Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer ’s Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway
This study aimed to clarify the mechanisms of LBP in the treatment of ICV-STZ mice model of AD from the perspectives of insulin resistance, IRS1/PI3K/AKT signaling pathway, and synaptic protein expression. We used male C57BL/6J mice injected with STZ (3 mg/kg) in the lateral ventricle as an AD model. After treatment with LBP, the learning and memory abilities of ICV-STZ mice were enhanced, and the pathological changes in brain tissue were alleviated. LBP can regulate the expression of proteins related to the IRS1/PI3K/AKT signaling pathway and th ereby reducing Aβ deposition and tau protein phosphorylation in the brain ...
Source: NeuroMolecular Medicine - April 23, 2024 Category: Neurology Source Type: research
Lycium barbarum polysaccharides attenuate nonylphenol and octylphenol-induced oxidative stress and neurotransmitter disorders in PC-12 cells
This study aims to explore the cytotoxicity of combined NP and OP exposure and evaluate the potential of Lycium barbarum polysaccharides (LBP) in mitigating the aforementioned toxicity. In present study, LBP (62.5, 125 and 250µg/mL) were applied to intervene rat adrenal pheochromocytoma (PC-12) cells treated with combined NP and OP (NP: OP = 4:1, w/w; 1, 2, 4 and 8µg/mL). The results showed that NP and OP induced oxidative stress, disrupted the 5-hydroxytryptamine (5-HT) and cholinergic systems in PC-12 cells. Additionally, they activated the p38 protein kinase (p38) and suppressed the expression of silent information re...
Source: Toxicology - April 20, 2024 Category: Toxicology Authors: Linjing Xu Huan Liu Yifeng Rang Lizi Zhou Xukai Wang Yinhuan Li Chunhong Liu Source Type: research
< em > Lycium barbarum < /em > polysaccharide ameliorates the accumulation of lipid droplets in adipose tissue via an ATF6/SIRT1-dependent mechanism
In this study, we hypothesize that LBP alleviates LD accumulation in adipose tissue (AT) by inhibiting fat-specific protein 27 (Fsp27) through an activating transcription factor-6 (ATF6)/small-molecule sirtuin 1 (SIRT1)-dependent mechanism. LD accumulation in AT is induced in high-fat diet (HFD)-fed mice, and differentiation of 3T3-L1 preadipocytes (PAs) is induced. The ability of LBP to alleviate LD accumulation and the possible underlying mechanism are then investigated both in vivo and in vitro. The influences of LBP on the expressions of LD-associated genes ( ATF6 and Fsp27) are also detected. The results show that HFD...
Source: Acta Biochimica et Biophysica Sinica - April 12, 2024 Category: Biochemistry Authors: Rui Zhou Yajing Liu Weiqian Hu Jing Yang Bing Lin Zhentian Zhang Mingyan Chen Jingwen Yi Cuifeng Zhu Source Type: research
< em > Lycium barbarum < /em > polysaccharide ameliorates the accumulation of lipid droplets in adipose tissue via an ATF6/SIRT1-dependent mechanism
In this study, we hypothesize that LBP alleviates LD accumulation in adipose tissue (AT) by inhibiting fat-specific protein 27 (Fsp27) through an activating transcription factor-6 (ATF6)/small-molecule sirtuin 1 (SIRT1)-dependent mechanism. LD accumulation in AT is induced in high-fat diet (HFD)-fed mice, and differentiation of 3T3-L1 preadipocytes (PAs) is induced. The ability of LBP to alleviate LD accumulation and the possible underlying mechanism are then investigated both in vivo and in vitro. The influences of LBP on the expressions of LD-associated genes ( ATF6 and Fsp27) are also detected. The results show that HFD...
Source: Acta Biochimica et Biophysica Sinica - April 12, 2024 Category: Biochemistry Authors: Rui Zhou Yajing Liu Weiqian Hu Jing Yang Bing Lin Zhentian Zhang Mingyan Chen Jingwen Yi Cuifeng Zhu Source Type: research
< em > Lycium barbarum < /em > polysaccharide ameliorates the accumulation of lipid droplets in adipose tissue via an ATF6/SIRT1-dependent mechanism
In this study, we hypothesize that LBP alleviates LD accumulation in adipose tissue (AT) by inhibiting fat-specific protein 27 (Fsp27) through an activating transcription factor-6 (ATF6)/small-molecule sirtuin 1 (SIRT1)-dependent mechanism. LD accumulation in AT is induced in high-fat diet (HFD)-fed mice, and differentiation of 3T3-L1 preadipocytes (PAs) is induced. The ability of LBP to alleviate LD accumulation and the possible underlying mechanism are then investigated both in vivo and in vitro. The influences of LBP on the expressions of LD-associated genes ( ATF6 and Fsp27) are also detected. The results show that HFD...
