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Z-drugs and risk for falls and fractures in older adults-a systematic review and meta-analysis - Treves N, Perlman A, Kolenberg Geron L, Asaly A, Matok I.
OBJECTIVE: zolpidem, zopiclone, eszopiclone and zaleplon, also known as 'Z-drugs', are commonly used as alternatives to benzodiazepines (BZDs) to treat insomnia. Z-drugs are often perceived as safer than BZDs. We conducted a systematic review and meta-anal... (Source: SafetyLit)
Source: SafetyLit - October 30, 2017 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Your Natural Sleep Trigger
Do you have trouble getting to sleep? Or staying asleep? You’re not alone. Sleeping a solid 7 to 9 hours every night should be the most natural thing in the world. But insomnia has become an epidemic. And modern medicine does very little to help you restore natural rest. Big Pharma’s answer is to knock you out with drugs. That’s not the same as sleep. “Sleep aids” like Ambien, Lunesta, and others cause dizziness, headache, depression and anxiety. They can lead to suicidal thoughts, memory loss and hallucinations. Some people report sleep-walking, and even unconscious sleep-eating or sleep-dr...
Source: Al Sears, MD Natural Remedies - October 19, 2017 Category: Complementary Medicine Authors: Cathy Card Tags: Health Source Type: news

FDA Issues Warning About Mixing Opioid Addiction Treatments With Other Meds
TRENTON, N.J. (AP) — The Food and Drug Administration issued new warnings Wednesday about the dangers of combining medication for opioid addiction with anti-anxiety medicines and other drugs that also slow breathing and brain activity. The FDA warned that mixing such drugs can cause difficulty breathing, coma or death, so it should be done with caution. The agency said a growing number of people fighting opioid addiction with methadone or buprenorphine also take other prescription drugs that slow action of the central nervous system. The warning lists several dozen brand-name and generic drugs that could be risky, in...
Source: JEMS Patient Care - September 20, 2017 Category: Emergency Medicine Authors: Linda A. Johnson, Associated Press Tags: Patient Care News Source Type: news

FDA Issues Warning About Mixing Opioid Addiction Treatments With Other Meds
TRENTON, N.J. (AP) — The Food and Drug Administration issued new warnings Wednesday about the dangers of combining medication for opioid addiction with anti-anxiety medicines and other drugs that also slow breathing and brain activity. The FDA warned that mixing such drugs can cause difficulty breathing, coma or death, so it should be done with caution. The agency said a growing number of people fighting opioid addiction with methadone or buprenorphine also take other prescription drugs that slow action of the central nervous system. The warning lists several dozen brand-name and generic drugs that could be risky, in...
Source: JEMS: Journal of Emergency Medical Services News - September 20, 2017 Category: Emergency Medicine Authors: Linda A. Johnson, Associated Press Tags: Patient Care News Source Type: news

Sleeping Pills Boost Danger of Falls, Fractures in Older Users
And newer drugs like Ambien, Lunesta are no safer in this regard, review found Source: HealthDay Related MedlinePlus Pages: Falls, Seniors' Health, Sleep Disorders (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - May 2, 2017 Category: Consumer Health News Source Type: news

Eszopiclone-induced parasomnia with suicide attempt: a case report - Pennington JG, Guina J.
Eszopiclone is a benzodiazepine-like hypnotic that is commonly prescribed to treat insomnia. However, eszopiclone's efficacy has been questionable in several clinical trials, and its pharmacologic profile makes its effects on sleep and behavior difficult t... (Source: SafetyLit)
Source: SafetyLit - December 20, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Lunesta (Eszopiclone) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - September 13, 2016 Category: Drugs & Pharmacology Source Type: news

A New Prescription for Sleepless Americans: Take Advice Not a Pill
For many sleepless Americans and their doctors, the go-to treatment for insomnia has long been a prescription for sleeping pills. But America may now be waking up to a new era of treatment ushered in by a recent recommendation from the American College of Physicians (ACP) that favors behavioral therapy over meds as the first-line treatment for insomnia. This is welcome news. Insomnia is a prevalent and debilitating condition that affects over 60 million Americans, and with associated healthcare costs that are estimated in the range of $30 to $107 billion each year. This overall total could double when the additional $60 b...
Source: Healthy Living - The Huffington Post - May 8, 2016 Category: Consumer Health News Source Type: news

