Rapidly Progressive Nonuremic Calciphylaxis in the Setting of Warfarin
A 63-year-old African American woman presented with multiple painful, violaceous nodules on her lower extremities for the preceding 3 weeks. Her past medical history was notable for mechanical aortic valve replacement 7 years prior, asthma, type 2 diabetes mellitus, congestive heart failure, hyperlipidemia, hypertension, and obesity. Her home medications included warfarin, longstanding low-dose prednisone for severe asthma, calcium, atorvastatin, glipizide, metformin, insulin, ipratropium-albuterol, montelukast, omalizumab, losartan, metoprolol, torsemide, and omeprazole. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - July 8, 2015 Category: Journals (General) Authors: Gordon H. Bae, Vinod E. Nambudiri, Daniel Q. Bach, John Danziger, Beverly Faulkner-Jones, Colm McMahon, Susan J. Huang Tags: Images in dermatology Source Type: research
Rapidly Progressive Nonuremic Calciphylaxis in Setting of Warfarin
A 63-year-old African American woman presented with multiple painful, violaceous, nodules on her lower extremities for the preceding three weeks. Her past medical history was notable for mechanical aortic valve replacement seven years prior, asthma, type 2 diabetes mellitus, congestive heart failure, hyperlipidemia, hypertension and obesity. Her home medications included warfarin, longstanding low-dose prednisone for severe asthma, calcium, atorvastatin, glipizide, metformin, insulin, ipratropium-albuterol, montelukast, omalizumab, losartan, metoprolol, torsemide, and omeprazole. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - July 8, 2015 Category: Journals (General) Authors: Gordon H. Bae, Vinod E. Nambudiri, Daniel Q. Bach, John Danziger, Beverly Faulkner-Jones, Colm McMahon, Susan J. Huang Tags: Images in Dermatology Source Type: research
The biopharmaceutics of successful controlled release drug product: Segmental-dependent permeability of glipizide vs. metoprolol throughout the intestinal tract
We present an analysis that identifies metoprolol’s jejunal permeability as the low/high permeability class benchmark anywhere throughout the intestinal tract; we show that the permeability of both glipizide and metoprolol matches/exceeds this threshold throughout the entire intestinal tract, accounting for their success as controlled-release dosage form. This represents a key biopharmaceutical characteristic for a successful controlled-release dosage form. Graphical abstract (Source: International Journal of Pharmaceutics)
Source: International Journal of Pharmaceutics - May 15, 2015 Category: Drugs & Pharmacology Source Type: research
Comparison of real-world hypoglycemia rates among Patients Initiating Treatment with Saxagliptin or Glipizide
This study compared hypoglycemia rates in patients with type 2 diabetes on metformin who augmented treatment with saxagliptin or glipizide 5-20 mg/day. (Source: Value in Health)
Source: Value in Health - May 1, 2015 Category: Global & Universal Authors: S. Johnston, K. Bell, E. Thomson, G. Lenhart, J. Sheehan Source Type: research
Glipsizide suppresses embryonic vasculogenesis and angiogenesis through targeting natriuretic peptide receptor A.
Abstract
Glipizide, a second-generation sulfonylurea, has been widely used for the treatment of type 2 diabetes. However, it is controversial whether or not glipizide would affect angiogenesis or vasculogenesis. In the present study, we used early chick embryo model to investigate the effect of glipizide on angiogenesis and vasculogenesis, which are the two major processes for embryonic vasculature formation as well as tumor neovascularization. We found that Glipizide suppressed both angiogenesis in yolk-sac membrane (YSM) and blood island formation during developmental vasculogenesis. Glipizide did not af...
Source: Experimental Cell Research - March 27, 2015 Category: Cytology Authors: Gu Q, Wang C, Wang G, Han Z, Li Y, Wang X, Li J, Qi C, Xu T, Yang X, Wang L Tags: Exp Cell Res Source Type: research
Glycaemic control efficacy of oral antidiabetic drugs in treating type 2 diabetes: a protocol for network meta-analysis
This study aims to fill this gap of research by conducting a Bayesian network meta-analysis to compare major antidiabetic drugs, including metformin, glimepiride, glyburide, glipizide, repaglinide, nateglinide, sitagliptin, vildagliptin, saxagliptin and SGLT-2 (sodium-glucose transporter-2) inhibitors.
Methods and analyses
Randomised controlled trials (RCTs) on the drug therapy of type 2 diabetes with outcome measures including glycosylated haemoglobin or fasting blood glucose will be included. The quality of included RTCs will be evaluated according to the Cochrane Collaboration's risk of bias tool. Traditional pairwise ...
Source: BMJ Open - March 11, 2015 Category: Journals (General) Authors: Jia, Y., Lao, Y., Leung, S.-w. Tags: Open access, Evidence based practice, Health informatics, Pharmacology and therapeutics, Diabetes and Endocrinology Protocol Source Type: research
Long-term glycaemic response and tolerability of dapagliflozin versus a sulphonylurea as add-on therapy to metformin in type 2 diabetes patients: 4-year data.
CONCLUSIONS: In patients completing 4 years of treatment, dapagliflozin was well tolerated and associated with sustained glycaemic efficacy and greater reductions in body weight and SBP versus glipizide.
PMID: 25735400 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - March 4, 2015 Category: Endocrinology Authors: Del Prato S, Nauck M, Durán-Garcia S, Maffei L, Rohwedder K, Theuerkauf A, Parikh S Tags: Diabetes Obes Metab Source Type: research
Impact of gelation period on modified locust bean-alginate interpenetrating beads for oral glipizide delivery.
