Current Progress on Central Cholinergic Receptors as Therapeutic Targets for Alzheimer's Disease
Curr Alzheimer Res. 2024 Mar 25. doi: 10.2174/0115672050306008240321034006. Online ahead of print.ABSTRACTAcetylcholine (ACh) is ubiquitously present in the nervous system and has been involved in the regulation of various brain functions. By modulating synaptic transmission and promoting synaptic plasticity, particularly in the hippocampus and cortex, ACh plays a pivotal role in the regulation of learning and memory. These procognitive actions of ACh are mediated by the neuronal muscarinic and nicotinic cholinergic receptors. The impairment of cholinergic transmission leads to cognitive decline associated with aging and d...
Source: Current Alzheimer Research - March 26, 2024 Category: Neurology Authors: Kushagra Nagori Madhulika Pradhan Mukesh Sharma None Ajazuddin Hemant R Badwaik Kartik T Nakhate Source Type: research
Recurrent Duodenal Ulceration —More Than Simple Peptic Ulcer Disease?
Question: A 77-year-old man with a pertinent medical history of dementia, recurrent small bowel obstruction resulting in small bowel resection secondary to intraabdominal adhesions related to a previous hernia repair resulting in small bowel resection, and nonsteroidal antiinflammatory drug (NSAID) –associated peptic ulcer disease presented with sharp epigastric abdominal pain, nausea, watery nonbloody diarrhea (approximately 4 bowel movements daily), weight loss, and intolerance to oral intake. Before admission, his medication regimen was 40 mg oral omeprazole daily, 1 g metformin twice dai ly, 1000 U cholecalciferol da...
Source: Gastroenterology - March 24, 2024 Category: Gastroenterology Authors: Govind Kallumkal, Justin McCallen, Michael Contarino Tags: Electronic Curbside Consult Source Type: research
Recognizing Alzheimer's disease from perspective of oligodendrocytes: Phenomena or pathogenesis?
CONCLUSIONS: We believe that OL dysfunction is one important pathogenesis of AD. Factors regulating OLs might be biomarkers for early diagnosis and agents stimulating OLs warrant the development of anti-AD drugs.PMID:38516808 | DOI:10.1111/cns.14688 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 22, 2024 Category: Neuroscience Authors: Jingji Wang Yilan Zhen Jun Yang Shaojie Yang Guoqi Zhu Source Type: research
Recognizing Alzheimer's disease from perspective of oligodendrocytes: Phenomena or pathogenesis?
CONCLUSIONS: We believe that OL dysfunction is one important pathogenesis of AD. Factors regulating OLs might be biomarkers for early diagnosis and agents stimulating OLs warrant the development of anti-AD drugs.PMID:38516808 | PMC:PMC10958408 | DOI:10.1111/cns.14688 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 22, 2024 Category: Neuroscience Authors: Jingji Wang Yilan Zhen Jun Yang Shaojie Yang Guoqi Zhu Source Type: research
Recognizing Alzheimer's disease from perspective of oligodendrocytes: Phenomena or pathogenesis?
