Behavioural Variant Frontotemporal Dementia due to < em > CCNF < /em > Gene Mutation: A Case Report
CONCLUSION: The early clinical manifestations of bvFTD are complex and variable, and the condition is easily misdiagnosed, thus delaying treatment. Therefore, for patients with a high clinical suspicion of FTD, in addition to a detailed understanding of their medical history and family history and improvement of relevant examinations, genetic testing should be performed as early as possible to help confirm the diagnosis. For diseases closely related to genes, genetic testing of other family members should be optimised as much as possible to allow early diagnosis and intervention and guide fertility in the next generation.P...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Feng-Ling You Gao-Fu Xia Jing Cai Source Type: research
Behavioural Variant Frontotemporal Dementia due to < em > CCNF < /em > Gene Mutation: A Case Report
CONCLUSION: The early clinical manifestations of bvFTD are complex and variable, and the condition is easily misdiagnosed, thus delaying treatment. Therefore, for patients with a high clinical suspicion of FTD, in addition to a detailed understanding of their medical history and family history and improvement of relevant examinations, genetic testing should be performed as early as possible to help confirm the diagnosis. For diseases closely related to genes, genetic testing of other family members should be optimised as much as possible to allow early diagnosis and intervention and guide fertility in the next generation.P...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Feng-Ling You Gao-Fu Xia Jing Cai Source Type: research
Behavioural Variant Frontotemporal Dementia due to < em > CCNF < /em > Gene Mutation: A Case Report
CONCLUSION: The early clinical manifestations of bvFTD are complex and variable, and the condition is easily misdiagnosed, thus delaying treatment. Therefore, for patients with a high clinical suspicion of FTD, in addition to a detailed understanding of their medical history and family history and improvement of relevant examinations, genetic testing should be performed as early as possible to help confirm the diagnosis. For diseases closely related to genes, genetic testing of other family members should be optimised as much as possible to allow early diagnosis and intervention and guide fertility in the next generation.P...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Feng-Ling You Gao-Fu Xia Jing Cai Source Type: research
Behavioural Variant Frontotemporal Dementia due to < em > CCNF < /em > Gene Mutation: A Case Report
CONCLUSION: The early clinical manifestations of bvFTD are complex and variable, and the condition is easily misdiagnosed, thus delaying treatment. Therefore, for patients with a high clinical suspicion of FTD, in addition to a detailed understanding of their medical history and family history and improvement of relevant examinations, genetic testing should be performed as early as possible to help confirm the diagnosis. For diseases closely related to genes, genetic testing of other family members should be optimised as much as possible to allow early diagnosis and intervention and guide fertility in the next generation.P...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Feng-Ling You Gao-Fu Xia Jing Cai Source Type: research
Behavioural Variant Frontotemporal Dementia due to < em > CCNF < /em > Gene Mutation: A Case Report
CONCLUSION: The early clinical manifestations of bvFTD are complex and variable, and the condition is easily misdiagnosed, thus delaying treatment. Therefore, for patients with a high clinical suspicion of FTD, in addition to a detailed understanding of their medical history and family history and improvement of relevant examinations, genetic testing should be performed as early as possible to help confirm the diagnosis. For diseases closely related to genes, genetic testing of other family members should be optimised as much as possible to allow early diagnosis and intervention and guide fertility in the next generation.P...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Feng-Ling You Gao-Fu Xia Jing Cai Source Type: research
Biological Evaluation of Anti-Cholinesterase Activity, in silico Molecular Docking Studies, and DFT calculations of Green Synthesized Thiadiazolo[3,2-a] Pyrimidine Derivatives
Chem Biodivers. 2023 Oct 23:e202301193. doi: 10.1002/cbdv.202301193. Online ahead of print.ABSTRACTA series of [1,3,4] thiadiazolo[3,2-a]pyrimidine-6-carboxylate derivatives 4(a-n) have been designed and synthesized as inhibitors of acetylcholinesterase (AChE). Synthesizing of thiadiazolo[3,2-a] pyrimidines was carried out in a single step, one-pot reaction using aromatic aldehydes, ethyl acetoacetate and different derivatives of 1,3,4-thiadiazoles (with molar ratio of 1:2:1 respectively) in conjunction with the catalyst, anhydrous iron(III) chloride by a grinding method under solvent-free conditions at room temperature. T...
Source: Chemistry and Biodiversity - October 23, 2023 Category: Biochemistry Authors: Behjat Pouramiri Mohsen Rashidi Safa Lotfi Mahnaz Mohammadi Khadijeh Rabiei Source Type: research
Biological Evaluation of Anti-Cholinesterase Activity, in silico Molecular Docking Studies, and DFT calculations of Green Synthesized Thiadiazolo[3,2-a] Pyrimidine Derivatives
Chem Biodivers. 2023 Oct 23:e202301193. doi: 10.1002/cbdv.202301193. Online ahead of print.ABSTRACTA series of [1,3,4] thiadiazolo[3,2-a]pyrimidine-6-carboxylate derivatives 4(a-n) have been designed and synthesized as inhibitors of acetylcholinesterase (AChE). Synthesizing of thiadiazolo[3,2-a] pyrimidines was carried out in a single step, one-pot reaction using aromatic aldehydes, ethyl acetoacetate and different derivatives of 1,3,4-thiadiazoles (with molar ratio of 1:2:1 respectively) in conjunction with the catalyst, anhydrous iron(III) chloride by a grinding method under solvent-free conditions at room temperature. T...
