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Montelukast Ameliorates Scopolamine-induced Alzheimer's Disease: Role on Cholinergic Neurotransmission, Antioxidant Defence System, Neuroinflammation and Expression of BDNF
Conclusion: Montelukast bestowed ameliorative effects in scopolamine-induced AD animal models as per the previous studies via attenuation of memory impairment, cholinesterase neurotransmission, oxidative stress, Amyloid-β levels, neuroinflammatory mediators and enhanced BDNF levels.PMID:37779395 | DOI:10.2174/0118715273258337230925040049 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - October 2, 2023 Category: Drugs & Pharmacology Authors: Bhavana Yerraguravagari Naga Pavani Penchikala Aravinda Sai Kolusu Grandhi Sandeep Ganesh Prasad Konduri Kumar V S Nemmani Pavan Kumar Samudrala Source Type: research

Therapeutic Effects of Combination of Nebivolol and Donepezil: Targeting Multifactorial Mechanisms in ALS
AbstractAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive loss of motor neurons in the spinal cord. Although the disease ’s pathophysiological mechanism remains poorly understood, multifactorial mechanisms affecting motor neuron loss converge to worsen the disease. Although two FDA-approved drugs, riluzole and edaravone, targeting excitotoxicity and oxidative stress, respectively, are available, their efficacies are limited to extending survival by only a few months. Here, we developed combinatorial drugs targeting multifactorial mechanisms underlying key components in...
Source: Neurotherapeutics - October 2, 2023 Category: Neurology Source Type: research

Unveiling Neuroprotective Potential of Spice Plant-Derived Compounds against Alzheimer's Disease: Insights from Computational Studies
This study investigated the therapeutic potential of phytochemicals that belong to the ten regularly used spice plants, based on their binding affinity with AD-associated proteins. Comprehensive docking studies were performed using AutoDock Vina in PyRx followed by molecular dynamic (MD) simulations using AMBER 14. The docking study of the chosen molecules revealed the binding energies of their interactions with the target proteins, while MD simulations were carried out to verify the steadiness of bound complexes. Through the Lipinski filter and admetSAR analysis, the chosen compounds' pharmacokinetic characteristics and d...
Source: International Journal of Alzheimers Disease - September 25, 2023 Category: Geriatrics Authors: Md Murshid Alom Rejwana Parvin Bonna Ariful Islam Md Wasim Alom Md Ekhtiar Rahman Md Omar Faruqe Md Khalekuzzaman Rashed Zaman Md Asadul Islam Source Type: research