Fight Aging! Newsletter, November 6th 2023
This study aimed to gather valuable insights from pharmaceutical experts and healthcare practitioners regarding the potential and challenges of translating senolytic drugs for treatment of vascular aging-related disorders. This study employed a qualitative approach by conducting in-depth interviews with healthcare practitioners and pharmaceutical experts. Participants were selected through purposeful sampling. Thematic analysis was used to identify themes from the interview transcripts. A total of six individuals were interviewed, with three being pharmaceutical experts and the remaining three healthcare practitioners.
...
Source: Fight Aging! - November 5, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing the Role of Insulin in Aging
The relationship between insulin metabolism and aging is one of the most studied areas of the field, with decades of researchers putting in time to deepen the understanding of the web of interactions surrounding insulin. Yet this has failed to lead to any practical outcome when it comes to slowing or reversing aging. Researchers now have an incrementally better idea as to why obesity, metabolic syndrome, and type 2 diabetes shorten life and worsen health, but that was well understood to be the case well prior to the advent of modern biotechnology.
Experimental studies in animal models of aging such as nematodes, f...
Source: Fight Aging! - October 31, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fruit and sugar: Debunking the myths
On many occasions, patients have asked me whether it’s OK to eat fruit. They’re worried about whether they should be eating foods high in sugar. Is fruit in that category? No, it is not. Does anyone really believe that fruit is what’s causing the paired epidemics of diabetes and obesity? This scourge is not being
Read more…
Fruit and sugar: Debunking the myths originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - October 13, 2023 Category: General Medicine Authors: Roxanne B. Sukol, MD Tags: Conditions Nutrition Source Type: blogs
Do dogs live in a black and white world?
As a child, I remember my mother telling me something she learned when she was an eye nurse – dogs are colourblind. Now, if I remember rightly, she didn’t mean they could only see in black and white as research in the 1940s had suggested, but that they had limited receptivity to the full colour palate. They were red-green colourblind, like some boys and men. The issue came up after they tested us boys at school for colour blindness with those spotty number colour charts.
The red colour of our lab’s collar would’ve looked grey to her
However, proof that the canine world isn’t monochrome didn...
Source: David Bradley Sciencebase - Songs, Snaps, Science - October 11, 2023 Category: Science Authors: David Bradley Tags: Biology Source Type: blogs
Is a dog ’ s life monochrome?
Do dogs live in a black-and-white world?
As a child, I remember my mother telling me something she learned when she was an eye nurse – dogs are colourblind. Now, if I remember rightly, she didn’t mean they could only see in black and white as research in the 1940s had suggested, but that they had limited receptivity to the full colour palate. They were red-green colourblind, like some boys and men. The issue came up after they tested us boys at school for colour blindness with those spotty number colour charts.
The red colour of our lab’s collar would’ve looked grey to her
However, proof that the ca...
Source: David Bradley Sciencebase - Songs, Snaps, Science - October 11, 2023 Category: Science Authors: David Bradley Tags: Biology Source Type: blogs
Out of Control Health Costs or a Broken Society
Flawed Accounting for the US Health Spending Problem
By Jeff Goldsmith
Source: OECD, Our World in Data
Late last year, I saw this chart which made my heart sink. It compared US life expectancy to its health spending since 1970 vs. other countries. As you can see, the US began peeling off from the rest of the civilized world in the mid-1980’s. Then US life expectancy began falling around 2015, even as health spending continued to rise. We lost two more full years of life expectancy to COVID. By the end of 2022, the US had given up 26 years-worth of progress in life expectancy gains. Adding four more ...
Source: The Health Care Blog - October 9, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy COVID Drug Overdoses gun violence Hospitals Jeff Goldsmith Maternal mortality Mental Health Obesity Poverty Regional Economy Society Source Type: blogs
Out of Control Health Costs or a Broken Society
Flawed Accounting for the US Health Spending Problem
By Jeff Goldsmith
Source: OECD, Our World in Data
Late last year, I saw this chart which made my heart sink. It compared US life expectancy to its health spending since 1970 vs. other countries. As you can see, the US began peeling off from the rest of the civilized world in the mid-1980’s. Then US life expectancy began falling around 2015, even as health spending continued to rise. We lost two more full years of life expectancy to COVID. By the end of 2022, the US had given up 26 years-worth of progress in life expecta...
