Cognitive behavioral therapy for insomnia combined with eszopiclone for the treatment of sleep disorder patients transferred out of the intensive care unit: A single-centred retrospective observational study
Patients transferred out of the intensive care unit (ICU) are always impaired by sleep disorders. Cognitive behavioral therapy for insomnia (CBT-I) and eszopiclone are 2 commonly prescribed strategies for insomnia. In the current study, the effect of the combined application of the 2 methods on sleep disorders in ICU transferred out patients was assessed.
Twenty-nine insomnia patients receiving combined treatment of CBT-I and eszopiclone and a corresponding number of patients treated with eszopiclone were collected. The incidence of discomfort experiences in ICU was recorded. Polysomnogram (PSG), Pittsburgh Sleep Quality ...
Source: Medicine - September 1, 2018 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Insomnia in Elderly Patients: Recommendations for Pharmacological Management
AbstractChronic insomnia affects 57% of the elderly in the United States, with impairment of quality of life, function, and health. Chronic insomnia burdens society with billions of dollars in direct and indirect costs of care. The main modalities in the treatment of insomnia in the elderly are psychological/behavioral therapies, pharmacological treatment, or a combination of both. Various specialty societies view psychological/behavioral therapies as the initial treatment intervention. Pharmacotherapy plays an adjunctive role when insomnia symptoms persist or when patients are unable to pursue cognitive behavioral therapi...
Source: Drugs and Aging - September 1, 2018 Category: Geriatrics Source Type: research
Treatment Options for Insomnia in Schizophrenia: A Systematic Review
Conclusions Despite a very limited number of specific studies on this matter, all 4 studies have shown good benefit/risk ratios and reviewed options—melatonin, paliperidone, and eszopiclone—might represent valid options for residual insomnia in schizophrenia. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - July 30, 2018 Category: Psychiatry Authors: Oliveira, Pedro Coroa, Manuel Madeira, Nuno Tags: Review Source Type: research
Zolpidem and Eszopiclone Pre-medication for PSG: Effects on Staging, Titration, and Adherence.
Conclusions: In a population with predominantly mild obstructive sleep apnea, NBSHs did not improve PSG or CPAP titration quality and did not increase CPAP adherence. There was no difference in effect between eszopiclone and zolpidem.
PMID: 29961838 [PubMed - in process] (Source: Military Medicine)
Source: Military Medicine - July 4, 2018 Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Sedative Hypnotics and the Risk of Falls and Fractures in the Elderly.
Authors: Andrade C
Abstract
Older age, poor sleep, and the use of the "Z" sedative hypnotic drugs (zopiclone, eszopiclone, zolpidem, and zaleplon) commonly go together. Each of these can increase the risk of falls and fractures through mechanisms related to cognitive and psychomotor impairment. A recent systematic review and meta-analysis examined the risk of falls and fractures associated with the use of the Z-drugs. The authors of that meta-analysis identified 14 relevant cohort and case-control studies. They found that Z-drugs increased the risk of falls in 2 out of 3 studies that provided information o...
Source: Journal of Clinical Psychiatry - June 8, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Long-Term Use of Hypnotics Up Significantly From 1999 to 2014, Study Finds
Long-term use of benzodiazepine (BZD) and non-benzodiazepine hypnotics (NBH) appears to have grown significantly during a 15-year period between 1999 and 2014, independent of demographic shifts, according to areport today inPsychiatric Services in Advance.Because clinical guidelines suggest that both types of medications should be used on a short-term basis, the findings highlight “the pressing need for better delineation of appropriate medium- and long-term use of these medications,” wrote lead author Christopher Kaufmann, Ph.D., M.H.S., of the University of California, San Diego, and colleagues.The researchers analyz...
