Fight Aging! Newsletter, December 11th 2017
In this study, we used the Clinical Practice Research Datalink (CPRD) to estimate clinically measured SBP and DBP trajectories for 20 years prior to death, for individuals dying at 60 years and older. Second, we compared the linear SBP trends for years 10 to 3 years before death in patients who died and age- and sex-matched controls who survived at least 9 years. These approaches aimed to separate age from end-of-life associations, and avoid healthy survivor biases.
Twenty years before death, estimated mean SBPs increased with increasing age at death (60-69 years, 139.5 mm Hg; ≥90 years, 150.0 mm Hg). All age-at-d...
Source: Fight Aging! - December 10, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
mTOR and the Age-Related Decline in Stem Cell Activity
As a companion piece to an earlier post on the relationship between the mechanistic target of rapamycin (mTOR) gene and cellular senescence in aging, you might take a look at the research here that investigates the relationship between mTOR and the characteristic decline in stem cell activity that occurs with advancing age. In addition to the large body of research focused on insulin and growth hormone metabolism, work on mTOR is among the most active areas of study resulting from investigations of calorie restriction. The practice of calorie restriction has been shown to slow aging in near all species and lineages studied...
Source: Fight Aging! - December 7, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, November 20th 2017
This study cohort is a healthy subset of the EpiPath cohort, excluding all participants with acute or chronic diseases. With a mediation analysis we examined whether CMV titers may account for immunosenescence observed in ELA.
In this study, we have shown that ELA is associated with higher levels of T cell senescence in healthy participants. Not only did we find a higher number of senescent cells (CD57+), these cells also expressed higher levels of CD57, a cell surface marker for senescence, and were more cytotoxic in ELA compared to controls. Control participants with high CMV titers showed a higher number of senes...
Source: Fight Aging! - November 19, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Evidence for Aging of the Thymus to have a More Subtle Detrimental Effect on the Immune System than Thought
The T cells of the adaptive immune system are created in the bone marrow by hematopoietic stem cells, but migrate to the thymus to mature. Both the stem cell population and the thymus decline with age, reducing the rate at which new immune cells arrive to take up the fight against pathogens and potentially cancerous cells. This reduced rate contributes to the age-related failure of the immune system, as misconfigured and damaged cells start to accumulate more rapidly than they can be replaced with fresh, functional cells. The open access paper here presents evidence to suggest that the effects of thymic decline are more su...
Source: Fight Aging! - November 10, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Baby Foreskin Is Being Used To Make Vaccines
Conclusion
Vaccine companies have regularly used blood and body parts from killed cows, dogs, worms, mice, chickens, human babies, monkeys, guinea pigs, rabbits, hamsters, rats, etc., to make these vaccines, so using foreskin from newborn babies may not surprise some. For many, it is appalling. [28]
Circumcisions fuel multi-billion dollar industries. If you see neonatal foreskin for sale, which is very easy to find on the internet, remember that these newborn children didn’t consent to being circumcised and they didn’t consent for their foreskin to be sold, used for research purposes, or to be injected into the people ...
Source: vactruth.com - September 28, 2017 Category: Allergy & Immunology Authors: Augustina Ursino Tags: Augustina Ursino Top Stories circumcision truth about vaccines Source Type: blogs
Fight Aging! Newsletter, September 11th 2017
This study developed the first procedure for the removal of epithelium from the lung airway with the full preservation of vascular epithelium, which could be applied in vivo to treat diseases of lung epithelium. Whole lung scaffolds with an intact vascular network may also allow for recellularization using patient-specific cells and bioengineering of chimeric lungs for transplantation. In addition to the clinical potential, lung scaffolds lacking an intact epithelial layer but with functional vascular and interstitial compartments may also serve as a valuable physiological model for investigating (i) lung development, (ii)...
Source: Fight Aging! - September 10, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More Evidence for Senescent Cell Signaling to be a Cause of Age-Related Fibrosis
Regeneration and tissue maintenance are highly complex, regulated processes. Unfortunately, these processes run awry as the low-level molecular damage of aging increases over the years. Cells change their behavior, change the signals they produce, and one of the detrimental outcomes of these changes is fibrosis. This is the creation of scar-like collagen structures in place of the expected arrangement of cells and extracellular matrix. Since the fine details of that arrangement matter greatly to the correct function of organs, fibrosis is very harmful. It features prominently in the most common age-related diseases of the ...
