Phase III Randomized, Placebo-Controlled Clinical Trial of Donepezil for Treatment of Cognitive Impairment in Breast Cancer Survivors After Adjuvant Chemotherapy (WF-97116)
CONCLUSION: BCS 1-5 years after completing chemotherapy with documented memory problems, randomly assigned to 24 weeks of 5-10 mg of donepezil once daily, did not perform differently at the end of treatment on tests of memory, other cognitive functions, or subjective functioning than those randomly assigned to placebo.PMID:38709986 | DOI:10.1200/JCO.23.01100 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - May 6, 2024 Category: Cancer & Oncology Authors: Stephen R Rapp Emily V Dressler W Mark Brown James L Wade Nguyet Le-Lindqwister David King Kendrith M Rowland Kathryn E Weaver Heidi D Klepin Edward G Shaw Glenn J Lesser Source Type: research
A comprehensive assessment of the cholinergic ‐supporting and cognitive‐enhancing effects of Rosa damascena Mill. (Damask rose) essential oil on scopolamine‐induced amnestic rats
ConclusionOur findings offer a solid experimental foundation for future RDEO-based medicinal product development for patients suffering from AD. (Source: Brain and Behavior)
Source: Brain and Behavior - May 1, 2024 Category: Neurology Authors: Kerem Teral ı,
Dilek Ozbeyli,
Duygu Yiğit‐Hanoğlu,
Kemal Hüsnü Can Başer,
Göksel Şener,
Asli Aykac Tags: ORIGINAL ARTICLE Source Type: research
Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell
The objectives of this research were investigating the effects of these compounds on the pathogenesis and progress of Alzheimer's disease in cells modeled by formaldehyde. MTT, flow cytometry, and RT-PCR were used to investigate the toxicity, survival rate and apoptosis of the cells, and the expression level of PP2A, GSK3, NMDAR, BACE1, and APP genes, respectively. Also, the total antioxidant capacity of the modeled cells was measured. The results showed that the two compounds as well as the plants extract and essential oil were able to increase the percentage of cell survival; among them, Thymus vulgaris essential oil had...
Source: Brain Research - April 30, 2024 Category: Neurology Authors: Saba Foroughi Kahin Shahanipour Ramesh Monajemi Ali Mohammad Ahadi Source Type: research
Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell
The objectives of this research were investigating the effects of these compounds on the pathogenesis and progress of Alzheimer's disease in cells modeled by formaldehyde. MTT, flow cytometry, and RT-PCR were used to investigate the toxicity, survival rate and apoptosis of the cells, and the expression level of PP2A, GSK3, NMDAR, BACE1, and APP genes, respectively. Also, the total antioxidant capacity of the modeled cells was measured. The results showed that the two compounds as well as the plants extract and essential oil were able to increase the percentage of cell survival; among them, Thymus vulgaris essential oil had...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Saba Foroughi Kahin Shahanipour Ramesh Monajemi Ali Mohammad Ahadi Source Type: research
Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell
The objectives of this research were investigating the effects of these compounds on the pathogenesis and progress of Alzheimer's disease in cells modeled by formaldehyde. MTT, flow cytometry, and RT-PCR were used to investigate the toxicity, survival rate and apoptosis of the cells, and the expression level of PP2A, GSK3, NMDAR, BACE1, and APP genes, respectively. Also, the total antioxidant capacity of the modeled cells was measured. The results showed that the two compounds as well as the plants extract and essential oil were able to increase the percentage of cell survival; among them, Thymus vulgaris essential oil had...
Source: Brain Research - April 30, 2024 Category: Neurology Authors: Saba Foroughi Kahin Shahanipour Ramesh Monajemi Ali Mohammad Ahadi Source Type: research
Role of Amyloidogenic and Non-Amyloidogenic Protein Spaces in Neurodegenerative Diseases and Their Mitigation Using Theranostic Agents
Chembiochem. 2024 Apr 26:e202400224. doi: 10.1002/cbic.202400224. Online ahead of print.ABSTRACTNeurodegenerative diseases (NDDs) refer to a complex heterogeneous group of diseases which are associated with the accumulation of amyloid fibrils or plaques in the brain leading to progressive loss of neuronal functions. Alzheimer's disease is one of the major NDD responsible for 60-80% of all dementia cases. Currently, there are no curative or disease-reversing/modifying molecules for NDDs except a few such as donepezil, rivastigmine, galantamine, carbidopa and levodopa which treat the disease-associated-symptoms. Similarly, t...
