Diversity of felodipine solvates: structure and physicochemical properties
CrystEngComm, 2015, Accepted ManuscriptDOI: 10.1039/C5CE00350D, PaperArtem Olegovich Surov, Katarzyna Solanko, Andrew Bond, Annette Bauer-Brandl, German L. PerlovichSolvates of the calcium-channel blocking agent felodipine with three structurally related common organic solvents, acetone (ATN), dimethyl sulfoxide (DMSO) and acetophenone (APN), are described. A relationship between the felodipine packing...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - April 20, 2015 Category: Chemistry Authors: Artem Olegovich Surov Source Type: research
Positive side effects of Ca antagonists for osteoarthritic joints¿results of an in vivo pilot study
Conclusion:
These results suggest that inhibition of hyaluronan export may have a beneficial effect on human osteoarthritis. (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - January 9, 2015 Category: Orthopaedics Authors: Kiriakos DaniilidisPhilipp GeorgesCarsten TibeskuPeter Prehm Source Type: research
Probing the Effects of Experimental Conditions on the Character of Drug-Polymer Phase Diagrams Constructed Using Flory-Huggins Theory
Conclusion
The potential implications of these findings when applied to a non-ambient processing method such as Hot Melt Extrusion (HME) are also discussed. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - January 1, 2015 Category: Drugs & Pharmacology Source Type: research
Lercanidipine hydrochloride versus felodipine sustained-release for mild-to-moderate hypertension: a multi-center, randomized clinical trial
Current Medical Research and Opinion, Ahead of Print. (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 26, 2014 Category: Research Tags: article Source Type: research
Multilayer encapsulated mesoporous silica nanospheres as an oral sustained drug delivery system for the poorly water-soluble drug felodipine
Publication date: 1 February 2015 Source:Materials Science and Engineering: C, Volume 47 Author(s): Liang Hu , Hongrui Sun , Qinfu Zhao , Ning Han , Ling Bai , Ying Wang , Tongying Jiang , Siling Wang We used a combination of mesoporous silica nanospheres (MSN) and layer-by-layer (LBL) self-assembly technology to establish a new oral sustained drug delivery system for the poorly water-soluble drug felodipine. Firstly, the model drug was loaded into MSN, and then the loaded MSN were repeatedly encapsulated by chitosan (CHI) and acacia (ACA) via LBL self-assembly method. The structural features of the samples wer...
Source: Materials Science and Engineering: C - November 21, 2014 Category: Materials Science Source Type: research
Effects of electroacupuncture on glycometabolism in metabolism syndrome
Conclusion Electroacupuncture intervention can significantly reduce weight, combination of acupuncture and medication shows better efficacy in reducing blood glucose, improving insulin sensitivity and insulin resistance in comparison to simple administration with medications. (Source: World Journal of Acupuncture Moxibustion)
Source: World Journal of Acupuncture Moxibustion - November 6, 2014 Category: Complementary Medicine Source Type: research
Studying Microstructure in Molecular Crystals With Nanoindentation: Intergrowth Polymorphism in Felodipine.
Abstract
Intergrowth polymorphism refers to the existence of distinct structural domains within a single crystal of a compound. The phenomenon is exhibited by form II of the active pharmaceutical ingredient felodipine, and the associated microstructure is a significant feature of the compound's structural identity. Employing the technique of nanoindentation on form II reveals a bimodal mechanical response on specific single-crystal faces, demonstrating distinct properties for two polymorphic forms within the same crystal.
PMID: 25264144 [PubMed - as supplied by publisher] (Source: Angewandte Chemie)
Source: Angewandte Chemie - September 26, 2014 Category: Chemistry Authors: Mishra MK, Desiraju GR, Ramamurty U, Bond AD Tags: Angew Chem Int Ed Engl Source Type: research
Clinical Pharmacokinetics of Drugs in Patients with Heart Failure: An Update (Part 2, Drugs Administered Orally)
Abstract
The purpose of the present review article is to update the information regarding pharmacokinetics of drugs in patients with heart failure that has accumulated since the last review article published in 1988 in Clinical Pharmacokinetics. Since this last review, our understanding of the pathophysiology of heart failure has changed from the cardio-renal model to the neuro-humoral model, and the pharmacologic approach to treatment of heart failure has been shifted from inotropic agents to those acting on the renin-angiotensin-aldosterone system. The pharmacologic agents now used for heart failure inc...
Source: Clinical Pharmacokinetics - September 24, 2014 Category: Drugs & Pharmacology Source Type: research
Pharmacological interventions for hypertension in children
Abstract
BackgroundHypertension is a major risk factor for stroke, coronary artery disease and kidney damage in adults. There is a paucity of data on the long‐term sequelae of persistent hypertension in children, but it is known that children with hypertension have evidence of end organ damage and are at risk of hypertension into adulthood. The prevalence of hypertension in children is rising, most likely due to a concurrent rise in obesity rates. In children with hypertension, non‐pharmacological measures are often recommended as first‐line therapy, but a significant proportion of children will eventually require ph...