Source: Psychiatr News - November 1, 2017 Category: Psychiatry Tags: benzodiazepines hypnotics long-term use non-benzodiazepine hypnotics sleep problems Source Type: research
Z-drugs and risk for falls and fractures in older adults —a systematic review and meta-analysis
Conclusionour results indicate that Z-drugs are associated with an increased risk for fractures, and suggest a possible increased risk for falls and injuries as well. However, studies included were observational and susceptible to confounding. Physicians should consider these potential risks before prescribing these medications in older adults. (Source: Age and Ageing)
Source: Age and Ageing - October 25, 2017 Category: Geriatrics Source Type: research
Benzodiazepine use in schizophrenia
I read with interest the paper by Mehta et al. (2017) addressing the issue of eszopiclone use for negative symptoms in schizophrenia as it points out to the novel therapeutic targets. Authors report on eszopiclone use in add-on therapy to antipsychotics being efficacious for persistent deficit symptoms in schizophrenia treatment including cognitive decline. Non-benzodiazepine hypnotic drugs produce its hypnotic effects via the GABA-A benzodiazepine receptor complex sharing pharmacodynamics with benzodiazepines, in particular, in higher doses (Cuba ła and Landowski, 2007). (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 25, 2017 Category: Psychiatry Authors: Adam W łodarczyk Tags: Letter to the Editor Source Type: research
Practitioner Review: Treatment of chronic insomnia in children and adolescents with neurodevelopmental disabilities
ConclusionsHere, we provided a tentative guide for the use of drugs for insomnia in children with NDDs. Well‐controlled studies employing both objective polysomnography and subjective sleep measures are needed to determine the efficacy, effectiveness, and safety of the currently prescribed pediatric sleep medicines in children with NDDs. (Source: Journal of Child Psychology and Psychiatry)
Source: Journal of Child Psychology and Psychiatry - September 18, 2017 Category: Psychiatry Authors: Oliviero Bruni, Marco Angriman, Fabrizio Calisti, Alessandro Comandini, Giovanna Esposito, Samuele Cortese, Raffaele Ferri Tags: Practitioner Review Source Type: research
Insomnia: Pharmacologic Therapy.
Abstract
Insomnia accounts for more than 5.5 million visits to family physicians each year. Although behavioral interventions are the mainstay of treatment, pharmacologic therapy may be necessary for some patients. Understanding the risks and benefits of insomnia medications is critical. Controlled-release melatonin and doxepin are recommended as first-line agents in older adults; the so-called z-drugs (zolpidem, eszopiclone, and zaleplon) should be reserved for use if the first-line agents are ineffective. For the general population with difficulty falling asleep, controlled-release melatonin and the z-dr...
Source: American Family Physician - July 1, 2017 Category: Primary Care Authors: Matheson E, Hainer BL Tags: Am Fam Physician Source Type: research
Eszopiclone for persistent negative symptoms in schizophrenia – An unintended N-of-1 study
In this report we highlight the potential utility of eszopiclone in treating persistent negative symptoms in a patient with chronic schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - June 21, 2017 Category: Psychiatry Authors: Urvakhsh Meherwan Mehta, Vinutha Ravishankar, Jagadisha Thirthalli Source Type: research
GABAA receptor positive allosteric modulators modify the abuse-related behavioral and neurochemical effects of methamphetamine in rhesus monkeys.
Abstract
GABAA receptor positive allosteric modulators (GABAA receptor modulators) are commonly used for the treatment of insomnia. Nevertheless, the effects of these compounds on psychostimulant-induced sleep impairment are poorly understood. Because GABAA receptor modulators have been shown to decrease the abuse-related effects of psychostimulants, the aim of the present study was to evaluate the effects of temazepam (0.3, 1.0 or 3.0 mg/kg) and eszopiclone (0.3, 1.0 or 3.0 mg/kg), two GABAA receptor modulators, on the behavioral neuropharmacology of methamphetamine in adult rhesus macaques (n = 5). S...
Source: Neuropharmacology - May 8, 2017 Category: Drugs & Pharmacology Authors: Berro LF, Andersen ML, Tufik S, Howell LL Tags: Neuropharmacology Source Type: research
Changes in prescribing and healthcare resource utilization after FDA Drug Safety Communications involving zolpidem ‐containing medications
ConclusionThe DSCs related to zolpidem‐containing products shifted prescribing toward the lower‐dose formulations, consistent with the recommendations in the DSCs. Copyright © 2017 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - April 27, 2017 Category: Drugs & Pharmacology Authors: Aaron S. Kesselheim, Macarius Donneyong, Gerald J. Dal Pan, Esther H. Zhou, Jerry Avorn, Sebastian Schneeweiss, John D. Seeger Tags: Original Report Source Type: research
