MicroRNA Expression Profiling in Hydatidiform Mole for the Prediction of Postmolar GTN : MicroRNA Profile in Postmolar GTN
Conclusion: We identified 21 miRNAs that were differentially expressed between GTN moles and remission moles suggesting that miRNA profiles can distinguish between the two groups. Although not reaching statistically significant, miR-608 expression was slightly lower in GTN moles compared to remission moles.PMID:35023789 | DOI:10.1177/15330338211067309 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 13, 2022 Category: Cancer & Oncology Authors: Chinachote Teerapakpinyo Wilasinee Areeruk Patou Tantbirojn Vorapong Phupong Shanop Shuangshoti Ruangsak Lertkhachonsuk Source Type: research

MicroRNA Expression Profiling in Hydatidiform Mole for the Prediction of Postmolar GTN : MicroRNA Profile in Postmolar GTN
Conclusion: We identified 21 miRNAs that were differentially expressed between GTN moles and remission moles suggesting that miRNA profiles can distinguish between the two groups. Although not reaching statistically significant, miR-608 expression was slightly lower in GTN moles compared to remission moles.PMID:35023789 | DOI:10.1177/15330338211067309 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 13, 2022 Category: Cancer & Oncology Authors: Chinachote Teerapakpinyo Wilasinee Areeruk Patou Tantbirojn Vorapong Phupong Shanop Shuangshoti Ruangsak Lertkhachonsuk Source Type: research

MicroRNA Expression Profiling in Hydatidiform Mole for the Prediction of Postmolar GTN : MicroRNA Profile in Postmolar GTN
Conclusion: We identified 21 miRNAs that were differentially expressed between GTN moles and remission moles suggesting that miRNA profiles can distinguish between the two groups. Although not reaching statistically significant, miR-608 expression was slightly lower in GTN moles compared to remission moles.PMID:35023789 | DOI:10.1177/15330338211067309 (Source: Cancer Control)
Source: Cancer Control - January 13, 2022 Category: Cancer & Oncology Authors: Chinachote Teerapakpinyo Wilasinee Areeruk Patou Tantbirojn Vorapong Phupong Shanop Shuangshoti Ruangsak Lertkhachonsuk Source Type: research

MicroRNA Expression Profiling in Hydatidiform Mole for the Prediction of Postmolar GTN : MicroRNA Profile in Postmolar GTN
Conclusion: We identified 21 miRNAs that were differentially expressed between GTN moles and remission moles suggesting that miRNA profiles can distinguish between the two groups. Although not reaching statistically significant, miR-608 expression was slightly lower in GTN moles compared to remission moles.PMID:35023789 | DOI:10.1177/15330338211067309 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 13, 2022 Category: Cancer & Oncology Authors: Chinachote Teerapakpinyo Wilasinee Areeruk Patou Tantbirojn Vorapong Phupong Shanop Shuangshoti Ruangsak Lertkhachonsuk Source Type: research

MicroRNA Expression Profiling in Hydatidiform Mole for the Prediction of Postmolar GTN : MicroRNA Profile in Postmolar GTN
Conclusion: We identified 21 miRNAs that were differentially expressed between GTN moles and remission moles suggesting that miRNA profiles can distinguish between the two groups. Although not reaching statistically significant, miR-608 expression was slightly lower in GTN moles compared to remission moles.PMID:35023789 | DOI:10.1177/15330338211067309 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 13, 2022 Category: Cancer & Oncology Authors: Chinachote Teerapakpinyo Wilasinee Areeruk Patou Tantbirojn Vorapong Phupong Shanop Shuangshoti Ruangsak Lertkhachonsuk Source Type: research

Diagnostic utility of p57 immunohistochemistry and DNA ploidy analysis by fluorescence in situ hybridisation in hydatidiform moles
CONCLUSION: This study highlighted the importance of the utility of combined p57 immunostain and DNA ploidy analysis in arriving at an accurate diagnosis in HMs. An algorithmic approach utilising these ancillary techniques is advocated in routine diagnostic workup for a more refined diagnostic approach to HMs.PMID:34958055 (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - December 27, 2021 Category: Pathology Authors: Y P Wong W K Chia A Selimin P Y Chia M Mustangin S Shuib T Y Khong G C Tan Source Type: research

