High Intensity Focused Ultrasound Therapy Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Ultrasound monitoring of simultaneous High-Intensity focused ultrasound (HIFU) therapy using Minimum-Peak-Sidelobe coded excitation
In this study, a novel single-transmit bipolar sequence with minimum-peak-sidelobe (MPS) level is developed not only to restore the image quality of US monitoring but also remove acoustic interference from simultaneous HIFU transmission. The proposed MPS code is designed with an equal number of positive and negative bits and the bit duration should be an integer multiple of the period of the HIFU waveform. In addition, different permutations of code sequence are searched in order to obtain the optimal encoding. The received imaging echo is firstly decoded by matched filtering to cancel HIFU interference and to enhance the ...
Source: Ultrasonics - December 22, 2023 Category: Physics Authors: Che-Chou Shen Nien-Hung Wu Source Type: research

Passive Elastography for Clinical HIFU Lesion Detection
High-intensity Focused Ultrasound (HIFU) is a promising treatment modality for a wide range of pathologies including prostate cancer. However, the lack of a reliable ultrasound-based monitoring technique limits its clinical use. Ultrasound currently provides real-time HIFU planning, but its use for monitoring is usually limited to detecting the backscatter increase resulting from chaotic bubble appearance. HIFU has been shown to generate stiffening in various tissues, so elastography is an interesting lead for ablation monitoring. However, the standard techniques usually require the generation of a controlled push which ca...
Source: IEE Transactions on Medical Imaging - December 18, 2023 Category: Biomedical Engineering Source Type: research

Changes in cerebral cortex activity during a simple motor task after MRgFUS treatment in patients affected by essential tremor and Parkinson's disease: a pilot study using functional NIRS
Phys Med Biol. 2023 Dec 15. doi: 10.1088/1361-6560/ad164e. Online ahead of print.ABSTRACTOBJECTIVE: Magnetic Resonance Imaging-guided Focused Ultrasound Surgery (MRgFUS) is a non-invasive thermal ablation method that involves high-intensity Focused Ultrasound Surgery (FUS) and Magnetic Resonance Imaging (MRI) for anatomical imaging and real-time thermal mapping. This technique is widely employed for the treatment of patients affected by essential tremor (ET) and Parkinson's disease (PD). In the current study, functional Near-Infrared Spectroscopy (fNIRS) was used to highlight hemodynamics changes in cerebral cortex activit...
Source: Physics in Medicine and Biology - December 15, 2023 Category: Physics Authors: Sergio Gurgone Simona De Salvo Lilla Bonanno Nunzio Muscar à Giuseppe Acri Francesco Caridi Giuseppe Paladini Daniele Borzelli Amelia Brigand ì Domenico La Torre Chiara Sorbera Carmelo Anfuso Giuseppe Di Lorenzo Valentina Venuti Andrea D'Avella Silvia M Source Type: research

Focused ultrasounds: What is their future in epileptology? A critical review
Rev Neurol (Paris). 2023 Dec 12:S0035-3787(23)01145-1. doi: 10.1016/j.neurol.2023.10.014. Online ahead of print.ABSTRACTHigh intensity focused ultrasounds (HIFU) are being increasingly advocated as a useful tool in the management of focal drug-resistant epilepsy. Our aim was to review current literature on the topic and perform an inventory of open trials assessing HIFU effectiveness and safety in epilepsy management. To do so, a review was conducted and yielded one prospective clinical trials, two case reports and one safety study were retrieved, indicating that HIFU is still in its infancy when it comes to focal drug-res...
Source: Revue Neurologique - December 13, 2023 Category: Neurology Authors: M D Maliia A Nica J Baxter M V Corniola Source Type: research

