The polysaccharides from the fruits of Lycium barbarum ameliorate high-fat and high-fructose diet-induced cognitive impairment via regulating blood glucose and mediating gut microbiota
Int J Biol Macromol. 2023 Dec 25:129036. doi: 10.1016/j.ijbiomac.2023.129036. Online ahead of print.ABSTRACTHigh-fat and high-fructose diet (HFFD) consumption can induce cognitive dysfunction and gut microbiota disorder. In the present study, the effects of the polysaccharides from the fruits of Lycium barbarum L. (LBPs) on HFFD-induced cognitive deficits and gut microbiota dysbiosis were investigated. The results showed that intervention of LBPs (200 mg/kg/day) for 14 weeks could significantly prevent learning and memory deficits in HFFD-fed mice, evidenced by a reduction of latency and increment of crossing parameters of...
Source: International Journal of Biological Macromolecules - December 27, 2023 Category: Biochemistry Authors: Xinyi Tian Wei Dong Wangting Zhou Yamei Yan Lu Lu Jia Mi Youlong Cao Yi Sun Xiaoxiong Zeng Source Type: research
Molecules, Vol. 29, Pages 49: Exploring the Role of Lycium barbarum Polysaccharide in Corneal Injury Repair and Investigating the Relevant Mechanisms through In Vivo and In Vitro Experiments
This study aims to explore the protective effects of LBP on human corneal epithelial cells (HCEC) and a rat corneal injury model. Potential target points for LBP improving corneal injury repair were screened from public databases, and functional and pathway enrichment analyses of core targets were conducted using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Rat corneal alkali burns and HCEC oxidative stress injury models were established, and the results were validated through slit lamp examination, HE staining, TUNEL assay, immunofluorescence, CCK-8 assay, flow cytometry, scratch assay, and qRT-P...
Source: Molecules - December 20, 2023 Category: Chemistry Authors: Qian Liu Yi Nan Yifan Yang Xiangyang Li Wenjie Jiang Taiqiang Jiao Jiaqing Li Xusheng Jia Mengyi Ye Yang Niu Ling Yuan Tags: Article Source Type: research
Molecules, Vol. 28, Pages 8088: Combined Transcriptomics and Metabolomics Analysis Reveals the Effect of Selenium Fertilization on Lycium barbarum Fruit
In this study, different types of selenium fertilizers were sprayed onto Lycium barbarum in Ningxia, and transcriptomics and metabolomics techniques were used to explore the effects of selenium on the fruit differentials and differential genes in Lycium barbarum. Taking the “Ning Qiyi No.1” wolfberry as the research object, sodium selenite, nano-selenium, and organic selenium were sprayed at a concentration of 100 mg·L−1 three times from the first fruiting period to the harvesting period, with a control treatment comprising the spraying of clear water. We determined ...
Source: Molecules - December 14, 2023 Category: Chemistry Authors: Wenqin Yang Tingting Jiang Yaqi Wang Xiaojing Wang Rui Wang Tags: Article Source Type: research
Molecules, Vol. 28, Pages 8044: Bioactive Components of Lycium barbarum and Deep-Processing Fermentation Products
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Min Wang
Lycium barbarum, a homology of medicine and food, contains many active ingredients including polysaccharides, polyphenol, betaine, and carotenoids, which has health benefits and economic value. The bioactive components in Lycium barbarum exhibit the effects of antioxidation, immune regulation, hypoglycemic effects, and vision improvement. Recently, the development of nutrition and health products of Lycium barbarum has been paid more and more attention with the increase in health awareness. A variety of nutrients and bioactive components in wolfberry can be retained or increased using modern fermentation ...
