Fight Aging! Newsletter, May 14th 2018
This study found that professional chess players had shorter lifespans than those players who had careers outside of chess and argued that this might be due to the mental strain of international chess competition.
In the present study, we focused on survival of International Chess Grandmasters (GMs) which represent players, of whom most are professional, at the highest level. In 2010, the overall life expectancy of GMs at the age of 30 years was 53.6 years, which is significantly greater than the overall weighted mean life expectancy of 45.9 years for the general population. In all three regions examined, mean life...
Source: Fight Aging! - May 13, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, April 30th 2018
In conclusion, in the Framingham Heart Study population, in the last 30 years, disease duration in persons with dementia has decreased. However, age-adjusted mortality risk has slightly decreased after 1977-1983. Consequences of such trends on dementia prevalence should be investigated.
Recent Research on the Benefits of Exercise in Later Life
https://www.fightaging.org/archives/2018/04/recent-research-on-the-benefits-of-exercise-in-later-life/
A sizable body of work points to the ability of older individuals to continue to obtain benefits through regular physical activity, and particularly in the case...
Source: Fight Aging! - April 29, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, April 9th 2018
This studycounters that notion, and the findings may suggest that many senior citizens remain more cognitively and emotionally intact than commonly believed.
"We found that older people have similar ability to make thousands of hippocampal new neurons from progenitor cells as younger people do. We also found equivalent volumes of the hippocampus (a brain structure used for emotion and cognition) across ages. Nevertheless, older individuals had less vascularization and maybe less ability of new neurons to make connections. It is possible that ongoing hippocampal neurogenesis sustains human-specific cognitive function...
Source: Fight Aging! - April 8, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Marker for Cancer Stem Cells that Might Also Lead to a Cell-Killing Treatment
At least some forms of cancers are generated and supported by a small population of cancer stem cells, a malfunctioning, rapidly growing mirror of the healthy tissue environment in which large number of somatic cells are supported by a small number of stem cells. It is the presence of these cancer stem cells that makes it challenging to permanently clear cancer from a patient - if only a few such cells survive, the cancer will return, and the present generation of cancer treatments cannot reliably remove 100% of the targeted cells. Looking on the bright side, if a method of selectively targeting and destroying cancer stem ...
Source: Fight Aging! - April 5, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Tropical Travel Trouble 005 RUQ Pain and Jaundice
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
aka Tropical Travel Trouble 005
Guest Post: Dr Branden Skarpiak – Global Health Fellow, Department of Emergency Medicine. UT Health San Antonio
A 35 year old male presents to your emergency room for right upper quadrant pain that has gotten worse over the last 2-3 days. He also describes associated nausea, vomiting, and fevers. He denies other abdominal pain, or change in his bowel or bladder habits. His wife notes that he has started to “look more yellow” recent...
Source: Life in the Fast Lane - March 19, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Clinical Cases Tropical Medicine amebic amoeba amoebiasis amoebic dysentery amoebic liver abscess bloody diarrhoea e.dispar e.histolytica entamoeba histolytica Source Type: blogs
Tetramethylpyrazine is Senolytic in Bone Marrow: Reduces Inflammation and Improves Stem Cell Function in Mice
In this study, we aimed to investigate the local effect of TMP on the bone marrow of aging mice and to determine whether the senescent phenotype of MSCs could be eliminated. Our findings revealed that local delivery of TMP eliminates the senescent phenotype of LepR+ MSCs via epigenetically modulating (Source: Fight Aging!)
Source: Fight Aging! - March 3, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, February 26th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - February 25, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, February 12th 2018
In conclusion, most experimental data on immune changes with aging show a decline in many immune parameters when compared to young healthy subjects. The bulk of these changes is termed immunosenescence. Immunosenescence has been considered for some time as detrimental because it often leads to subclinical accumulation of pro-inflammatory factors and inflammaging. Together, immunosenescence and inflammaging are suggested to stand at the origin of most of the diseases of the elderly, such as infections, cancer, autoimmune disorders, and chronic inflammatory diseases. However, an increasing number of gerontologists have chall...
