Neuro-modulatory impact of felodipine against experimentally-induced Parkinson's disease: Possible contribution of PINK1-Parkin mitophagy pathway
In conclusion, felodipine restored dopamine synthesis, attenuated oxidative stress, inflammation, and mitochondrial dysfunction, and improved the mitophagy process resulting in improved PD-associated motor impairment.PMID:38494124 | DOI:10.1016/j.neuropharm.2024.109909 (Source: Neuropharmacology)
Source: Neuropharmacology - March 17, 2024 Category: Drugs & Pharmacology Authors: Hadeer O Abou-Hany Mohamed El-Sherbiny Sally Elshaer Eman Said Tarek Moustafa Source Type: research
Neuro-modulatory impact of felodipine against experimentally-induced Parkinson's disease: Possible contribution of PINK1-Parkin mitophagy pathway
In conclusion, felodipine restored dopamine synthesis, attenuated oxidative stress, inflammation, and mitochondrial dysfunction, and improved the mitophagy process resulting in improved PD-associated motor impairment.PMID:38494124 | DOI:10.1016/j.neuropharm.2024.109909 (Source: Neuropharmacology)
Source: Neuropharmacology - March 17, 2024 Category: Drugs & Pharmacology Authors: Hadeer O Abou-Hany Mohamed El-Sherbiny Sally Elshaer Eman Said Tarek Moustafa Source Type: research
Neuro-modulatory impact of felodipine against experimentally-induced Parkinson's disease: Possible contribution of PINK1-Parkin mitophagy pathway
In conclusion, felodipine restored dopamine synthesis, attenuated oxidative stress, inflammation, and mitochondrial dysfunction, and improved the mitophagy process resulting in improved PD-associated motor impairment.PMID:38494124 | DOI:10.1016/j.neuropharm.2024.109909 (Source: Neuropharmacology)
Source: Neuropharmacology - March 17, 2024 Category: Drugs & Pharmacology Authors: Hadeer O Abou-Hany Mohamed El-Sherbiny Sally Elshaer Eman Said Tarek Moustafa Source Type: research
Immunoglobulin A vasculitis involving the duodenum and jejunum
A 66-year-old woman with a history of hypertension and coronary atherosclerotic heart disease presented with acute onset of paroxysmal epigastric pain for 3 days. She was taking oral aspirin and felodipine. She denied a history of vomiting and diarrhea. Physical examination showed tenderness in the upper abdomen. Laboratory findings revealed mild leucocytosis. Fecal occult blood test was positive. Urine microscopy was normal. Chest computed tomography (CT) and electrocardiography showed no significant abnormalities. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 8, 2023 Category: Gastroenterology Authors: Dong-Ge Han, Xu Liu, Wei Liu Tags: Image of the Month Source Type: research
Structured solubility behaviour in fed simulated intestinal fluids
This study has utilised nine bioequivalent simulated fed intestinal media recipes that cover over 90% of the compositional variability of sampled fed human intestinal fluid. The solubility of 24 drugs (Acidic; furosemide, ibuprofen, indomethacin, mefenamic acid, naproxen, phenytoin, piroxicam, valsartan, zafirlukast: Basic; aprepitant, atazanavir, bromocriptine, carvedilol, dipyridamole, posaconazole, tadalafil: Neutral; acyclovir, carbamazepine, felodipine, fenofibrate, griseofulvin, itraconazole, paracetamol, probucol) has been assessed to determine if structured solubility behaviour is present. The measured solubility b...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 27, 2023 Category: Drugs & Pharmacology Authors: Maria In ês Silva Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research
Structured solubility behaviour in fed simulated intestinal fluids
This study has utilised nine bioequivalent simulated fed intestinal media recipes that cover over 90% of the compositional variability of sampled fed human intestinal fluid. The solubility of 24 drugs (Acidic; furosemide, ibuprofen, indomethacin, mefenamic acid, naproxen, phenytoin, piroxicam, valsartan, zafirlukast: Basic; aprepitant, atazanavir, bromocriptine, carvedilol, dipyridamole, posaconazole, tadalafil: Neutral; acyclovir, carbamazepine, felodipine, fenofibrate, griseofulvin, itraconazole, paracetamol, probucol) has been assessed to determine if structured solubility behaviour is present. The measured solubility b...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 27, 2023 Category: Drugs & Pharmacology Authors: Maria In ês Silva Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research
Structured solubility behaviour in fed simulated intestinal fluids