How Flight Crews Really Deal With All That Jet Lag
Find yourself draggy for a week after a redeye? Just think of the flight attendants and pilots who do it all the time. Former Continental Airlines flight attendant Abbie Unger told The Huffington Post that for her, the most grueling part of working transcontinental flights was the varied schedule. Unger, who is also a HuffPost blogger, was an on-call flight attendant and did not have a set number of flights she worked per month. “I never worked a day that was nine to five, so I was constantly trying to regulate my body clock as I juggled early morning check-ins followed by late night check-ins,” she said. To he...
Source: Healthy Living - The Huffington Post - April 27, 2016 Category: Consumer Health News Source Type: news

The Sleep Mistake Flight Attendants Make When It Comes To Jet Lag
Find yourself draggy for a week after a redeye? Just think of the flight attendants and pilots who do it all the time. Former Continental Airlines flight attendant Abbie Unger told The Huffington Post that for her, the most grueling part of working transcontinental flights was the varied schedule. Unger, who is also a HuffPost blogger, was an on-call flight attendant and did not have a set number of flights she worked per month. “I never worked a day that was nine to five, so I was constantly trying to regulate my body clock as I juggled early morning check-ins followed by late night check-ins,” she said. To he...
Source: Science - The Huffington Post - April 27, 2016 Category: Science Source Type: news

How A Nearly Fatal Drowsy Driving Accident Saved One Man's Life
David Claxton is not your typical candidate for sleep apnea, a common disorder in which you stop breathing while you sleep. The 40-year-old Kentucky writer doesn't have any of the major risk factors: He's not overweight or elderly, nor does he have any family history of the condition. And he may never have found out that he suffered from it -- were it not for a dramatic accident. For nearly a decade, Claxton put up with poor sleep patterns and complained of daytime sleepiness to his doctors, who prescribed him sleeping pills and antidepressants. None of them worked. He wasn't a chronic insomniac, nor was he depressed....
Source: Healthy Living - The Huffington Post - April 8, 2016 Category: Consumer Health News Source Type: news

Nonbenzodiazepine sedative hypnotics and risk of fall-related injury - Tom SE, Wickwire EM, Park Y, Albrecht JS.
The objective of this study was to test the hypothesis that use of zolpidem, eszopiclone, and zaleplon would be associated with increased risk of traumatic brain injury (TBI) and hip fracture. METHODS: We conducted a case-crossove... (Source: SafetyLit)
Source: SafetyLit - March 8, 2016 Category: Global & Universal Tags: Age: Elder Adults Source Type: news

What You Should Know Before Trying New Sleeping Pill Belsomra
Since the early 1990s, the most commonly prescribed sleeping pills have followed a formula that works by increasing levels of GABA, a neurotransmitter that slows down brain activity.   But a new insomnia treatment, Belsomra (suvorexant), is the first of its kind to do the opposite: Rather than increasing a neurotransmitter that slows brain activity, it decreases the neurotransmitter Orexin, which promotes wakefulness.  By turning off the brain's "awake" switch, Belsomra promotes sleep. And it's hugely popular, thanks in no small part to a major advertising push, which includes print ads, TV commercials ...
Source: Science - The Huffington Post - September 11, 2015 Category: Science Source Type: news

5 Scary Health Effects Of Sleep Deprivation During The Teen Years
  Sleep loss can take a devastating toll on the mind and body at any stage of life, from early childhood to older adulthood. But for teenagers, who are at a critical stage of development, skipping out on sleep can be particularly dangerous.  "[Sleep deprivation] is extremely detrimental at all stages of life," Dr. Michael Breus, a clinical psychologist and sleep specialist, told The Huffington Post in an email. "In the teen years, when development continues ... the sleep deprivation effects of brain and body development are significant." Though sleep is arguably most critical during ...
Source: Science - The Huffington Post - July 24, 2015 Category: Science Source Type: news