Source: Chembiochem - April 26, 2024 Category: Biochemistry Authors: Kapali Suri Madhu Ramesh Mansi Bhandari Vishakha Gupta Virendra Kumar Thimmaiah Govindaraju N Arul Murugan Source Type: research
Role of Amyloidogenic and Non-Amyloidogenic Protein Spaces in Neurodegenerative Diseases and Their Mitigation Using Theranostic Agents
Chembiochem. 2024 Apr 26:e202400224. doi: 10.1002/cbic.202400224. Online ahead of print.ABSTRACTNeurodegenerative diseases (NDDs) refer to a complex heterogeneous group of diseases which are associated with the accumulation of amyloid fibrils or plaques in the brain leading to progressive loss of neuronal functions. Alzheimer's disease is one of the major NDD responsible for 60-80% of all dementia cases. Currently, there are no curative or disease-reversing/modifying molecules for NDDs except a few such as donepezil, rivastigmine, galantamine, carbidopa and levodopa which treat the disease-associated-symptoms. Similarly, t...
Source: Chembiochem - April 26, 2024 Category: Biochemistry Authors: Kapali Suri Madhu Ramesh Mansi Bhandari Vishakha Gupta Virendra Kumar Thimmaiah Govindaraju N Arul Murugan Source Type: research
Role of Amyloidogenic and Non-Amyloidogenic Protein Spaces in Neurodegenerative Diseases and Their Mitigation Using Theranostic Agents
Chembiochem. 2024 Apr 26:e202400224. doi: 10.1002/cbic.202400224. Online ahead of print.ABSTRACTNeurodegenerative diseases (NDDs) refer to a complex heterogeneous group of diseases which are associated with the accumulation of amyloid fibrils or plaques in the brain leading to progressive loss of neuronal functions. Alzheimer's disease is one of the major NDD responsible for 60-80% of all dementia cases. Currently, there are no curative or disease-reversing/modifying molecules for NDDs except a few such as donepezil, rivastigmine, galantamine, carbidopa and levodopa which treat the disease-associated-symptoms. Similarly, t...
Source: Chembiochem - April 26, 2024 Category: Biochemistry Authors: Kapali Suri Madhu Ramesh Mansi Bhandari Vishakha Gupta Virendra Kumar Thimmaiah Govindaraju N Arul Murugan Source Type: research
Design, synthesis, and biological evaluation of some 2-(3-oxo-5,6-diphenyl-1,2,4-triazin-2(3H)-yl)-N-phenylacetamide hybrids as MTDLs for Alzheimer's disease therapy
Eur J Med Chem. 2024 Apr 16;271:116409. doi: 10.1016/j.ejmech.2024.116409. Online ahead of print.ABSTRACTInspite of established symptomatic relief drug targets, a multi targeting approach is highly in demand to cure Alzheimer's disease (AD). Simultaneous inhibition of cholinesterase (ChE), β secretase-1 (BACE-1) and Dyrk1A could be promising in complete cure of AD. A series of 18 diaryl triazine based molecular hybrids were successfully designed, synthesized, and tested for their hChE, hBACE-1, Dyrk1A and Aβ aggregation inhibitory potentials. Compounds S-11 and S-12 were the representative molecules amongst the series wi...
Source: European Journal of Medicinal Chemistry - April 25, 2024 Category: Chemistry Authors: Digambar Kumar Waiker Akash Verma T A Gajendra None Namrata Anima Roy Pradeep Kumar Surendra Kumar Trigun Saripella Srikrishna Sairam Krishnamurthy Vincent Jo Davisson Sushant Kumar Shrivastava Source Type: research
Synthesis and biological evaluation of Halogen-Substituted novel α-Ketoamides as potential protein aggregation modulators in Alzheimer's disease
In this study, a series of α-ketoamide derivatives was synthesized from β,γ-unsaturated α-keto thioesters, achieving high purity and good yield. Thioflavin T based Aβ aggregation assay identified four promising compounds (BD19, BD23, BD24, and BD27) that demonstrated significant inhibitory effects on Aβ aggregation. BD23, selected for its better solubility (0.045 ± 0.0012 mg/ml), was further subjected to in vitro Parallel Artificial Membrane Permeability Assay to determine the Blood-Brain-Barrier permeability and emerged as BBB permeable with permeability rate (Pe) of 10.66 ± 8.11 × 10-6 cm/s. In addition to its A...
