Fight Aging! Newsletter, June 20th 2022
This study showed a negative relationship between the gaps and the number of senescence cells. Moreover, we found a similar reduction in 30-month-old naturally and 7-month-old D-gal-induced aging rats. Given these consistent data from different eukaryotic organisms, it suggests that the Youth-DNA-GAP is a marker of phenotype-related aging degree
Towards Scaffold-Based Regeneration of Dental Pulp
https://www.fightaging.org/archives/2022/06/towards-scaffold-based-regeneration-of-dental-pulp/
Researchers are working towards the ability to regenerate the dental pulp inside teeth. Full regeneration of teeth ...
Source: Fight Aging! - June 19, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Five Reasons Why Restrictive Diets Do More Harm Than Good
If you’re anything like the vast majority of the population, you started this year with one of these goals as a top priority: “get in shape”, “lose weight”, “get fit” or “get healthy”.
I get it. For the longest time my Januarys started with a rigid healthy eating plan to get back in shape and lose the holiday bulge.
Having tried almost every diet imaginable, it’s clear that most diets we follow do one of two things, they either restrict calories or restrict food groups. Even so-called it’s not a diet but a lifestyles are still a diet because you cut the amount of food, or food groups (despite th...
Source: PickTheBrain | Motivation and Self Improvement - June 14, 2022 Category: Consumer Health News Authors: drlarazib Tags: diet featured health and fitness self-improvement Source Type: blogs
Vision Influences Circadian Rhythms to Interact with Calorie Restriction and Aging
Circadian mechanisms have been found to influence aging in short-lived species, though the degree to which this is relevant to treating aging in longer-lived species such as our own is up for debate. All too much of the metabolic response to stress, and items such as circadian rhythms that have an impact on that response, have far larger effects on the pace of aging in short-lived species than in long-lived ones. The work here, in which vision is found to alter circadian mechanisms and thus also the beneficial calorie restriction response, is interesting in the academic sense, in the same way that it is interesting that sc...
Source: Fight Aging! - June 14, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Sunday Sermonette: Miracle overkill
First, a brief report about the author. I was still too sick yesterday to do a second post. Today I ' m on the mend, not coughing any more but I am pretty tired and weak. Also I can ' t taste my food, everything just tastes bitter. We ' ll see how it goes. Chapter 4 has Elisha performing five different miracles, pretty much at random. Presumably the miracles of Jesus as reported in the gospels are inspired by these and Elijah ' s miracles -- they ' re variations on some of these themes. To be God ' s designee, you have to do miracles of this nature. Curiously, it is not the power of God that does these miracles. Elish...
Source: Stayin' Alive - June 12, 2022 Category: American Health Source Type: blogs
Case of the Week 683
Answer to Case 683:Cryptosporidiumsp. oocystsThe following OUTSTANDING discussion is from our guest author, Hadel Go, a third year medical student with a strong interest in clinical parasitology._________________________________________We received some excellent feedback! Thank you all for leaving comments on the blog, on Twitter, and on LinkedIn.Yes, these areCryptosporidium oocysts. These protozoans can be identified by their size and consistent red color on modified acid-fast staining of stool samples. They can also be diagnosed from H&E stained tissue biopsies (see images here:Cryptosporidium, parasitewonders.com),...
Source: Creepy Dreadful Wonderful Parasites - May 22, 2022 Category: Parasitology Source Type: blogs
Sugar and Mental Health
Sugar tastes amazing and is in so many products that most people aren’t even aware of how much they are consuming daily.
Most people are aware that sugar isn’t a healthy food, but may not realize how detrimental sugar is to your overall health.
More recent research is showing a strong link between mental health and diet, suggesting that there is a two-way street between our bellies and our brains.
What has sugar in it?
When people talk about sugar, the first thing that comes to mind is the white, granulated stuff that the Brits pour into their tea.
However, there are many forms of sugar...
Source: PickTheBrain | Motivation and Self Improvement - May 17, 2022 Category: Consumer Health News Authors: Erin Falconer Tags: diet featured happiness health and fitness psychology self-improvement sugar Source Type: blogs
Fight Aging! Newsletter, May 2nd 2022
In this study, we tested the therapeutic potential of VHHASC and a newly generated VHH against murine ASC (VHHmASC) to target ASC specks in vitro and in vivo. We show that pre-incubation of extracellular ASC specks with VHHASC abrogated their inflammatory functions in vitro. Recombinant VHHASC rapidly disassembled pre-formed ASC specks and thus inhibited their ability to seed the nucleation of soluble ASC. Notably, VHHASC required prior cytosolic access to prevent inflammasome activation within cells, but it was effective against extracellular ASC specks released following caspase-1-dependent loss of membrane integrity, an...