This study has utilised nine bioequivalent simulated fed intestinal media recipes that cover over 90% of the compositional variability of sampled fed human intestinal fluid. The solubility of 24 drugs (Acidic; furosemide, ibuprofen, indomethacin, mefenamic acid, naproxen, phenytoin, piroxicam, valsartan, zafirlukast: Basic; aprepitant, atazanavir, bromocriptine, carvedilol, dipyridamole, posaconazole, tadalafil: Neutral; acyclovir, carbamazepine, felodipine, fenofibrate, griseofulvin, itraconazole, paracetamol, probucol) has been assessed to determine if structured solubility behaviour is present. The measured solubility b...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 27, 2023 Category: Drugs & Pharmacology Authors: Maria In ês Silva Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research
Structured solubility behaviour in fed simulated intestinal fluids
This study has utilised nine bioequivalent simulated fed intestinal media recipes that cover over 90% of the compositional variability of sampled fed human intestinal fluid. The solubility of 24 drugs (Acidic; furosemide, ibuprofen, indomethacin, mefenamic acid, naproxen, phenytoin, piroxicam, valsartan, zafirlukast: Basic; aprepitant, atazanavir, bromocriptine, carvedilol, dipyridamole, posaconazole, tadalafil: Neutral; acyclovir, carbamazepine, felodipine, fenofibrate, griseofulvin, itraconazole, paracetamol, probucol) has been assessed to determine if structured solubility behaviour is present. The measured solubility b...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 27, 2023 Category: Drugs & Pharmacology Authors: Maria In ês Silva Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research
Structured solubility behaviour in fed simulated intestinal fluids
This study has utilised nine bioequivalent simulated fed intestinal media recipes that cover over 90% of the compositional variability of sampled fed human intestinal fluid. The solubility of 24 drugs (Acidic; furosemide, ibuprofen, indomethacin, mefenamic acid, naproxen, phenytoin, piroxicam, valsartan, zafirlukast: Basic; aprepitant, atazanavir, bromocriptine, carvedilol, dipyridamole, posaconazole, tadalafil: Neutral; acyclovir, carbamazepine, felodipine, fenofibrate, griseofulvin, itraconazole, paracetamol, probucol) has been assessed to determine if structured solubility behaviour is present. The measured solubility b...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 27, 2023 Category: Drugs & Pharmacology Authors: Maria In ês Silva Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research
Drug-Polymer Miscibility and the Overlap Concentration (C*) as Measured by Rheology: Variation of Polymer Structure
ConclusionsOur findings will aid researchers in designing or selecting appropriate polymers to inhibit crystallization of poorly soluble drugs. This research also suggests thatC* as determined by rheology can be used to compare drug-polymer interactions for similar molecular weight polymers.Graphical abstract (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - August 8, 2023 Category: Drugs & Pharmacology Source Type: research
Effect of felodipine on indomethacin-induced gastric ulcers in rats
Exp Anim. 2023 Jun 13. doi: 10.1538/expanim.23-0052. Online ahead of print.ABSTRACTFelodipine is a calcium channel blocker with antioxidant and anti-inflammatory properties. Researchers have stated that oxidative stress and inflammation also play a role in the pathophysiology of gastric ulcers caused by nonsteroidal anti-inflammatory drugs. The aim of this study was to investigate the antiulcer effect of felodipine on indomethacin-induced gastric ulcers in Wistar rats and compare it with that of famotidine. The antiulcer activities of felodipine (5 mg/kg) and famotidine were investigated biochemically and macroscopically i...
Source: Experimental Animals - June 14, 2023 Category: Research Authors: Nergis Akba ş Bahad ır Süleyman Renad Mammadov Mine G ülaboğlu Emin Murat Akba ş Halis S üleyman Source Type: research
A SARS-CoV-2-specific CAR-T-cell model identifies felodipine, fasudil, imatinib, and caspofungin as potential treatments for lethal COVID-19
Cell Mol Immunol. 2023 Mar 2:1-14. doi: 10.1038/s41423-023-00985-3. Online ahead of print.ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced cytokine storm is closely associated with coronavirus disease 2019 (COVID-19) severity and lethality. However, drugs that are effective against inflammation to treat lethal COVID-19 are still urgently needed. Here, we constructed a SARS-CoV-2 spike protein-specific CAR, and human T cells infected with this CAR (SARS-CoV-2-S CAR-T) and stimulated with spike protein mimicked the T-cell responses seen in COVID-19 patients, causing cytokine storm and displaying a...
Source: Cellular and Molecular Immunology - March 2, 2023 Category: Molecular Biology Authors: Lin Xia Lun-Zhi Yuan Ya-Hong Hu Jun-Yi Liu Guo-Sheng Hu Ruo-Yao Qi Tian-Ying Zhang Hua-Long Xiong Zao-Zao Zheng Hong-Wei Lin Jia-Mo Zhang Chao Yu Ming Zhou Jian Ma Tong Cheng Ri-Rong Chen Yi Guan Ning-Shao Xia Wen Liu Source Type: research
