Fight Aging! Newsletter, April 1st 2024
This study supports the proposed model that aging-related loss of colonic crypt epithelial cell AMP gene expression can promote increased relative abundances of Gn inflammaging-associated bacteria and gene expression markers of colonic inflammaging. These data may support new targets for aging-related therapies based on intestinal genes and microbiomes.
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A Skeptical View of the Role of Nuclear DNA Damage in Aging
https://www.fightaging.org/archives/2024/03/a-skeptical-view-of-the-role-of-nuclear-dna-damage-in-aging/
It is evident and settled that stochastic nuclear DNA damag...
Source: Fight Aging! - March 31, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Regulatory T Cells Contribute to Reduced Myelination in the Aging Brain
Myelin surrounds the axons that connect neurons to one another, and is required for the transmission of electrical impulses. This myelin sheath is maintained by oligodendrocytes. These cells do not carry out their work in isolation; a great many factors are involved in determining the size and capabilities of the oligodendrocyte population. Aging is disruptive to the myelination carried out by oligodendrocytes. The consequences are not as bad as the profound loss of myelin that takes place in demyelinating diseases such as multiple sclerosis, but age-related loss of myelination does appear to degrade cognitive function. Re...
Source: Fight Aging! - March 29, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Advantages, Challenges, and Costs of Healthcare at Home Services
Switching to fully remote operations during the pandemic was a rushed adventure into what was mostly uncharted territory. There were a lot of challenges and bugs to work out, but there were also plenty of advantages and unforeseen benefits. And it is thanks to those advantages and benefits that healthcare at home is continuing, even as there are still challenges to work on and in-person operations return. While our first big push into remote care was a leap into the unknown, this time we want to make sure that we are surveying the landscape to make this a safe, smart, and financially responsible decision.
So let’s ta...
Source: EMR and HIPAA - March 28, 2024 Category: Information Technology Authors: Grayson Miller Tags: Clinical Health IT Company Healthcare IT Hospital - Health System LTPAC Revenue Cycle Management Telemedicine and Remote Monitoring Alaina Victoria Ash Wellness Brenden Hayden Carenet Health Carium Chris Darland David McCormick Source Type: blogs
Investigating the Primary Cilium: Q & A With Xuecai Ge
Credit: Courtesy of Dr. Xuecai Ge.
The brain is a large and complex organ, but some very small structures guide its development. Xuecai Ge, Ph.D., an associate professor of molecular and cell biology at the University of California, Merced (UC Merced), has devoted her career to understanding one of these structures called the primary cilium. In an interview, Dr. Ge shared how her childhood experience inspired her to study science and what makes the primary cilium fascinating.
Q: How did you first become interested in science?
A: When I was a little kid, my mom was a primary care doctor, and I saw her treat patients...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 27, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Cellular Processes Profiles Source Type: blogs
Predicting the Order of Arrival of the First Rejuvenation Therapies
It has been going on eight years since I last speculated on the order of arrival of the first rejuvenation therapies. Tempus fugit, and time for an updated version! Eight years is a long enough span of time for the first of those rejuvenation therapies to now exist, albeit in a prototypical form, arguably proven in principle but not concretely. The world progresses but my biases remain much the same: the first rejuvenation therapies to work well enough to merit the name will be based on the SENS vision, that aging is at root caused by a few classes of accumulated cell and tissue damage, and biotechnologies that either repa...
Source: Fight Aging! - March 25, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 25th 2024
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology.
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Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length
https://www.fightaging.org/archives/2024/03/interesting-insight-into-the-relationship-between-t...
Source: Fight Aging! - March 24, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Weekly Roundup – March 23, 2024
Welcome to our Healthcare IT Today Weekly Roundup. Each week, we’ll be providing a look back at the articles we posted and why they’re important to the healthcare IT community. We hope this gives you a chance to catch up on anything you may have missed during the week.
Addressing the Billing Cycle With Ambient Clinical Voice. John Lynn talked to Gautamdev Chowdary and Sean Ross at Medvise.AI, which has trained voice-to-text transcription to assign the best ICD or CPT codes and aims to provide fully automated and accurate billing. Read more…
A Look at Interesting Innovations at HIMSS 2024. Healthcare IT Today reco...