Source: Bioorganic Chemistry - April 23, 2024 Category: Chemistry Authors: Bhanuranjan Das Anurag Tk Baidya Sourabh Chakrabarti Deepak Chouhan Banita Thakur Taher Darreh-Shori Gefei Chen Vinod Tiwari Rajnish Kumar Source Type: research
Synthesis and biological evaluation of Halogen-Substituted novel α-Ketoamides as potential protein aggregation modulators in Alzheimer's disease
In this study, a series of α-ketoamide derivatives was synthesized from β,γ-unsaturated α-keto thioesters, achieving high purity and good yield. Thioflavin T based Aβ aggregation assay identified four promising compounds (BD19, BD23, BD24, and BD27) that demonstrated significant inhibitory effects on Aβ aggregation. BD23, selected for its better solubility (0.045 ± 0.0012 mg/ml), was further subjected to in vitro Parallel Artificial Membrane Permeability Assay to determine the Blood-Brain-Barrier permeability and emerged as BBB permeable with permeability rate (Pe) of 10.66 ± 8.11 × 10-6 cm/s. In addition to its A...
Source: Bioorganic Chemistry - April 23, 2024 Category: Chemistry Authors: Bhanuranjan Das Anurag Tk Baidya Sourabh Chakrabarti Deepak Chouhan Banita Thakur Taher Darreh-Shori Gefei Chen Vinod Tiwari Rajnish Kumar Source Type: research
Predicting the efficacy of donepezil intervention in Alzheimer's disease patients using regional homogeneity in the inferior orbitofrontal cortex
CONCLUSIONS: These findings deepen our understanding of the brain mechanisms underlying the clinical efficacy of donepezil in AD patients, and provide a novel way to predict its clinical efficacy in such patients.PMID:38630202 | DOI:10.1007/s40520-023-02691-6 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - April 17, 2024 Category: Geriatrics Authors: Min Dai Zhongwei Guo Honglian Xia Hong Zhu Jiapeng Li Hongtao Hou Guizhi Zhao Xiaozheng Liu Source Type: research
Predicting the efficacy of donepezil intervention in Alzheimer's disease patients using regional homogeneity in the inferior orbitofrontal cortex
CONCLUSIONS: These findings deepen our understanding of the brain mechanisms underlying the clinical efficacy of donepezil in AD patients, and provide a novel way to predict its clinical efficacy in such patients.PMID:38630202 | PMC:PMC11024046 | DOI:10.1007/s40520-023-02691-6 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - April 17, 2024 Category: Geriatrics Authors: Min Dai Zhongwei Guo Honglian Xia Hong Zhu Jiapeng Li Hongtao Hou Guizhi Zhao Xiaozheng Liu Source Type: research
Ameliorative anti-coagulant, anti-oxidative and anti-ferroptotic activities of nanocurcumin and donepezil on coagulation, oxidation and ferroptosis in Alzheimer's disease
The objective of the current investigation was to examine the neuroprotective and anti-ferroptotic role of nanocurcumin and Donepezil against model of aluminum chloride AlCl3 and D-galactose induced ad. The experiment was performed on 70 rats divided into (G1: control, G2: NCMN, G3: Donepezil, G4: ad-model, G5: Donepezil co-treatment, G6: NCMN co-treatment and G7: NCMN+Donepezil co-treatment). Hematological parameters and biochemical investigations as oxidative stress, liver function, kidney function, iron profile and plasma fibrinogen were evaluated. Treatment with Nanocurcumin alone or in combination with Donepezil impro...
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Nagat F Nawar Doha M Beltagy Tarek M Mohamed Ehab Tousson Mai M El-Keey Source Type: research
Review on anti-alzheimer drug development: approaches, challenges and perspectives
RSC Adv. 2024 Apr 5;14(16):11057-11088. doi: 10.1039/d3ra08333k. eCollection 2024 Apr 3.ABSTRACTAlzheimer is an irreversible progressive neurodegenerative disease that causes failure of cerebral neurons and disability of the affected person to practice normal daily life activities. There is no concrete evidence to identify the exact reason behind the disease, so several relevant hypotheses emerged, highlighting many possible therapeutic targets, such as acetylcholinesterase, cholinergic receptors, N-methyl d-aspartate receptors, phosphodiesterase, amyloid β protein, protein phosphatase 2A, glycogen synthase kinase-3 beta,...
Source: Adv Data - April 8, 2024 Category: Epidemiology Authors: Abdallah E Abdallah Source Type: research
