Atrophic Myenteric and Submucosal Neurons Are Observed in Parkinson's Disease.
Conclusion: It seems possible to identify a morphologic intestinal disease substrate in Parkinson's disease by H&E staining, showing ganglion cell pycnosis and degeneration in both plexa. This finding may indicate a potential to diagnose enteric neuropathy in highly accessible sites. PMID: 31321021 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - July 21, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Age Matters: Objective Gait Assessment in Early Parkinson's Disease Using an RGB-D Camera.
Authors: Muñoz Ospina B, Valderrama Chaparro JA, Arango Paredes JD, Castaño Pino YJ, Navarro A, Orozco JL Abstract Background: Gait alterations are hallmarks for the diagnosis and follow-up of patients with Parkinson's disease (PD). In normal conditions, age could affect gait dynamics. Although it is known that objective assessment of gait is a valuable tool for diagnosis and follow-up of patients with PD, only few studies evaluate the effect of aging on the gait pattern of patients with PD. Objective: The purpose of this study was to assess differences in gait dynamics between PD patients and hea...
Source: Parkinsons Disease - July 19, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Behavioral and Emotional Dysfunction in Parkinson's Disease.
Authors: Bologna M, Merola A, Ricciardi L PMID: 31316745 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - July 19, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Blue Light Therapy Glasses in Parkinson's Disease: Patients' Experience.
Conclusion: Blue light therapy appears to have a positive effect on sleep, mood, and motor symptoms in PD. PD patients had an overall positive attitude towards blue light glasses as treatment for sleep disorders. PMID: 31316746 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - July 19, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Satisfaction with Care in Late Stage Parkinson's Disease.
Authors: Rosqvist K, Hagell P, Iwarsson S, Nilsson MH, Odin P Abstract In late stage Parkinson's disease (PD) (i.e., Hoehn and Yahr (HY) stages IV-V), both motor and nonmotor symptoms (NMS) are pronounced, and the patients become increasingly dependent on help in their daily life. Consequently, there is an increasing demand on health-care and social care resources for these patients and support for their informal caregivers. The aim of this study was to assess satisfaction with care in late stage PD patients and to identify factors associated with satisfaction with care. Moreover, to assess their informal caregiver...
Source: Parkinsons Disease - July 11, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Repetitive Transcranial Magnetic Stimulation Does Not Improve the Sequence Effect in Freezing of Gait.
Conclusions: High-frequency rTMS over the SMA cannot alleviate the SE in PD patients with FOG. rTMS has a long-lasting beneficial effect on FOG; however, this effect is not achieved by improving the SE but may be through improving some other gait parameters. PMID: 31275542 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - July 7, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Elevated Serum Homocysteine Levels Have Differential Gender-Specific Associations with Motor and Cognitive States in Parkinson's Disease.
This study aimed to investigate elevated serum homocysteine levels and symptom progression in a cohort of PD patients. Methods: Serum homocysteine, folate, and vitamin B12 levels were measured in 205 people with PD and 78 age-matched healthy controls. People with Parkinson's disease underwent a battery of clinical assessments to evaluate symptom severity, including motor (MDS-UPDRS) and cognitive (ACE-R) assessments. Multivariate generalised linear models were created, controlling for confounding variables, and were used to determine whether serum markers are associated with various symptom outcome measures. Result...
Source: Parkinsons Disease - July 7, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Impairment in Theory of Mind in Parkinson's Disease Is Explained by Deficits in Inhibition.
Conclusions: This study provides convincing evidence that the apparent impairment observed on ToM tests in PD is explained by deficits in inhibition. PMID: 31275544 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - July 7, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Salidroside Protects Dopaminergic Neurons by Preserving Complex I Activity via DJ-1/Nrf2-Mediated Antioxidant Pathway.
Authors: Li R, Wang S, Li T, Wu L, Fang Y, Feng Y, Zhang L, Chen J, Wang X Abstract The pathogenic mechanism of Parkinson's disease (PD) remains to be elucidated; however, mitochondrial dysfunction at the level of complex I and oxidative stress is suggestively involved in the development of PD. In our previous work, salidroside (Sal), an active component extracted from the medicinal plant Rhodiola rosea L., might protect dopaminergic (DA) neurons through modulating ROS-NO-related pathway. However, the mechanism of Sal-induced neuroprotective effects against PD remains poorly understood. Therefore, we further invest...
