Lets redefine cancer
The question has arisen as to how to redefine cancer. A scientific panel states we are using a 19th century definition in the 21st century. The issue is should some precancerous conditions be redefined with out the use of the words cancer or carcinoma."In one example, they say that some premalignant conditions, such as one that affects the breast called ductal carcinoma in situ — which many doctors agree is not cancer — should be renamed to exclude the word carcinoma. That way, patients are less frightened and less likely to seek what may be unneeded and potentially harmful treatments that can include the sur...
Source: Caroline's Breast Cancer Blog - July 30, 2013 Category: Cancer Tags: cancer diagnosis Source Type: blogs
Paget's disease if Nipple- Review
Clinical:
Approximately 1%–3% of women with adenocarcinoma of the
breast have Paget disease. Clinically-Paget disease has common dermatitis-like appearance,
as originally described in 1874, when Sir James Paget recorded that such
lesions may resemble “ordinary chronic eczema” or present as nipple erosion or
ulceration. Paget disease often has a deceptively banal clinical morphology but
should lead the list of differential diagnoses when evaluating unilateral
lesions of the nipple–areola complex in adults.
Paget disease presenting with nipple erosion.
Most women with the histopathologic finding o...
Source: Oncopathology - June 28, 2013 Category: Pathologists Tags: Breast Biopsy Procedure Breast Carcinoma vs. Pulmonary Adenocarcinoma a common misdiagnosis. Source Type: blogs
Paget's disease if Nipple- Review
Clinical:Approximately 1% –3% of women with adenocarcinoma of the breast have Paget disease. Clinically-Paget disease has common dermatitis-like appearance, as originally described in 1874, when Sir James Paget recorded that such lesions may resemble “ordinary chronic eczema” or present as nipple erosion or ulceration. Paget disease often has a deceptively banal clinical morphology but should lead the list of differential diagnoses when evaluating unilateral lesions of the nipple–areola complex in adults.Paget disease presenting with nipple erosion. Most women with the histopathologic finding of Paget disease ...
Source: Oncopathology - June 28, 2013 Category: Cancer & Oncology Tags: a common misdiagnosis. breast Breast Biopsy Procedure Breast Carcinoma vs. Pulmonary Adenocarcinoma Source Type: blogs
How Senescent Cells Can Promote Cancer Formation
We present evidence that MMPs act by activating the protease-activated receptor 1 (PAR-1), whose expression is specifically increased in post-senescence emergent keratinocytes.
Developing the means to periodically clear out and destroy senescent cells is a necessary part of any future package of rejuvenation therapies, such as those of the SENS research program. Good progress is being made in targeted cell killing technologies by the cancer research community, and there are a number of possible mechanisms that might be used to distinguish senescent cells from healthy cells, so this type of therapy looks very feasible from...
Source: Fight Aging! - May 22, 2013 Category: Health Medicine and Bioethics Commentators Authors: Reason Tags: Daily News Source Type: blogs
A Possible Biomarker for Senescent Cells
There are any number of techniques under development that allow individual cells to be destroyed provided that you can distinguish them from their neighbors: the challenge is in finding characteristic differences in the cells you want destroyed, such as cancer cells or senescent cells. Most of the efforts aimed at producing targeted cell destruction therapies are taking place in the cancer research community, but senescent cells accumulate with age and contribute to degenerative aging - they must also be destroyed. Unfortunately good ways to target senescent cells are somewhat lacking. Candidate mechanisms are emerging, ho...
Source: Fight Aging! - May 17, 2013 Category: Health Medicine and Bioethics Commentators Authors: Reason Tags: Daily News Source Type: blogs
Breast Cancer
Pathophysiology of Breast Cancer
Breast cancer is a:
1) neoplastic transformation of glandular epithelium of the terminal duct unit, lactiferous proximal ducts, or lobules of the breast
2) almost always adenocarcinoma
3) classification is controversial, but most experts recognize in situ (malignant cells do not invade through the basement membrane) and invasive forms
4) in situ types – intraductal (comedo and noncomedo sutypes) in situ, lobular in situ, and papillary in situ
5) invasive types – ductal, lobular, tubular, colloid, and medullary
Signs and Symptoms
1) palpable mass – hard, irregular, no discr...
