Electrochemical detection of manganese ions using aptamer-based layers
Talanta. 2024 Mar 20;273:125926. doi: 10.1016/j.talanta.2024.125926. Online ahead of print.ABSTRACTHeavy metals are one of the major pollutants found in drinking water and their abnormal level may pose a threat to human's health and life. Manganese also belongs to heavy metals group, and it is generally used in production of batteries, fertilizers, and ceramics. Even though, Mn is necessary for proper development of central nervous system, its elevated concentration might lead to certain diseases such as epilepsies, cell death in focal cerebral ischemia as well as neurodegenerative diseases such as Huntington and Alzheimer...
Source: Talanta - March 24, 2024 Category: Chemistry Authors: Marta Jarczewska Magdalena Borowska Marcin Olszewski Elzbieta Malinowska Source Type: research
An assessment of crucial structural contributors of HDAC6 inhibitors through fragment-based non-linear pattern recognition and molecular dynamics simulation approaches
Comput Biol Chem. 2024 Mar 11;110:108051. doi: 10.1016/j.compbiolchem.2024.108051. Online ahead of print.ABSTRACTAmidst the Zn2+-dependant isoforms of the HDAC family, HDAC6 has emerged as a potential target associated with an array of diseases, especially cancer and neuronal disorders like Rett's Syndrome, Alzheimer's disease, Huntington's disease, etc. Also, despite the availability of a handful of HDAC inhibitors in the market, their non-selective nature has restricted their use in different disease conditions. In this situation, the development of selective and potent HDAC6 inhibitors will provide efficacious therapeut...
Source: Computational Biology and Chemistry - March 23, 2024 Category: Bioinformatics Authors: Suvankar Banerjee Sandeep Jana Tarun Jha Balaram Ghosh Nilanjan Adhikari Source Type: research
An assessment of crucial structural contributors of HDAC6 inhibitors through fragment-based non-linear pattern recognition and molecular dynamics simulation approaches
Comput Biol Chem. 2024 Mar 11;110:108051. doi: 10.1016/j.compbiolchem.2024.108051. Online ahead of print.ABSTRACTAmidst the Zn2+-dependant isoforms of the HDAC family, HDAC6 has emerged as a potential target associated with an array of diseases, especially cancer and neuronal disorders like Rett's Syndrome, Alzheimer's disease, Huntington's disease, etc. Also, despite the availability of a handful of HDAC inhibitors in the market, their non-selective nature has restricted their use in different disease conditions. In this situation, the development of selective and potent HDAC6 inhibitors will provide efficacious therapeut...
Source: Computational Biology and Chemistry - March 23, 2024 Category: Bioinformatics Authors: Suvankar Banerjee Sandeep Jana Tarun Jha Balaram Ghosh Nilanjan Adhikari Source Type: research
Can new drugs stop a deadly set of brain-eating diseases?
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BY
Sarah Crespi
,
Katherine Irving
,
Meredith Wadman
Podcast
21 Mar 2024
My friend Charlie Clark began complaining that his eyeglasses were faulty in September 2023. A trip to the optician didn’t fix them; they were still “out of alignment,” he said. The same month, his insomnia,...
