Exploring the mechanism of interaction of glipizide with DNA: Combined in vitro and bioinformatics approach
This study delves into the interaction between glipizide and DNA utilizing various biophysical tools and computational technique to gain insights into the interaction mechanism. Analysis of UV-visible and fluorescence data reveals the formation of complex between DNA and glipizide. The binding affinity of glipizide to DNA was of moderate strength. Examination of thermodynamic parameters at different temperatures suggests that the binding was entropically spontaneous and energetically favourable. Various experiments such as thermal melting assays, viscosity measurement, and dye displacement assays confirmed the minor grove ...
Source: International Journal of Biological Macromolecules - April 13, 2024 Category: Biochemistry Authors: Faizan Abul Qais Mohammad Furkan Mohammad Altaf Iqbal Ahmad Rizwan Hasan Khan Source Type: research
Encyclopaedic Review of Glipizide Pre-clinical and Clinical
Status
In conclusion, glipizide has shown promising
therapeutic efficacy across a variety of disorders. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - February 26, 2024 Category: Drugs & Pharmacology Authors: Mohammad, Saad Mahmood, Tarique Shamim, Arshiya Ahsan, Farogh Shariq, Mohammad Parveen, Saba Waseem, Rufaida Singh, Aditya Tags: Review Source Type: research
Patient In-Use Stability Testing of FDA-Approved Metformin Combination Products for N-Nitrosamine Impurity
In conclusion, in-use stability study provides quality and safety risk assessment of drug products where nitroso impurities are detected in the probable condition of use.PMID:38267707 | DOI:10.1208/s12249-023-02724-3 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - January 24, 2024 Category: Drugs & Pharmacology Authors: Sathish Dharani Eman M Mohamed Ziyaur Rahman Mansoor A Khan Source Type: research
Design, Development, and Evaluation of SA-F127:TPGS Polymeric Mixed Micelles for Improved Delivery of Glipizide Drug: In-vitro, Ex-vivo, and In-vivo Investigations
AAPS PharmSciTech. 2023 Oct 17;24(8):213. doi: 10.1208/s12249-023-02659-9.ABSTRACTThe anti-diabetic glipizide (GLN) drug has notable pharmaceutical advantages, but poor aqueous solubility restricts its wide applications. The present work was to develop a mixed polymeric micelle system composed of SA-F127 and TPGS to improve the water solubility and effective delivery of the GLN. First, we synthesized SA-F127 and confirmed it through FTIR, NMR, and GPC techniques. The GLN-PMM were fabricated with the thin-film technique and optimized with CCD design. The developed GLN-PMM was characterized using DLS, Zeta, TEM, Rheology, FT...
Source: AAPS PharmSciTech - October 17, 2023 Category: Drugs & Pharmacology Authors: Hemil S Patel Bhavin A Vyas Subhash Tripathi Rakesh K Sharma Source Type: research
Design, Development, and Evaluation of SA-F127:TPGS Polymeric Mixed Micelles for Improved Delivery of Glipizide Drug: In-vitro, Ex-vivo, and In-vivo Investigations
AAPS PharmSciTech. 2023 Oct 17;24(8):213. doi: 10.1208/s12249-023-02659-9.ABSTRACTThe anti-diabetic glipizide (GLN) drug has notable pharmaceutical advantages, but poor aqueous solubility restricts its wide applications. The present work was to develop a mixed polymeric micelle system composed of SA-F127 and TPGS to improve the water solubility and effective delivery of the GLN. First, we synthesized SA-F127 and confirmed it through FTIR, NMR, and GPC techniques. The GLN-PMM were fabricated with the thin-film technique and optimized with CCD design. The developed GLN-PMM was characterized using DLS, Zeta, TEM, Rheology, FT...
Source: AAPS PharmSciTech - October 17, 2023 Category: Drugs & Pharmacology Authors: Hemil S Patel Bhavin A Vyas Subhash Tripathi Rakesh K Sharma Source Type: research
Stability-indicating method development and validation for quantitative estimation of organic impurities of the antidiabetic drug glipizide in drug substance and pharmaceutical dosage form using HPLC
Biomed Chromatogr. 2023 Aug 27:e5727. doi: 10.1002/bmc.5727. Online ahead of print.ABSTRACTGlipizide is an antidiabetic drug used for the treatment of type 2 diabetes. A simple, reliable and robust reverse-phase liquid chromatographic method (RP-HPLC) was developed and validated as per International Conference on Harmonization Q2(R1) for estimating the impurities of glipizide in pharmaceutical formulations. The chromatographic separation was carried out on a Phenomenex Luna C18 (2), 250 × 4.6 mm, 5 μm with a binary solvent delivery system [MP-A, a homogenous mixture of water and acetonitrile in a ratio of 90:10 (v/v) and...
