Neurobehavioral impairments from chromium exposure: Insights from a zebrafish model and drug validation
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Oct 24:109780. doi: 10.1016/j.cbpc.2023.109780. Online ahead of print.ABSTRACTWe have developed a zebrafish model to explore the alterations in neurobehaviors resulting from both acute and chronic exposure to chromium (Cr). Zebrafish exposed to half (HC group: 19.7 mg/L) and a quarter (LC group: 9.85 mg/L) of the LD50 concentration of Cr for a span of 2 weeks exhibited aberrant locomotion, heightened anxiety, cognitive impairment, and reduced aggression - hallmark traits reminiscent of an Alzheimer's Disease (AD)-like syndrome. Furthermore, Zebrafish exposed to an environmenta...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - October 26, 2023 Category: Biochemistry Authors: Seenivasan Boopathi B Haridevamuthu Akash Gandhi S P Ramya Ranjan Nayak Gokul Sudhakaran R Rajakrishnan Selvaraj Arokiyaraj Jesu Arockiaraj Source Type: research
Neurobehavioral impairments from chromium exposure: Insights from a zebrafish model and drug validation
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Oct 24:109780. doi: 10.1016/j.cbpc.2023.109780. Online ahead of print.ABSTRACTWe have developed a zebrafish model to explore the alterations in neurobehaviors resulting from both acute and chronic exposure to chromium (Cr). Zebrafish exposed to half (HC group: 19.7 mg/L) and a quarter (LC group: 9.85 mg/L) of the LD50 concentration of Cr for a span of 2 weeks exhibited aberrant locomotion, heightened anxiety, cognitive impairment, and reduced aggression - hallmark traits reminiscent of an Alzheimer's Disease (AD)-like syndrome. Furthermore, Zebrafish exposed to an environmenta...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - October 26, 2023 Category: Biochemistry Authors: Seenivasan Boopathi B Haridevamuthu Akash Gandhi S P Ramya Ranjan Nayak Gokul Sudhakaran R Rajakrishnan Selvaraj Arokiyaraj Jesu Arockiaraj Source Type: research
Neurobehavioral impairments from chromium exposure: Insights from a zebrafish model and drug validation
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Oct 24:109780. doi: 10.1016/j.cbpc.2023.109780. Online ahead of print.ABSTRACTWe have developed a zebrafish model to explore the alterations in neurobehaviors resulting from both acute and chronic exposure to chromium (Cr). Zebrafish exposed to half (HC group: 19.7 mg/L) and a quarter (LC group: 9.85 mg/L) of the LD50 concentration of Cr for a span of 2 weeks exhibited aberrant locomotion, heightened anxiety, cognitive impairment, and reduced aggression - hallmark traits reminiscent of an Alzheimer's Disease (AD)-like syndrome. Furthermore, Zebrafish exposed to an environmenta...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - October 26, 2023 Category: Biochemistry Authors: Seenivasan Boopathi B Haridevamuthu Akash Gandhi S P Ramya Ranjan Nayak Gokul Sudhakaran R Rajakrishnan Selvaraj Arokiyaraj Jesu Arockiaraj Source Type: research
Neurobehavioral impairments from chromium exposure: Insights from a zebrafish model and drug validation
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Oct 24:109780. doi: 10.1016/j.cbpc.2023.109780. Online ahead of print.ABSTRACTWe have developed a zebrafish model to explore the alterations in neurobehaviors resulting from both acute and chronic exposure to chromium (Cr). Zebrafish exposed to half (HC group: 19.7 mg/L) and a quarter (LC group: 9.85 mg/L) of the LD50 concentration of Cr for a span of 2 weeks exhibited aberrant locomotion, heightened anxiety, cognitive impairment, and reduced aggression - hallmark traits reminiscent of an Alzheimer's Disease (AD)-like syndrome. Furthermore, Zebrafish exposed to an environmenta...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - October 26, 2023 Category: Biochemistry Authors: Seenivasan Boopathi B Haridevamuthu Akash Gandhi S P Ramya Ranjan Nayak Gokul Sudhakaran R Rajakrishnan Selvaraj Arokiyaraj Jesu Arockiaraj Source Type: research
Neurobehavioral impairments from chromium exposure: Insights from a zebrafish model and drug validation
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Oct 24:109780. doi: 10.1016/j.cbpc.2023.109780. Online ahead of print.ABSTRACTWe have developed a zebrafish model to explore the alterations in neurobehaviors resulting from both acute and chronic exposure to chromium (Cr). Zebrafish exposed to half (HC group: 19.7 mg/L) and a quarter (LC group: 9.85 mg/L) of the LD50 concentration of Cr for a span of 2 weeks exhibited aberrant locomotion, heightened anxiety, cognitive impairment, and reduced aggression - hallmark traits reminiscent of an Alzheimer's Disease (AD)-like syndrome. Furthermore, Zebrafish exposed to an environmenta...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - October 26, 2023 Category: Biochemistry Authors: Seenivasan Boopathi B Haridevamuthu Akash Gandhi S P Ramya Ranjan Nayak Gokul Sudhakaran R Rajakrishnan Selvaraj Arokiyaraj Jesu Arockiaraj Source Type: research
