Mixed nut consumption improves brain insulin sensitivity: a randomized, single-blinded, controlled, crossover trial in older adults with overweight or obesity
CONCLUSIONS: Longer-term mixed nut consumption affected insulin action in brain regions involved in the modulation of metabolic and cognitive processes in older adults with overweight/obesity. Intrahepatic lipid content and different cardiometabolic risk markers also improved, but peripheral insulin sensitivity was not affected.TRIAL REGISTRATION NUMBER: NCT04210869 (ClinicalTrials.gov).PMID:38128733 | DOI:10.1016/j.ajcnut.2023.12.010 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - December 21, 2023 Category: Nutrition Authors: Kevin M R Nijssen Ronald P Mensink Jogchum Plat Dimo Ivanov Hubert Preissl Peter J Joris Source Type: research
Mixed nut consumption improves brain insulin sensitivity: a randomized, single-blinded, controlled, crossover trial in older adults with overweight or obesity
CONCLUSIONS: Longer-term mixed nut consumption affected insulin action in brain regions involved in the modulation of metabolic and cognitive processes in older adults with overweight/obesity. Intrahepatic lipid content and different cardiometabolic risk markers also improved, but peripheral insulin sensitivity was not affected.TRIAL REGISTRATION NUMBER: NCT04210869 (ClinicalTrials.gov).PMID:38128733 | DOI:10.1016/j.ajcnut.2023.12.010 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - December 21, 2023 Category: Nutrition Authors: Kevin M R Nijssen Ronald P Mensink Jogchum Plat Dimo Ivanov Hubert Preissl Peter J Joris Source Type: research
Mixed nut consumption improves brain insulin sensitivity: a randomized, single-blinded, controlled, crossover trial in older adults with overweight or obesity
CONCLUSIONS: Longer-term mixed nut consumption affected insulin action in brain regions involved in the modulation of metabolic and cognitive processes in older adults with overweight/obesity. Intrahepatic lipid content and different cardiometabolic risk markers also improved, but peripheral insulin sensitivity was not affected.TRIAL REGISTRATION NUMBER: NCT04210869 (ClinicalTrials.gov).PMID:38128733 | DOI:10.1016/j.ajcnut.2023.12.010 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - December 21, 2023 Category: Nutrition Authors: Kevin M R Nijssen Ronald P Mensink Jogchum Plat Dimo Ivanov Hubert Preissl Peter J Joris Source Type: research
Mixed nut consumption improves brain insulin sensitivity: a randomized, single-blinded, controlled, crossover trial in older adults with overweight or obesity
CONCLUSIONS: Longer-term mixed nut consumption affected insulin action in brain regions involved in the modulation of metabolic and cognitive processes in older adults with overweight/obesity. Intrahepatic lipid content and different cardiometabolic risk markers also improved, but peripheral insulin sensitivity was not affected.TRIAL REGISTRATION NUMBER: NCT04210869 (ClinicalTrials.gov).PMID:38128733 | DOI:10.1016/j.ajcnut.2023.12.010 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - December 21, 2023 Category: Nutrition Authors: Kevin M R Nijssen Ronald P Mensink Jogchum Plat Dimo Ivanov Hubert Preissl Peter J Joris Source Type: research
Mixed nut consumption improves brain insulin sensitivity: a randomized, single-blinded, controlled, crossover trial in older adults with overweight or obesity
CONCLUSIONS: Longer-term mixed nut consumption affected insulin action in brain regions involved in the modulation of metabolic and cognitive processes in older adults with overweight/obesity. Intrahepatic lipid content and different cardiometabolic risk markers also improved, but peripheral insulin sensitivity was not affected.TRIAL REGISTRATION NUMBER: NCT04210869 (ClinicalTrials.gov).PMID:38128733 | DOI:10.1016/j.ajcnut.2023.12.010 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - December 21, 2023 Category: Nutrition Authors: Kevin M R Nijssen Ronald P Mensink Jogchum Plat Dimo Ivanov Hubert Preissl Peter J Joris Source Type: research