Source: Parkinsons Disease - June 22, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

MicroRNAs: Game Changers in the Regulation of α-Synuclein in Parkinson's Disease.
MicroRNAs: Game Changers in the Regulation of α-Synuclein in Parkinson's Disease. Parkinsons Dis. 2019;2019:1743183 Authors: Zhao L, Wang Z Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder. Its neuropathological hallmarks include neuronal loss in the substantia nigra pars compacta (SNpc) and the presence of Lewy bodies containing aggregates of α-synuclein (α-syn). An imbalance between the rates of α-syn synthesis, aggregation, and clearance can result in abnormal α-syn levels and contribute to the pathogenesis of PD. MicroRNAs (miRNAs)...
Source: Parkinsons Disease - June 15, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Optimization of SVM Parameters with Hybrid CS-PSO Algorithms for Parkinson's Disease in LabVIEW Environment.
Authors: Kaya D Abstract Optimization is the process of achieving the best solution for a problem. LabVIEW based on an SVM model is proposed in this paper to get the best SVM parameters using the hybrid CS and PSO method. PCA is used as a preprocessor of SVM for reducing the dimension of data and extracting features of training samples. Also, SVM parameters are optimized for Parkinson's disease data by combining CS and PSO. The designed system is used to determine the best SVM parameters, and it is compared to PSO and CS optimization methods and found that the used CS-PSO hybrid optimization method is better. The h...
Source: Parkinsons Disease - June 15, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Increased Cortical Thickness in Attentional Networks in Parkinson's Disease with Minor Hallucinations.
Authors: Sawczak CM, Barnett AJ, Cohn M Abstract Hallucinations are common in Parkinson's disease (PD). Based on functional brain MRI data, hallucinations are proposed to result from alterations in the dorsal attention network (DAN), ventral attention network (VAN), and default mode network. Using structural MRI data from Parkinson's Progression Markers Initiative (PPMI), we examined cortical thickness in these networks in PD patients with (n=30) and without (n=30) minor hallucinations who were matched on multiple clinical characteristics (e.g., age, sex, education, cognitive diagnosis, MoCA score, medication, dise...
Source: Parkinsons Disease - June 15, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Emotional Processing Impairments in Apathetic Patients with Parkinson's Disease: An ERP Study in Early Time Windows.
Authors: Wei W, Ruan J, Duan X, Luo H Abstract We investigated emotional processing in apathetic patients with Parkinson's disease (PD) by observing components of event-related potentials (ERPs) in early time windows. Forty PD patients and 21 healthy controls (HCs) were enrolled. The Starkstein Apathy Scale (SAS) was used to divide the PD patients into apathetic and nonapathetic groups. Cognitive function was evaluated by the forward and backward Digit Span tests, Trail Making Test (TMT), and Word Fluency Test. The participants were required to recognize positive, neutral, and negative emotional faces and engage in...
Source: Parkinsons Disease - June 1, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

The Association between DRD3 Ser9Gly Polymorphism and Depression Severity in Parkinson's Disease.
Authors: Zhi Y, Yuan Y, Si Q, Wang M, Shen Y, Wang L, Zhang H, Zhang K Abstract More and more evidence suggests that dopamine receptor D3 gene (DRD3) plays an important role in the clinical manifestations and the treatment of Parkinson's disease (PD). DRD3 Ser9Gly polymorphism is the most frequently studied variant point. Our aim was to investigate the potential effect of DRD3 Ser9Gly polymorphism on modulating resting-state brain function and associative clinical manifestations in PD patients. We consecutively recruited 61 idiopathic PD patients and 47 healthy controls (HC) who were evaluated by clinical scales, g...
Source: Parkinsons Disease - June 1, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Evaluating the Potential of Portulaca oleracea L. for Parkinson's Disease Treatment Using a Drosophila Model with dUCH-Knockdown.
Authors: Truong HKT, Huynh MA, Vuu MD, Dang TPT Abstract Parkinson's disease (PD), which is characterized by the decreased motor function and the loss of dopaminergic neurons, is a common neurodegenerative disorder in elders. There have been numerous in vitro and in vivo models developed to study mechanisms of PD and screen potential drug. Recently, dUCH-knockdown Drosophila model has been established and showed potential for screening antioxidants for PD treatment. The dUCH-knockdown Drosophila model of PD mimics most of main PD pathologies such as dopaminergic neurons degeneration, locomotor dysfunction, and shor...
