Polymorphism of felodipine co-crystals with 4,4[prime or minute]-bipyridine
CrystEngComm, 2014, Accepted ManuscriptDOI: 10.1039/C4CE00756E, PaperArtem Olegovich Surov, Katarzyna Solanko, Andrew Bond, Annette Bauer-Brandl, German L. PerlovichThe calcium-channel blocking agent felodipine (Fel) forms co-crystals with 4,4[prime or minute]-bipyridine (BP) with 1:1 and 2:1 molar ratios. The [Fel+BP] (1:1) co-crystal exists in two polymorphic forms. Differential scanning calorimetry and...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - May 16, 2014 Category: Chemistry Authors: Artem Olegovich Surov Source Type: research
Prediction of the extent and variation of grapefruit juice‐drug interactions from the pharmacokinetic profile in the absence of grapefruit juice
This article is protected by copyright. All rights reserved. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - May 1, 2014 Category: Drugs & Pharmacology Authors: Natsuki Kogure, Takeshi Akiyoshi, Ayuko Imaoka, Hisakazu Ohtani Tags: Original Paper Source Type: research
The efficacy and safety of arotinolol combined with a different calcium channel blocker in the treatment of Chinese patients with essential hypertension: a one-year follow-up study.
Conclusions: The therapy approached of arotinolol combined with nifedipine or amlodipine could be effective and well-tolerated, and they can be used as the better chosen antihypertensive drug.
PMID: 24678807 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - March 28, 2014 Category: Cardiology Authors: Fang H, Chen W, Liu X, Xu W Tags: Clin Exp Hypertens Source Type: research
Supersaturation, nucleation, and crystal growthduring single- and biphasic dissolution of amorphous solid dispersions: polymer effects and implicationsfor oral bioavailability enhancement of poorly water soluble drugs.
Abstract
The influence of polymers on the dissolution, supersaturation, crystallization, and partitioning of poorly water soluble compounds in biphasic media was evaluated. Amorphous solid dispersions (ASDs) containing felodipine (FLD) and itraconazole (ITZ) were prepared by hot melt mixing (HMM) using various polymers. The ASDs were analyzed using powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), and HPLC. Amorphous drug conversion was confirmed using DSC and PXRD, and drug stability by HPLC. Single- and biphasic dissolution studies of the ASDs with concurrent dynamic light scatter...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 23, 2013 Category: Drugs & Pharmacology Authors: Sarode A, Wang P, Obara S, Worthen DR Tags: Eur J Pharm Biopharm Source Type: research
Re: The Effect of Combined Antihypertensive Treatment (Felodipine with Either Irbesartan or Metoprolol) on Erectile Function: A Randomized Controlled Trial
L. Yang, J. Yu, R. Ma, F. Zhao, X. Lin, P. Liu, H. Hu and F. Bai Department of Cardiology, Second Hospital of Lanzhou University, Lanzhou, China (Source: The Journal of Urology)
Source: The Journal of Urology - October 7, 2013 Category: Urology & Nephrology Authors: Allen D. Seftel Tags: Male and Female Sexual Function and Dysfunction; Andrology Source Type: research
Evaluation of the Crystal Growth Rate of Felodipine
Polymorphs in the Presence and Absence of Additives As a Function
of Temperature
Crystal Growth & DesignDOI: 10.1021/cg400708p (Source: Crystal Growth and Design)
Source: Crystal Growth and Design - August 26, 2013 Category: Chemistry Authors: Umesh S. Kestur and Lynne S. Taylor Source Type: research
Evaluation of First‐Pass Cytochrome P4503A (CYP3A) and P‐glycoprotein Activities Using Felodipine and Hesperetin in Combination in Wistar Rats and Everted Rat Gut Sacs in Vitro
The effects of hesperetin on the pharmacokinetics and the role of P‐glycoprotein (P‐gp) in the transport of felodipine were investigated in rats and in vitro. Felodipine was administered orally (10 mg/kg) without or with hesperetin (25, 50 and 100 mg/kg) to rats for 15 consecutive days. Blood samples were collected at different time intervals on 1st day in single dose pharmacokinetic study (SDS) and on 15th day in multiple dose pharmacokinetic study (MDS). The area under the plasma concentration–time curve (AUC0–∞) and the peak plasma concentration (Cmax) of felodipine were dose‐dependently increased in SDS...
