Real-World Survival, Healthcare Resource Utilization, and Costs Among U.S. Elderly Patients With Diffuse Large B-Cell Lymphoma (DLBCL) Treated With R-GemOx in the Relapsed/Refractory Setting
CONCLUSION: Elderly U.S. Medicare beneficiaries diagnosed with DLBCL who initiated R-GemOx treatment in the R/R setting have poor overall survival, high rates of HCRU, and substantial costs.PMID:38433043 | DOI:10.1016/j.clml.2024.01.010 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - March 3, 2024 Category: Cancer & Oncology Authors: Mahek Garg Justin Puckett Sachin Kamal-Bahl Monika Raut Katherine Elizabeth Ryland Jalpa A Doshi Scott F Huntington Source Type: research
Real-World Survival, Healthcare Resource Utilization, and Costs Among U.S. Elderly Patients With Diffuse Large B-Cell Lymphoma (DLBCL) Treated With R-GemOx in the Relapsed/Refractory Setting
CONCLUSION: Elderly U.S. Medicare beneficiaries diagnosed with DLBCL who initiated R-GemOx treatment in the R/R setting have poor overall survival, high rates of HCRU, and substantial costs.PMID:38433043 | DOI:10.1016/j.clml.2024.01.010 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - March 3, 2024 Category: Cancer & Oncology Authors: Mahek Garg Justin Puckett Sachin Kamal-Bahl Monika Raut Katherine Elizabeth Ryland Jalpa A Doshi Scott F Huntington Source Type: research
ASOs are an effective treatment for disease-associated oligodendrocyte signatures in premanifest and symptomatic SCA3 mice
We report a severe, but modifiable, deficit in oligodendrocyte maturation caused by the toxic gain-of-function of mutant ATXN3 early in SCA3 disease that is transcriptionally, biochemically, and functionally rescued with anti-ATXN3 ASO. Our results highlight the promising use of an ASO therapy across neurodegenerative diseases that requires glial targeting in addition to affected neuronal populations.PMID:38429929 | DOI:10.1016/j.ymthe.2024.02.033 (Source: Molecular Medicine)
Source: Molecular Medicine - March 2, 2024 Category: Molecular Biology Authors: Kristen H Schuster Annie J Zalon Danielle M DiFranco Alexandra F Putka Nicholas R Stec Sabrina I Jarrah Arsal Naeem Zaid Haque Hanrui Zhang Yuanfang Guan Hayley S McLoughlin Source Type: research
ASOs are an effective treatment for disease-associated oligodendrocyte signatures in premanifest and symptomatic SCA3 mice
We report a severe, but modifiable, deficit in oligodendrocyte maturation caused by the toxic gain-of-function of mutant ATXN3 early in SCA3 disease that is transcriptionally, biochemically, and functionally rescued with anti-ATXN3 ASO. Our results highlight the promising use of an ASO therapy across neurodegenerative diseases that requires glial targeting in addition to affected neuronal populations.PMID:38429929 | DOI:10.1016/j.ymthe.2024.02.033 (Source: Molecular Medicine)
Source: Molecular Medicine - March 2, 2024 Category: Molecular Biology Authors: Kristen H Schuster Annie J Zalon Danielle M DiFranco Alexandra F Putka Nicholas R Stec Sabrina I Jarrah Arsal Naeem Zaid Haque Hanrui Zhang Yuanfang Guan Hayley S McLoughlin Source Type: research
Imaging and Assay of the Dynamics of Cytotoxic Huntingtin (HTT) Protein Aggregates Regulated by lncRNAs
Methods Mol Biol. 2024;2761:421-430. doi: 10.1007/978-1-0716-3662-6_29.ABSTRACTHuntington's disease (HD) pathogenesis involves deregulation of coding and noncoding RNA transcripts of which the involvement of long noncoding RNAs (lncRNA) has been realized recently. Of these, Meg3, Neat1, and Xist showed a consistent and significant increase in HD cell and animal models. In the present study, we formulate a methodology to visualize and quantify intracellular aggregates formed by mutant HTT protein. This method employs the use of both confocal laser scanning and super resolution (N-SIM) microscopy to accurately estimate aggre...
Source: Mol Biol Cell - March 1, 2024 Category: Molecular Biology Authors: Kaushik Chanda Debashis Mukhopadhyay Source Type: research
Imaging and Assay of the Dynamics of Cytotoxic Huntingtin (HTT) Protein Aggregates Regulated by lncRNAs
Methods Mol Biol. 2024;2761:421-430. doi: 10.1007/978-1-0716-3662-6_29.ABSTRACTHuntington's disease (HD) pathogenesis involves deregulation of coding and noncoding RNA transcripts of which the involvement of long noncoding RNAs (lncRNA) has been realized recently. Of these, Meg3, Neat1, and Xist showed a consistent and significant increase in HD cell and animal models. In the present study, we formulate a methodology to visualize and quantify intracellular aggregates formed by mutant HTT protein. This method employs the use of both confocal laser scanning and super resolution (N-SIM) microscopy to accurately estimate aggre...