Source: Molecules - December 12, 2023 Category: Chemistry Authors: Xiao Qiang Ting Xia Beibei Geng Man Zhao Xuan Li Yu Zheng Min Wang Tags: Review Source Type: research
< em > Lycium barbarum < /em > polysaccharide alleviates DSS-induced chronic ulcerative colitis by restoring intestinal barrier function and modulating gut microbiota
CONCLUSION: LBP can alleviate DSS-induced UC by regulating inflammatory cytokines and tight junction proteins. Moreover, LBP promotes probiotics, suppresses conditional pathogens and increases SCFAs production, showing a strong prebiotic effect.PMID:38061697 | DOI:10.1080/07853890.2023.2290213 (Source: Annals of Medicine)
Source: Annals of Medicine - December 7, 2023 Category: Internal Medicine Authors: Zhi-Yu Li Lan-Hui Lin He-Jun Liang Ya-Qi Li Fu-Qian Zhao Ting-Yi Sun Zi-Yu Liu Jing-Yi Zhu Feng Gu Jia-Ning Xu Qi-Yuan Hao De-Shan Zhou Hui-Hong Zhai Source Type: research
Endophytic fungi of Lycium barbarum: isolation, determination, bioactivity and separation of compounds
In conclusion, endophytic fungi ofL. barbarum from eastern China can serve as a potential source of active natural products with antibacterial and antioxidant properties. (Source: World Journal of Microbiology and Biotechnology)
Source: World Journal of Microbiology and Biotechnology - December 7, 2023 Category: Microbiology Source Type: research
Lycium barbarum (Goji) as functional food: a review of its nutrition, phytochemical structure, biological features, and food industry prospects
(Source: Critical Reviews in Food Science and Nutrition)
Source: Critical Reviews in Food Science and Nutrition - November 30, 2023 Category: Nutrition Authors: Ma, Run-Hui Zhang, Xiu-Xiu Ni, Zhi-Jing Thakur, Kiran Wang, Wei Yan, Ya-Mei Cao, You-Long Zhang, Jian-Guo Rengasamy, Kannan R. R. Wei, Zhao-Jun Source Type: research
Separation of polysaccharides from Lycium barbarum L. by high-speed countercurrent chromatography with aqueous two-phase system
Int J Biol Macromol. 2023 Nov 24:128282. doi: 10.1016/j.ijbiomac.2023.128282. Online ahead of print.ABSTRACTThe traditional method for isolation and purification of polysaccharides is time-consuming. It often involves toxic solvents that destroy the function and structure of the polysaccharides, thus limiting in-depth research on the essential active ingredient of Lycium barbarum L. Therefore, in this study, high-speed countercurrent chromatography (HSCCC) and aqueous two-phase system (ATPS) were combined for the separation of crude polysaccharides of Lycium barbarum L. (LBPs). Under the optimized HSCCC conditions of PEG10...
Source: International Journal of Biological Macromolecules - November 26, 2023 Category: Biochemistry Authors: Yu Cao Renbo Kou Xinyi Huang Ningli Wang Duolong Di Han Wang Jianfei Liu Source Type: research
Effects of slit dual-frequency ultrasound-assisted pulping on the structure, functional properties and antioxidant activity of Lycium barbarum proteins and in situ real-time monitoring process
Ultrason Sonochem. 2023 Nov 17;101:106696. doi: 10.1016/j.ultsonch.2023.106696. Online ahead of print.ABSTRACTTo improve the protein dissolution rate and the quality of fresh Lycium barbarum pulp (LBP), we optimized the slit dual-frequency ultrasound-assisted pulping process, explored the dissolution kinetics of Lycium barbarum protein (LBPr), and established a near-infrared spectroscopy in situ real-time monitoring model for LBPr dissolution through spectral information analysis and chemometric methods. The results showed that under optimal conditions (dual-frequency 28-33 kHz, 300 W, 31 min, 40 °C, interval ratio 5:2 s/...
Source: Ultrasonics Sonochemistry - November 21, 2023 Category: Chemistry Authors: Shuhan Liu Tianyu Kong Yuqin Feng Yanli Fan Junwei Yu Yuqing Duan Meihong Cai Kai Hu Haile Ma Haihui Zhang Source Type: research
Effects of slit dual-frequency ultrasound-assisted pulping on the structure, functional properties and antioxidant activity of Lycium barbarum proteins and in situ real-time monitoring process
Ultrason Sonochem. 2023 Nov 17;101:106696. doi: 10.1016/j.ultsonch.2023.106696. Online ahead of print.ABSTRACTTo improve the protein dissolution rate and the quality of fresh Lycium barbarum pulp (LBP), we optimized the slit dual-frequency ultrasound-assisted pulping process, explored the dissolution kinetics of Lycium barbarum protein (LBPr), and established a near-infrared spectroscopy in situ real-time monitoring model for LBPr dissolution through spectral information analysis and chemometric methods. The results showed that under optimal conditions (dual-frequency 28-33 kHz, 300 W, 31 min, 40 °C, interval ratio 5:2 s/...