Source: Chemistry and Biodiversity - October 23, 2023 Category: Biochemistry Authors: Behjat Pouramiri Mohsen Rashidi Safa Lotfi Mahnaz Mohammadi Khadijeh Rabiei Source Type: research
Compliance with National and International Guidelines in the Treatment of Nonmotor Symptoms in Late-Stage Parkinson's Disease
CONCLUSIONS: The present analyses suggest a need for clinicians to further screen for and treat NMS. Optimizing treatment of NMS according to the national and international treatment guidelines may improve symptomatology and enhance quality of life in late-stage PD.PMID:37854895 | PMC:PMC10581854 | DOI:10.1155/2023/6667339 (Source: Parkinsons Disease)
Source: Parkinsons Disease - October 19, 2023 Category: Neurology Authors: Kristina Rosqvist Per Odin Source Type: research
Neuroprotective evaluation of diospyrin against drug-induced Alzheimer's disease
Fitoterapia. 2023 Oct 16:105703. doi: 10.1016/j.fitote.2023.105703. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a progressive neurodegenerative disease linked to memory impairment. A current investigation was performed to assess the neuroprotective effect of Diospyrin, a novel therapeutic agent, for the curing of Alzheimer's disease. For this purpose, in-vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory assays and antioxidant studies were conducted, whereas in-vivo studies involved different behavioral animal models tests such as elevated plus maze (EPM), morris water maze (MWM) an...
Source: Fitoterapia - October 18, 2023 Category: Biochemistry Authors: Aftab Alam Gowhar Ali Asif Nawaz Taghrid S AlOmar Abdur Rauf Muhammad Ayaz Sajjad Ahmad Najla Almasoud Abdulaziz S AlOmar Anees Ahmed Khalil Polrat Wilairatana Source Type: research
Neuroprotective evaluation of diospyrin against drug-induced Alzheimer's disease
Fitoterapia. 2023 Oct 16:105703. doi: 10.1016/j.fitote.2023.105703. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a progressive neurodegenerative disease linked to memory impairment. A current investigation was performed to assess the neuroprotective effect of Diospyrin, a novel therapeutic agent, for the curing of Alzheimer's disease. For this purpose, in-vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory assays and antioxidant studies were conducted, whereas in-vivo studies involved different behavioral animal models tests such as elevated plus maze (EPM), morris water maze (MWM) an...
Source: Fitoterapia - October 18, 2023 Category: Biochemistry Authors: Aftab Alam Gowhar Ali Asif Nawaz Taghrid S AlOmar Abdur Rauf Muhammad Ayaz Sajjad Ahmad Najla Almasoud Abdulaziz S AlOmar Anees Ahmed Khalil Polrat Wilairatana Source Type: research
Fluoroethylnormemantine (FENM) shows synergistic protection in combination with a sigma-1 receptor agonist in a mouse model of Alzheimer's disease
Neuropharmacology. 2023 Oct 14:109733. doi: 10.1016/j.neuropharm.2023.109733. Online ahead of print.ABSTRACTFluoroethylnormemantine (FENM) is a Memantine derivative with anti-amnesic and neuroprotective activities showed in the Aβ25-35 pharmacological mouse model of Alzheimer's disease (AD). As AD is a complex multi-factorial neurodegenerative pathology, combination therapies relying on drugs acting through different pathways, have been suggested to more adequately address neuroprotection. As several agonists of the sigma-1 receptor (S1R), an intracellular chaperone, are presently in phase 2 or 3 clinical trials in neurod...
Source: Neuropharmacology - October 16, 2023 Category: Drugs & Pharmacology Authors: Aline Freyssin Allison Carles Sarra Guehairia Gilles Rubinstenn Tangui Maurice Source Type: research
Fluoroethylnormemantine (FENM) shows synergistic protection in combination with a sigma-1 receptor agonist in a mouse model of Alzheimer's disease
Neuropharmacology. 2023 Oct 14:109733. doi: 10.1016/j.neuropharm.2023.109733. Online ahead of print.ABSTRACTFluoroethylnormemantine (FENM) is a Memantine derivative with anti-amnesic and neuroprotective activities showed in the Aβ25-35 pharmacological mouse model of Alzheimer's disease (AD). As AD is a complex multi-factorial neurodegenerative pathology, combination therapies relying on drugs acting through different pathways, have been suggested to more adequately address neuroprotection. As several agonists of the sigma-1 receptor (S1R), an intracellular chaperone, are presently in phase 2 or 3 clinical trials in neurod...
Source: Neuropharmacology - October 16, 2023 Category: Drugs & Pharmacology Authors: Aline Freyssin Allison Carles Sarra Guehairia Gilles Rubinstenn Tangui Maurice Source Type: research
