Video discussing red cell storage lesion
As a follow-up to my post on the red cell storage lesion from a couple days ago, Transfusion News has posted avideo interviewwith Dr. Zimring, the author of the recent article in Blood that I referenced. (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - May 1, 2015 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Tags: Red Cell Storage Lesion Source Type: blogs
Video discussing red cell storage lesion
As a follow-up to my post on the red cell storage lesion from a couple days ago, Transfusion News has posted a video interview with Dr. Zimring, the author of the recent article in Blood that I referenced. (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - May 1, 2015 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Tags: Red Cell Storage Lesion Source Type: blogs
Reassessment of the red cell storage lesion
James C. Zimring has published a wonderful perspectives article in the April 2, 2015 issue of Blood (abstract) that nicely summarizes what is known about the red cell storage lesion from clinical and experimental studies. However, recent RCTs (ARIPI abstract,RECESS abstract, andABLE presentation) have failed to show in clinically significant difference between groups receiving fresher versus older blood. So why should we bother about the red cell storage lesion when there doesn't appear to be any clinically relevant differences in outcome whether a patient is transfused with"old...
Source: The Daily Sign-Out - April 30, 2015 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Tags: Blood Banking RBC Transfusion Red Cell Storage Lesion Source Type: blogs
Reassessment of the red cell storage lesion
James C. Zimring has published a wonderful perspectives article in the April 2, 2015 issue of Blood (abstract) that nicely summarizes what is known about the red cell storage lesion from clinical and experimental studies. However, recent RCTs (ARIPI abstract, RECESS abstract, and ABLE presentation) have failed to show in clinically significant difference between groups receiving fresher versus older blood. So why should we bother about the red cell storage lesion when there doesn't appear to be any clinically relevant differences in outcome whether a patient is transfused with &quo...
Source: The Daily Sign-Out - April 30, 2015 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Tags: Blood Banking RBC Transfusion Red Cell Storage Lesion Source Type: blogs
New International Society of Blood Transfusion Website
The International Society of Blood Transfusion (ISBT) recently highlighted its newwebsite, which is more user-friendly and has links to other useful content, including their LinkedIn page and recent presentations. You can also register for their"My ISBT" that provides additional content. (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - March 9, 2015 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Tags: Blood Banking Transfusion Medicine Source Type: blogs
New International Society of Blood Transfusion Website
The International Society of Blood Transfusion (ISBT) recently highlighted its new website, which is more user-friendly and has links to other useful content, including their LinkedIn page and recent presentations. You can also register for their "My ISBT" that provides additional content. (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - March 9, 2015 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Tags: Blood Banking Transfusion Medicine Source Type: blogs
RBC Transfusion Associated with Increased Susceptibility to Lung Inflammation
Another recent article that I finally had a chance to read and ruminate on: Danielle Qing and colleagues from have published an intriguingarticle in the December 1, 2014 issue of theAmerican Journal of Critical Care and Respiratory Medicine, "Red Blood Cells Induce Necroptosis of Lung Endothelial Cells and Increase Susceptibility to Lung Inflammation." The article merits a read if you're interested in either transfusion medicine or lung pathology.In both in vitro and murine models, RBC transfusion seems to prime lung inflammation throughnecroptosis (link to recent review article) of lung end...
Source: The Daily Sign-Out - February 13, 2015 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Tags: Adverse reactions to blood transfusion Lung Pathology Source Type: blogs
RBC Transfusion Associated with Increased Susceptibility to Lung Inflammation
Another recent article that I finally had a chance to read and ruminate on: Danielle Qing and colleagues from have published an intriguing article in the December 1, 2014 issue of the American Journal of Critical Care and Respiratory Medicine, "Red Blood Cells Induce Necroptosis of Lung Endothelial Cells and Increase Susceptibility to Lung Inflammation." The article merits a read if you're interested in either transfusion medicine or lung pathology.
In both in vitro and murine models, RBC transfusion seems to prime lung inflammation through necroptosis (link to recent review article) of lun...
Source: The Daily Sign-Out - February 13, 2015 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Tags: Adverse reactions to blood transfusion Lung Pathology Source Type: blogs
Procalcitonin in Critically Ill Patients: ProGUARD study results
We recently implemented a procalcitonin assay in my lab in the evaluation of patients with clinically suspected sepsis with undifferentiated infections. How timely then that lead author Yahya Shehabi and members of the ProGUARD study group of the Australian and New Zealand Intensive Care Society (ANZICS) published quite interesting findings from a randomized prospective single-blind study of the use of procalcitonin to guide antibiotic decisions in ICU patients. Thisarticle was published in the November 15, 2014 issue of the American Journal of Respiratory and Critical Care Medicine.One of the challenges ...
Source: The Daily Sign-Out - February 12, 2015 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Tags: Biomarkers in Disease Source Type: blogs
Procalcitonin in Critically Ill Patients: ProGUARD study results
This article was published in the November 15, 2014 issue of the American Journal of Respiratory and Critical Care Medicine.
One of the challenges in bringing this test online is determining an appropriate cut-off value for "rule-out." The authors report their results using an algorithm with a low cut-off but show that it did not achieve the desired endpoint of reducing antibiotic duration. The study did show, however, that the decline rate in log(PCT) over the first 72 hours independently predicted hospital and 90-day mortality.
In a personal communication with the lead author, Dr. Shehabi con...
Source: The Daily Sign-Out - February 12, 2015 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Tags: Biomarkers in Disease Source Type: blogs
