Glipizide blocks renal interstitial fibrosis by inhibiting AKT signaling pathway.
CONCLUSIONS: Glipizide blocks renal interstitial fibrosis by inhibiting AKT signaling pathway.
PMID: 28272693 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 10, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Simultaneous determination of glipizide and its four hydroxylated metabolites in human urine using LC –MS/MS and its application in urinary phenotype study
Publication date: 30 May 2017 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 139 Author(s): Bo Tan, Aidong Yang, Weian Yuan, Yue Li, Lei Jiang, Jian Jiang, Furong Qiu Cytochrome P450 (CYP) 2C9 and CYP2C19 genetic mutant could influence the plasma concentration of glipizide in human subjects, which refers to glipizide safety and adverse effects in clinic practice. A further study to investigate the relationship of the concentrations between glipizide and its metabolites in human with different CYP mutants was valuable. We firstly develop a validated liquid chromatography–tandem mass spectrometry...
Source: Journal of Pharmaceutical and Biomedical Analysis - March 8, 2017 Category: Drugs & Pharmacology Source Type: research
Incretin Therapies Do Not Expand β-cell Mass or Alter Pancreatic Histology in Young Male Mice.
Abstract
The impact of incretins upon pancreatic β-cell expansion remains extremely controversial. Multiple studies indicate that incretin-based therapies can increase β-cell proliferation, and incretins have been hypothesized to expand β-cell mass. However, considerable disagreement exists on whether incretins actually increase β-cell mass. Moreover, some reports indicate that incretins may cause metaplastic changes in pancreatic histology. To resolve these questions we treated a large cohort of mice with incretin-based therapies and carried out a rigorous analysis of β-cell turnover and pancreatic h...
Source: Endocrinology - March 8, 2017 Category: Endocrinology Authors: Cox AR, Lam CJ, Rankin MM, Rios JS, Chavez J, Bonnyman CW, King KB, Wells RA, Anthony D, Tu JX, Kim JJ, Li C, Kushner JA Tags: Endocrinology Source Type: research
A randomised, double ‐blind, trial of the safety and efficacy of omarigliptin (a once‐weekly DPP‐4 inhibitor) in subjects with type 2 diabetes and renal impairment
ConclusionsIn this study in subjects with T2DM and RI, relative to placebo, omarigliptin provided clinically meaningful reductions in HbA1c, had a similar incidence of symptomatic hypoglycaemia and was generally well tolerated. (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - March 1, 2017 Category: Internal Medicine Authors: Antonio Chacra, Ira Gantz, Geraldine Mendizabal, Lucila Durlach, Edward A. O'Neill, Zachary Zimmer, Shailaja Suryawanshi, Samuel S. Engel, Eseng Lai Tags: ORIGINAL PAPER Source Type: research
Glucose-lowering agents for treating pre-existing and new-onset diabetes in kidney transplant recipients.
CONCLUSIONS: Evidence concerning the efficacy and safety of glucose-lowering agents for treating pre-existing and new-onset diabetes in kidney transplant recipients is limited. Existing studies examine more intensive versus less intensive insulin therapy, and the use of DPP4 inhibitors and pioglitazone. The safety and efficacy of more intensive compared to less intensive insulin therapy is very uncertain and the safety and efficacy of DPP4 inhibitors and pioglitazone is uncertain, due to data being limited and of poor quality. Additional RCTs are required to clarify the safety and efficacy of current glucose-lowering agent...
Source: Cochrane Database of Systematic Reviews - February 26, 2017 Category: Journals (General) Authors: Lo C, Jun M, Badve SV, Pilmore H, White SL, Hawley C, Cass A, Perkovic V, Zoungas S Tags: Cochrane Database Syst Rev Source Type: research
Stable Co-crystals of Glipizide with Enhanced Dissolution Profiles: Preparation and Characterization.
Abstract
Present study deciphers preparation of co-crystals of lipophilic glipizide by using four different acids, oxalic, malonic, stearic, and benzoic acids, in order to achieve enhanced solubility and dissolution along with stability. All co-crystals were prepared by dissolving drug and individual acids in the ratio of 1:0.5 in acetonitrile at 60-70°C for 15 min, followed by cooling at room temperature for 24 h. FT-IR spectroscopy revealed no molecular interaction between acids and drug as the internal structure and their geometric configurations remain unchanged. Differential scanning calorimetry re...
