Mitochondrial Dysfunction: A Key Player in Brain Aging and Diseases
Curr Issues Mol Biol. 2024 Mar 2;46(3):1987-2026. doi: 10.3390/cimb46030130.ABSTRACTMitochondria are thought to have become incorporated within the eukaryotic cell approximately 2 billion years ago and play a role in a variety of cellular processes, such as energy production, calcium buffering and homeostasis, steroid synthesis, cell growth, and apoptosis, as well as inflammation and ROS production. Considering that mitochondria are involved in a multitude of cellular processes, mitochondrial dysfunction has been shown to play a role within several age-related diseases, including cancers, diabetes (type 2), and neurodegene...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Sydney Bartman Giuseppe Coppotelli Jaime M Ross Source Type: research
Mitochondrial Dysfunction: A Key Player in Brain Aging and Diseases
Curr Issues Mol Biol. 2024 Mar 2;46(3):1987-2026. doi: 10.3390/cimb46030130.ABSTRACTMitochondria are thought to have become incorporated within the eukaryotic cell approximately 2 billion years ago and play a role in a variety of cellular processes, such as energy production, calcium buffering and homeostasis, steroid synthesis, cell growth, and apoptosis, as well as inflammation and ROS production. Considering that mitochondria are involved in a multitude of cellular processes, mitochondrial dysfunction has been shown to play a role within several age-related diseases, including cancers, diabetes (type 2), and neurodegene...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Sydney Bartman Giuseppe Coppotelli Jaime M Ross Source Type: research
Mitochondrial Dysfunction: A Key Player in Brain Aging and Diseases
Curr Issues Mol Biol. 2024 Mar 2;46(3):1987-2026. doi: 10.3390/cimb46030130.ABSTRACTMitochondria are thought to have become incorporated within the eukaryotic cell approximately 2 billion years ago and play a role in a variety of cellular processes, such as energy production, calcium buffering and homeostasis, steroid synthesis, cell growth, and apoptosis, as well as inflammation and ROS production. Considering that mitochondria are involved in a multitude of cellular processes, mitochondrial dysfunction has been shown to play a role within several age-related diseases, including cancers, diabetes (type 2), and neurodegene...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Sydney Bartman Giuseppe Coppotelli Jaime M Ross Source Type: research
Mitochondrial Dysfunction: A Key Player in Brain Aging and Diseases
Curr Issues Mol Biol. 2024 Mar 2;46(3):1987-2026. doi: 10.3390/cimb46030130.ABSTRACTMitochondria are thought to have become incorporated within the eukaryotic cell approximately 2 billion years ago and play a role in a variety of cellular processes, such as energy production, calcium buffering and homeostasis, steroid synthesis, cell growth, and apoptosis, as well as inflammation and ROS production. Considering that mitochondria are involved in a multitude of cellular processes, mitochondrial dysfunction has been shown to play a role within several age-related diseases, including cancers, diabetes (type 2), and neurodegene...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Sydney Bartman Giuseppe Coppotelli Jaime M Ross Source Type: research
Mitochondrial Dysfunction: A Key Player in Brain Aging and Diseases
Curr Issues Mol Biol. 2024 Mar 2;46(3):1987-2026. doi: 10.3390/cimb46030130.ABSTRACTMitochondria are thought to have become incorporated within the eukaryotic cell approximately 2 billion years ago and play a role in a variety of cellular processes, such as energy production, calcium buffering and homeostasis, steroid synthesis, cell growth, and apoptosis, as well as inflammation and ROS production. Considering that mitochondria are involved in a multitude of cellular processes, mitochondrial dysfunction has been shown to play a role within several age-related diseases, including cancers, diabetes (type 2), and neurodegene...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Sydney Bartman Giuseppe Coppotelli Jaime M Ross Source Type: research
Mitochondrial Dysfunction: A Key Player in Brain Aging and Diseases
Curr Issues Mol Biol. 2024 Mar 2;46(3):1987-2026. doi: 10.3390/cimb46030130.ABSTRACTMitochondria are thought to have become incorporated within the eukaryotic cell approximately 2 billion years ago and play a role in a variety of cellular processes, such as energy production, calcium buffering and homeostasis, steroid synthesis, cell growth, and apoptosis, as well as inflammation and ROS production. Considering that mitochondria are involved in a multitude of cellular processes, mitochondrial dysfunction has been shown to play a role within several age-related diseases, including cancers, diabetes (type 2), and neurodegene...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Sydney Bartman Giuseppe Coppotelli Jaime M Ross Source Type: research
Mitochondrial Dysfunction: A Key Player in Brain Aging and Diseases
Curr Issues Mol Biol. 2024 Mar 2;46(3):1987-2026. doi: 10.3390/cimb46030130.ABSTRACTMitochondria are thought to have become incorporated within the eukaryotic cell approximately 2 billion years ago and play a role in a variety of cellular processes, such as energy production, calcium buffering and homeostasis, steroid synthesis, cell growth, and apoptosis, as well as inflammation and ROS production. Considering that mitochondria are involved in a multitude of cellular processes, mitochondrial dysfunction has been shown to play a role within several age-related diseases, including cancers, diabetes (type 2), and neurodegene...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Sydney Bartman Giuseppe Coppotelli Jaime M Ross Source Type: research
Mitochondrial Dysfunction: A Key Player in Brain Aging and Diseases
Curr Issues Mol Biol. 2024 Mar 2;46(3):1987-2026. doi: 10.3390/cimb46030130.ABSTRACTMitochondria are thought to have become incorporated within the eukaryotic cell approximately 2 billion years ago and play a role in a variety of cellular processes, such as energy production, calcium buffering and homeostasis, steroid synthesis, cell growth, and apoptosis, as well as inflammation and ROS production. Considering that mitochondria are involved in a multitude of cellular processes, mitochondrial dysfunction has been shown to play a role within several age-related diseases, including cancers, diabetes (type 2), and neurodegene...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Sydney Bartman Giuseppe Coppotelli Jaime M Ross Source Type: research
Mitochondrial Dysfunction: A Key Player in Brain Aging and Diseases
Curr Issues Mol Biol. 2024 Mar 2;46(3):1987-2026. doi: 10.3390/cimb46030130.ABSTRACTMitochondria are thought to have become incorporated within the eukaryotic cell approximately 2 billion years ago and play a role in a variety of cellular processes, such as energy production, calcium buffering and homeostasis, steroid synthesis, cell growth, and apoptosis, as well as inflammation and ROS production. Considering that mitochondria are involved in a multitude of cellular processes, mitochondrial dysfunction has been shown to play a role within several age-related diseases, including cancers, diabetes (type 2), and neurodegene...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Sydney Bartman Giuseppe Coppotelli Jaime M Ross Source Type: research
Continuing the search for fluid biomarkers to enhance Huntington disease staging and therapeutic response
In Huntington's disease (HD), a neurodegenerative disorder caused by expanded CAG trinucleotide repeats in the gene HTT encoding the huntingtin protein, mutation carriers produce abnormally long polyglutamine sequences that predispose the protein to fragmentation, causing neuronal dysfunction and death. Clinically, this results in characteristic choreiform movements, behavioral disturbances, and dementia [1]. As disease-modifying therapies continue to move toward fruition, it would be paramount to bring them to those who are premanifest at the earliest timepoint along the disease spectrum to maximize benefits and intervene...
