Disentangling the neurobiological bases of temporal impulsivity in Huntington's disease
ConclusionsThe present findings highlight the importance of investigating the spectrum of temporal impulsivity in HD. As, while less prevalent than other psychiatric features, this symptom is still reported to significantly impact the quality of life of patients and caregivers. This study provides evidence that individual differences observed in temporal impulsivity may be explained by variability in limbic frontostriatal tracts, while shedding light on the role of sensitivity to reward in modulating impulsive behavior through the selection of immediate rewards. (Source: Brain and Behavior)
Source: Brain and Behavior - March 7, 2024 Category: Neurology Authors: Helena Pardina ‐Torner,
Audrey E. De Paepe,
Clara Garcia‐Gorro,
Nadia Rodriguez‐Dechicha,
Irene Vaquer,
Matilde Calopa,
Jesus Ruiz‐Idiago,
Celia Mareca,
Ruth de Diego‐Balaguer,
Estela Camara Tags: ORIGINAL ARTICLE Source Type: research
Assessment of Fitbit Charge 4 for sleep stage and heart rate monitoring against polysomnography and during home monitoring in Huntington ’s disease
Journal of Clinical Sleep Medicine, Ahead of Print. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - March 7, 2024 Category: Sleep Medicine Authors: Emer P. Doheny
Klavs Renerts
Andreas Braun
Esther Werth
Christian Baumann
Philipp Baumgartner
Philippa Morgan-Jones
Monica Busse
Madeleine M. Lowery
Hans H. Jung
1School of Electrical and Electronic Engineering, University College Dublin, Dublin, Ireland
Source Type: research
Ribosome Profiling and Mass Spectrometry Reveal Widespread Mitochondrial Translation Defects in a Striatal Cell Model of Huntington Disease
Mol Cell Proteomics. 2024 Mar 4:100746. doi: 10.1016/j.mcpro.2024.100746. Online ahead of print.ABSTRACTHuntington disease (HD) is caused by an expanded polyglutamine mutation in huntingtin (mHTT) that promotes prominent atrophy in the striatum and subsequent psychiatric, cognitive, and choreiform movements. Multiple lines of evidence point to an association between HD and aberrant striatal mitochondrial functions; however, the present knowledge about whether (or how) mitochondrial mRNA translation is differentially regulated in HD remains unclear. We found that protein synthesis is diminished in HD mitochondria compared t...
Source: Molecular and Cellular Proteomics : MCP - March 6, 2024 Category: Molecular Biology Authors: Sunayana Dagar Manish Sharma George Tsaprailis Catherina Scharager Tapia Gogce Crynen Preksha Sandipkumar Joshi Neelam Shahani Srinivasa Subramaniam Source Type: research
Ribosome Profiling and Mass Spectrometry Reveal Widespread Mitochondrial Translation Defects in a Striatal Cell Model of Huntington Disease
Mol Cell Proteomics. 2024 Mar 4:100746. doi: 10.1016/j.mcpro.2024.100746. Online ahead of print.ABSTRACTHuntington disease (HD) is caused by an expanded polyglutamine mutation in huntingtin (mHTT) that promotes prominent atrophy in the striatum and subsequent psychiatric, cognitive, and choreiform movements. Multiple lines of evidence point to an association between HD and aberrant striatal mitochondrial functions; however, the present knowledge about whether (or how) mitochondrial mRNA translation is differentially regulated in HD remains unclear. We found that protein synthesis is diminished in HD mitochondria compared t...
Source: Molecular and Cellular Proteomics : MCP - March 6, 2024 Category: Molecular Biology Authors: Sunayana Dagar Manish Sharma George Tsaprailis Catherina Scharager Tapia Gogce Crynen Preksha Sandipkumar Joshi Neelam Shahani Srinivasa Subramaniam Source Type: research
Ribosome Profiling and Mass Spectrometry Reveal Widespread Mitochondrial Translation Defects in a Striatal Cell Model of Huntington Disease
Mol Cell Proteomics. 2024 Mar 4:100746. doi: 10.1016/j.mcpro.2024.100746. Online ahead of print.ABSTRACTHuntington disease (HD) is caused by an expanded polyglutamine mutation in huntingtin (mHTT) that promotes prominent atrophy in the striatum and subsequent psychiatric, cognitive, and choreiform movements. Multiple lines of evidence point to an association between HD and aberrant striatal mitochondrial functions; however, the present knowledge about whether (or how) mitochondrial mRNA translation is differentially regulated in HD remains unclear. We found that protein synthesis is diminished in HD mitochondria compared t...