Rare Complete Hydatidiform Mole With p57 Expression in Villous Mesenchyme: Case Report and Review of Discordant p57 Expression in Hydatidiform Moles
Complete hydatidiform mole (CHM) is a premalignant proliferative disease of the placenta characterized by misexpression of imprinted gene products, most notably p57. The majority of CHM exhibit immunohistochemical absence of p57 protein in villous mesenchyme (VM) and cytotrophoblast (CT) and are thus p57 VM/CT concordant. However, some gestations show loss of p57 in only VM or CT, either in all chorionic villi or a subset thereof (VM/CT discordant). Here, we present a rare case of a p57 VM/CT-discordant CHM with diffuse retention of p57 expression in VM but complete absence in CT. Histologically, the case exhibited typical...
Source: International Journal of Gynecological Pathology - December 17, 2021 Category: Pathology Tags: Pathology of the Corpus: Case Reports Source Type: research

Loss of p57 Expression in Conceptions Other Than Complete Hydatidiform Mole: A Case Series With Emphasis on the Etiology, Genetics, and Clinical Significance
Combined p57 immunohistochemistry and DNA genotyping refines classification of products of conception specimens into specific types of hydatidiform moles and various nonmolar entities that can simulate them. p57 expression is highly correlated with genotyping and in practice can reliably be used to identify virtually all complete hydatidiform moles (CHM), but aberrant retained or lost p57 expression in rare CHMs and partial hydatidiform moles (PHM), as well as loss in some nonmolar abortuses, has been reported. Among a series of 2329 products of conceptions, we identified 10 cases for which loss of p57 expression was incon...
Source: The American Journal of Surgical Pathology - December 13, 2021 Category: Pathology Tags: Original Articles Source Type: research

Quadruplet Pregnancy with Complete Mole and Three Viable Fetuses
Conclusion: Despite the difficulty in conceiving, elective termination of a multiple pregnancy associated with a molar pregnancy may be the most judicious course of action to protect the mother's life.PMID:34807794 | DOI:10.1080/15513815.2021.2006377 (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - November 22, 2021 Category: Pathology Authors: Cem Yener N Cenk Say ın Fatma Elif Ustural ı Keskin Esra Altan Sinan Ate ş F üsun Varol Source Type: research

When a vesicular placenta meets a live fetus: case report of twin pregnancy with a partial hydatidiform mole
Hydatidiform moles exhibit a distinctive gross appearance of multiple vesicles in the placenta. The advances in cytogenetic technologies have helped uncover novel entities of hydatidiform moles and enabled ela... (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - October 13, 2021 Category: OBGYN Authors: Minhuan Lin, Jinzhu Chen, Bing Liao, Zhiming He, Shaobin Lin and Yanmin Luo Tags: Case report Source Type: research

Early prediction of post-molar gestational trophoblastic neoplasia and resistance to methotrexate, based on a single serum human chorionic gonadotropin measurement
CONCLUSION: The nomograms and cut-off levels can be used to assist in counseling for patients diagnosed with CHM.PMID:34602288 | DOI:10.1016/j.ygyno.2021.09.016 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - October 4, 2021 Category: Cancer & Oncology Authors: Yvonne M Hoeijmakers Yalck K Eysbouts Leon F A G Massuger Rana Dandis Joanna Inthout N E van Trommel Petronella B Ottevanger Chris M G Thomas Fred C G J Sweep Source Type: research

Early prediction of post-molar gestational trophoblastic neoplasia and resistance to methotrexate, based on a single serum human chorionic gonadotropin measurement
CONCLUSION: The nomograms and cut-off levels can be used to assist in counseling for patients diagnosed with CHM.PMID:34602288 | DOI:10.1016/j.ygyno.2021.09.016 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - October 4, 2021 Category: Cancer & Oncology Authors: Yvonne M Hoeijmakers Yalck K Eysbouts Leon F A G Massuger Rana Dandis Joanna Inthout N E van Trommel Petronella B Ottevanger Chris M G Thomas Fred C G J Sweep Source Type: research