Source: Inside Surgery - March 21, 2013 Category: Surgeons Authors: Editor Tags: Breast Surgery Oncology adenocarcinoma BRCA1 BRCA2 comedo in situ invasive ductal Li Fraumeni lobular peau d'orange Source Type: blogs
Fight Aging! Newsletter, February 18th 2013
Discussion
- Latest Headlines from Fight Aging!
- Nitric Oxide and Longevity in Nematodes
- On Greater Longevity in Colder Environments
- Searching for Commonalities in Cancer
- Dietary Fatty Acids and Autophagy
- Comments on Teaching an Ethical View of Life Extension
- Arguing DNA Damage as a Cause of Aging
- Relative Risk For Causes of Cognitive Decline
- An Upcoming Oxford Debate With Aubrey de Grey and Richard Faragher
&nbs...
Source: Fight Aging! - February 17, 2013 Category: Health Medicine and Bioethics Commentators Authors: Reason Tags: Newsletters Source Type: blogs
Searching for Commonalities in Cancer
The broad variety and rapid change in mechanisms within cancerous cells is one of the reasons that cancer is hard to tackle - every cancer is different and evolving. Circumventing this to find truly effective cancer therapies will require the discovery of some mechanistic commonality that can be targeted, some biological process that all cancers depend on and which distinguishes their cells from non-cancerous cells. The proposed SENS approach, for example, is to go right to the root and remove all ability to lengthen telomeres in the body, as all cancers depend on that. The mainstream research community aims to find marker...
Source: Fight Aging! - February 14, 2013 Category: Health Medicine and Bioethics Commentators Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 4th 2013
Discussion
- Latest Headlines from Fight Aging!
- A Podcast Interview With Aubrey de Grey
- Wrapping Nanoparticles in Cell Membranes
- Vegetarianism Associated With Lower Risk of Heart Disease
- A Commentary on Radical Life Extension
- The View of Mortality as Not Easily Explainable By Common Genetic Variants
- Foundational Work For Nervous System Repair
- Magnetic Levitation in Tissue Engineering
- Advocating Intermittent Fasting
&nb...
Source: Fight Aging! - February 3, 2013 Category: Health Medicine and Bioethics Commentators Authors: Reason Tags: Newsletters Source Type: blogs
ENMD-2076 Monotherapy Demonstrates Anti-Cancer Activity in Recurrent, Platinum-Resistant Ovarian Clear Cell Carcinoma
An Aurora A/angiogenic kinase inhibitor named “ENMD-2076″ demonstrated anti-cancer activity in recurrent, platinum-resistant epithelial ovarian cancer patients, including three patients with a difficult-to-treat subtype of the disease referred to as “clear cell carcinoma.” An Aurora A/angiogenic kinase inhibitor named “ENMD-2076” demonstrated anti-cancer activity in recurrent, platinum-resistant epithelial ovarian cancer patients, including three patients with a [...] (Source: Libby's H*O*P*E*)
Source: Libby's H*O*P*E* - January 14, 2013 Category: Cancer Authors: Paul Cacciatore Tags: Clinical Trial Results Novel Therapies Pipeline Drugs Targeted Therapies angiogenic kinase inhibitor Aurora A kinase inhibitor Campbell Family Institute for Cancer Research clear cell carcinoma Dana-Farber Cancer Institute ENMD-2076 En Source Type: blogs
Reactive Oxygen Species Are Your Friends!
The line under James Watson's name reads, of course, "Co-discoverer of DNA. Nobel Prize". But it could also read "Provocateur", since he's been pretty good at that over the years. He seems to have the right personality for it - both The Double Helix (fancy new edition there) and its notorious follow-up volume Avoid Boring People illustrate the point. There are any number of people who've interacted with him over the years who can't stand the guy.
But it would be a simpler world if everyone that we found hard to take was wrong about everything, wouldn't it? I bring this up because Watson has published an article, again del...
Source: In the Pipeline - January 11, 2013 Category: Chemists Tags: Cancer Source Type: blogs
Epithelial-Mesenchymal Transition and Lung Cancer: Mechanism for Resistance to EGFR-TKIs?
Despite all of the encouraging clinical results with molecularly targeted therapies against non-small cell lung cancer, there are still important and significant questions that continue to vex. The discovery of activating mutations in EGFR radically changed the treatment options for... (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - January 2, 2013 Category: Pathologists Authors: Mark D. Pool, M.D. Tags: Biomarkers in Lung Cancer Epithelial-to-Mesenchymal Transition Non small cell lung cancer Source Type: blogs