Source: Molecular and Cellular Proteomics : MCP - March 6, 2024 Category: Molecular Biology Authors: Sunayana Dagar Manish Sharma George Tsaprailis Catherina Scharager Tapia Gogce Crynen Preksha Sandipkumar Joshi Neelam Shahani Srinivasa Subramaniam Source Type: research
Ribosome Profiling and Mass Spectrometry Reveal Widespread Mitochondrial Translation Defects in a Striatal Cell Model of Huntington Disease
Mol Cell Proteomics. 2024 Mar 4:100746. doi: 10.1016/j.mcpro.2024.100746. Online ahead of print.ABSTRACTHuntington disease (HD) is caused by an expanded polyglutamine mutation in huntingtin (mHTT) that promotes prominent atrophy in the striatum and subsequent psychiatric, cognitive, and choreiform movements. Multiple lines of evidence point to an association between HD and aberrant striatal mitochondrial functions; however, the present knowledge about whether (or how) mitochondrial mRNA translation is differentially regulated in HD remains unclear. We found that protein synthesis is diminished in HD mitochondria compared t...
Source: Molecular and Cellular Proteomics : MCP - March 6, 2024 Category: Molecular Biology Authors: Sunayana Dagar Manish Sharma George Tsaprailis Catherina Scharager Tapia Gogce Crynen Preksha Sandipkumar Joshi Neelam Shahani Srinivasa Subramaniam Source Type: research
Ribosome Profiling and Mass Spectrometry Reveal Widespread Mitochondrial Translation Defects in a Striatal Cell Model of Huntington Disease
Mol Cell Proteomics. 2024 Mar 4:100746. doi: 10.1016/j.mcpro.2024.100746. Online ahead of print.ABSTRACTHuntington disease (HD) is caused by an expanded polyglutamine mutation in huntingtin (mHTT) that promotes prominent atrophy in the striatum and subsequent psychiatric, cognitive, and choreiform movements. Multiple lines of evidence point to an association between HD and aberrant striatal mitochondrial functions; however, the present knowledge about whether (or how) mitochondrial mRNA translation is differentially regulated in HD remains unclear. We found that protein synthesis is diminished in HD mitochondria compared t...
Source: Molecular and Cellular Proteomics : MCP - March 6, 2024 Category: Molecular Biology Authors: Sunayana Dagar Manish Sharma George Tsaprailis Catherina Scharager Tapia Gogce Crynen Preksha Sandipkumar Joshi Neelam Shahani Srinivasa Subramaniam Source Type: research
Ribosome Profiling and Mass Spectrometry Reveal Widespread Mitochondrial Translation Defects in a Striatal Cell Model of Huntington Disease
Mol Cell Proteomics. 2024 Mar 4:100746. doi: 10.1016/j.mcpro.2024.100746. Online ahead of print.ABSTRACTHuntington disease (HD) is caused by an expanded polyglutamine mutation in huntingtin (mHTT) that promotes prominent atrophy in the striatum and subsequent psychiatric, cognitive, and choreiform movements. Multiple lines of evidence point to an association between HD and aberrant striatal mitochondrial functions; however, the present knowledge about whether (or how) mitochondrial mRNA translation is differentially regulated in HD remains unclear. We found that protein synthesis is diminished in HD mitochondria compared t...
Source: Molecular and Cellular Proteomics : MCP - March 6, 2024 Category: Molecular Biology Authors: Sunayana Dagar Manish Sharma George Tsaprailis Catherina Scharager Tapia Gogce Crynen Preksha Sandipkumar Joshi Neelam Shahani Srinivasa Subramaniam Source Type: research
Ribosome Profiling and Mass Spectrometry Reveal Widespread Mitochondrial Translation Defects in a Striatal Cell Model of Huntington Disease
Mol Cell Proteomics. 2024 Mar 4:100746. doi: 10.1016/j.mcpro.2024.100746. Online ahead of print.ABSTRACTHuntington disease (HD) is caused by an expanded polyglutamine mutation in huntingtin (mHTT) that promotes prominent atrophy in the striatum and subsequent psychiatric, cognitive, and choreiform movements. Multiple lines of evidence point to an association between HD and aberrant striatal mitochondrial functions; however, the present knowledge about whether (or how) mitochondrial mRNA translation is differentially regulated in HD remains unclear. We found that protein synthesis is diminished in HD mitochondria compared t...
