Risks of Adverse Events Following Coprescription of Statins and Calcium Channel Blockers: A Nationwide Population-Based Study
In this study, 5857 patients received coprescription of CYP3A4-metabolized statins and CCBs that inhibit CYP3A4. There were no differences in comorbidity or use of antihypertensive drugs between patients who received CYP3A4-metabolized statins and those who received non-CYP3A4-metabolized statins. Patients who received CYP3A4-metabolized statins had significantly higher risk of acute kidney injury (adjusted odds ratio [OR] = 2.12; 95% CI = 1.35–3.35), hyperkalemia (adjusted OR = 2.94; 95% CI = 1.36–6.35), acute myocardial infarction (adjusted OR = 1.55; 95% CI = 1.16–2.07), and acute ischemic ...
Source: Medicine - January 1, 2016 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Apoptosis-like cell death induced by nematocyst venom from Chrysaora helvola Brandt jellyfish and an in vitro evaluation of commonly used antidotes
Publication date: February 2016 Source:Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, Volume 180 Author(s): Xiaosheng Qu, Xianghua Xia, Zefeng Lai, Taozheng Zhong, Gang Li, Lanlan Fan, Wei Shu The present work investigated the in vitro cytotoxicity of nematocyst venom (NV) from Chrysaora helvola Brandt (C. helvola) jellyfish against human MCF-7 and CNE-2 tumor cell lines. Potent cytotoxicity was quantified using the MTT assay (LC50 =12.07±3.13 and 1.6±0.22μg/mL (n=4), respectively). Apoptosis-like cell death was further confirmed using the LDH release assay and Annex...
Source: Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology - December 11, 2015 Category: Toxicology Source Type: research
Preparation of a novel starch-derived three-dimensional ordered macroporous carbon for improving the dissolution rate and oral bioavailability of water-insoluble drugs
Publication date: 25 January 2016 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 118 Author(s): Ying Liu, Chao Wu, Yanna Hao, Jie Xu, Ying Zhao, Yang Qiu, Jie Jiang, Tong Yu, Peng Ji In our study, soluble starch was applied as a novel carbon source for preparing three-dimensional ordered macroporous carbon (3DOMC) using monodisperse silica nanospheres as the hard template. The 3DOMC was used as an insoluble drug carrier when it was found that it could markedly improve the water solubility of felodipine (FDP). The structural features of 3DOMC were characterized by scanning electron mi...
Source: Journal of Pharmaceutical and Biomedical Analysis - November 14, 2015 Category: Drugs & Pharmacology Source Type: research
Apoptosis-like cell death induced by nematocyst venom from Tamoya alata Uchida jellyfish and an in vitro evaluation of commonly used antidotes
Publication date: Available online 30 October 2015 Source:Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology Author(s): Xiaosheng Qu, Xianghua Xia, Zefeng Lai, LanLan Fan, Gang Li, Taozheng Zhong, Wei Shu The present work investigated the in vitro cytotoxicity of nematocyst venom (NV) from Tamoya alata Uchida (T. alata) jellyfish against human MCF-7 and CNE-2 tumor cell lines. Potent cytotoxicity was quantified using the MTT assay (LC50 =12.07±3.13 and 1.6±0.22μg/mL (n=4), respectively). Apoptosis-like cell death was further confirmed using the LDH release assay and Annex...
Source: Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology - November 1, 2015 Category: Toxicology Source Type: research
Apoptosis-like cell death induced by nematocysts venom from Tamoya alata Uchida jellyfish and an in vitro evaluation of commonly used antidotes
Publication date: Available online 30 October 2015 Source:Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology Author(s): Xiaosheng Qu, Xianghua Xia, Zefeng Lai, LanLan Fan, Gang Li, Taozheng Zhong, Wei Shu The present work investigated the in vitro cytotoxicity of nematocyst venom (NV) from Tamoya alata Uchida (T. alata) jellyfish against human MCF-7 and CNE-2 tumor cell lines. Potent cytotoxicity was quantified using the MTT assay (LC50 =12.07±3.13 and 1.6±0.22μg/mL (n=4), respectively). Apoptosis-like cell death was further confirmed using the LDH release assay and Annex...
Source: Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology - October 30, 2015 Category: Toxicology Source Type: research
Apoptosis-like cell death induced by nematocysts venom from Tamoya alata Uchida jellyfish and an in vitro evaluation of commonly used antidotes.
