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< em > In Silico < /em > Investigation of Novel Compounds as Inhibitors of Acetylcholinesterase Enzyme for the Treatment of Alzheimer's Diseases
Int J Alzheimers Dis. 2024 Feb 8;2024:2988685. doi: 10.1155/2024/2988685. eCollection 2024.ABSTRACTAlzheimer's disease (AD) is a "progressive, neurodegenerative disease that occurs when nerve cells in the brain die." There are only 4 drugs approved by the United States Food and Drug Administration (FDA). Three (donepezil, rivastigmine, and galantamine) out of these four drugs are anticholinesterase inhibitors, while the fourth one memantine is an N-methyl-D-aspartate (NMDA) receptor inhibitor. Currently, two immunotherapy drugs that target amyloid protein (donanemab and lecanemab) are being considered for the treatment of ...
Source: International Journal of Alzheimers Disease - February 19, 2024 Category: Geriatrics Authors: Kassim Adebambo Oghenekevwe Claudia Ojoh Source Type: research