Androgenetic/biparental mosaicism in a diploid mole-like conceptus: report of a case with triple paternal contribution

We report a case with atypical pathologic and genetic findings that correspond neither to CHM nor to PHM. Two populations of villi with divergent and discordant p57 expression were observed: morphologically normal p57  + villi and molar-like p57 discordant villi with p57 + stromal cells and p57 − cytotrophoblasts. Genotyping of DNA extracted from microdissected villi demonstrated that the conceptus was an androgenetic/biparental mosaic, originating from a zygote with triple paternal contribution, an d that only the p57 − cytotrophoblasts were purely androgenetic, increasing the risk of neoplastic transformation.
Source: Virchows Archiv - Category: Pathology Source Type: research