Source: Evidence-Based Child Health: A Cochrane Review Journal - September 19, 2014 Category: Pediatrics Authors: Swasti Chaturvedi, Deborah H Lipszyc, Christoph Licht, Jonathan C Craig, Rulan Parekh Tags: Intervention Review Source Type: research
Time course for blood pressure lowering of dihydropyridine calcium channel blockers.
CONCLUSIONS: Six dihydropyridine calcium channel blockers studied in this review lowered blood pressure by a relatively similar amount each hour over the course of 24 hours. The benefits and harms of this pattern of blood pressure lowering are unknown. Further trials are needed with accurate recording of time of drug intake and with reporting of standard deviation of blood pressure at each hour. We did not attempt to assess adverse effects in this review due to the lack of reporting and the short duration of follow-up.
PMID: 25173808 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - September 4, 2014 Category: Journals (General) Authors: Ghamami N, Chiang SH, Dormuth C, Wright JM Tags: Cochrane Database Syst Rev Source Type: research
Preparation and in vitro/in vivo evaluation of felodipine nanosuspension
Abstract
The purpose of
this study was to develop a nanosuspension of a poorly soluble drug felodipine by nanoprecipitation to achieve superior in vitro dissolution and high oral absorption in vivo in rats. Felodipine nanosuspensions were prepared by precipitation with ultrasonication method using polyvinyl alcohol (PVA) and hydroxy propyl methyl cellulose (HPMC) as stabilizers. The particle size of nanosuspension with PVA was 60–200 nm, while with HPMC is 300–410 nm. The in vitro dissolution and pharmacokinetics of optimized nanosuspensions were studied after oral administration in male wi...
Source: European Journal of Drug Metabolism and Pharmacokinetics - September 1, 2014 Category: Drugs & Pharmacology Source Type: research
Prediction of the extent and variation of grapefruit juice–drug interactions from the pharmacokinetic profile in the absence of grapefruit juice
ABSTRACT
The aim of this study was to develop a method for predicting the extent of grapefruit juice (GFJ)–drug interactions and their interindividual variations from the pharmacokinetic profile in the absence of GFJ. The pharmacokinetic profiles of 13 drugs after intravenous and oral administration were used to develop and validate the method. For each drug, the proportion absorbed into the intestine and the intestinal availability (Fg) were calculated from clinical data taken from the literature. Then, the AUC ratio (the ratio of the AUC with GFJ to that without GFJ) was predicted by assuming that Fg was 1.0 when GFJ w...
Source: Biopharmaceutics and Drug Disposition - August 29, 2014 Category: Drugs & Pharmacology Authors: Natsuki Kogure, Takeshi Akiyoshi, Ayuko Imaoka, Hisakazu Ohtani Tags: Original Paper Source Type: research
The effect of processing on the surface physical stability of amorphous solid dispersions.
In conclusion it was found the amorphous molecular dispersions prepared by spin coating had a significantly higher surface physical stability than the corresponding HME samples, which may be attributed to the increased process-related apparent drug-polymer solubility and reduced molecular mobility due to the quenching effect caused by the rapid solvent evaporation in spin coating.
PMID: 25111184 [PubMed - as supplied by publisher] (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - August 8, 2014 Category: Drugs & Pharmacology Authors: Yang Z, Nollenberger K, Albers J, Moffat J, Craig D, Qi S Tags: Eur J Pharm Biopharm Source Type: research
SERS as a potential tool for drug discovery [Biophysics and Computational Biology]
We demonstrate the use of surface-enhanced Raman spectroscopy (SERS) as an excellent tool for identifying the binding site of small molecules on a therapeutically important protein. As an example, we show the specific binding of the common antihypertension drug felodipine to the oncogenic Aurora A kinase protein via hydrogen bonding... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - July 22, 2014 Category: Science Authors: Karthigeyan, D., Siddhanta, S., Kishore, A. H., Perumal, S. S. R. R., Agren, H., Sudevan, S., Bhat, A. V., Balasubramanyam, K., Subbegowda, R. K., Kundu, T. K., Narayana, C. Tags: Physical Sciences Source Type: research
Drug efficacy in treating stable angina pectoris: a protocol for network meta-analysis of randomised controlled trials
This study aims to fill this gap of research by conducting a Bayesian network meta-analysis to compare all these antianginal drugs.
Methods and analyses
Randomised controlled trials (RCT) on the drug therapy of stable angina pectoris with multiple outcome measures, selected from symptomatic relief, ECG tests, exercise tests, heart rates and blood pressures, etc, will be included. Overall effect sizes will be represented as mean differences with 95% credible intervals (CrI) for continuous outcome data and as ORs with 95% CrI for dichotomous outcome data. Bayesian network meta-analysis by WinBUGS will be conducted to compar...
Source: BMJ Open - June 19, 2014 Category: Journals (General) Authors: Jia, Y., Leung, S.-w. Tags: Open access, Cardiovascular medicine, Evidence based practice Protocol Source Type: research