Source: Acta Biochimica et Biophysica Sinica - April 12, 2024 Category: Biochemistry Authors: Rui Zhou Yajing Liu Weiqian Hu Jing Yang Bing Lin Zhentian Zhang Mingyan Chen Jingwen Yi Cuifeng Zhu Source Type: research
< em > Lycium barbarum < /em > polysaccharide ameliorates the accumulation of lipid droplets in adipose tissue via an ATF6/SIRT1-dependent mechanism
In this study, we hypothesize that LBP alleviates LD accumulation in adipose tissue (AT) by inhibiting fat-specific protein 27 (Fsp27) through an activating transcription factor-6 (ATF6)/small-molecule sirtuin 1 (SIRT1)-dependent mechanism. LD accumulation in AT is induced in high-fat diet (HFD)-fed mice, and differentiation of 3T3-L1 preadipocytes (PAs) is induced. The ability of LBP to alleviate LD accumulation and the possible underlying mechanism are then investigated both in vivo and in vitro. The influences of LBP on the expressions of LD-associated genes ( ATF6 and Fsp27) are also detected. The results show that HFD...
Source: Acta Biochimica et Biophysica Sinica - April 12, 2024 Category: Biochemistry Authors: Rui Zhou Yajing Liu Weiqian Hu Jing Yang Bing Lin Zhentian Zhang Mingyan Chen Jingwen Yi Cuifeng Zhu Source Type: research
< em > Lycium barbarum < /em > polysaccharide ameliorates the accumulation of lipid droplets in adipose tissue via an ATF6/SIRT1-dependent mechanism
In this study, we hypothesize that LBP alleviates LD accumulation in adipose tissue (AT) by inhibiting fat-specific protein 27 (Fsp27) through an activating transcription factor-6 (ATF6)/small-molecule sirtuin 1 (SIRT1)-dependent mechanism. LD accumulation in AT is induced in high-fat diet (HFD)-fed mice, and differentiation of 3T3-L1 preadipocytes (PAs) is induced. The ability of LBP to alleviate LD accumulation and the possible underlying mechanism are then investigated both in vivo and in vitro. The influences of LBP on the expressions of LD-associated genes ( ATF6 and Fsp27) are also detected. The results show that HFD...
Source: Acta Biochimica et Biophysica Sinica - April 12, 2024 Category: Biochemistry Authors: Rui Zhou Yajing Liu Weiqian Hu Jing Yang Bing Lin Zhentian Zhang Mingyan Chen Jingwen Yi Cuifeng Zhu Source Type: research
Recent progress of Lycium barbarum polysaccharides on intestinal microbiota, microbial metabolites and health: a review
(Source: Critical Reviews in Food Science and Nutrition)
Source: Critical Reviews in Food Science and Nutrition - April 6, 2024 Category: Nutrition Authors: Feng, Yuqin Song, Yating Zhou, Jie Duan, Yuqing Kong, Tianyu Ma, Haile Zhang, Haihui Source Type: research
Lycium barbarum polysaccharide reverses drug resistance in oxaliplatin-resistant colon cancer cells by inhibiting PI3K/AKT-dependent phosphomannose isomerase
Objective: Here, we aimed to explore the effect of LBP in combination with Oxaliplatin (OXA) on reversing drug resistance in colon cancer cells through in vitro and in vivo experiments. We also aimed to explore the possible mechanism underlying this effect. Finally, we aimed to determine potential targets of Lycium barbarum polysaccharide (LBP) in colon cancer (CC) through network pharmacology and molecular docking.Methods: The invasion ability of colon cancer cells was assessed using the invasion assay. The migration ability of these cells was assessed using the migration assay and wound healing assay. Cell cycle analysis...
Source: Frontiers in Pharmacology - March 21, 2024 Category: Drugs & Pharmacology Source Type: research
Lycium barbarum polysaccharide's protective effects against PM < sub > 2.5 < /sub > -induced cellular senescence in HUVECs
In this study, we investigated the impact of PM2.5 exposure on vascular endothelial senescence and explored the intervention effects of LBP in human umbilical vein endothelial cells (HUVECs). We found that PM2.5 exposure dose-dependently reduced cell viability and proliferation in HUVECs while increasing the production of reactive oxygen species (ROS), malondialdehyde (MDA), and hydrogen peroxide (H2O2). Additionally, PM2.5 exposure inhibited the activity of superoxide dismutase (SOD). Notably, PM2.5 exposure induced autophagy impairments and cellular senescence. However, LBP mitigated PM2.5-induced cell damage. Further st...