Mixed nut consumption improves brain insulin sensitivity: a randomized, single-blinded, controlled, crossover trial in older adults with overweight or obesity
CONCLUSIONS: Longer-term mixed nut consumption affected insulin action in brain regions involved in the modulation of metabolic and cognitive processes in older adults with overweight/obesity. Intrahepatic lipid content and different cardiometabolic risk markers also improved, but peripheral insulin sensitivity was not affected.TRIAL REGISTRATION NUMBER: NCT04210869 (ClinicalTrials.gov).PMID:38128733 | DOI:10.1016/j.ajcnut.2023.12.010 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - December 21, 2023 Category: Nutrition Authors: Kevin M R Nijssen Ronald P Mensink Jogchum Plat Dimo Ivanov Hubert Preissl Peter J Joris Source Type: research
Mixed nut consumption improves brain insulin sensitivity: a randomized, single-blinded, controlled, crossover trial in older adults with overweight or obesity
CONCLUSIONS: Longer-term mixed nut consumption affected insulin action in brain regions involved in the modulation of metabolic and cognitive processes in older adults with overweight/obesity. Intrahepatic lipid content and different cardiometabolic risk markers also improved, but peripheral insulin sensitivity was not affected.TRIAL REGISTRATION NUMBER: NCT04210869 (ClinicalTrials.gov).PMID:38128733 | DOI:10.1016/j.ajcnut.2023.12.010 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - December 21, 2023 Category: Nutrition Authors: Kevin M R Nijssen Ronald P Mensink Jogchum Plat Dimo Ivanov Hubert Preissl Peter J Joris Source Type: research
Mixed nut consumption improves brain insulin sensitivity: a randomized, single-blinded, controlled, crossover trial in older adults with overweight or obesity
CONCLUSIONS: Longer-term mixed nut consumption affected insulin action in brain regions involved in the modulation of metabolic and cognitive processes in older adults with overweight/obesity. Intrahepatic lipid content and different cardiometabolic risk markers also improved, but peripheral insulin sensitivity was not affected.TRIAL REGISTRATION NUMBER: NCT04210869 (ClinicalTrials.gov).PMID:38128733 | DOI:10.1016/j.ajcnut.2023.12.010 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - December 21, 2023 Category: Nutrition Authors: Kevin M R Nijssen Ronald P Mensink Jogchum Plat Dimo Ivanov Hubert Preissl Peter J Joris Source Type: research
Effects of hazelnut soluble dietary fiber on lipid-lowering and gut microbiota in high-fat-diet-fed rats
In this study, soluble dietary fiber (SDF) was extracted from hazelnut kernels, and its physicochemical properties and absorbability were explored. Hazelnut-SDF exhibited ideal water-holding, oil-holding and swelling capacity, and glucose, cholesterol and cholate absorbing ability. Scanning electron microscopy and fourier transform infrared spectroscopy showed that hazelnut-SDF had typical polysaccharide structure of functional groups. The main monosaccharides were identified as arabinose, rhamnose, xylose, ribose, glucuronic acid, mannose and glucose by gas chromatography-mass spectrometry. In high-fat diet rats, hazelnut...
Source: International Journal of Biological Macromolecules - December 3, 2023 Category: Biochemistry Authors: He Lin Jun Li Mingyang Sun Xinhe Wang Jiarui Zhao Wenjing Zhang Guangfu Lv Yuchen Wang Zhe Lin Source Type: research
The ethanolic extract of < em > Corylus avellana L. < /em > drives a microRNA-based cytotoxic effect on HepG2 hepatocarcinoma cells
Nat Prod Res. 2023 Nov 27:1-8. doi: 10.1080/14786419.2023.2287170. Online ahead of print.ABSTRACTAn ethanolic extract of Corylus avellana L. hazelnut was characterised by liquid chromatography coupled to high resolution mass spectrometry. We here evaluated the in vitro cytotoxic response to such extract in HepG2 cells and tried to depict the underlying mechanism(s) in terms of microRNA-34b/c involvement. Following long-term exposure (144h) of HepG2 cells with 0.04-0.4 mg/ml of hazelnut extract, we demonstrated that miR-34 precursor RNA and both mature miR-34b and miR-34c molecules underwent a significant stimulation (>2...
