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Emerging antibody-based therapies for Huntington's disease: current status and perspectives for future development
Expert Rev Neurother. 2024 Mar;24(3):299-312. doi: 10.1080/14737175.2024.2314183. Epub 2024 Feb 7.ABSTRACTINTRODUCTION: Being an inherited neurodegenerative disease with an identifiable genetic defect, Huntington's disease (HD) is a suitable candidate for early intervention, possibly even in the pre-symptomatic stage. Our recent advances in elucidating the pathogenesis of HD have revealed a series of novel potential therapeutic targets, among which immunotherapies are actively pursued in preclinical experiments.AREAS COVERED: This review focuses on the potential of antibody-based treatments targeting various epitopes (of m...
Source: Expert Review of Neurotherapeutics - February 7, 2024 Category: Neurology Authors: Anamaria Jurcau Aurel Simion Maria Carolina Jurcau Source Type: research