Is It Bedtime for Benzos?
“Bernard also laughed; after two grams of soma the joke seemed, for some reason, good. Laughed and then, almost immediately, dropped off to sleep.” — Aldous Huxley, Brave New World It’s been a tough few years for benzodiazepines, the pharmaceutical industry’s top-selling family of prescription drugs. Tough in every way, that is, except sales: Xanax remains the world’s most popular pill, and U.S. prescriptions for it and other benzos grow by 12 percent every year. It’s their reputation, long enjoyed, as harmless and effective medicines that’s taking a flurry of hits — so...
Source: Science - The Huffington Post - June 25, 2015 Category: Science Source Type: news

Cognitive behavioral therapy offers a drug-free method for managing insomnia
Bleary-eyed insomniacs know all too well that problems with sleep aren’t limited to nighttime hours. In fact, people who have trouble falling or staying asleep often feel crummy all day long. Many people with insomnia turn to sleeping pills, which often have unwanted side effects. Few of them know about an equally effective therapy that targets the root cause of insomnia without medications. Called cognitive behavioral therapy for insomnia, or CBT-i, this short-term talk therapy teaches people to change the unproductive thinking patterns and habits that get in the way of a good night’s sleep. While this therapy...
Source: New Harvard Health Information - June 10, 2015 Category: Consumer Health News Authors: Julie Corliss Tags: Complementary and alternative medicine Sleep cognitive behavioral therapy cognitive behaviors insomnia Source Type: news

Medication and Sleep
This article was adapted from a previous article written by Dr. Moore for his column “Kevlar for the Mind.” (Source: Psych Central)
Source: Psych Central - March 30, 2015 Category: Psychiatry Authors: Bret Moore, PsyD Tags: Anti-anxiety Antidepressants Atypical Antipsychotics Benzodiazepines Depression Disorders General Medications Sleep Insomnia sleep disorder Sleeping Pills Source Type: news

My Q and A With Patrick Fuller on How Neuroscience Can Unlock Sleep's Mysteries
Patrick Fuller is a neuroscientist at Harvard Medical School's esteemed Division of Sleep Medicine. In answer to my questions, he shared his insights on the importance of good sleep hygiene, how our brain's clock is connected to our overall well-being, and the problem with sleeping pills. What have you found in your research on the "neurocircuit basis" that supports sleep? In specific reference to our recent work on the brainstem slow-wave-sleep promoter "center," we showed that this region of the brain is first connected (synaptically) to an important wake-promoting region of the brainstem that in tu...
Source: Science - The Huffington Post - March 26, 2015 Category: Science Source Type: news

Medicationdiscountcard.com recognizes sleep awareness week with...
Rest Easy During Sleep Awareness Week With Discount Cards on Top Sleep Aids From Medicationdiscountcard.com(PRWeb March 03, 2015)Read the full story at http://www.prweb.com/releases/sleep/lunesta-sonata-ambien/prweb12557379.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - March 4, 2015 Category: Pharmaceuticals Source Type: news

FDA Warns Lunesta and Generics Can Cause Next-Day Impairment:...
On May 15, the FDA warned that Eszopiclone Containing Sleep Aids (including Lunesta and generics) can cause next-day impairment of driving and other activities that require alertness. In light of this...(PRWeb May 20, 2014)Read the full story at http://www.prweb.com/releases/2014/05/prweb11867345.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - May 20, 2014 Category: Pharmaceuticals Source Type: news

Lower Starting Dose for Sleep Drug Lunesta
FDA Requiring Lower Starting Dose for Sleep Drug Lunesta (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - May 20, 2014 Category: Journals (General) Source Type: news

FDA requiring lower starting dose for another sleep drug, eszopiclone
Read the full story on MD Consult: FDA requiring lower starting dose for another sleep drug, eszopiclone (Source: MD Consult: News: Top Stories)
Source: MD Consult: News: Top Stories - May 19, 2014 Category: Journals (General) Source Type: news

This Week: Resveratrol, Lung Ca Screening, Lunesta Dosing
(MedPage Today) -- Health benefits from the red-wine chemical resveratrol appear to have been overblown, lung cancer screening is effective but costly, and low starting doses are now recommended for Lunesta. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - May 16, 2014 Category: Cardiology Source Type: news

FDA cuts recommended Lunesta dose in half
Lunesta may help you doze off at night, but it's the morning after that has officials concerned -- which is why on Thursday they halved the recommended dosage for the well-known sleep aid. (Source: WDSU.com - Health)
Source: WDSU.com - Health - May 16, 2014 Category: Consumer Health News Source Type: news