Source: Mol Biol Cell - March 1, 2024 Category: Molecular Biology Authors: Kaushik Chanda Debashis Mukhopadhyay Source Type: research
Childhood-onset Huntignton ´s disease. A rare presentation
CONCLUSION: Childhood-onset HD differs from adult-form´s clinical manifestations. It should be considered in patients with progressive motor and cognitive impairment. Due to family inheritance, it is important to carefully examine family history and take it into account even without relatives affected, considering the anticipation phenomenon.PMID:38416505 | DOI:10.33588/rn.7805.2024039 (Source: Revista de Neurologia)
Source: Revista de Neurologia - February 28, 2024 Category: Neurology Authors: A Gauto E Bellantonio P Pedernera-Bradichansky P Cafiero E Rodriguez P Massaro Source Type: research
Childhood-onset Huntignton ´s disease. A rare presentation
CONCLUSION: Childhood-onset HD differs from adult-form´s clinical manifestations. It should be considered in patients with progressive motor and cognitive impairment. Due to family inheritance, it is important to carefully examine family history and take it into account even without relatives affected, considering the anticipation phenomenon.PMID:38416505 | DOI:10.33588/rn.7805.2024039 (Source: Revista de Neurologia)
Source: Revista de Neurologia - February 28, 2024 Category: Neurology Authors: A Gauto E Bellantonio P Pedernera-Bradichansky P Cafiero E Rodriguez P Massaro Source Type: research
Childhood-onset Huntignton ´s disease. A rare presentation
CONCLUSION: Childhood-onset HD differs from adult-form´s clinical manifestations. It should be considered in patients with progressive motor and cognitive impairment. Due to family inheritance, it is important to carefully examine family history and take it into account even without relatives affected, considering the anticipation phenomenon.PMID:38416505 | DOI:10.33588/rn.7805.2024039 (Source: Revista de Neurologia)
Source: Revista de Neurologia - February 28, 2024 Category: Neurology Authors: A Gauto E Bellantonio P Pedernera-Bradichansky P Cafiero E Rodriguez P Massaro Source Type: research
Childhood-onset Huntignton ´s disease. A rare presentation
CONCLUSION: Childhood-onset HD differs from adult-form´s clinical manifestations. It should be considered in patients with progressive motor and cognitive impairment. Due to family inheritance, it is important to carefully examine family history and take it into account even without relatives affected, considering the anticipation phenomenon.PMID:38416505 | DOI:10.33588/rn.7805.2024039 (Source: Revista de Neurologia)
Source: Revista de Neurologia - February 28, 2024 Category: Neurology Authors: A Gauto E Bellantonio P Pedernera-Bradichansky P Cafiero E Rodriguez P Massaro Source Type: research
Childhood-onset Huntignton ´s disease. A rare presentation
CONCLUSION: Childhood-onset HD differs from adult-form´s clinical manifestations. It should be considered in patients with progressive motor and cognitive impairment. Due to family inheritance, it is important to carefully examine family history and take it into account even without relatives affected, considering the anticipation phenomenon.PMID:38416505 | DOI:10.33588/rn.7805.2024039 (Source: Revista de Neurologia)
Source: Revista de Neurologia - February 28, 2024 Category: Neurology Authors: A Gauto E Bellantonio P Pedernera-Bradichansky P Cafiero E Rodriguez P Massaro Source Type: research
Childhood-onset Huntignton ´s disease. A rare presentation
CONCLUSION: Childhood-onset HD differs from adult-form´s clinical manifestations. It should be considered in patients with progressive motor and cognitive impairment. Due to family inheritance, it is important to carefully examine family history and take it into account even without relatives affected, considering the anticipation phenomenon.PMID:38416505 | DOI:10.33588/rn.7805.2024039 (Source: Revista de Neurologia)
Source: Revista de Neurologia - February 28, 2024 Category: Neurology Authors: A Gauto E Bellantonio P Pedernera-Bradichansky P Cafiero E Rodriguez P Massaro Source Type: research
Childhood-onset Huntignton ´s disease. A rare presentation
CONCLUSION: Childhood-onset HD differs from adult-form´s clinical manifestations. It should be considered in patients with progressive motor and cognitive impairment. Due to family inheritance, it is important to carefully examine family history and take it into account even without relatives affected, considering the anticipation phenomenon.PMID:38416505 | DOI:10.33588/rn.7805.2024039 (Source: Revista de Neurologia)
Source: Revista de Neurologia - February 28, 2024 Category: Neurology Authors: A Gauto E Bellantonio P Pedernera-Bradichansky P Cafiero E Rodriguez P Massaro Source Type: research
Childhood-onset Huntignton ´s disease. A rare presentation
CONCLUSION: Childhood-onset HD differs from adult-form´s clinical manifestations. It should be considered in patients with progressive motor and cognitive impairment. Due to family inheritance, it is important to carefully examine family history and take it into account even without relatives affected, considering the anticipation phenomenon.PMID:38416505 | DOI:10.33588/rn.7805.2024039 (Source: Revista de Neurologia)
Source: Revista de Neurologia - February 28, 2024 Category: Neurology Authors: A Gauto E Bellantonio P Pedernera-Bradichansky P Cafiero E Rodriguez P Massaro Source Type: research
Childhood-onset Huntignton ´s disease. A rare presentation
CONCLUSION: Childhood-onset HD differs from adult-form´s clinical manifestations. It should be considered in patients with progressive motor and cognitive impairment. Due to family inheritance, it is important to carefully examine family history and take it into account even without relatives affected, considering the anticipation phenomenon.PMID:38416505 | DOI:10.33588/rn.7805.2024039 (Source: Revista de Neurologia)
Source: Revista de Neurologia - February 28, 2024 Category: Neurology Authors: A Gauto E Bellantonio P Pedernera-Bradichansky P Cafiero E Rodriguez P Massaro Source Type: research