Abstract
The present work investigated the in vitro cytotoxicity of nematocyst venom (NV) from Tamoya alata Uchida (T. alata) jellyfish against human MCF-7 and CNE-2 tumor cell lines. Potent cytotoxicity was quantified using the MTT assay (LC50=12.07±3.13 and 1.6±0.22μg/mL (n=4), respectively). Apoptosis-like cell death was further confirmed using the LDH release assay and Annexin V/PI double staining-based flow cytometry analysis. However, only activation of caspase-4 was observed. It is possible that some caspase-independent pathways were activated by the NV treatment. Since no reference or antivenom ...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - October 29, 2015 Category: Biochemistry Authors: Qu X, Xia X, Lai Z, Fan L, Li G, Zhong T, Shu W Tags: Comp Biochem Physiol C Toxicol Pharmacol Source Type: research
Design And Evaluation of Transdermal Patch of Felodipine
To design and evaluate the transdermal drug delivery system with low dose of felodipine. And to develop matrix type transdermal patch of felodipine to avoid first pass metabolism and to study the effect of permeation enhancer in formulated patches. (Source: Value in Health)
Source: Value in Health - October 23, 2015 Category: Global & Universal Authors: A Singh, S Chauhan Source Type: research
Detailed NOESY/T-ROESY analysis as an effective method for eliminating spin diffusion from 2D NOE spectra of small flexible molecules
Publication date: 15 January 2016 Source:Journal of Molecular Structure, Volume 1104 Author(s): S.V. Efimov, I.A. Khodov, E.L. Ratkova, M.G. Kiselev, S. Berger, V.V. Klochkov An intriguing property of the multistep magnetization transfer, so-called spin diffusion, is that it can affect the results of NMR-based analysis of conformer distribution of small molecules in solution. Therefore, the contribution of spin diffusion should be subtracted in order to obtain accurate data on molecular conformations and their distributions. Several methods have been developed for this purpose, but many of them have a lack ...
Source: Journal of Molecular Structure - October 23, 2015 Category: Molecular Biology Source Type: research
Influence of Polymers on the Crystal Growth Rate of
Felodipine: Correlating Adsorbed Polymer Surface Coverage to Solution
Crystal Growth Inhibition
LangmuirDOI: 10.1021/acs.langmuir.5b02486 (Source: Langmuir)
Source: Langmuir - October 6, 2015 Category: Chemistry Authors: Caitlin J. Schram, Lynne S. Taylor and Stephen P. Beaudoin Source Type: research
Impact of Solubilizing Additives on Supersaturation and Membrane Transport of Drugs
Conclusions
These findings clearly point out the flaws in using solute concentration in estimating solute activity or supersaturation, and reaffirm the use of flux measurements to understand supersaturated systems. Clear differentiation between solubilization and supersaturation, as well as thorough understanding of their respective impacts on membrane transport kinetics is important for the rational design of enabling formulations for poorly soluble compounds. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - September 23, 2015 Category: Drugs & Pharmacology Source Type: research
Role of surface chemistry in crystal morphology and its associated properties
CrystEngComm, 2015, Accepted ManuscriptDOI: 10.1039/C5CE01182E, CommunicationDinesh Kumar, Rajesh Thipparaboina, B Sreedhar, Nalini R ShastriAcetonitrile induced a remarkable enhancement of Felodipine crystal facet {11-1}. This facet was polar in nature as concluded from surface chemistry and resulted in significant improvement in dissolution rate and...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - August 7, 2015 Category: Chemistry Authors: Dinesh Kumar Source Type: research
Recent trends in preclinical drug–drug interaction studies of flavonoids — Review of case studies, issues and perspectives
Because of health benefits that are manifested across various disease areas, the consumption of herbal products and/or health supplements containing different kinds of flavonoids has been on the rise. While the drug–drug interaction potential between flavonoids and co‐ingested drugs still remain an issue, opportunities exist for the combination of flavonoids with suitable anti‐cancer drugs to enhance the bioavailability of anti‐cancer drugs and thereby reduce the dose size of the anti‐cancer drugs and improve its therapeutic index. In recent years, scores of flavonoids have undergone preclinical investigation wit...
Source: Phytotherapy Research - August 1, 2015 Category: Biochemistry Authors: Nuggehally R. Srinivas Tags: Review Source Type: research
Enhanced oral bioavailability of felodipine by novel solid self-microemulsifying tablets
Drug Development and Industrial Pharmacy, Ahead of Print. (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - July 15, 2015 Category: Drugs & Pharmacology Tags: article Source Type: research
Cellulose crosslinked pH-responsive polyurethanes for drug delivery: α-hydroxy acids as drug release modifiers.
Abstract
Cellulose crosslinked waterborne polyurethanes (PUs) based on poly ɛ-caprolactone with lactic acid/glycolic acid/dimethylol-propionic acid as a drug release modifiers cum chain extenders were prepared. PUs were loaded with felodipine and drug release was monitored at different pH values. The structure of the polymers was characterized by FTIR, DSC & TGA and SEM. The encapsulation of dug inside PU matrix and the morphology of polymer after drug release were studied by using SEM. All the PUs were observed to degrade under highly basic conditions. The PUs act as pH sensitive drug carriers with a...
Source: International Journal of Biological Macromolecules - July 15, 2015 Category: Biochemistry Authors: Solanki A, Thakore S Tags: Int J Biol Macromol Source Type: research
Pharmacology, Efficacy and Safety of Felodipine with a Focus on Hypertension and Angina Pectoris.
Abstract
Calcium channel blockers (CCBs) are a heterogeneous group of drugs often used in the therapy for hypertension and angina. Though CCBs are generally similar in terms of their efficacy yet, they differ in their ability of causing selective inhibition in the contractility of vascular smooth muscle in comparison to cardiac muscle. Felodipine is one of the most vascular selective of the available CCBs and it has no negative inotropic effects at clinically administered doses. Focus of this review is to comprehensively summarize the pharmacokinetics, efficacy, safety and tolerability of felodipine. This ...
Source: Current Drug Safety - May 14, 2015 Category: Drugs & Pharmacology Authors: Navadiya K, Tiwari S Tags: Curr Drug Saf Source Type: research