Source: Fight Aging! - September 9, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, August 7th 2017
Discussions of radical life extension, technological acceleration, and artificial general intelligence were far more fringe concerns back then than is now the case, but this growth in awareness isn't a coincidence. Visions slowly become reality because people work to make that happen. Technological progress is not accidental: it is led by our desires.
I should say that de Magalhães is here generous in not passing judgement on the value (or lack thereof) of most of the various ventures and classes of approach he surveys. But some approaches are definitely better than others, and to my eyes one the principal challeng...
Source: Fight Aging! - August 6, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More Evidence for Senolytic Therapies as a Treatment for Lung Fibrosis
Research into cellular senescence as a cause of aging and age-related disease has expanded greatly these past few years. Several companies are developing approaches to safely remove these unwanted cells. Very compelling evidence has emerged for the role of senescent cells in aging; a number of research teams have demonstrated reversal of specific measures of aging in various tissues, with one study reporting extended life spans in normal mice in which senescent cells were cleared. The evidence to date is particular interesting in the case of lung conditions, especially those in which inflammation and fibrosis are prominent...
Source: Fight Aging! - August 4, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Progress in Engineering Digestive System Tissue Structures
Researchers here report on progress in engineering a few parts of the digestive system. The intestine and sphincter work here goes together with advances in the production of small sections of functional stomach tissue reported earlier this year. The field is doing well, considering that the challenge of generating the blood vessel networks necessary to support larger tissue masses has not yet been resolved. Researchers are finding a fair number of areas where they can proceed to potentially produce useful therapeutic outcomes even absent that capability.
Researchers have reached important milestones in their ques...
Source: Fight Aging! - July 6, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Evolutionary Trade-Offs in Stem Cell Populations: Repair Capacity versus Cancer Risk
This open access paper is an interesting companion piece to yesterday's discussion of the potential for expansion of mutations in stem cell populations to contribute to degenerative aging. What evolutionary constraints have led to the present state of stem cell populations in mammals: why are they not larger, with more capacity for tissue maintenance and regeneration in later life, for example?
Multicellular organisms continually accumulate mutations within their somatic tissues, constituting a significant, but poorly quantified, burden on tissue maintenance. To investigate this burden in a specific, well-paramete...
Source: Fight Aging! - June 27, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, May 8th 2017
This report captures the state of the research community in a nutshell: progress in the sense that ever more scientists are willing to make the treatment of aging the explicit goal of their research, but, unfortunately, there is still a long way to go in improving the nature of that research. It is still near entirely made up of projects that cannot possibly produce a robust and large impact on human life span. The only course of action likely to extend life by decades in the near future is implementation of the SENS vision for rejuvenation therapies - to repair the molecular damage that causes aging. Everything else on th...
Source: Fight Aging! - May 7, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, March 27th 2017
In conclusion, DNAm of multiple disease-related genes are strongly linked to mortality outcomes.
The recently established epigenetic clock (DNAm age) has received growing attention as an increasing number of studies have uncovered it to be a proxy of biological ageing and thus potentially providing a measure for assessing health and mortality. Intriguingly, we targeted mortality-related DNAm changes and did not find any overlap with previously established CpGs that are used to determine the DNAm age. Our findings are in line with evidence, suggesting that DNAm involved in ageing or health-related outcomes are mostly...
Source: Fight Aging! - March 26, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Why the Increased Incidence of Colonic Cancer Among Younger Americans?
A spate of stories has been published recently about the increased incidence of colonic cancer among younger Americans (see: Why Are More Young Americans Getting Colon Cancer?). I have been interested in the epidemiology of colonic cancer since I was a medical student when I was taught that cancer of the colon ws very common in Argentina and Scotland because of the high beef consumption (see:Review on meat consumption and cancer in South America). This was believed to alter the colonic bacteria flora which, in turn, produced carcinogenic chemicals in the gut. Many decad...
Source: Lab Soft News - March 4, 2017 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Medical Consumerism Medical Research Preventive Medicine Source Type: blogs
Reviewing Methionine Restriction as a Basis for Calorie Restriction Benefits
The practice of calorie restriction has been shown to extend life in most mammalian species tested, including primates, and to at least greatly improve measures of health in humans. There is some consensus for the primary mechanism of calorie restriction to involve sensing of methionine levels in the diet, as feeding animals a normal level of calories using foods that contain very little methionine produces fairly similar outcomes to those observed in calorie restricted animals. Methionine is one of the essential amino acids, those not manufactured by our biochemistry and which must be obtained via the diet. It is required...
Source: Fight Aging! - February 8, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