Source: Fight Aging! - February 11, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
MDM2 Antagonists Attenuate Harmful Signaling from Senescent Cells
A fair number of the scientists working towards therapies to address cellular senescence, one of the causes of aging, are more interested in suppressing signaling from these cells than in destroying them. Cynically, a treatment one has to keep using consistently is much more interesting to pharmaceutical companies than a treatment that only has to be applied once every few years at most. Until researchers encounter a population of senescent cells that cannot be safely removed, destruction continues to look like the far better option. Senescent cells are harmful because of the mix of signals they generate, a mix that is sti...
Source: Fight Aging! - February 9, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Models Suggest that Declining T Cell Production is the Primary Reason for Age-Related Increases in Cancer Risk
In the open access paper noted here, researchers use modeling to suggest that age-related decline of the thymus, and thus of the immune system, is more important than mutation as a determinant of cancer risk. Cancer is at root caused by mutational damage to DNA. While DNA repair and replication mechanisms are highly efficient, mutations nonetheless occur - and must occur at some rate in order for evolution to take place. It is a numbers game, in that the more time, the more cells, and the more cell activity, the greater the odds that a cancerous mutation will occur. Mutation rates are also affected by external factors such...
Source: Fight Aging! - February 7, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Precision Medicine and the Reinvention of Human Disease (Book Index)
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book ' s index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 198, 220geAcq...
Source: Specified Life - January 23, 2018 Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs
EBV and myeloma stem cells. Chapter 2.
One thing Dr. Biswas discovered is that the subset of EBV-positive (as opposed to the EBV-negative) myeloma cells are the blasted stem cells, which have CD19 on their surface. What does that mean? Simply that we’re not talking about plasma cells here, but about B-cells that have the ability to REPRODUCE themselves, turning into plasma cells (which do not have that ability, btw).
Confused? Well then, let’s have a look at something different.
On page 12, Dr. Biswas discusses the 90% percentage that I mentioned in my previous post. While EBV “is benign in acute stages and latent in chronic stages […], in some cas...
Source: Margaret's Corner - January 18, 2018 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll Dr. Sunetra Biswas EBV myeloma Source Type: blogs
A Role for Alpha-2-Macroglobulin in the Cancer Immunity of Naked Mole-Rats
Naked mole-rats are near immune to cancer, in addition to living far longer and with far less of a functional decline over the course of a lifetime than is the case for other, similarly sized rodent species. Research into this cancer resistance has so far led to evidence for greater efficiency in cancer suppression genes, particularly with regard to being triggered by cell crowding of the sort that takes place in tumors, and higher prevalence of high molecular weight hyaluronan in naked mole-rat tissues. These are unlikely to be the only factors involved.
Here researchers outline a role for alpha-2-macroglobulin (A2...
Source: Fight Aging! - January 8, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Links Between Induced Pluripotency and Cellular Senescence
Cellular senescence is one of the causes of aging. Lingering senescent cells produce the senescence-associated secretory phenotype, a damaging mix of secreted molecules that generate inflammation and tissue dysfunction. However, senescence is also an early defense against cancerous cells, especially those that gain the embryonic-like ability to replicate without limit and spawn many different cell types. Such cells are near all shut down and destroyed by the senescence process, at least in the earlier stages of life. Further, cellular senescence is also involved in tissue repair in a different, transient way. Wounds spur t...
Source: Fight Aging! - January 5, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 18th 2017
In this study, we asked people in an open-ended way about their desire for longer life: Would you like to have more time? What age would you like to become? This was something more specific than asking about a preference for survival without reference to any length of time; about one's plans for the future; or whether people see the future as open or limited, as in studies of future time perspective. Our attempt was to discover whether there were preferred temporal spans with which older adults framed their futures and plans.
The two-question series about extra years and desired age ("How old would you like to becom...
Source: Fight Aging! - December 17, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