Application of next-generation sequencing to preimplantation genetic testing for recurrent hydatidiform mole patients
ConclusionAnalyzing the copy number variants and the numbers of heterozygous single nucleotide polymorphism on the basis of next-generation sequencing can be utilized in the procedure of preimplantation genetic testing among part of recurrent hydatidiform mole patients. The current study is effective to reduce the occurrence of hydatidiform mole with improved clinical strategy, the advanced testing technology and analysis methods, as three of seven patients have conceived or delivered successfully. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 4, 2021 Category: Reproduction Medicine Source Type: research

A molecular classification of moles and its use in filiation tests
J Forensic Sci. 2021 Oct 1. doi: 10.1111/1556-4029.14890. Online ahead of print.ABSTRACTPregnancies, including ones that follow sexual assaults, occasionally produce hydatidiform moles. The alleged fathers (AFs) of moles have been tested for paternity by identifying the mole's locus phenotype-the one or two visible paternal obligate alleles (POAs) per locus. The probability that the mole inherited the POAs from the AF was divided by the probability that the mole inherited the POAs from a random man. This likelihood ratio (LR) would increase if the mole's specific genotype was known. Moles are generated in five different wa...
Source: Journal of Forensic Sciences - October 1, 2021 Category: Forensic Medicine Authors: Robert E Wenk John Peterson Michael Baird Source Type: research

A molecular classification of moles and its use in filiation tests
J Forensic Sci. 2021 Oct 1. doi: 10.1111/1556-4029.14890. Online ahead of print.ABSTRACTPregnancies, including ones that follow sexual assaults, occasionally produce hydatidiform moles. The alleged fathers (AFs) of moles have been tested for paternity by identifying the mole's locus phenotype-the one or two visible paternal obligate alleles (POAs) per locus. The probability that the mole inherited the POAs from the AF was divided by the probability that the mole inherited the POAs from a random man. This likelihood ratio (LR) would increase if the mole's specific genotype was known. Moles are generated in five different wa...
Source: Journal of Forensic Sciences - October 1, 2021 Category: Forensic Medicine Authors: Robert E Wenk John Peterson Michael Baird Source Type: research

A molecular classification of moles and its use in filiation tests
J Forensic Sci. 2021 Oct 1. doi: 10.1111/1556-4029.14890. Online ahead of print.ABSTRACTPregnancies, including ones that follow sexual assaults, occasionally produce hydatidiform moles. The alleged fathers (AFs) of moles have been tested for paternity by identifying the mole's locus phenotype-the one or two visible paternal obligate alleles (POAs) per locus. The probability that the mole inherited the POAs from the AF was divided by the probability that the mole inherited the POAs from a random man. This likelihood ratio (LR) would increase if the mole's specific genotype was known. Moles are generated in five different wa...
Source: Journal of Forensic Sciences - October 1, 2021 Category: Forensic Medicine Authors: Robert E Wenk John Peterson Michael Baird Source Type: research

GSE125592 A Patient specific iPSC-based model of Hydatidiform mole reveals abnormal BMP4 signaling caused by NLRP7 deficiency
Contributors : Aybuke Alici-Garipcan ; Burcu Özçimen ; Tamer T Önder ; Nesrin ÖzörenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensComplete Hydatidiform Mole (HM) is a gestational trophoblastic disease resulting in hyper proliferation of trophoblast cells and absence of embryo development. Mutations in NLRP7 gene is a major cause of familial recurrent complete HM, where no embryonic tissue is present during the pregnancy. NLRP7 is a novel protein and its function is poorly understood. Lack of NLRP7 in the mouse genome and challenges in studying human embryo...
Source: GEO: Gene Expression Omnibus - September 9, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Androgenetic/Biparental Mosaic/Chimeric Conceptions With a Molar Component: A Diagnostic and Clinical Challenge
In this report, we provide detailed characterizations of 2 such cases of ABMC conceptions with a molar component. Both patients (ages 34 and 31) were in the first trimester of pregnancy and had ultrasound findings concerning for HM. Increased comprehension of the pathogenesis and morphology of ABMC conceptions, combined with ancillary techniques including p57 immunohistochemistry, fluorescence in situ hybridization, and molar genotyping, has allowed us to accurately and efficiently identify these lesions. However, a number of pitfalls exist which may lead to misdiagnosis. (Source: International Journal of Gynecological Pathology)
Source: International Journal of Gynecological Pathology - August 21, 2021 Category: Pathology Tags: PATHOLOGY OF THE CORPUS: CASE REPORTS Source Type: research