Lunesta dose cut in half
Lunesta may help you doze off at night, but it's the morning after that has officials concerned -- which is why on Thursday they halved the recommended dosage for the well-known sleep aid drug. (Source: CNN.com - Health)
Source: CNN.com - Health - May 16, 2014 Category: Consumer Health News Source Type: news

Start Sleep Drug Lunesta at Lower Dose for Safety, FDA Says
Title: Start Sleep Drug Lunesta at Lower Dose for Safety, FDA SaysCategory: Health NewsCreated: 5/15/2014 2:36:00 PMLast Editorial Review: 5/16/2014 12:00:00 AM (Source: MedicineNet Sleep General)
Source: MedicineNet Sleep General - May 16, 2014 Category: Sleep Medicine Source Type: news

F.D.A. Recommends Lower Dose of the Sleeping Pill Lunesta
The agency recommended a new starting dose of one milligram, down from two milligrams, and told the pill’s manufacturer, Sunovion Pharmaceuticals, to change its labels to reflect that. (Source: NYT Health)
Source: NYT Health - May 16, 2014 Category: Consumer Health News Authors: By SABRINA TAVERNISE Tags: Lunesta Drugs (Pharmaceuticals) Food and Drug Administration Source Type: news

FDA Halves Initial Dose for Lunesta (FREE)
By Kelly Young The FDA has recommended that the starting dose of the sleep drug eszopiclone (Lunesta) be lowered from 2 mg to 1 mg after a study found that patients taking higher doses … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - May 16, 2014 Category: Primary Care Source Type: news

FDA lowers starting dose for sleep medication Lunesta
Alex CukanWASHINGTON, May 15 (UPI) -- The U.S. Food and Drug Administration said Thursday the manufacturer of Lunesta, or eszopiclone, must change the label to recommend a lower starting dose. (Source: Health News - UPI.com)
Source: Health News - UPI.com - May 15, 2014 Category: Consumer Health News Source Type: news

FDA Cuts Recommended Lunesta Dose
The FDA cut in half the recommended dose of the sleeping pill Lunesta, concluding some patients were impaired the morning after taking it even if they felt fully awake. (Source: WSJ.com: Health)
Source: WSJ.com: Health - May 15, 2014 Category: Pharmaceuticals Tags: PAID Source Type: news

FDA Slashes Starting Dose for Lunesta
(MedPage Today) -- SILVER SPRING, Md. -- Patients starting on the sleep drug eszopiclone (Lunesta) should take no more than 1 mg at bedtime -- one-third the current label-recommended dose -- because of the risk of next-day impairment, the FDA said Thursday. (Source: MedPage Today Psychiatry)
Source: MedPage Today Psychiatry - May 15, 2014 Category: Psychiatry Source Type: news

FDA halves Lunesta dose
Lunesta may help you doze off at night, but it's the morning after that has officials concerned -- which is why on Thursday they halved the recommended dosage for the well-known sleep aid drug. (Source: CNN.com - Health)
Source: CNN.com - Health - May 15, 2014 Category: Consumer Health News Source Type: news

FDA halves recommended Lunesta dose
Lunesta may help you doze off at night, but it's the morning after that has officials concerned -- which is why on Thursday they halved the recommended dosage for the well-known sleep aid drug. (Source: CNN.com - Health)
Source: CNN.com - Health - May 15, 2014 Category: Consumer Health News Source Type: news

Start Sleep Drug Lunesta at Lower Dose for Safety, FDA Says
Agency points to studies showing daytime drowsiness that could interfere with driving (Source: WebMD Health)
Source: WebMD Health - May 15, 2014 Category: Consumer Health News Source Type: news

Eszopiclone Containing Sleep Aids: Drug Safety Communication - Can Cause Next-Day Impairment
FDA recommends a decreased starting dose for both women and men. (Source: FDA MedWatch)
Source: FDA MedWatch - May 15, 2014 Category: American Health Source Type: news