Source: Ecotoxicology and Environmental Safety - March 17, 2024 Category: Environmental Health Authors: Haochong Shen Meidi Gong Juan Hu Qing Yan Minghao Zhang Rao Zheng Jing Wu Yi Cao Source Type: research
Lycium barbarum polysaccharide's protective effects against PM < sub > 2.5 < /sub > -induced cellular senescence in HUVECs
In this study, we investigated the impact of PM2.5 exposure on vascular endothelial senescence and explored the intervention effects of LBP in human umbilical vein endothelial cells (HUVECs). We found that PM2.5 exposure dose-dependently reduced cell viability and proliferation in HUVECs while increasing the production of reactive oxygen species (ROS), malondialdehyde (MDA), and hydrogen peroxide (H2O2). Additionally, PM2.5 exposure inhibited the activity of superoxide dismutase (SOD). Notably, PM2.5 exposure induced autophagy impairments and cellular senescence. However, LBP mitigated PM2.5-induced cell damage. Further st...
Source: Ecotoxicology and Environmental Safety - March 17, 2024 Category: Environmental Health Authors: Haochong Shen Meidi Gong Juan Hu Qing Yan Minghao Zhang Rao Zheng Jing Wu Yi Cao Source Type: research
Lycium barbarum polysaccharide's protective effects against PM < sub > 2.5 < /sub > -induced cellular senescence in HUVECs
In this study, we investigated the impact of PM2.5 exposure on vascular endothelial senescence and explored the intervention effects of LBP in human umbilical vein endothelial cells (HUVECs). We found that PM2.5 exposure dose-dependently reduced cell viability and proliferation in HUVECs while increasing the production of reactive oxygen species (ROS), malondialdehyde (MDA), and hydrogen peroxide (H2O2). Additionally, PM2.5 exposure inhibited the activity of superoxide dismutase (SOD). Notably, PM2.5 exposure induced autophagy impairments and cellular senescence. However, LBP mitigated PM2.5-induced cell damage. Further st...
Source: Ecotoxicology and Environmental Safety - March 17, 2024 Category: Environmental Health Authors: Haochong Shen Meidi Gong Juan Hu Qing Yan Minghao Zhang Rao Zheng Jing Wu Yi Cao Source Type: research
Sonic Hedgehog Signalling Pathway Contributes in Age-Related Disorders and Alzheimer's Disease
Ageing Res Rev. 2024 Mar 14:102271. doi: 10.1016/j.arr.2024.102271. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is caused by the aging process and manifested by cognitive deficits and progressive memory loss. During aging, several conditions, including hypertension, diabetes, and cholesterol, have been identified as potential causes of AD by affecting Sonic hedgehog (Shh) signalling. In addition to being essential for cell differentiation and proliferation, Shh signalling is involved in tissue repair and the prevention of neurodegeneration. Neurogenesis is dependent on Shh signalling; inhibition of this pathway ...
Source: Ageing Research Reviews - March 16, 2024 Category: Genetics & Stem Cells Authors: Arun Parashar Dhruv Jha Vineet Mehta Bonney Chauhan Pappu Ghosh Prashanta Kumar Deb Mohit Jaiswal Santosh Kumar Prajapati Source Type: research
Sonic Hedgehog Signalling Pathway Contributes in Age-Related Disorders and Alzheimer's Disease
Ageing Res Rev. 2024 Mar 14:102271. doi: 10.1016/j.arr.2024.102271. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is caused by the aging process and manifested by cognitive deficits and progressive memory loss. During aging, several conditions, including hypertension, diabetes, and cholesterol, have been identified as potential causes of AD by affecting Sonic hedgehog (Shh) signalling. In addition to being essential for cell differentiation and proliferation, Shh signalling is involved in tissue repair and the prevention of neurodegeneration. Neurogenesis is dependent on Shh signalling; inhibition of this pathway ...
Source: Cell Research - March 16, 2024 Category: Cytology Authors: Arun Parashar Dhruv Jha Vineet Mehta Bonney Chauhan Pappu Ghosh Prashanta Kumar Deb Mohit Jaiswal Santosh Kumar Prajapati Source Type: research
Lycium barbarum glycopeptide (wolfberry extract) slows N-methyl-N-nitrosourea-induced degradation of photoreceptors
In conclusion, LbGP effectively slowed the rate of photoreceptor degeneration in N-methyl-N-nitrosourea-injured mice, possibly through an anti-inflammatory mechanism, and has potential as a candidate drug for the clinical treatment of photoreceptor degeneration.PMID:38488563 | DOI:10.4103/1673-5374.390958 (Source: Cell Research)
Source: Cell Research - March 15, 2024 Category: Cytology Authors: Qihang Kong Xiu Han Haiyang Cheng Jiayu Liu Huijun Zhang Tangrong Dong Jiansu Chen Kwok-Fai So Xuesong Mi Ying Xu Shibo Tang Source Type: research