Source: AAPS PharmSciTech - February 6, 2017 Category: Drugs & Pharmacology Authors: Pandey NK, Sehal HR, Garg V, Gaur T, Kumar B, Singh SK, Gulati M, Gowthamarajan K, Bawa P, Rajesh SY, Sharma P, Narang R Tags: AAPS PharmSciTech Source Type: research
A model of type 2 diabetes in the guinea pig using sequential diet-induced glucose intolerance and streptozotocin treatment [RESEARCH ARTICLE]
In this study, we have developed a model of sequential glucose intolerance and β-cell loss, through high-fat, high-carbohydrate diet and extensive optimization of STZ treatment in the guinea pig, which closely resembles human type 2 diabetes. This model will prove useful in the study of insulin-independent diabetes pathogenesis with or without comorbidities, where the guinea pig serves as a relevant model species. (Source: DMM Disease Models and Mechanisms)
Source: DMM Disease Models and Mechanisms - January 31, 2017 Category: Biomedical Science Authors: Podell, B. K., Ackart, D. F., Richardson, M. A., DiLisio, J. E., Pulford, B., Basaraba, R. J. Tags: Metabolic Disorders RESEARCH ARTICLE Source Type: research
Sulfonylurea challenge test in subjects diagnosed with type 1 diabetes mellitus
Conclusions: We propose that this sulfonylurea challenge test should be explored more extensively, as it may prove useful as a clinical and scientific tool. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - January 23, 2017 Category: Endocrinology Authors: Maria S. Remedi, Mareen Thomas, Colin G. Nichols, Bess A. Marshall Tags: Original Article Source Type: research
Antidiabetic agents and cardiovascular outcomes in patients with heart diseases.
This article reviews evidence of benefits and risk of antidiabetic agents in cardiovascular (CV) outcomes, with a focus on medications approved by the FDA since 2008. Peer-reviewed articles were identified from MEDLINE and Current Content database (both 1966 to October 1, 2016) using the search terms insulin, metformin, rosiglitazone, pioglitazone, glyburide, glipizide, glimepiride, acarbose, miglitol, albiglutide, exenatide, liraglutide, lixisenatide, dulaglutide, pramlintide, meglitinide, alogliptin, linagliptin, saxagliptin, sitagliptin, canagliflozin, dapagliflozin, empagliflozin, colesevalam, bromocriptine, mortality,...
Source: Current Medical Research and Opinion - January 19, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research
Evaluation and Optimization of Blood Micro-Sampling Methods: Serial Sampling in a Cross-Over Design from an Individual Mouse.
CONCLUSIONS: Of the methods that allowed serial sampling, the saphenous method when executed as described in this report, was most practical, reproducible and provided for assessment of inter-animal variability. It enabled the collection of complete exposure profiles from a single mouse and the conduct of an intravenous/oral cross-over study design. This methodology can be used routinely, it promotes the 3Rs principles by achieving reductions in the number of animals used, decreased restraints and animal stress, and improved the quality of data obtained in mouse PK studies. This article is open to POST-PUBLICATION ...
Source: Journal of Pharmacy and Pharmaceutical Sciences - January 7, 2017 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research
Glipizide
(Source: Reactions Weekly)
Source: Reactions Weekly - December 31, 2016 Category: Drugs & Pharmacology Source Type: research
Sulfonylurea Poisoning in a Healthy Toddler
AbstractIngestion of sulfonylureas is life-threatening in toddlers and children due to its strong and prolonged hypoglycemic effect. The authors present a 15-mo-old boy with accidental ingestion of Glipizide who presented with encephalopathy, seizure and severe hypoglycemia. The management included parenteral dextrose and octreotide administration to maintain euglycemia, followed by complete neurological recovery within 24 h. Sulphonylurea intoxication should be considered in previously healthy toddlers and children presenting with hypoglycemia especially if any caregiver is on sulfonylurea drugs. (Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - October 30, 2016 Category: Pediatrics Source Type: research
Antiobesity and antihyperglycaemic effects of Adiantum capillus-veneris extracts: in vitro and in vivo evaluations.
CONCLUSION: A. capillus-veneris, modulating pancreatic digestive enzymes, may be advocated as a combinatorial diabesity prevention/phytotherapy agent.
PMID: 27663206 [PubMed - as supplied by publisher] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 26, 2016 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Simultaneous determination of epalrestat and puerarin in rat plasma by UHPLC-MS/MS: application to their pharmacokinetic interaction study.
Abstract
In the present work, a simple, rapid and reliable ultra high performance liquid chromatography -tandem mass spectrometric (UHPLC-MS/MS) method was developed and validated to simultaneously determine epalrestat (EPA) and puerarin (PUE) in rat plasma for evaluation the pharmacokinetic interaction of this two drugs. Both the analytes and glipizide (IS) were extracted using protein precipitation method. The separation was performed on C18 reversed phase column using acetonitrile and 5 mmol/L ammonium acetate in water as mobile phase with a gradient elution program. The analytes including IS were qua...
Source: Biomedical Chromatography : BMC - September 20, 2016 Category: Biomedical Science Authors: Sun H, Bo Y, Zhang M, Wu X, Zhou M, Zhao L, Xiong Z Tags: Biomed Chromatogr Source Type: research
Prehospital Glucose Testing for Children with Seizures: A Proposed Change in Management.
CONCLUSION: Hypoglycemia in the pediatric seizure patient is extremely rare, thus universal field BGT has low utility and potential downstream effects. We propose a novel algorithm for the initial evaluation and management of prehospital pediatric seizures. Although limited to a retrospective analysis of a single medical center, our findings suggest the importance of reassessing prehospital seizure protocols. A larger patient sample should be studied to validate these findings and identify unique cases where glucose testing might be useful.
PMID: 27636352 [PubMed - as supplied by publisher] (Source: Prehospital Emergency Care)
Source: Prehospital Emergency Care - September 18, 2016 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research