CONCLUSIONS: We believe that OL dysfunction is one important pathogenesis of AD. Factors regulating OLs might be biomarkers for early diagnosis and agents stimulating OLs warrant the development of anti-AD drugs.PMID:38516808 | PMC:PMC10958408 | DOI:10.1111/cns.14688 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 22, 2024 Category: Neuroscience Authors: Jingji Wang Yilan Zhen Jun Yang Shaojie Yang Guoqi Zhu Source Type: research
Beyond Conventional Therapies: Molecular Dynamics of Alzheimer's Treatment through CLOCK/BMAL1 Interactions
Conclusion: A novel therapeutic approach emerges, suggesting the combination of melatonin with Lecanemab as a monoclonal antibody therapy. Importantly, prior research has not explored the effects of FDA-approved drugs on Bmal1 expression or their potential for synergistic effects.PMID:38509675 | DOI:10.2174/0115672050301014240315065235 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 21, 2024 Category: Neurology Authors: Ismail Celil Haskologlu Emine Erdag Ahmet Ozer Sehirli Orhan Uludag Nurettin Abacioglu Source Type: research
Beyond Conventional Therapies: Molecular Dynamics of Alzheimer's Treatment through CLOCK/BMAL1 Interactions
Conclusion: A novel therapeutic approach emerges, suggesting the combination of melatonin with Lecanemab as a monoclonal antibody therapy. Importantly, prior research has not explored the effects of FDA-approved drugs on Bmal1 expression or their potential for synergistic effects.PMID:38509675 | DOI:10.2174/0115672050301014240315065235 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 21, 2024 Category: Neurology Authors: Ismail Celil Haskologlu Emine Erdag Ahmet Ozer Sehirli Orhan Uludag Nurettin Abacioglu Source Type: research
Beyond Conventional Therapies: Molecular Dynamics of Alzheimer's Treatment through CLOCK/BMAL1 Interactions
Conclusion: A novel therapeutic approach emerges, suggesting the combination of melatonin with Lecanemab as a monoclonal antibody therapy. Importantly, prior research has not explored the effects of FDA-approved drugs on Bmal1 expression or their potential for synergistic effects.PMID:38509675 | DOI:10.2174/0115672050301014240315065235 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 21, 2024 Category: Neurology Authors: Ismail Celil Haskologlu Emine Erdag Ahmet Ozer Sehirli Orhan Uludag Nurettin Abacioglu Source Type: research
Efficacy of Sailuotong on neurovascular unit in amyloid precursor protein/presenilin-1 transgenic mice with Alzheimer's disease
CONCLUSIONS: By increasing the expression of VEGF, SLT can promote vascular proliferation, up-regulate the expression of LRP-1, promote the clearance of Aβ and improve the cognitive impairment of APP/PS1 mice. These results confirm that SLT can improve AD by promoting vascular proliferation and Aβ clearance to protect the function of NVUs.PMID:38504535 | DOI:10.19852/j.cnki.jtcm.20240203.007 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - March 20, 2024 Category: Complementary Medicine Authors: Sun Linjuan L I Chengfu Liu Jiangang L I Nannan Han Fuhua Qiao Dandan Tao Zhuang Zhan Min Chen Wenjie Zhang Xiaohui Tong Chenguang Chen Dong Qi Jiangxia Liu Yang Liang Xiao Zheng Xiaoying Zhang Yunling Source Type: research
Efficacy of Sailuotong on neurovascular unit in amyloid precursor protein/presenilin-1 transgenic mice with Alzheimer's disease
CONCLUSIONS: By increasing the expression of VEGF, SLT can promote vascular proliferation, up-regulate the expression of LRP-1, promote the clearance of Aβ and improve the cognitive impairment of APP/PS1 mice. These results confirm that SLT can improve AD by promoting vascular proliferation and Aβ clearance to protect the function of NVUs.PMID:38504535 | PMC:PMC10927413 | DOI:10.19852/j.cnki.jtcm.20240203.007 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - March 20, 2024 Category: Complementary Medicine Authors: Sun Linjuan L I Chengfu Liu Jiangang L I Nannan Han Fuhua Qiao Dandan Tao Zhuang Zhan Min Chen Wenjie Zhang Xiaohui Tong Chenguang Chen Dong Qi Jiangxia Liu Yang Liang Xiao Zheng Xiaoying Zhang Yunling Source Type: research
Efficacy of Sailuotong on neurovascular unit in amyloid precursor protein/presenilin-1 transgenic mice with Alzheimer's disease