Source: Fight Aging! - May 1, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
This Fruit Reverses Brain Aging
“At 10 months, the differences between these two groups were striking.” - Dr Pamela Maher (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - April 29, 2022 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia Source Type: blogs
An Outline of Present Work on Partial Reprogramming as a Rejuvenation Therapy
Here I'll point out a good, lengthy introduction to the ongoing, suddenly very well funded work on partial reprogramming as the basis for rejuvenation therapies. Reprogramming somatic cells to induced pluripotent stem cells requires exposure to the Yamanaka factors, but is a lengthy process with low efficiency. Early in that process, epigenetic patterns in a cell are restored to a more youthful configuration without the loss of differentiated somatic cell state, and this is the goal that partial reprogramming aims to achieve: restore mitochondrial function and many other cell activities in old tissues without changing cell...
Source: Fight Aging! - April 25, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 25th 2022
We examined central genetic and environmental lifespan regulators (putative anti-aging interventions, PAAIs; the following PAAIs were examined: mTOR loss-of-function, loss-of-function in growth hormone signaling, dietary restriction) for a possible countering of the signs and symptoms of aging. Importantly, in our study design, we included young treated groups of animals, subjected to PAAIs prior to the onset of detectable age-dependent phenotypic change. In parallel to our studies in mice, we assessed genetic variants for their effects on age-sensitive phenotypes in humans.
We observed that, surprisingly, many PAAI...
Source: Fight Aging! - April 24, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Deregulate Home Food Businesses
Chris EdwardsThe pandemic has created lasting changes to the economy. More employees are working from home, videocalls are replacing business travel, and home ‐based entrepreneurship is booming. The internet is a key driver of home entrepreneurship —the number of arts‐and‐crafts businesses on Etsy.com, for example,jumped from 2.6 million in 2019 to 7.5 million by 2021.Another thriving area of internet ‐driven entrepreneurship is home‐based food production for retail sale, often called the cottage food industry. Popular cottage foods include baked goods, canned goods, pickled goods, chocol...
Source: Cato-at-liberty - April 20, 2022 Category: American Health Authors: Chris Edwards Source Type: blogs
FGF21 is Required for Protein Restriction to Extend Life in Mice
In today's open access research, scientists demonstrate that mice lacking FGF21 do not benefit from protein restriction, a dietary intervention that usually produces slowed aging and extended life span in that species. FGF21 has been the subject of a fair amount of attention from the research community in the context of aging in recent years, attention drawn to this gene because it is upregulated by the practice of calorie restriction, as well as by protein restriction. Artificially increasing FGF21 expression via genetic engineering has been shown to extend life in mice.
Like many aspects of cellular biochemistry a...
Source: Fight Aging! - April 20, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
An Anti-Inflammatory Fruit That Reduces Cancer Risk By 23%
Eating this anti-inflammatory fruit commonly used in traditional medicine and food may give you a longer life. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - April 19, 2022 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Nutrition Source Type: blogs
This Fruit Lowers Your Blood Pressure
Eating a handful of this fruit per day can reduce the risk of cardiovascular disease. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - April 15, 2022 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Blood Pressure Source Type: blogs
10 Simple Ways to Spread the Optimism and Positive Energy Starting Today
“A pessimist sees the difficulty in every opportunity; an optimist sees the opportunity in every difficulty.”
Winston Churchill
Optimism.
It can turn a situation that looks negative or bleak into an opportunity or something to learn from.
It can replace the draining thoughts of pessimism with something that will create more positive energy and enthusiasm again.
And it can help you to jump over obstacles, to keep moving when you fall or stumble and to not give up just because you have had a couple of temporary setbacks.
So not just adding more of it to your own life but to the lives of the people in your world too is a ...
Source: Practical Happiness and Awesomeness Advice That Works | The Positivity Blog - April 12, 2022 Category: Consumer Health News Authors: Henrik Edberg Tags: Happiness Personal Development Source Type: blogs