Source: Natural Product Research - November 28, 2023 Category: Biochemistry Authors: Maria Pierdomenico Loretta Bacchetta Barbara Benassi Source Type: research
The ethanolic extract of < em > Corylus avellana L. < /em > drives a microRNA-based cytotoxic effect on HepG2 hepatocarcinoma cells
Nat Prod Res. 2023 Nov 27:1-8. doi: 10.1080/14786419.2023.2287170. Online ahead of print.ABSTRACTAn ethanolic extract of Corylus avellana L. hazelnut was characterised by liquid chromatography coupled to high resolution mass spectrometry. We here evaluated the in vitro cytotoxic response to such extract in HepG2 cells and tried to depict the underlying mechanism(s) in terms of microRNA-34b/c involvement. Following long-term exposure (144h) of HepG2 cells with 0.04-0.4 mg/ml of hazelnut extract, we demonstrated that miR-34 precursor RNA and both mature miR-34b and miR-34c molecules underwent a significant stimulation (>2...
Source: Cell Research - November 28, 2023 Category: Cytology Authors: Maria Pierdomenico Loretta Bacchetta Barbara Benassi Source Type: research
Toxicological assessment of E-cigarette flavored E-liquids aerosols using Calu-3 cells: A 3D lung model approach
Toxicology. 2023 Nov 25;500:153683. doi: 10.1016/j.tox.2023.153683. Online ahead of print.ABSTRACTScientific progress and ethical considerations are increasingly shifting the toxicological focus from in vivo animal models to in vitro studies utilizing physiologically relevant cell cultures. Consequently, we evaluated and validated a three-dimensional (3D) model of the human lung using Calu-3 cells cultured at an air-liquid interface (ALI) for 28 days. Assessment of seven essential genes of differentiation and transepithelial electrical resistance (TEER) measurements, in conjunction with mucin (MUC5AC) staining, validated t...
Source: Toxicology - November 28, 2023 Category: Toxicology Authors: Felix Effah John Adragna David Luglio Alexis Bailey Tim Marczylo Terry Gordon Source Type: research
The ethanolic extract of < em > Corylus avellana L. < /em > drives a microRNA-based cytotoxic effect on HepG2 hepatocarcinoma cells
Nat Prod Res. 2023 Nov 27:1-8. doi: 10.1080/14786419.2023.2287170. Online ahead of print.ABSTRACTAn ethanolic extract of Corylus avellana L. hazelnut was characterised by liquid chromatography coupled to high resolution mass spectrometry. We here evaluated the in vitro cytotoxic response to such extract in HepG2 cells and tried to depict the underlying mechanism(s) in terms of microRNA-34b/c involvement. Following long-term exposure (144h) of HepG2 cells with 0.04-0.4 mg/ml of hazelnut extract, we demonstrated that miR-34 precursor RNA and both mature miR-34b and miR-34c molecules underwent a significant stimulation (>2...
Source: Natural Product Research - November 28, 2023 Category: Biochemistry Authors: Maria Pierdomenico Loretta Bacchetta Barbara Benassi Source Type: research
Toxicological assessment of E-cigarette flavored E-liquids aerosols using Calu-3 cells: A 3D lung model approach
Toxicology. 2023 Nov 25;500:153683. doi: 10.1016/j.tox.2023.153683. Online ahead of print.ABSTRACTScientific progress and ethical considerations are increasingly shifting the toxicological focus from in vivo animal models to in vitro studies utilizing physiologically relevant cell cultures. Consequently, we evaluated and validated a three-dimensional (3D) model of the human lung using Calu-3 cells cultured at an air-liquid interface (ALI) for 28 days. Assessment of seven essential genes of differentiation and transepithelial electrical resistance (TEER) measurements, in conjunction with mucin (MUC5AC) staining, validated t...
Source: Toxicology - November 28, 2023 Category: Toxicology Authors: Felix Effah John Adragna David Luglio Alexis Bailey Tim Marczylo Terry Gordon Source Type: research