Source: Phytotherapy Research - July 23, 2013 Category: Biochemistry Authors: V. Sridhar, M. Surya Sandeep, P. Ravindra Babu, K. Naveen Babu Tags: Research Article Source Type: research
Crystal architecture and physicochemical properties of felodipine solvates
CrystEngComm, 2013, Accepted ManuscriptDOI: 10.1039/C3CE40715B, PaperArtem Olegovich Surov, Katarzyna Solanko, Andrew Bond, Annette Bauer-Brandl, German L. PerlovichSolvates of the calcium-channel blocking agent felodipine with three structurally related high-boiling point solvents, dimethylacetamide (DMAA), dimethylethyleneurea (DMEU) and tetramethylurea (TMU), are described. The solvates can be formed either by...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - May 30, 2013 Category: Chemistry Authors: Artem Olegovich Surov Source Type: research
Effects of felodipine combined with puerarin on ACE2-Ang (1-7)-Mas axis in renovascular hypertensive rat.
This study aimed to investigate the effect of combination of felodipine+puerarin on ACE2-Ang (1-7)-Mas axis, and to explore the protective effect of the combination against kidney in renovascular hypertensive rats. Goldblatt rats were randomly divided into 5 groups as follows: 4 groups which were treated with felodipine (Felo), puerarin (Pue), Felo+Pue, and Felo+captopril (Cap), respectively, and a control group of animals that were administrated with distilled water. Contents of Ang II and Ang (1-7) in renal tissues were determined by ELISA kit. The mRNA expression of ACE2/Mas and ACE/AT1 in kidneys was analyzed by RT-PCR...
Source: Regulatory Peptides - May 22, 2013 Category: Biochemistry Authors: Bai S, Huang ZG, Chen L, Wang JT, Ding BP Tags: Regul Pept Source Type: research
Stabilisation of amorphous drugs under high humidity using pharmaceutical thin films.
In this study, the stabilization effects of three polymers on four model drugs (felodipine, fenofibrate, carbamazepine, and celecoxib) under saturated humidity were investigated. Three different types of thin films (solid dispersions, drug films with a polymer film coating and drug films laid on top of polymer coated surfaces) were prepared and compared with films containing the drug alone. ATR-FTIR spectroscopy, polarised light microscopy (PLM), scanning electron microscopy (SEM) and nano-thermal analysis (nano-TA) were performed on the model systems after storage under saturated humidity. The recrystallisation tendency o...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 9, 2013 Category: Drugs & Pharmacology Authors: Ng YC, Yang Z, McAuley WJ, Qi S Tags: Eur J Pharm Biopharm Source Type: research
Validated LC-ESI-MS/MS method for simultaneous quantitation of felodipine and metoprolol in rat plasma: application to a pharmacokinetic study in rats.
Abstract
A highly sensitive and specific LC-ESI-MS/MS method has been developed and validated for simultaneous quantification of felodipine (FDP) and metoprolol (MPL) in rat plasma (50 μL) using phenacetin as an internal standard (IS) as per the FDA guidelines. Liquid-liquid extraction method was used to extract the analytes and IS from rat plasma. The chromatographic resolution of FDP, MPL and IS was achieved with a mobile phase consisting of 0.2% formic acid in water-acetonitrile (25:75, v/v) with a time program flow gradient on a C(18) column. The total chromatographic run time was 4.0 min and the...
Source: Biomedical Chromatography : BMC - January 10, 2013 Category: Biomedical Science Authors: Kallem RR, Ramesh M, Seshagirirao JV Tags: Biomed Chromatogr Source Type: research