Neurobehavioral impairments from chromium exposure: Insights from a zebrafish model and drug validation
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Oct 25;275:109780. doi: 10.1016/j.cbpc.2023.109780. Online ahead of print.ABSTRACTWe have developed a zebrafish model to explore the alterations in neurobehaviors resulting from both acute and chronic exposure to chromium (Cr). Zebrafish exposed to half (HC group: 19.7 mg/L) and a quarter (LC group: 9.85 mg/L) of the LD50 concentration of Cr for a span of 2 weeks exhibited aberrant locomotion, heightened anxiety, cognitive impairment, and reduced aggression - hallmark traits reminiscent of an Alzheimer's Disease (AD)-like syndrome. Furthermore, zebrafish exposed to an environm...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - October 26, 2023 Category: Biochemistry Authors: Seenivasan Boopathi B Haridevamuthu Akash Gandhi S P Ramya Ranjan Nayak Gokul Sudhakaran Rajakrishnan Rajagopal Selvaraj Arokiyaraj Jesu Arockiaraj Source Type: research
Neurobehavioral impairments from chromium exposure: Insights from a zebrafish model and drug validation
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Oct 25;275:109780. doi: 10.1016/j.cbpc.2023.109780. Online ahead of print.ABSTRACTWe have developed a zebrafish model to explore the alterations in neurobehaviors resulting from both acute and chronic exposure to chromium (Cr). Zebrafish exposed to half (HC group: 19.7 mg/L) and a quarter (LC group: 9.85 mg/L) of the LD50 concentration of Cr for a span of 2 weeks exhibited aberrant locomotion, heightened anxiety, cognitive impairment, and reduced aggression - hallmark traits reminiscent of an Alzheimer's Disease (AD)-like syndrome. Furthermore, zebrafish exposed to an environm...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - October 26, 2023 Category: Biochemistry Authors: Seenivasan Boopathi B Haridevamuthu Akash Gandhi S P Ramya Ranjan Nayak Gokul Sudhakaran Rajakrishnan Rajagopal Selvaraj Arokiyaraj Jesu Arockiaraj Source Type: research
Behavioural Variant Frontotemporal Dementia due to < em > CCNF < /em > Gene Mutation: A Case Report
CONCLUSION: The early clinical manifestations of bvFTD are complex and variable, and the condition is easily misdiagnosed, thus delaying treatment. Therefore, for patients with a high clinical suspicion of FTD, in addition to a detailed understanding of their medical history and family history and improvement of relevant examinations, genetic testing should be performed as early as possible to help confirm the diagnosis. For diseases closely related to genes, genetic testing of other family members should be optimised as much as possible to allow early diagnosis and intervention and guide fertility in the next generation.P...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Feng-Ling You Gao-Fu Xia Jing Cai Source Type: research
Behavioural Variant Frontotemporal Dementia due to < em > CCNF < /em > Gene Mutation: A Case Report
CONCLUSION: The early clinical manifestations of bvFTD are complex and variable, and the condition is easily misdiagnosed, thus delaying treatment. Therefore, for patients with a high clinical suspicion of FTD, in addition to a detailed understanding of their medical history and family history and improvement of relevant examinations, genetic testing should be performed as early as possible to help confirm the diagnosis. For diseases closely related to genes, genetic testing of other family members should be optimised as much as possible to allow early diagnosis and intervention and guide fertility in the next generation.P...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Feng-Ling You Gao-Fu Xia Jing Cai Source Type: research
Behavioural Variant Frontotemporal Dementia due to < em > CCNF < /em > Gene Mutation: A Case Report