Source: The Health Care Blog - October 9, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy COVID Drug Overdoses gun violence Hospitals Jeff Goldsmith Maternal mortality Mental Health Obesity Poverty Regional Economy Society Source Type: blogs
Fight Aging! Newsletter, September 25th 2023
In conclusion, this individual patient data meta-analysis of longitudinal cohort studies found that antihypertensive use was associated with decreased dementia risk compared with individuals with untreated hypertension through all ages in late life. Individuals with treated hypertension had no increased risk of dementia compared with healthy controls.
« Back to Top
Results from Human Clinical Trials Do Not Support Metformin as a Longevity Drug
https://www.fightaging.org/archives/2023/09/results-from-human-clinical-trials-do-not-support-metformin-as-a-longevity-drug/
The SENS Research Fou...
Source: Fight Aging! - September 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Call for Matching Donors for the LEV Foundation " Robust Mouse Rejuvenation 2 " Fundraiser
The Longevity Escape Velocity (LEV) Foundation was founded by Aubrey de Grey to address an important missing aspect of the ongoing work to produce treatments that target the underlying mechanisms of aging. While the research and development community has made sizable strides in the past decade, and the first rejuvenation therapies now exist in at least prototype form, it remains the case that next to no-one is conducting combination studies that use two or more of these interventions. When considering therapies that can repair forms of the cell and tissue damage that cause aging, it seems plausible that two different thera...
Source: Fight Aging! - September 22, 2023 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Fall Activities for NIGMS Trainees
Welcome to the NIGMS Feedback Loop! As a current NIGMS trainee, you’re automatically subscribed to our blog so that we can provide you with information about upcoming meetings and events, opportunities to provide your input, program news, and more.
As the school yearbegins, we’d like to start by sharing upcoming NIGMS-supported events you can participate in.
We’re holding our annual Judith H. Greenberg Early Career Investigator Lecture virtually and on the NIH campus in Bethesda, Maryland, on September 27. The speaker is Akhila Rajan, Ph.D., from the Fred Hutchinson Cancer Center, and she’ll describe her ...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - September 18, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: NIGMS Trainee Community Source Type: blogs
My First MDMA Journey (Solo)
Yesterday I had my first MDMA journey, alone. I had planned to do it about two weeks in advance, knowing it was going to be a big deal for me. It was not what I expected. But I think it was the most remarkably life-shifting experience I’ve ever had. I can tell it changed me profoundly.
The short version is that it was like having my higher self embody me fully for 8-9 hours, letting me feel HIS feelings, hear HIS thoughts, speak with HIS voice, understand HIS perspective, and experience HIS energy. No, it wasn’t LIKE that. It was EXACTLY that.
Here’s the more detailed version:
I got up early that...
Source: Steve Pavlina's Personal Development Blog - September 17, 2023 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Creating Reality Lifestyle Source Type: blogs
Organoids Produce Tooth Enamel Proteins
Researchers at the University of Washington School of Medicine have developed a method to create stem cell-derived organoids that can produce tooth enamel proteins. The breakthrough could pave the way for lab grown enamel that can be used in dental repairs and may even allow for living fillings or completely new living teeth that can be implanted into a patient’s jaw. The researchers studied the genetic activity that occurs during tooth development, and then used this information to steer stem cells into becoming ameloblasts, which are the cell type responsible for enamel creation. Once present in organoids, the cells ca...
Source: Medgadget - September 12, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Dentistry Genetics Materials uwsomwwami Source Type: blogs
Daily Orange Juice Intake Lowers Blood Pressure, Study Finds
Conclusion
The University of Toronto’s groundbreaking study makes waves in the health community.
It demonstrates that a glass of orange juice a day can indeed lower high blood pressure, a key factor in cardiovascular health.
This adds nuance to our understanding of dietary impacts on blood pressure.
However, it’s critical to remember that this isn’t a silver bullet.
The study still underscores the superior benefits of consuming whole fruits.
As we navigate our health journeys, it appears orange juice could be a helpful ally—when consumed in moderation and as part of a balanced diet...
Source: The EMT Spot - September 11, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How Cold Weather Affects Blood Pressure? New Study Reveals Surprising Facts
Conclusion
In the vast tapestry of medical research, the recent study on seasonal trends in high blood pressure is a particularly illuminating thread. It’s shown us that something as seemingly benign as the changing of the seasons can impact a major health metric – our blood pressure.
This isn’t just about statistics and numbers. It’s about lives. Recognizing and anticipating these patterns means healthcare providers can be better equipped to offer timely, effective care. And for those living with high blood pressure? It offers a roadmap. A guide to navigate the challenges of each season, with...
Source: The EMT Spot - September 8, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