FDA Cuts Starting Dose of Eszopiclone (Lunesta) in HalfFDA Cuts Starting Dose of Eszopiclone (Lunesta) in Half
The label change stems from new data on the risk for impaired alertness in some people the morning after use of the sleep aid. News Alerts (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - May 15, 2014 Category: Neurology Tags: Neurology & Neurosurgery News Alert Source Type: news

Start Sleep Drug Lunesta at Lower Dose for Safety, FDA Says
Agency points to studies showing daytime drowsiness that could interfere with driving Source: HealthDay Related MedlinePlus Pages: Drug Reactions, Insomnia (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - May 15, 2014 Category: Consumer Health News Source Type: news

U.S. FDA lowers starting dose of sleep drug Lunesta over safety
(Reuters) - U.S. health regulators on Thursday said they required a label change for the sleep drug Lunesta to cut the recommended starting dose over concerns it could impair alertness in some people the following morning. (Source: Reuters: Health)
Source: Reuters: Health - May 15, 2014 Category: Consumer Health News Tags: healthNews Source Type: news

FDA requiring lower starting dose for sleep drug Lunesta
The U.S. Food and Drug Administration today announced it required the manufacturer of the sleep drug Lunesta (eszopiclone) to change the drug label and lower the current recommended starting dose. Data show that eszopiclone levels in some patients may be high enough the morning after use to impair activities that require alertness, including driving, even if they feel fully awake. (Source: Food and Drug Administration)
Source: Food and Drug Administration - May 15, 2014 Category: American Health Source Type: news

Dr Reddy's launches insomnia drug in US; Glenmark gets FDA nod
The company has started selling 1 mg, 2 mg and 3 mg tablets of Eszopiclone, a generic version of Lunesta, a sedative drug that is used for the treatment of insomnia. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - April 16, 2014 Category: Pharmaceuticals Source Type: news

Why You Don't Need Those Sleeping Pills
It's an easy trap to fall into. You have a bad night of sleep and before you know it, this stretches into a run of bad nights. You try to observe good sleep hygiene, making a few changes to make things better, but your insomnia persists. You mention it to your doctor and you receive a prescription for a sleeping pill. Then the real trouble begins. Sleeping pills are one of the most widely prescribed medications in the world. In a recent report by the Centers for Disease Control and Prevention, it was estimated that between 2005 and 2010 about 4 percent of U.S. adults aged 20 and older used sleeping pills in the previous m...
Source: About Sleep Disorders - October 8, 2013 Category: Sleep Medicine Source Type: news

Reddy's will infringe on Lunesta's patent: US court
The United States Court of Appeals for the Federal Circuit has ruled that Dr Reddy's Laboratories Ltd will (rpt will) infringe on the patent of Sunovion Pharmaceuticals blockbuster drug Lunesta. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - September 27, 2013 Category: Pharmaceuticals Source Type: news

Experimental sleep drug may cause fewer side effects: Merck study
CHICAGO (Reuters) - A study in rats and monkeys suggests an experimental Merck & Co sleep drug may help induce sleep without causing the memory loss and attention problems sometimes seen in the commonly used drugs Ambien and Lunesta, company researchers said on Wednesday. (Source: Reuters: Health)
Source: Reuters: Health - April 3, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

Certain Sleep Aids May Raise Hip Fracture Risk in Nursing Homes
List includes common drugs such as Lunesta and Ambien, researchers say Source: HealthDay Related MedlinePlus Pages: Fractures, Insomnia, Nursing Homes (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - March 4, 2013 Category: Consumer Health News Source Type: news

Review of Z-drug toxicology
4 out of 5 stars The Clinical and Forensic Toxicology of Z-drugs. Gunja N. J Med Toxicol 2013 Feb 13 [Epub ahead of print] Abstract This well done article is the most comprehensive discussion I’ve seen about the pharmacology and toxicology of the so-called Z-drugs: zolpidem (Ambien), zopiclone (Imovane), and zaleplon (Sonata). It also touches on eszopiclone (Lunesta), the active enantiomer of zopiclone. All these drugs are non-benzodiazepine sedative-hypnotic agents that act as agonists at the GABAA receptor. These drugs tend to have relatively short durations, making them effective at inducing but not necessari...
Source: The Poison Review - February 20, 2013 Category: Toxicology Authors: Leon Tags: Medical overdose pharmacology toxicology zaleplon zolpidem zopiclone Source Type: news