Source: Ultrasonics Sonochemistry - November 21, 2023 Category: Chemistry Authors: Shuhan Liu Tianyu Kong Yuqin Feng Yanli Fan Junwei Yu Yuqing Duan Meihong Cai Kai Hu Haile Ma Haihui Zhang Source Type: research
Effects of slit dual-frequency ultrasound-assisted pulping on the structure, functional properties and antioxidant activity of Lycium barbarum proteins and in situ real-time monitoring process
Ultrason Sonochem. 2023 Nov 17;101:106696. doi: 10.1016/j.ultsonch.2023.106696. Online ahead of print.ABSTRACTTo improve the protein dissolution rate and the quality of fresh Lycium barbarum pulp (LBP), we optimized the slit dual-frequency ultrasound-assisted pulping process, explored the dissolution kinetics of Lycium barbarum protein (LBPr), and established a near-infrared spectroscopy in situ real-time monitoring model for LBPr dissolution through spectral information analysis and chemometric methods. The results showed that under optimal conditions (dual-frequency 28-33 kHz, 300 W, 31 min, 40 °C, interval ratio 5:2 s/...
Source: Ultrasonics Sonochemistry - November 21, 2023 Category: Chemistry Authors: Shuhan Liu Tianyu Kong Yuqin Feng Yanli Fan Junwei Yu Yuqing Duan Meihong Cai Kai Hu Haile Ma Haihui Zhang Source Type: research
Effects of slit dual-frequency ultrasound-assisted pulping on the structure, functional properties and antioxidant activity of Lycium barbarum proteins and in situ real-time monitoring process
Ultrason Sonochem. 2023 Nov 17;101:106696. doi: 10.1016/j.ultsonch.2023.106696. Online ahead of print.ABSTRACTTo improve the protein dissolution rate and the quality of fresh Lycium barbarum pulp (LBP), we optimized the slit dual-frequency ultrasound-assisted pulping process, explored the dissolution kinetics of Lycium barbarum protein (LBPr), and established a near-infrared spectroscopy in situ real-time monitoring model for LBPr dissolution through spectral information analysis and chemometric methods. The results showed that under optimal conditions (dual-frequency 28-33 kHz, 300 W, 31 min, 40 °C, interval ratio 5:2 s/...
Source: Ultrasonics Sonochemistry - November 21, 2023 Category: Chemistry Authors: Shuhan Liu Tianyu Kong Yuqin Feng Yanli Fan Junwei Yu Yuqing Duan Meihong Cai Kai Hu Haile Ma Haihui Zhang Source Type: research
Fruit development and ripening orchestrating the biosynthesis and regulation of Lycium barbarum polysaccharides in goji berry
In this study, physiological indicators, including LBPs, were monitored in goji berry during fruit development and ripening (FDR), suggesting that pectin might be the major component of LBPs with increased content reaching 235.8 mg/g DW. Proteomic and transcriptomic analysis show that 6410 differentially expressed genes (DEGs) and 2052 differentially expressed proteins (DEPs) were identified with overrepresentation of flavonoids and polysaccharides-related gene ontology (GO) terms and KEGG pathways. Weighted gene co-expression network analysis (WGCNA) showed that LBPs coexpress with genes involved in pectin biosynthesis (L...
Source: International Journal of Biological Macromolecules - November 9, 2023 Category: Biochemistry Authors: Guoqi Zheng Zhiqiang Wang Jinrong Wei Juanhong Zhao Chen Zhang Juanjuan Mi Yuan Zong Genhong Liu Ying Wang Xing Xu Shaohua Zeng Source Type: research
Network pharmacology and molecular docking-based study on exploring the potential mechanism of Lycium barbarum L: In the treatment of atherosclerosis
CONCLUSION: This study demonstrates that network pharmacology and molecular docking analyses contribute to a better understanding of Goji berries active compounds and targets as potential therapeutic drugs for treating AS.PMID:37932998 | DOI:10.1097/MD.0000000000035734 (Source: Atherosclerosis)
Source: Atherosclerosis - November 7, 2023 Category: Cardiology Authors: Xinchen Qin Zikai Xie Xi Chen Xiaoxuan Wang Lijuan Ma Source Type: research