Source: EMR and HIPAA - March 23, 2024 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Healthcare IT Today Weekly Roundup Source Type: blogs
Fostering Black joy in an anti-DEI environment: community, resilience, and equity
As Black History Month draws to a close, it is crucial to recognize the ongoing challenges faced by Black physicians and the importance of fostering diversity, equity, inclusion (DEI), and belonging in the medical field. National rhetoric condemning DEI efforts has made for an increasingly difficult environment for Black medical trainees to thrive. This Black
Read more…
Fostering Black joy in an anti-DEI environment: community, resilience, and equity originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 22, 2024 Category: General Medicine Authors: Bernice Fokum, MD, Udoka Oji, MD, and Abdullah Pratt, MD Tags: Physician Medical school Source Type: blogs
Human Exosomes Harvested from Stem Cells in Urine Produce Rejuvenation in Mice
In this study, we further analyzed these data and found that a class of USC-EVs-enriched proteins have been previously shown to possess anti-aging function, such as tissue inhibitor of metalloproteinases 1 (TIMP1), plasminogen activator urokinase (PLAU), insulin-like growth factor binding protein 5, senescence marker protein-30, and connective tissue growth factor. Thus, we hypothesized that USC-EVs might be capable of rejuvenating old organs from aging via transferring of anti-aging proteins.
Here, we tested the effects of USC-EVs on cellular senescence in vitro and on the aging-related phenotypes in different orga...
Source: Fight Aging! - March 22, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Evolution of How Provider Organizations Share Data with Payers
It’s reasonable for a company like MRO to have a chief interoperability officer. According to their chief interoperability officer, Anthony Murray, the company has spent 22 years building tools to “exchange data seamlessly” in healthcare. This includes much of the healthcare data that’s been locked up in free text data in many healthcare systems.
In our interview with Murray below, he shares some of the main challenges that healthcare has with achieving interoperability in today’s environment. This includes an important focus area of MRO to be able to share data between providers and payers....
Source: EMR and HIPAA - March 21, 2024 Category: Information Technology Authors: John Lynn Tags: Analytics/Big Data EMR-EHR Health IT Company Healthcare IT HIM Hospital - Health System Interoperability Anthony Murray FHIR Healthcare Data Exchange Healthcare IT Video Interviews Healthcare Payers Healthcare ROI Healthcare Scen Source Type: blogs
The Puzzling Lack of Autoimmunity in Centenarians
Today's open access paper presents an interesting discussion of the apparent lack of age-related autoimmunity in centenarians. The immune system becomes ever more dysfunctional with age, and some of that dysfunction can take the form of maladaptive changes that either (a) allow the immune system to direct attack tissues or (b) disrupt important relationships between immune cells and the rest of a tissue. Far from all of these issues are well understood or even well identified as discrete problems distinct from the rest of degenerative aging. A potential type 4 diabetes was only comparatively recently discovered, for exampl...
Source: Fight Aging! - March 20, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
What Is the Microbiome?
Have you ever noticed a skin care product advertised as “microbiome friendly” and wondered what that meant? The microbiome is the collection of all the microbes—including bacteria, viruses, and fungi—that live in a specific environment, such as on the skin or in the digestive tract.
Escherichia coli (E. coli) is a bacterial species commonly found in the human intestine. While some strains of E. coli cause foodborne illness, others are helpful members of the gut microbiome.Credit: Mark Ellisman and Thomas Deerinck, National Center for Microscopy and Imaging Research, University of California, San Diego.
It’s ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 20, 2024 Category: Research Authors: Chrissa Chverchko Tags: Cells Common questions Microbes Microbiome Source Type: blogs
Yet More Development of Proteomic Signatures of Longevity
The cost of obtaining transcriptomic and proteomic data, and then using machine learning techniques to develop insights based on that data, has fallen dramatically over the past decade. As a result there is a proliferation of signatures of aging and longevity, as many different research groups analyze many different large transcriptomic and proteomic databases. The example here is one of a number of such signatures created with the idea of finding potential targets for therapy. It is far from clear that one can alter any of the various protein levels related to aging and longevity and obtain meaningful benefits, however. A...
Source: Fight Aging! - March 19, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Microplastics, Major Problem
By KIM BELLARD
It’s been almost four years since I first wrote about microplastics; long story short, they’re everywhere. In the ground, in the oceans (even at the very bottom), in the atmosphere. More to the point, they’re in the air you breathe and in the food you eat. They’re in you, and no one thinks that is a good thing. But we’re only starting to understand the harm they cause.
The Washington Post recently reported:
Scientists have found microplastics — or their tinier cousins, nanoplastics — embedded in the human placenta, in blood, in the heart and in the liver and bowels. In one re...
Source: The Health Care Blog - March 19, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Kim Bellard Microplastics Source Type: blogs
An assessment of the Institute for Research Design in Librarianship (IRDL)
When our second grant for the Institute for Research Design in Librarianship (IRDL) was ending in 2019, we wanted to take the opportunity to look back on the program, through the eyes of the 124 participants who had been through the program. The grant funding had been given to us to devise a model for continuing education for professional librarians and archivists with an interest in conducting research, so part of our looking back was to see if the model we designed had been impactful. We wanted to know about the possible short-term impacts, as well as longer-term impacts, the program had on their career trajectories, fro...
Source: Organization Monkey - March 18, 2024 Category: Databases & Libraries Authors: Marie Kennedy Tags: library Source Type: blogs