CONCLUSION: The early clinical manifestations of bvFTD are complex and variable, and the condition is easily misdiagnosed, thus delaying treatment. Therefore, for patients with a high clinical suspicion of FTD, in addition to a detailed understanding of their medical history and family history and improvement of relevant examinations, genetic testing should be performed as early as possible to help confirm the diagnosis. For diseases closely related to genes, genetic testing of other family members should be optimised as much as possible to allow early diagnosis and intervention and guide fertility in the next generation.P...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Feng-Ling You Gao-Fu Xia Jing Cai Source Type: research
Behavioural Variant Frontotemporal Dementia due to < em > CCNF < /em > Gene Mutation: A Case Report
CONCLUSION: The early clinical manifestations of bvFTD are complex and variable, and the condition is easily misdiagnosed, thus delaying treatment. Therefore, for patients with a high clinical suspicion of FTD, in addition to a detailed understanding of their medical history and family history and improvement of relevant examinations, genetic testing should be performed as early as possible to help confirm the diagnosis. For diseases closely related to genes, genetic testing of other family members should be optimised as much as possible to allow early diagnosis and intervention and guide fertility in the next generation.P...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Feng-Ling You Gao-Fu Xia Jing Cai Source Type: research
Behavioural Variant Frontotemporal Dementia due to < em > CCNF < /em > Gene Mutation: A Case Report
CONCLUSION: The early clinical manifestations of bvFTD are complex and variable, and the condition is easily misdiagnosed, thus delaying treatment. Therefore, for patients with a high clinical suspicion of FTD, in addition to a detailed understanding of their medical history and family history and improvement of relevant examinations, genetic testing should be performed as early as possible to help confirm the diagnosis. For diseases closely related to genes, genetic testing of other family members should be optimised as much as possible to allow early diagnosis and intervention and guide fertility in the next generation.P...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Feng-Ling You Gao-Fu Xia Jing Cai Source Type: research
Behavioural Variant Frontotemporal Dementia due to < em > CCNF < /em > Gene Mutation: A Case Report
CONCLUSION: The early clinical manifestations of bvFTD are complex and variable, and the condition is easily misdiagnosed, thus delaying treatment. Therefore, for patients with a high clinical suspicion of FTD, in addition to a detailed understanding of their medical history and family history and improvement of relevant examinations, genetic testing should be performed as early as possible to help confirm the diagnosis. For diseases closely related to genes, genetic testing of other family members should be optimised as much as possible to allow early diagnosis and intervention and guide fertility in the next generation.P...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Feng-Ling You Gao-Fu Xia Jing Cai Source Type: research
Behavioural Variant Frontotemporal Dementia due to < em > CCNF < /em > Gene Mutation: A Case Report
CONCLUSION: The early clinical manifestations of bvFTD are complex and variable, and the condition is easily misdiagnosed, thus delaying treatment. Therefore, for patients with a high clinical suspicion of FTD, in addition to a detailed understanding of their medical history and family history and improvement of relevant examinations, genetic testing should be performed as early as possible to help confirm the diagnosis. For diseases closely related to genes, genetic testing of other family members should be optimised as much as possible to allow early diagnosis and intervention and guide fertility in the next generation.P...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Feng-Ling You Gao-Fu Xia Jing Cai Source Type: research
Behavioural Variant Frontotemporal Dementia due to < em > CCNF < /em > Gene Mutation: A Case Report
CONCLUSION: The early clinical manifestations of bvFTD are complex and variable, and the condition is easily misdiagnosed, thus delaying treatment. Therefore, for patients with a high clinical suspicion of FTD, in addition to a detailed understanding of their medical history and family history and improvement of relevant examinations, genetic testing should be performed as early as possible to help confirm the diagnosis. For diseases closely related to genes, genetic testing of other family members should be optimised as much as possible to allow early diagnosis and intervention and guide fertility in the next generation.P...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Feng-Ling You Gao-Fu Xia Jing Cai Source Type: research