Abstract
In this work, the effect of hydrogelation period in the design of glipizide-loaded biopolymer-based interpenetrating network (IPN) beads was investigated. Carboxymethyl locust bean gum and sodium alginate IPN beads were prepared by ionic crosslinking method using aqueous aluminum chloride salt solution as gelation medium. The longer exposure of the IPN beads in the gelation medium caused a considerable loss of the drug (∼8%), and also affected their surface morphology and drug release performance. Spherical shape of the IPN beads was observed under scanning electron microscope (SEM). The diamete...
Source: International Journal of Biological Macromolecules - March 3, 2015 Category: Biochemistry Authors: Dey P, Sa B, Maiti S Tags: Int J Biol Macromol Source Type: research
Long‐term glycaemic response and tolerability of dapagliflozin versus a sulphonylurea as add‐on therapy to metformin in type 2 diabetes patients: 4‐year data
ConclusionsIn patients completing 4 years of treatment, dapagliflozin was well tolerated and associated with sustained glycaemic efficacy and greater reductions in body weight and SBP versus glipizide. (Source: Diabetes, Obesity and Metabolism)
Source: Diabetes, Obesity and Metabolism - March 1, 2015 Category: Endocrinology Authors: Stefano Del Prato, Michael Nauck, Santiago Durán‐Garcia, Laura Maffei, Katja Rohwedder, Anett Theuerkauf, Shamik Parikh Tags: ORIGINAL ARTICLE Source Type: research
Design, optimization and evaluation of glipizide solid self-nanoemulsifying drug delivery for enhanced solubility and dissolution
Publication date: Available online 19 February 2015 Source:Saudi Pharmaceutical Journal Author(s): Rajendra Narayan Dash , Mohammed Habibuddin , Touseef Humaira , Devi Ramesh A solid self-nanoemulsifying drug-delivery system (Solid SNEDDS) has been explored to improve the solubility and dissolution profile of glipizide. SNEDDS preconcentrate was systematically optimized using a circumscribed central composite design by varying Captex 355 (Oil), Solutol HS15 (Surfactant) and Imwitor 988 (Co-surfactant). The optimized SNEDDS preconcentrate consisted of Captex 355 (30% w/w), Solutol HS15 (45% w/w) and Imwitor 988 (25%...
Source: Saudi Pharmaceutical Journal - February 19, 2015 Category: Drugs & Pharmacology Source Type: research
Some antimicrobials increased admissions and ED visits for hypoglycemia in older users of glipizide or glyburide.
PMID: 25686188 [PubMed - in process] (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - February 17, 2015 Category: Internal Medicine Authors: Eliakim-Raz N, Leibovici L Tags: Ann Intern Med Source Type: research
A comparison of glycaemic effects of sitagliptin and sulfonylureas in elderly patients with type 2 diabetes mellitus
ConclusionIn this analysis of elderly patients with T2DM, compared with sulfonylurea, sitagliptin provided similar glycaemic efficacy with less hypoglycaemia and with body weight loss. (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - February 4, 2015 Category: Internal Medicine Authors: R. R. Shankar, L. Xu, G. T. Golm, E. A. O'Neill, B. J. Goldstein, K. D. Kaufman, S. S. Engel Tags: Original Paper Source Type: research
Coadministration of Co-trimoxazole With Sulfonylureas: Hypoglycemia Events and Pattern of Use
Conclusions.
Coadministration of co-trimoxazole with sulfonylureas is associated with increased risk of hypoglycemia, compared with noninteracting antibiotics. Such coadministration is prevalent among older diabetic patients in the United States, especially in patients without an identifiable primary care physician. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 21, 2015 Category: Geriatrics Authors: Tan, A., Holmes, H. M., Kuo, Y.-F., Raji, M. A., Goodwin, J. S. Tags: Research Article Source Type: research
Drugs Commonly Associated With Weight Change: A Systematic Review and Meta-analysis.
Conclusions: Several drugs are associated with weight change of varying magnitude. Data are provided to guide the choice of drug when several options exist and institute preemptive weight loss strategies when obesogenic drugs are prescribed.
PMID: 25590213 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - January 15, 2015 Category: Endocrinology Authors: Domecq JP, Prutsky G, Leppin A, Sonbol MB, Altayar O, Undavalli C, Wang Z, Elraiyah T, Brito JP, Mauck KF, Lababidi MH, Prokop LJ, Asi N, Wei J, Fidahussein S, Montori VM, Murad MH Tags: J Clin Endocrinol Metab Source Type: research
Mortality risk among sulfonylureas: a systematic review and network meta-analysis
We examined differences in cardiovascular event risk among sulfonylureas with random effects models for direct pairwise comparisons and network meta-analyses to incorporate direct and indirect data. Findings 14 970 (9%) of 167 327 patients in 18 studies died: 841 (4%) of 19 334 gliclazide users, 5482 (11%) of 49 389 glimepiride users, 2106 (15%) of 14 464 glipizide users, 5296 (7%) of 77 169 glibenclamide users, 1066 (17%) of 6187 tolbutamide users, and 179 (23%) of 784 chlorpropamide users. Inconsistency was low for the network meta-analysis of all-cause mortality, and the relative risk of death compared wit...
Source: The Lancet Diabetes and Endocrinology - January 1, 2015 Category: Endocrinology Source Type: research