Source: Science of Aging Knowledge Environment - March 21, 2024 Category: Geriatrics Source Type: research
Activation of alpha-7 nicotinic acetylcholine receptor by tropisetron mitigates 3-nitropropionic acid-induced Huntington's disease in rats: Role of PI3K/Akt and JAK2/NF- κB signaling pathways
In conclusion, tropisetron showed a neuroprotective activity against 3-NP-induced HD via activating PI3K/Akt signaling and suppressing JAK2/NF-κB inflammatory axis. Thus, repositioning of tropisetron could represent a promising therapeutic strategy in management of HD.PMID:38513929 | DOI:10.1016/j.cbi.2024.110957 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - March 21, 2024 Category: Molecular Biology Authors: Mostafa A Rabie Ahmed T Ghoneim Mohamed I Fahmy Mohammed F El-Yamany Rabab H Sayed Source Type: research
Activation of alpha-7 nicotinic acetylcholine receptor by tropisetron mitigates 3-nitropropionic acid-induced Huntington's disease in rats: Role of PI3K/Akt and JAK2/NF- κB signaling pathways
In conclusion, tropisetron showed a neuroprotective activity against 3-NP-induced HD via activating PI3K/Akt signaling and suppressing JAK2/NF-κB inflammatory axis. Thus, repositioning of tropisetron could represent a promising therapeutic strategy in management of HD.PMID:38513929 | DOI:10.1016/j.cbi.2024.110957 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - March 21, 2024 Category: Molecular Biology Authors: Mostafa A Rabie Ahmed T Ghoneim Mohamed I Fahmy Mohammed F El-Yamany Rabab H Sayed Source Type: research
Identifying and verifying Huntington's disease subtypes: Clinical features, neuroimaging, and cytokine changes
ConclusionWe have identified three HD clusters via clinical manifestations with distinct biomarkers. Our data shed light on better understanding about the pathophysiology of HD. (Source: Brain and Behavior)
Source: Brain and Behavior - March 18, 2024 Category: Neurology Authors: Ling ‐Xiao Cao,
Jin‐Hui Yin,
Gang Du,
Qing Yang,
Yue Huang Tags: ORIGINAL ARTICLE Source Type: research
Revisiting the Mitochondrial Function and Communication in Neurodegenerative Diseases
Curr Pharm Des. 2024 Mar 12. doi: 10.2174/0113816128286655240304070740. Online ahead of print.ABSTRACTNeurodegenerative disorders are distinguished by the progressive loss of anatomically or physiologically relevant neural systems. Atypical mitochondrial morphology and metabolic malfunction are found in many neurodegenerative disorders. Alteration in mitochondrial function can occur as a result of aberrant mitochondrial DNA, altered nuclear enzymes that interact with mitochondria actively or passively, or due to unexplained reasons. Mitochondria are intimately linked to the Endoplasmic reticulum (ER), and ER-mitochondrial ...
Source: Current Pharmaceutical Design - March 14, 2024 Category: Drugs & Pharmacology Authors: Nitu L Wankhede Mayur B Kale Mohit D Umare Sanket Lokhande Aman B Upaganlawar Pranay Wal Brijesh G Taksande Milind J Umekar Prasanna Shama Khandige Bhupendra Singh Vandana Sadananda Seema Ramniwas Tapan Behl Source Type: research
Revisiting the Mitochondrial Function and Communication in Neurodegenerative Diseases
Curr Pharm Des. 2024 Mar 12. doi: 10.2174/0113816128286655240304070740. Online ahead of print.ABSTRACTNeurodegenerative disorders are distinguished by the progressive loss of anatomically or physiologically relevant neural systems. Atypical mitochondrial morphology and metabolic malfunction are found in many neurodegenerative disorders. Alteration in mitochondrial function can occur as a result of aberrant mitochondrial DNA, altered nuclear enzymes that interact with mitochondria actively or passively, or due to unexplained reasons. Mitochondria are intimately linked to the Endoplasmic reticulum (ER), and ER-mitochondrial ...
Source: Current Pharmaceutical Design - March 14, 2024 Category: Drugs & Pharmacology Authors: Nitu L Wankhede Mayur B Kale Mohit D Umare Sanket Lokhande Aman B Upaganlawar Pranay Wal Brijesh G Taksande Milind J Umekar Prasanna Shama Khandige Bhupendra Singh Vandana Sadananda Seema Ramniwas Tapan Behl Source Type: research
Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues
CONCLUSIONS: Our results show that HTT1a expression occurs throughout a wide range of tissues and likely with all CAG lengths. Our data from peripheral sample sources demonstrate that HTT1a is indeed generated throughout the body in a CAG repeat-length-dependent manner. Therefore, the levels of HTT1a might be a sensitive marker of disease state and/or progression and should be monitored over time, especially in clinical trials targeting HTT expression.PMID:38459427 | DOI:10.1186/s10020-024-00801-2 (Source: Molecular Medicine)
Source: Molecular Medicine - March 8, 2024 Category: Molecular Biology Authors: Franziska Hoschek Julia Natan Maximilian Wagner Kirupa Sathasivam Alshaimaa Abdelmoez Bj örn von Einem Gillian P Bates G Bernhard Landwehrmeyer Andreas Neueder Source Type: research
TYROBP/DAP12 knockout in Huntington ’s disease Q175 mice cell-autonomously decreases microglial expression of disease-associated genes and non-cell-autonomously mitigates astrogliosis and motor deterioration
Huntington ’s disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the Huntingtin gene (HTT). Immune activation is abundant in the striatum of HD patients. D... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 8, 2024 Category: Neurology Authors: Jordi Creus-Muncunill, Jean Vianney Haure-Mirande, Daniele Mattei, Joanna Bons, Angie V. Ramirez, B. Wade Hamilton, Chuhyon Corwin, Sarah Chowdhury, Birgit Schilling, Lisa M. Ellerby and Michelle E. Ehrlich Tags: Research Source Type: research
Agmatine mitigates behavioral abnormalities and neurochemical dysregulation associated with 3-Nitropropionic acid-induced Huntington's disease in rats
Neurotoxicology. 2024 Mar 5:S0161-813X(24)00022-6. doi: 10.1016/j.neuro.2024.03.002. Online ahead of print.ABSTRACTHuntington's disease (HD) is a progressive neurodegenerative condition characterized by a severe motor incoordination, cognitive decline, and psychiatric complications. However, a definitive cure for this devastating disorder remains elusive. Agmatine, a biogenic amine, has gain attention for its reported neuromodulatory and neuroprotective properties. The present study was designed to examine the influence of agmatine on the behavioral, biochemical, and molecular aspects of HD in an animal model. A mitochondr...