Source: Biomedical Chromatography : BMC - August 27, 2023 Category: Biomedical Science Authors: Bhujanga Rao Nagulancha Koteswara Rao Vandavasi Source Type: research
Stability-indicating method development and validation for quantitative estimation of organic impurities of the antidiabetic drug glipizide in drug substance and pharmaceutical dosage form using HPLC
Biomed Chromatogr. 2023 Aug 27:e5727. doi: 10.1002/bmc.5727. Online ahead of print.ABSTRACTGlipizide is an antidiabetic drug used for the treatment of type 2 diabetes. A simple, reliable and robust reverse-phase liquid chromatographic method (RP-HPLC) was developed and validated as per International Conference on Harmonization Q2(R1) for estimating the impurities of glipizide in pharmaceutical formulations. The chromatographic separation was carried out on a Phenomenex Luna C18 (2), 250 × 4.6 mm, 5 μm with a binary solvent delivery system [MP-A, a homogenous mixture of water and acetonitrile in a ratio of 90:10 (v/v) and...
Source: Biomedical Chromatography : BMC - August 27, 2023 Category: Biomedical Science Authors: Bhujanga Rao Nagulancha Koteswara Rao Vandavasi Source Type: research
The Patient Faints in the Waiting Area with a Suspected Hypoglycemic Event
An older adult with diabetes is taking glipizide, a sulfonylurea class drug. Subsequently, she experiences a hypoglycemic episode in the dental office. Prompt recognition of hypoglycemia and administration of glucose or sugar is vital. Patient and provider education about the risks of hypoglycemia in older adults may help to prevent future hypoglycemic episodes. (Source: Dental Clinics of North America)
Source: Dental Clinics of North America - July 6, 2023 Category: Dentistry Authors: Milda Chmieliauskaite, Marie D. Grosh, Ali Syed, Andres Pinto Source Type: research
Effects of water-sodium balance and regulation of electrolytes associated with antidiabetic drugs
Eur Rev Med Pharmacol Sci. 2023 Jun;27(12):5784-5794. doi: 10.26355/eurrev_202306_32817.ABSTRACTAs the prevalence of diabetes rises, the use of antidiabetic drugs becomes more frequent. Thus, focusing on the effects of these drugs on water-sodium balance and electrolyte regulation is necessary. This review discusses the effects and the mechanisms behind them. Several sulfonylureas, such as chlorpropamide, methanesulfonamide, and tolbutamide, exhibit water-retaining properties. Other sulfonylureas, such as glipizide, glibenclamide, acetohexamide, and tolazamide, are not antidiuretic or even diuretic. Numerous clinical studi...
Source: European Review for Medical and Pharmacological Sciences - July 4, 2023 Category: Drugs & Pharmacology Authors: J Zhang M-N Li G-M Yang X-T Hou D Yang M-M Han Y Zhang Y-F Liu Source Type: research
Effects of water-sodium balance and regulation of electrolytes associated with antidiabetic drugs
Eur Rev Med Pharmacol Sci. 2023 Jun;27(12):5784-5794. doi: 10.26355/eurrev_202306_32817.ABSTRACTAs the prevalence of diabetes rises, the use of antidiabetic drugs becomes more frequent. Thus, focusing on the effects of these drugs on water-sodium balance and electrolyte regulation is necessary. This review discusses the effects and the mechanisms behind them. Several sulfonylureas, such as chlorpropamide, methanesulfonamide, and tolbutamide, exhibit water-retaining properties. Other sulfonylureas, such as glipizide, glibenclamide, acetohexamide, and tolazamide, are not antidiuretic or even diuretic. Numerous clinical studi...
Source: Pharmacological Reviews - July 4, 2023 Category: Drugs & Pharmacology Authors: J Zhang M-N Li G-M Yang X-T Hou D Yang M-M Han Y Zhang Y-F Liu Source Type: research
Effects of water-sodium balance and regulation of electrolytes associated with antidiabetic drugs
Eur Rev Med Pharmacol Sci. 2023 Jun;27(12):5784-5794. doi: 10.26355/eurrev_202306_32817.ABSTRACTAs the prevalence of diabetes rises, the use of antidiabetic drugs becomes more frequent. Thus, focusing on the effects of these drugs on water-sodium balance and electrolyte regulation is necessary. This review discusses the effects and the mechanisms behind them. Several sulfonylureas, such as chlorpropamide, methanesulfonamide, and tolbutamide, exhibit water-retaining properties. Other sulfonylureas, such as glipizide, glibenclamide, acetohexamide, and tolazamide, are not antidiuretic or even diuretic. Numerous clinical studi...
Source: European Review for Medical and Pharmacological Sciences - July 4, 2023 Category: Drugs & Pharmacology Authors: J Zhang M-N Li G-M Yang X-T Hou D Yang M-M Han Y Zhang Y-F Liu Source Type: research