CONCLUSIONS: By increasing the expression of VEGF, SLT can promote vascular proliferation, up-regulate the expression of LRP-1, promote the clearance of Aβ and improve the cognitive impairment of APP/PS1 mice. These results confirm that SLT can improve AD by promoting vascular proliferation and Aβ clearance to protect the function of NVUs.PMID:38504535 | PMC:PMC10927413 | DOI:10.19852/j.cnki.jtcm.20240203.007 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - March 20, 2024 Category: Complementary Medicine Authors: Sun Linjuan L I Chengfu Liu Jiangang L I Nannan Han Fuhua Qiao Dandan Tao Zhuang Zhan Min Chen Wenjie Zhang Xiaohui Tong Chenguang Chen Dong Qi Jiangxia Liu Yang Liang Xiao Zheng Xiaoying Zhang Yunling Source Type: research
Efficacy of Sailuotong on neurovascular unit in amyloid precursor protein/presenilin-1 transgenic mice with Alzheimer's disease
CONCLUSIONS: By increasing the expression of VEGF, SLT can promote vascular proliferation, up-regulate the expression of LRP-1, promote the clearance of Aβ and improve the cognitive impairment of APP/PS1 mice. These results confirm that SLT can improve AD by promoting vascular proliferation and Aβ clearance to protect the function of NVUs.PMID:38504535 | PMC:PMC10927413 | DOI:10.19852/j.cnki.jtcm.20240203.007 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - March 20, 2024 Category: Complementary Medicine Authors: Sun Linjuan L I Chengfu Liu Jiangang L I Nannan Han Fuhua Qiao Dandan Tao Zhuang Zhan Min Chen Wenjie Zhang Xiaohui Tong Chenguang Chen Dong Qi Jiangxia Liu Yang Liang Xiao Zheng Xiaoying Zhang Yunling Source Type: research
Efficacy of Sailuotong on neurovascular unit in amyloid precursor protein/presenilin-1 transgenic mice with Alzheimer's disease
CONCLUSIONS: By increasing the expression of VEGF, SLT can promote vascular proliferation, up-regulate the expression of LRP-1, promote the clearance of Aβ and improve the cognitive impairment of APP/PS1 mice. These results confirm that SLT can improve AD by promoting vascular proliferation and Aβ clearance to protect the function of NVUs.PMID:38504535 | PMC:PMC10927413 | DOI:10.19852/j.cnki.jtcm.20240203.007 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - March 20, 2024 Category: Complementary Medicine Authors: Sun Linjuan L I Chengfu Liu Jiangang L I Nannan Han Fuhua Qiao Dandan Tao Zhuang Zhan Min Chen Wenjie Zhang Xiaohui Tong Chenguang Chen Dong Qi Jiangxia Liu Yang Liang Xiao Zheng Xiaoying Zhang Yunling Source Type: research
Efficacy of Sailuotong on neurovascular unit in amyloid precursor protein/presenilin-1 transgenic mice with Alzheimer's disease
CONCLUSIONS: By increasing the expression of VEGF, SLT can promote vascular proliferation, up-regulate the expression of LRP-1, promote the clearance of Aβ and improve the cognitive impairment of APP/PS1 mice. These results confirm that SLT can improve AD by promoting vascular proliferation and Aβ clearance to protect the function of NVUs.PMID:38504535 | PMC:PMC10927413 | DOI:10.19852/j.cnki.jtcm.20240203.007 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - March 20, 2024 Category: Complementary Medicine Authors: Sun Linjuan L I Chengfu Liu Jiangang L I Nannan Han Fuhua Qiao Dandan Tao Zhuang Zhan Min Chen Wenjie Zhang Xiaohui Tong Chenguang Chen Dong Qi Jiangxia Liu Yang Liang Xiao Zheng Xiaoying Zhang Yunling Source Type: research
Efficacy of Sailuotong on neurovascular unit in amyloid precursor protein/presenilin-1 transgenic mice with Alzheimer's disease
CONCLUSIONS: By increasing the expression of VEGF, SLT can promote vascular proliferation, up-regulate the expression of LRP-1, promote the clearance of Aβ and improve the cognitive impairment of APP/PS1 mice. These results confirm that SLT can improve AD by promoting vascular proliferation and Aβ clearance to protect the function of NVUs.PMID:38504535 | PMC:PMC10927413 | DOI:10.19852/j.cnki.jtcm.20240203.007 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - March 20, 2024 Category: Complementary Medicine Authors: Sun Linjuan L I Chengfu Liu Jiangang L I Nannan Han Fuhua Qiao Dandan Tao Zhuang Zhan Min Chen Wenjie Zhang Xiaohui Tong Chenguang Chen Dong Qi Jiangxia Liu Yang Liang Xiao Zheng Xiaoying Zhang Yunling Source Type: research