Source: Journal of the Neurological Sciences - March 27, 2024 Category: Neurology Authors: Eilrayna Gelyana, Rebecca Khamishon, Jee Bang Source Type: research
Continuing the search for fluid biomarkers to enhance Huntington's disease staging and therapeutic response
In Huntington's disease (HD), a neurodegenerative disorder caused by expanded CAG trinucleotide repeats in the gene HTT encoding the huntingtin protein, mutation carriers produce abnormally long polyglutamine sequences that predispose the protein to fragmentation, causing neuronal dysfunction and death. Clinically, this results in characteristic choreiform movements, behavioral disturbances, and dementia [1]. As disease-modifying therapies continue to move toward fruition, it would be paramount to bring them to those who are premanifest at the earliest timepoint along the disease spectrum to maximize benefits and intervene...
Source: Journal of the Neurological Sciences - March 27, 2024 Category: Neurology Authors: Eilrayna Gelyana, Rebecca Khamishon, Jee Bang Source Type: research
Language-Independent Acoustic Biomarkers for Quantifying Speech Impairment in Huntington's Disease
CONCLUSION: The results support the application of acoustic features to objectively quantify speech impairment and disease severity in HD in multilanguage studies.SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.25447171.PMID:38530396 | DOI:10.1044/2024_AJSLP-23-00175 (Source: American Journal of Speech-Language Pathology)
Source: American Journal of Speech-Language Pathology - March 26, 2024 Category: Speech-Language Pathology Authors: Vit ória S Fahed Emer P Doheny Carla Collazo Joanna Krzysztofik Elliot Mann Philippa Morgan-Jones Laura Mills Cheney Drew Anne E Rosser Rebecca Cousins Grzegorz Witkowski Esther Cubo Monica Busse Madeleine M Lowery Source Type: research
Treatment of Depression in Huntington's Disease: A Systematic Review
The objective of this systematic review was to conduct a comprehensive evaluation of the available evidence. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. Studies on the treatment of depression in HD were identified by searching MEDLINE, Embase, and PsycInfo. The initial search yielded 2,771 records, 41 of which were ultimately included. There were 19 case reports, seven case series, three cross-sectional studies, one qualitative study, nine nonrandomized studies, and two randomized trials among the included studies. The most common assessment tools were the Hospital Anxie...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - March 26, 2024 Category: Psychiatry Authors: Shayan Abdollah Zadegan Frank Ramirez Kirthan S Reddy Onur Sahin Natalia Pessoa Rocha Antonio L Teixeira Erin Furr Stimming Source Type: research
Language-Independent Acoustic Biomarkers for Quantifying Speech Impairment in Huntington's Disease
CONCLUSION: The results support the application of acoustic features to objectively quantify speech impairment and disease severity in HD in multilanguage studies.SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.25447171.PMID:38530396 | DOI:10.1044/2024_AJSLP-23-00175 (Source: American Journal of Speech-Language Pathology)
Source: American Journal of Speech-Language Pathology - March 26, 2024 Category: Speech-Language Pathology Authors: Vit ória S Fahed Emer P Doheny Carla Collazo Joanna Krzysztofik Elliot Mann Philippa Morgan-Jones Laura Mills Cheney Drew Anne E Rosser Rebecca Cousins Grzegorz Witkowski Esther Cubo Monica Busse Madeleine M Lowery Source Type: research
Treatment of Depression in Huntington's Disease: A Systematic Review
The objective of this systematic review was to conduct a comprehensive evaluation of the available evidence. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. Studies on the treatment of depression in HD were identified by searching MEDLINE, Embase, and PsycInfo. The initial search yielded 2,771 records, 41 of which were ultimately included. There were 19 case reports, seven case series, three cross-sectional studies, one qualitative study, nine nonrandomized studies, and two randomized trials among the included studies. The most common assessment tools were the Hospital Anxie...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - March 26, 2024 Category: Psychiatry Authors: Shayan Abdollah Zadegan Frank Ramirez Kirthan S Reddy Onur Sahin Natalia Pessoa Rocha Antonio L Teixeira Erin Furr Stimming Source Type: research