Source: Neurotoxicology - March 7, 2024 Category: Neurology Authors: Raj Katariya Kartikey Mishra Shivkumar Sammeta Milind Umekar Nandkishor Kotagale Brijesh Taksande Source Type: research
Agmatine mitigates behavioral abnormalities and neurochemical dysregulation associated with 3-Nitropropionic acid-induced Huntington's disease in rats
Neurotoxicology. 2024 Mar 5:S0161-813X(24)00022-6. doi: 10.1016/j.neuro.2024.03.002. Online ahead of print.ABSTRACTHuntington's disease (HD) is a progressive neurodegenerative condition characterized by a severe motor incoordination, cognitive decline, and psychiatric complications. However, a definitive cure for this devastating disorder remains elusive. Agmatine, a biogenic amine, has gain attention for its reported neuromodulatory and neuroprotective properties. The present study was designed to examine the influence of agmatine on the behavioral, biochemical, and molecular aspects of HD in an animal model. A mitochondr...
Source: Neurotoxicology - March 7, 2024 Category: Neurology Authors: Raj Katariya Kartikey Mishra Shivkumar Sammeta Milind Umekar Nandkishor Kotagale Brijesh Taksande Source Type: research
Agmatine mitigates behavioral abnormalities and neurochemical dysregulation associated with 3-Nitropropionic acid-induced Huntington's disease in rats
Neurotoxicology. 2024 Mar 5:S0161-813X(24)00022-6. doi: 10.1016/j.neuro.2024.03.002. Online ahead of print.ABSTRACTHuntington's disease (HD) is a progressive neurodegenerative condition characterized by a severe motor incoordination, cognitive decline, and psychiatric complications. However, a definitive cure for this devastating disorder remains elusive. Agmatine, a biogenic amine, has gain attention for its reported neuromodulatory and neuroprotective properties. The present study was designed to examine the influence of agmatine on the behavioral, biochemical, and molecular aspects of HD in an animal model. A mitochondr...
Source: Neurotoxicology - March 7, 2024 Category: Neurology Authors: Raj Katariya Kartikey Mishra Shivkumar Sammeta Milind Umekar Nandkishor Kotagale Brijesh Taksande Source Type: research
Agmatine mitigates behavioral abnormalities and neurochemical dysregulation associated with 3-Nitropropionic acid-induced Huntington's disease in rats
Neurotoxicology. 2024 Mar 5:S0161-813X(24)00022-6. doi: 10.1016/j.neuro.2024.03.002. Online ahead of print.ABSTRACTHuntington's disease (HD) is a progressive neurodegenerative condition characterized by a severe motor incoordination, cognitive decline, and psychiatric complications. However, a definitive cure for this devastating disorder remains elusive. Agmatine, a biogenic amine, has gain attention for its reported neuromodulatory and neuroprotective properties. The present study was designed to examine the influence of agmatine on the behavioral, biochemical, and molecular aspects of HD in an animal model. A mitochondr...
Source: Neurotoxicology - March 7, 2024 Category: Neurology Authors: Raj Katariya Kartikey Mishra Shivkumar Sammeta Milind Umekar Nandkishor Kotagale Brijesh Taksande Source Type: research
