research
Double Trisomy 16 and 22 Clinically Mimic Partial Hydatidiform Mole in a Case of Subsequent Pregnancy Loss
In conclusion, aneuploidies can mimic partial hydatidiform mole. Genetic analysis is helpful on the one hand to rule out partial hydatidiform mole and on the other hand to identify aneuploidies and in this way to determine the cause of miscarriage.PMID:37888974 (Source: Physiological Research)
Source: Physiological Research - October 27, 2023 Category: Physiology Authors: L Gergely M Korbe ľ A Adamec V Repisk á P Bab ál K Meli šová P Pri ščáková Source Type: research
Systematic Evaluation and Nursing Outlook of Clinical Characteristics of 60 Twin Pregnancies with Complete Hydatidiform Mole and a Coexistent Viable Foetus
(Source: Patient Preference and Adherence)
Source: Patient Preference and Adherence - October 27, 2023 Category: International Medicine & Public Health Tags: Patient Preference and Adherence Source Type: research
Practical guidelines of the EOTTD for pathological and genetic diagnosis of hydatidiform moles
AbstractHydatidiform moles are rare and thus most pathologists and geneticists have little experience with their diagnosis. It is important to promptly and correctly identify hydatidiform moles given that they are premalignant disorders associated with a risk of persistent gestational trophoblastic disease and gestational trophoblastic neoplasia. Improvement in diagnosis can be achieved with uniformization of diagnostic criteria and establishment of algorithms. To this aim, the Pathology and Genetics Working Party of the European Organisation for Treatment of Trophoblastic Diseases has developed guidelines that describe th...
Source: Virchows Archiv - October 19, 2023 Category: Pathology Source Type: research
Complete Hydatidiform Mole with a Coexisting Viable Male Fetus Detected by Cell-Free DNA
AJP Rep 2023; 13: e49-e52 DOI: 10.1055/s-0043-1774727Complete hydatidiform mole with coexisting fetus (CHMCF) is rare, and diagnosis is challenging due to limited data. Here, we present the case of a patient with noninvasive prenatal test (NIPT) resulting in “likely molar pregnancy” in the second trimester. Subsequent ultrasound confirmed a cystic appearing portion of the placenta. At 22 weeks, the patient delivered a demised fetus and two placentas. Pathology was consistent with CHMCF. This case is the first to show primary detection of a CHMCF with single-nucleotide polymorphism (SNP)-based NIPT prior to ultrasound i...
Source: American Journal of Perinatology Reports - September 30, 2023 Category: Perinatology & Neonatology Authors: Lemieux, Mackenzie Kus, Lauren Stewart, Kali He, Mai Rowe, Jackson Brady, Matthew Bligard, Katherine Lawlor, Megan Kelly, Jeannie Tags: Case Report Source Type: research
Multiple pregnancy with complete hydatidiform mole and coexisting normal fetus in a retrospective cohort of 141 patients.
Multiple pregnancy with a complete hydatidiform mole and a normal fetus is prone to severe obstetrical complications and malignant transformation after birth. Prognostic information is limited for this rare form of gestational trophoblastic disease. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - September 16, 2023 Category: OBGYN Authors: Touria Hajri, Mona Massoud, Margot Vergne, Pierre Descargues, Fabienne Allias, Benoit You, Jean-Pierre Lotz, Julie Haesebaert, Pierre-Adrien Bolze, Fran çois Golfier, Jerome Massardier Tags: Original Research: Obstetrics Source Type: research
Androgenetic/biparental mosaicism in a diploid mole-like conceptus: report of a case with triple paternal contribution
We report a case with atypical pathologic and genetic findings that correspond neither to CHM nor to PHM. Two populations of villi with divergent and discordant p57 expression were observed: morphologically normal p57 + villi and molar-like p57 discordant villi with p57 + stromal cells and p57 − cytotrophoblasts. Genotyping of DNA extracted from microdissected villi demonstrated that the conceptus was an androgenetic/biparental mosaic, originating from a zygote with triple paternal contribution, an d that only the p57 − cytotrophoblasts were purely androgenetic, increasing the risk of neoplastic transf...
Source: Virchows Archiv - September 11, 2023 Category: Pathology Source Type: research