Prediction of non-perfusion volume ratio for uterine fibroids treated with ultrasound-guided high-intensity focused ultrasound based on MRI radiomics combined with clinical parameters
Prediction of non-perfusion volume ratio (NPVR) is critical in selecting patients with uterine fibroids who will potentially benefit from ultrasound-guided high-intensity focused ultrasound (HIFU) treatment, a... (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - December 13, 2023 Category: Biomedical Engineering Authors: Ye Zhou, Jinwei Zhang, Chenghai Li, Jinyun Chen, Fajin Lv, Yongbin Deng, Siyao Chen, Yuling Du and Faqi Li Tags: Research Source Type: research

Ultrasonic therapies for seizures and drug-resistant epilepsy
Ultrasonic therapy is an increasingly promising approach for the treatment of seizures and drug-resistant epilepsy (DRE). Therapeutic focused ultrasound (FUS) uses thermal or nonthermal energy to either ablate neural tissue or modulate neural activity through high- or low-intensity FUS (HIFU, LIFU), respectively. Both HIFU and LIFU approaches have been investigated for reducing seizure activity in DRE, and additional FUS applications include disrupting the blood–brain barrier in the presence of microbubbles for targeted-drug delivery to the seizure foci. Here, we review the preclinical and clinical studies that have used...
Source: Frontiers in Neurology - December 12, 2023 Category: Neurology Source Type: research

Metal ‐Organic Framework‐Mediated Synergistic Hypoxia‐Activated Chemo‐Immunotherapy Induced by High Intensity Focused Ultrasound for Enhanced Cancer Theranostics
The HIFU-specific metal-organic framework nanosystem (ADMOFs) is constructed by coordinating AQ4N, Mn2+, and DOX. ADMOFs can efficiently enhance PA/MR imaging to more accurately guide HIFU surgery. Moreover, ADMOFs utilize the severe tumor hypoxic environment created by HIFU to conquer hypoxia-associated drug resistance and kill residual hypoxic/normoxic tumor cells. This strategy innovatively combines hypoxic-activated chemotherapy with HIFU to enhance cancer treatment. AbstractHigh intensity focused ultrasound (HIFU) has attracted considerable attention as a noninvasive, efficient, and economic therapeutic modality for s...
Source: Small - December 11, 2023 Category: Nanotechnology Authors: Tingyu Sun, Jingnan Li, Yinglin Zhou, Chao Zeng, Chengyan Luo, Xirui Luo, Huanan Li Tags: Research Article Source Type: research

MRI compatibility testing of commercial high intensity focused ultrasound transducers
High Intensity Focused Ultrasound (HIFU) has emerged in the oncological sector as a non-invasive modality to ablate tissue [1]. By combining HIFU with Magnetic Resonance Imaging (MRI), physicians can precisely guide and monitor the therapeutic procedure [2]. There are though numerous challenges in safely integrating and operating a HIFU system in the MRI environment due to the potential interference caused by the strong magnetic fields [3]. Ensuring MRI compatibility of HIFU transducers thus constitutes a critical step in the evaluation process of MRI-guided HIFU systems. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - December 3, 2023 Category: General Medicine Authors: Nikolas Evripidou, Anastasia Antoniou, Leonidas Georgiou, Cleanthis Ioannides, Kyriakos Spanoudes, Christakis Damianou Source Type: research

A Data-Driven Approach for Estimating Temperature Variations Based on B-mode Ultrasound Images and Changes in Backscattered Energy
Ultrason Imaging. 2023 Dec 1:1617346231205810. doi: 10.1177/01617346231205810. Online ahead of print.ABSTRACTThermal treatments that use ultrasound devices as a tool have as a key point the temperature control to be applied in a specific region of the patient's body. This kind of procedure requires caution because the wrong regulation can either limit the treatment or aggravate an existing injury. Therefore, determining the temperature in a region of interest in real-time is a subject of high interest. Although this is still an open problem, in the field of ultrasound analysis, the use of machine learning as a tool for bot...
Source: Ultrasonic Imaging - December 2, 2023 Category: Radiology Authors: Luiz F R Oliveira Felipe M G Fran ça Wagner C A Pereira Source Type: research