APDS patients with immune-complex vasculitis and resolution with leniolisib
Clin Immunol. 2024 Mar 8:110176. doi: 10.1016/j.clim.2024.110176. Online ahead of print.ABSTRACTActivated phosphoinositide 3-kinase delta syndrome (APDS) is an inborn error of immunity with heterogeneity in the clinical manifestations of immune dysregulation, including recurrent sinopulmonary infections, bronchiectasis, chronic herpesvirus infections, autoimmunity, lymphoproliferation, and malignancy. Immune complexmediated vasculitides have not yet been described in APDS patients. Here we offer a case series of three patients with APDS who have refractory IgA vasculitis (also called Henoch-Schönlein purpura), a form of i...
Source: Clinical Immunology - March 10, 2024 Category: Allergy & Immunology Authors: Mohammad-Ali Dorodouchi Alexis V Stephens Ziwei Wang Jaspreet Dhami Manish J Butte Source Type: research
APDS patients with immune-complex vasculitis and resolution with leniolisib
Clin Immunol. 2024 Mar 8:110176. doi: 10.1016/j.clim.2024.110176. Online ahead of print.ABSTRACTActivated phosphoinositide 3-kinase delta syndrome (APDS) is an inborn error of immunity with heterogeneity in the clinical manifestations of immune dysregulation, including recurrent sinopulmonary infections, bronchiectasis, chronic herpesvirus infections, autoimmunity, lymphoproliferation, and malignancy. Immune complexmediated vasculitides have not yet been described in APDS patients. Here we offer a case series of three patients with APDS who have refractory IgA vasculitis (also called Henoch-Schönlein purpura), a form of i...
Source: Clinical Immunology - March 10, 2024 Category: Allergy & Immunology Authors: Mohammad-Ali Dorodouchi Alexis V Stephens Ziwei Wang Jaspreet Dhami Manish J Butte Source Type: research
APDS patients with immune-complex vasculitis and resolution with leniolisib
Clin Immunol. 2024 Mar 8:110176. doi: 10.1016/j.clim.2024.110176. Online ahead of print.ABSTRACTActivated phosphoinositide 3-kinase delta syndrome (APDS) is an inborn error of immunity with heterogeneity in the clinical manifestations of immune dysregulation, including recurrent sinopulmonary infections, bronchiectasis, chronic herpesvirus infections, autoimmunity, lymphoproliferation, and malignancy. Immune complexmediated vasculitides have not yet been described in APDS patients. Here we offer a case series of three patients with APDS who have refractory IgA vasculitis (also called Henoch-Schönlein purpura), a form of i...
Source: Clinical Immunology - March 10, 2024 Category: Allergy & Immunology Authors: Mohammad-Ali Dorodouchi Alexis V Stephens Ziwei Wang Jaspreet Dhami Manish J Butte Source Type: research
Unusual endoscopic appearance of the rectum in a patient with Henoch-Sch önlein purpura
Am J Med Sci. 2024 Mar 7:S0002-9629(24)01116-9. doi: 10.1016/j.amjms.2024.03.010. Online ahead of print.NO ABSTRACTPMID:38460920 | DOI:10.1016/j.amjms.2024.03.010 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - March 9, 2024 Category: General Medicine Authors: Yibing Hu Jin Ding Qunying Wang Source Type: research
Unusual endoscopic appearance of the rectum in a patient with Henoch-Sch önlein purpura
Am J Med Sci. 2024 Mar 7:S0002-9629(24)01116-9. doi: 10.1016/j.amjms.2024.03.010. Online ahead of print.NO ABSTRACTPMID:38460920 | DOI:10.1016/j.amjms.2024.03.010 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - March 9, 2024 Category: General Medicine Authors: Yibing Hu Jin Ding Qunying Wang Source Type: research
An Unusual Case of Abdominal Pain in a Geriatric Man
Immunoglobulin A Vasculitis, historically known as Henoch-Schonlein Purpura is a rare form of autoimmune-induced vasculitis most common in children. This disease is characterized by a purpuric rash, arthritis, digestive tract complication, and renal inflammation (Hopkins). (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - February 26, 2024 Category: Emergency Medicine Authors: Skyler Sloane, Rachna Subramony, Cameron Olandt, Colleen Campbell Tags: Clinical Communications: Adult Source Type: research
Regulatory T and B cells in pediatric Henoch-Sch önlein purpura: friends or foes?
CONCLUSIONS: In pediatric HSP, immune activation persists in spite of an increase in Th3 and Tregs. Th3 could be involved in IgA hyperproduction, inefficiently downregulated by Tregs. Lack of Bregs appears linked to renal impairment.PMID:38365843 | DOI:10.1186/s13075-024-03278-w (Source: Cell Research)
Source: Cell Research - February 16, 2024 Category: Cytology Authors: Anne Filleron Renaud Cezar Marc Fila Nastassja Protsenko Kathleen Van Den Hende Eric Jeziorski Bob Occean Thierry Chevallier Pierre Corbeau Tu Anh Tran Source Type: research
Regulatory T and B cells in pediatric Henoch –Schönlein purpura: friends or foes?
Henoch –Schönlein purpura (HSP) is the most common immunoglobulin A-mediated systemic vasculitis in childhood. We studied immune dysregulation in HSP by analyzing regulatory T (Treg), T helper 3 (Th3), and regu... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 16, 2024 Category: Rheumatology Authors: Anne Filleron, Renaud Cezar, Marc Fila, Nastassja Protsenko, Kathleen Van Den Hende, Eric Jeziorski, Bob Occean, Thierry Chevallier, Pierre Corbeau and Tu Anh Tran Tags: Research Source Type: research
ASSOCIATION BETWEEN HIGH MOBILITY GROUP BOX 1 PROTEIN GENE (rs41369348) POLYMORPHISM AND IMMUNOGLOBULIN A VASCULITIS IN CHILDREN
In conclusion, in this study, polymorphism rs41369348 for HMGB1 was not associated with increased susceptibility to childhood IgAV, its severity or different clinical manifestations.PMID:38304371 | PMC:PMC10829956 | DOI:10.20471/acc.2023.62.01.04 (Source: Acta Clinica Croatica)
Source: Acta Clinica Croatica - February 2, 2024 Category: General Medicine Authors: Mateja Batno žić Varga Mario Šestan Jasenka Wagner Kristina Crkvenac Gornik Nastasia Kifer Marijan Frkovi ć Laura Stefinovec Valentina Vu čemilović Jurić Danica Grguri ć Silvija Pu šeljić Marija Jelu šić Source Type: research