Source: Molecular and Cellular Proteomics : MCP - March 6, 2024 Category: Molecular Biology Authors: Sunayana Dagar Manish Sharma George Tsaprailis Catherina Scharager Tapia Gogce Crynen Preksha Sandipkumar Joshi Neelam Shahani Srinivasa Subramaniam Source Type: research
Ribosome Profiling and Mass Spectrometry Reveal Widespread Mitochondrial Translation Defects in a Striatal Cell Model of Huntington Disease
Mol Cell Proteomics. 2024 Mar 4:100746. doi: 10.1016/j.mcpro.2024.100746. Online ahead of print.ABSTRACTHuntington disease (HD) is caused by an expanded polyglutamine mutation in huntingtin (mHTT) that promotes prominent atrophy in the striatum and subsequent psychiatric, cognitive, and choreiform movements. Multiple lines of evidence point to an association between HD and aberrant striatal mitochondrial functions; however, the present knowledge about whether (or how) mitochondrial mRNA translation is differentially regulated in HD remains unclear. We found that protein synthesis is diminished in HD mitochondria compared t...
Source: Molecular and Cellular Proteomics : MCP - March 6, 2024 Category: Molecular Biology Authors: Sunayana Dagar Manish Sharma George Tsaprailis Catherina Scharager Tapia Gogce Crynen Preksha Sandipkumar Joshi Neelam Shahani Srinivasa Subramaniam Source Type: research
Involvement of Autophagic Machinery in Neuropathogenesis: Targeting and Relevant Methods of Detection
Methods Mol Biol. 2024 Mar 6. doi: 10.1007/7651_2024_516. Online ahead of print.ABSTRACTThe exquisite balance between cellular prosurvival and death pathways is extremely necessary for homeostasis. Different forms of programmed cell death have been widely studied and reported such as apoptosis, necroptosis, pyroptosis, and autophagy. Autophagy is a catabolic process important for normal cellular functioning. The main aim of this machinery is to degrade the misfolded or damaged proteins, unuseful organelles, and pathogens, which invade the cells, thereby maintaining cellular homeostasis and assuring the regular renewal of c...
Source: Mol Biol Cell - March 5, 2024 Category: Molecular Biology Authors: Nourhan Sayed Alaa Emam Ali Doaa Mokhtar Elsherbiny Samar S Azab Source Type: research
Cross Talks between CNS and CVS Diseases: An Alliance to Annihilate
Curr Cardiol Rev. 2024 Mar 4. doi: 10.2174/011573403X278550240221112636. Online ahead of print.ABSTRACTCardiovascular and neurological diseases cause substantial morbidity and mortality globally. Moreover, cardiovascular diseases are the leading cause of death globally. About 17.9 million people are affected by cardiovascular diseases and 6.8 million people die every year due to neurological diseases. The common neurologic manifestations of cardiovascular illness include stroke syndrome which is responsible for unconsciousness and several other morbidities significantly diminished the quality of life of patients. Therefore...
Source: Current Cardiology Reviews - March 5, 2024 Category: Cardiology Authors: Shivani Chib Sushma Devi Rishabh Chalotra Neeraj Mittal Thakur Gurjeet Singh Puneet Kumar Randhir Singh Source Type: research
Involvement of Autophagic Machinery in Neuropathogenesis: Targeting and Relevant Methods of Detection
Methods Mol Biol. 2024 Mar 6. doi: 10.1007/7651_2024_516. Online ahead of print.ABSTRACTThe exquisite balance between cellular prosurvival and death pathways is extremely necessary for homeostasis. Different forms of programmed cell death have been widely studied and reported such as apoptosis, necroptosis, pyroptosis, and autophagy. Autophagy is a catabolic process important for normal cellular functioning. The main aim of this machinery is to degrade the misfolded or damaged proteins, unuseful organelles, and pathogens, which invade the cells, thereby maintaining cellular homeostasis and assuring the regular renewal of c...
Source: Mol Biol Cell - March 5, 2024 Category: Molecular Biology Authors: Nourhan Sayed Alaa Emam Ali Doaa Mokhtar Elsherbiny Samar S Azab Source Type: research
Cross Talks between CNS and CVS Diseases: An Alliance to Annihilate
Curr Cardiol Rev. 2024 Mar 4. doi: 10.2174/011573403X278550240221112636. Online ahead of print.ABSTRACTCardiovascular and neurological diseases cause substantial morbidity and mortality globally. Moreover, cardiovascular diseases are the leading cause of death globally. About 17.9 million people are affected by cardiovascular diseases and 6.8 million people die every year due to neurological diseases. The common neurologic manifestations of cardiovascular illness include stroke syndrome which is responsible for unconsciousness and several other morbidities significantly diminished the quality of life of patients. Therefore...
Source: Current Cardiology Reviews - March 5, 2024 Category: Cardiology Authors: Shivani Chib Sushma Devi Rishabh Chalotra Neeraj Mittal Thakur Gurjeet Singh Puneet Kumar Randhir Singh Source Type: research
