Ribosome Profiling and Mass Spectrometry Reveal Widespread Mitochondrial Translation Defects in a Striatal Cell Model of Huntington Disease
Mol Cell Proteomics. 2024 Mar 4:100746. doi: 10.1016/j.mcpro.2024.100746. Online ahead of print.ABSTRACTHuntington disease (HD) is caused by an expanded polyglutamine mutation in huntingtin (mHTT) that promotes prominent atrophy in the striatum and subsequent psychiatric, cognitive, and choreiform movements. Multiple lines of evidence point to an association between HD and aberrant striatal mitochondrial functions; however, the present knowledge about whether (or how) mitochondrial mRNA translation is differentially regulated in HD remains unclear. We found that protein synthesis is diminished in HD mitochondria compared t...
Source: Molecular and Cellular Proteomics : MCP - March 6, 2024 Category: Molecular Biology Authors: Sunayana Dagar Manish Sharma George Tsaprailis Catherina Scharager Tapia Gogce Crynen Preksha Sandipkumar Joshi Neelam Shahani Srinivasa Subramaniam Source Type: research
Ribosome Profiling and Mass Spectrometry Reveal Widespread Mitochondrial Translation Defects in a Striatal Cell Model of Huntington Disease
Mol Cell Proteomics. 2024 Mar 4:100746. doi: 10.1016/j.mcpro.2024.100746. Online ahead of print.ABSTRACTHuntington disease (HD) is caused by an expanded polyglutamine mutation in huntingtin (mHTT) that promotes prominent atrophy in the striatum and subsequent psychiatric, cognitive, and choreiform movements. Multiple lines of evidence point to an association between HD and aberrant striatal mitochondrial functions; however, the present knowledge about whether (or how) mitochondrial mRNA translation is differentially regulated in HD remains unclear. We found that protein synthesis is diminished in HD mitochondria compared t...
Source: Molecular and Cellular Proteomics : MCP - March 6, 2024 Category: Molecular Biology Authors: Sunayana Dagar Manish Sharma George Tsaprailis Catherina Scharager Tapia Gogce Crynen Preksha Sandipkumar Joshi Neelam Shahani Srinivasa Subramaniam Source Type: research
Ribosome Profiling and Mass Spectrometry Reveal Widespread Mitochondrial Translation Defects in a Striatal Cell Model of Huntington Disease
Mol Cell Proteomics. 2024 Mar 4:100746. doi: 10.1016/j.mcpro.2024.100746. Online ahead of print.ABSTRACTHuntington disease (HD) is caused by an expanded polyglutamine mutation in huntingtin (mHTT) that promotes prominent atrophy in the striatum and subsequent psychiatric, cognitive, and choreiform movements. Multiple lines of evidence point to an association between HD and aberrant striatal mitochondrial functions; however, the present knowledge about whether (or how) mitochondrial mRNA translation is differentially regulated in HD remains unclear. We found that protein synthesis is diminished in HD mitochondria compared t...
Source: Molecular and Cellular Proteomics : MCP - March 6, 2024 Category: Molecular Biology Authors: Sunayana Dagar Manish Sharma George Tsaprailis Catherina Scharager Tapia Gogce Crynen Preksha Sandipkumar Joshi Neelam Shahani Srinivasa Subramaniam Source Type: research
Ribosome Profiling and Mass Spectrometry Reveal Widespread Mitochondrial Translation Defects in a Striatal Cell Model of Huntington Disease
Mol Cell Proteomics. 2024 Mar 4:100746. doi: 10.1016/j.mcpro.2024.100746. Online ahead of print.ABSTRACTHuntington disease (HD) is caused by an expanded polyglutamine mutation in huntingtin (mHTT) that promotes prominent atrophy in the striatum and subsequent psychiatric, cognitive, and choreiform movements. Multiple lines of evidence point to an association between HD and aberrant striatal mitochondrial functions; however, the present knowledge about whether (or how) mitochondrial mRNA translation is differentially regulated in HD remains unclear. We found that protein synthesis is diminished in HD mitochondria compared t...
Source: Molecular and Cellular Proteomics : MCP - March 6, 2024 Category: Molecular Biology Authors: Sunayana Dagar Manish Sharma George Tsaprailis Catherina Scharager Tapia Gogce Crynen Preksha Sandipkumar Joshi Neelam Shahani Srinivasa Subramaniam Source Type: research
Involvement of Autophagic Machinery in Neuropathogenesis: Targeting and Relevant Methods of Detection
Methods Mol Biol. 2024 Mar 6. doi: 10.1007/7651_2024_516. Online ahead of print.ABSTRACTThe exquisite balance between cellular prosurvival and death pathways is extremely necessary for homeostasis. Different forms of programmed cell death have been widely studied and reported such as apoptosis, necroptosis, pyroptosis, and autophagy. Autophagy is a catabolic process important for normal cellular functioning. The main aim of this machinery is to degrade the misfolded or damaged proteins, unuseful organelles, and pathogens, which invade the cells, thereby maintaining cellular homeostasis and assuring the regular renewal of c...