Genes, Vol. 12, Pages 1214: DNA Methylation Dynamics in the Female Germline and Maternal-Effect Mutations That Disrupt Genomic Imprinting
den Veyver Genomic imprinting is an epigenetic marking process that results in the monoallelic expression of a subset of genes. Many of these ‘imprinted’ genes in mice and humans are involved in embryonic and extraembryonic growth and development, and some have life-long impacts on metabolism. During mammalian development, the genome undergoes waves of (re)programming of DNA methylation and other epigenetic marks. Disturbances in these events can cause imprinting disorders and compromise development. Multi-locus imprinting disturbance (MLID) is a condition by which imprinting defects touch more than one lo...
Source: Genes - August 6, 2021 Category: Genetics & Stem Cells Authors: Zahra Anvar Imen Chakchouk Hannah Demond Momal Sharif Gavin Kelsey Ignatia B. Van den Veyver Tags: Review Source Type: research

O-234 Using serum metabolomics to identify biomarkers of viable early, intrauterine pregnancy: an untargeted 1H NMR-based approach
This study identifies a metabolite profile associated with VIUPs. These findings may be useful in the development of a diagnostic test to confirm VIUPs and thus exclude potentially life-threatening pregnancy outcomes. Such a test would be invaluable in clinical emergencies.Trial registration numberNA (Source: Human Reproduction)
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research

P –553 Women with molar pregnancies have a genetic susceptibility to aneuploid miscarriages
AbstractStudy questionWhat causes non-molar miscarriages in women with one hydatidiform mole (HM)?Summary answerWe found a higher rate of aneuploidies in the non-molar miscarriages of women with HM than in those from women with sporadic or recurrent miscarriages.What is known alreadyWomen with hydatidiform moles have higher rates of miscarriages and women with recurrent miscarriages have higher rates of moles than women from the general population.Study design, size, durationWe retrieved archived formalin-fixed paraffin embedded tissues from non-molar miscarriages of patients with one HM and analyzed them for the presence ...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research

Corrigendum to "Reprogramming of human peripheral blood mononuclear cells from a patient suffering from recurrent hydatidiform mole to an iPSC line FAHZUi001-A carrying a homozygous p.Gln421Ter mutation in NLRP7 gene" [Stem Cell Res. 53 (2021) 102361]
Stem Cell Res. 2021 Jul 27;55:102479. doi: 10.1016/j.scr.2021.102479. Online ahead of print.NO ABSTRACTPMID:34330032 | DOI:10.1016/j.scr.2021.102479 (Source: Cell Research)
Source: Cell Research - July 30, 2021 Category: Cytology Authors: Tingyu Gong Hongkun Wang Bo Huang Hao Wang Peiwen Zhang Jianhua Qian Source Type: research

Maternal Effect Mutations: A Novel Cause for Human Reproductive Failure
Geburtshilfe Frauenheilkd. 2021 Jul;81(7):780-788. doi: 10.1055/a-1396-4390. Epub 2021 Jul 13.ABSTRACTGenetic alterations significantly contribute to the aetiology of reproductive failure and comprise monogenic, chromosomal and epigenetic disturbances. The implementation of next-generation sequencing (NGS) based approaches in research and diagnostics allows the comprehensive analysis of these genetic causes, and the increasing detection rates of genetic mutations causing reproductive complications confirm the potential of the new techniques. Whereas mutations affecting the fetal genome are well known to affect pregnancies ...
Source: Geburtshilfe und Frauenheilkunde - July 23, 2021 Category: OBGYN Authors: Thomas Eggermann Source Type: research