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Network pharmacology and molecular docking-based study on exploring the potential mechanism of Lycium barbarum L: In the treatment of atherosclerosis
CONCLUSION: This study demonstrates that network pharmacology and molecular docking analyses contribute to a better understanding of Goji berries active compounds and targets as potential therapeutic drugs for treating AS.PMID:37932998 | DOI:10.1097/MD.0000000000035734 (Source: Atherosclerosis)
Source: Atherosclerosis - November 7, 2023 Category: Cardiology Authors: Xinchen Qin Zikai Xie Xi Chen Xiaoxuan Wang Lijuan Ma Source Type: research

Lycium barbarum glycopeptide alleviates neuroinflammation in spinal cord injury via modulating docosahexaenoic acid to inhibiting MAPKs/NF-kB and pyroptosis pathways
Lycium barbarum polysaccharide (LBP) is an active ingredient extracted from Lycium barbarum that inhibits neuroinflammation, and Lycium barbarum glycopeptide (LbGp) is a glycoprotein with immunological activit... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - October 31, 2023 Category: Research Authors: Zhanfeng Jiang, Zhong Zeng, He He, Mei Li, Yuanxiang Lan, Jianwen Hui, Pengfei Bie, Yanjun Chen, Hao Liu, Heng Fan and Hechun Xia Tags: Research Source Type: research

iTRAQ-based proteomics identifies proteins associated with betaine accumulation in Lycium barbarum L
J Proteomics. 2023 Oct 23:105033. doi: 10.1016/j.jprot.2023.105033. Online ahead of print.ABSTRACTIn order to better understand the mechanism of betaine accumulation in Lycium barbarum L. (LBL), we used iTRAQ (Isotope relative and absolute quantitative labeling) proteomics to screen and identify differentially expressed proteins (DEPs) at five stages (S1-young fruit stage, S2-green fruit stage, S3- early yellowing stage, S4-late yellowing stage, S5-ripening stage). A total of 1799 DEPs and 171 betaine-related DEPs were identified, and phosphatidylethanolamine N-methyltransferase (NMT), choline monooxygenase (CMO), and beta...
Source: Journal of Proteomics - October 25, 2023 Category: Biochemistry Authors: Lingli Tian Xiaolu Zhao Ziying Hu Jun Liu Jiao Ma Yanli Fan Dunhua Liu Source Type: research

Genes, Vol. 14, Pages 1943: Comparative Analysis of the GATA Transcription Factors in Five Solanaceae Species and Their Responses to Salt Stress in Wolfberry (Lycium barbarum L.)
In conclusion, this study contributes significantly to our understanding of the evolution and function of GATA genes among the Solanaceae species, including wolfberry. (Source: Genes)
Source: Genes - October 15, 2023 Category: Genetics & Stem Cells Authors: Fengfeng Zhang Yan Wu Xin Shi Xiaojing Wang Yue Yin Tags: Article Source Type: research

Lycium barbarum polysaccharide inhibits blue ‐light‐induced skin oxidative damage with the involvement of mitophagy
Lycium barbarum polysaccharide (LBP), the main active ingredient extracted from the traditional Chinese medicineLycium barbarum, can ameliorate blue-light-induced skin damage in vitro and in vivo, which is closely related to its antioxidant effect involving mechanism of mitophagy. AbstractAlthough blue light can damage the skin to a certain extent, the pathogenesis of its damage remains still unclear. The available evidence suggests that oxidative stress may be the main cause of its damage.Lycium barbarum polysaccharide (LBP) has antioxidative effects in a variety of cells. In this paper, we investigated the protective rol...
Source: Photochemistry and Photobiology - October 10, 2023 Category: Science Authors: Fen Wu, Bingrong Dang, Liming Hu, Sen Zhu, Zuohao Liu, Xinhui Cao, Zhen Li, Chunming Wang, Changjun Lin Tags: RESEARCH ARTICLE Source Type: research

Protective effect of Lycium barbarum leaf extracts on atopic dermatitis: in vitro and in vivo studies
CONCLUSIONS: These results suggest that LLE potentially improves inflammation by reducing the expression of chemokines that inhibit T helper 2 cell migration. LLE(Ch-) showed similar effects to LLE on blood levels of IgE, TNF-α and IL-6 and protein expression in HaCat cells, but the ultimate effect of skin improvement was not statistically significant. Therefore, both LLE and LLE(Ch-) can be used as functional materials to alleviate AD, but LLE(Ch-) appears to require more research to improve inflammation.PMID:37780223 | PMC:PMC10522814 | DOI:10.4162/nrp.2023.17.5.855 (Source: Cell Research)
Source: Cell Research - October 2, 2023 Category: Cytology Authors: Han Sol Lee Eun Young Bae Sun Yung Ly Source Type: research

Retracted: Protective Effects and Molecular Mechanism of Total Flavonoids from Lycium Barbarum Leaves on Photoaged Human Dermal Fibroblasts
Evid Based Complement Alternat Med. 2023 Sep 20;2023:9783847. doi: 10.1155/2023/9783847. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2022/4156330.].PMID:37771951 | PMC:PMC10533263 | DOI:10.1155/2023/9783847 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 29, 2023 Category: Complementary Medicine Authors: Evidence-Based Complementary And Alternative Medicine Source Type: research