Source: Mol Biol Cell - March 5, 2024 Category: Molecular Biology Authors: Nourhan Sayed Alaa Emam Ali Doaa Mokhtar Elsherbiny Samar S Azab Source Type: research
Cross Talks between CNS and CVS Diseases: An Alliance to Annihilate
Curr Cardiol Rev. 2024 Mar 4. doi: 10.2174/011573403X278550240221112636. Online ahead of print.ABSTRACTCardiovascular and neurological diseases cause substantial morbidity and mortality globally. Moreover, cardiovascular diseases are the leading cause of death globally. About 17.9 million people are affected by cardiovascular diseases and 6.8 million people die every year due to neurological diseases. The common neurologic manifestations of cardiovascular illness include stroke syndrome which is responsible for unconsciousness and several other morbidities significantly diminished the quality of life of patients. Therefore...
Source: Current Cardiology Reviews - March 5, 2024 Category: Cardiology Authors: Shivani Chib Sushma Devi Rishabh Chalotra Neeraj Mittal Thakur Gurjeet Singh Puneet Kumar Randhir Singh Source Type: research
Involvement of Autophagic Machinery in Neuropathogenesis: Targeting and Relevant Methods of Detection
Methods Mol Biol. 2024 Mar 6. doi: 10.1007/7651_2024_516. Online ahead of print.ABSTRACTThe exquisite balance between cellular prosurvival and death pathways is extremely necessary for homeostasis. Different forms of programmed cell death have been widely studied and reported such as apoptosis, necroptosis, pyroptosis, and autophagy. Autophagy is a catabolic process important for normal cellular functioning. The main aim of this machinery is to degrade the misfolded or damaged proteins, unuseful organelles, and pathogens, which invade the cells, thereby maintaining cellular homeostasis and assuring the regular renewal of c...
Source: Mol Biol Cell - March 5, 2024 Category: Molecular Biology Authors: Nourhan Sayed Alaa Emam Ali Doaa Mokhtar Elsherbiny Samar S Azab Source Type: research
Cross Talks between CNS and CVS Diseases: An Alliance to Annihilate
Curr Cardiol Rev. 2024 Mar 4. doi: 10.2174/011573403X278550240221112636. Online ahead of print.ABSTRACTCardiovascular and neurological diseases cause substantial morbidity and mortality globally. Moreover, cardiovascular diseases are the leading cause of death globally. About 17.9 million people are affected by cardiovascular diseases and 6.8 million people die every year due to neurological diseases. The common neurologic manifestations of cardiovascular illness include stroke syndrome which is responsible for unconsciousness and several other morbidities significantly diminished the quality of life of patients. Therefore...
Source: Current Cardiology Reviews - March 5, 2024 Category: Cardiology Authors: Shivani Chib Sushma Devi Rishabh Chalotra Neeraj Mittal Thakur Gurjeet Singh Puneet Kumar Randhir Singh Source Type: research
Cardiac autonomic involvement in Huntington ’s disease
ConclusionCardiac disfunction increases, and autonomic functions change in HD, but more comprehensive studies are needed to distinguish sympathetic and parasympathetic involvement. (Source: Neurological Sciences)
Source: Neurological Sciences - March 4, 2024 Category: Neurology Source Type: research
Real-World Survival, Healthcare Resource Utilization, and Costs Among U.S. Elderly Patients With Diffuse Large B-Cell Lymphoma (DLBCL) Treated With R-GemOx in the Relapsed/Refractory Setting
CONCLUSION: Elderly U.S. Medicare beneficiaries diagnosed with DLBCL who initiated R-GemOx treatment in the R/R setting have poor overall survival, high rates of HCRU, and substantial costs.PMID:38433043 | DOI:10.1016/j.clml.2024.01.010 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - March 3, 2024 Category: Cancer & Oncology Authors: Mahek Garg Justin Puckett Sachin Kamal-Bahl Monika Raut Katherine Elizabeth Ryland Jalpa A Doshi Scott F Huntington Source Type: research
Real-World Survival, Healthcare Resource Utilization, and Costs Among U.S. Elderly Patients With Diffuse Large B-Cell Lymphoma (DLBCL) Treated With R-GemOx in the Relapsed/Refractory Setting
CONCLUSION: Elderly U.S. Medicare beneficiaries diagnosed with DLBCL who initiated R-GemOx treatment in the R/R setting have poor overall survival, high rates of HCRU, and substantial costs.PMID:38433043 | DOI:10.1016/j.clml.2024.01.010 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - March 3, 2024 Category: Cancer & Oncology Authors: Mahek Garg Justin Puckett Sachin Kamal-Bahl Monika Raut Katherine Elizabeth Ryland Jalpa A Doshi Scott F Huntington Source Type: research
ASOs are an effective treatment for disease-associated oligodendrocyte signatures in premanifest and symptomatic SCA3 mice
We report a severe, but modifiable, deficit in oligodendrocyte maturation caused by the toxic gain-of-function of mutant ATXN3 early in SCA3 disease that is transcriptionally, biochemically, and functionally rescued with anti-ATXN3 ASO. Our results highlight the promising use of an ASO therapy across neurodegenerative diseases that requires glial targeting in addition to affected neuronal populations.PMID:38429929 | DOI:10.1016/j.ymthe.2024.02.033 (Source: Molecular Medicine)
Source: Molecular Medicine - March 2, 2024 Category: Molecular Biology Authors: Kristen H Schuster Annie J Zalon Danielle M DiFranco Alexandra F Putka Nicholas R Stec Sabrina I Jarrah Arsal Naeem Zaid Haque Hanrui Zhang Yuanfang Guan Hayley S McLoughlin Source Type: research