Source: Parkinsons Disease - June 1, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Patient Knowledge and Attitudes towards Genetic Testing in Parkinson's Disease Subjects with Deep Brain Stimulation.
Discussion: These results reveal that there is a major knowledge gap regarding genetic testing in PD and the implications of testing results on treatment, work, insurance, and privacy. Also, subjects would mainly seek genetic testing to participate in clinical trials, with spouses and children being the key stakeholders in decision-making. PMID: 31143438 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - June 1, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Erectile Dysfunction Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study in Olmsted County.
Conclusions: Early erectile dysfunction may be a premotor symptom of MSA and DLB, reflecting premonitory dysautonomia. It was not associated with premotor PD or PDD. PMID: 31093326 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - May 18, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Subjective Vertical Position Allows Prediction of Postural Deterioration in Patients with Parkinson's Disease.
Conclusion: Our data suggest that the SV contributes to increased FFT. PMID: 31061695 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - May 9, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Kinematic Metrics from a Wireless Stylus Quantify Tremor and Bradykinesia in Parkinson's Disease.
Authors: Maldonado-Naranjo A, Koop MM, Hogue O, Alberts J, Machado A Abstract A fundamental challenge in the clinical care of Parkinson disease (PD) is the current dependence on subjective evaluations of tremor and bradykinesia. New technologies offer the ability to evaluate motor deficits using purely objective measures. The aim of this study was to develop and evaluate the efficacy of a wireless stylus (Cleveland Clinic Stylus) with an embedded motion sensor to quantitatively assess tremor and bradykinesia in patients with PD with subthalamic nucleus (STN) deep brain stimulation (DBS). Twenty-one subjects were te...
Source: Parkinsons Disease - May 9, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Psychometric Properties of the Apathy Scale in Advanced Parkinson's Disease.
Conclusions: The AS showed satisfactory feasibility, acceptability, scaling assumptions, internal consistency, and convergent validity. Responsiveness parameters were poor, probably due to the characteristics of the clinical study from which these data came. This trial is registered with NCT02289729. PMID: 31031906 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - May 1, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Impulsive-Compulsive Behaviours in Belgian-Flemish Parkinson's Disease Patients: A Questionnaire-Based Study.
Conclusions: We have developed a Belgian-Flemish version of the QUIP, which can be used as a screening questionnaire for ICB in PD patients. Our data suggest that sensitivity is high, specificity is low, and validity of the questionnaire is similar to the original version. We confirm the necessity of additional clinical assessment of QUIP-positive patients to ascertain a diagnosis of ICB. PMID: 31011412 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - April 25, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Analysis of Contact Position for Subthalamic Nucleus Deep Brain Stimulation-Induced Hyperhidrosis.
Conclusions: STN-DBS-induced sweat indicated that the contact was at superior medial of STN. PMID: 30956787 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - April 9, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

High-Cadence Cycling Promotes Sustained Improvement in Bradykinesia, Rigidity, and Mobility in Individuals with Mild-Moderate Parkinson's Disease.
Conclusions: These findings suggest that they are both acute and sustained improvements in motor function and mobility after high-cadence cycling. Future research should examine how exercise type, frequency, and intensity can be optimized for each individual. PMID: 30944720 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - April 6, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Motor Improvement-Related Regional Cerebral Blood Flow Changes in Parkinson's Disease in Response to Antiparkinsonian Drugs.
Authors: Taguchi S, Tanabe N, Niwa JI, Doyu M Abstract Little is known about the relationship between regional cerebral blood flow (rCBF) change and clinical improvement in patients with Parkinson's disease (PD). Single-photon emission computed tomography (SPECT) measurement of cerebral blood flow allows evaluation of temporal changes in brain function, and using SPECT, we aimed to identify motor improvement-related rCBF changes in response to the administration of antiparkinsonian drugs. Thirty PD patients (16 without dementia; 14 with dementia) were scanned with technetium-99m labeled ethyl cysteinate dimer SPECT...
Source: Parkinsons Disease - April 6, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

7,8-Dihydroxyflavone Protects Nigrostriatal Dopaminergic Neurons from Rotenone-Induced Neurotoxicity in Rodents.
Authors: Nie S, Ma K, Sun M, Lee M, Tan Y, Chen G, Zhang Z, Zhang Z, Cao X Abstract 7,8-Dihydroxyflavone (7,8-DHF) is thought to be a promising therapeutic agent for various neurodegenerative diseases. The major purpose of this study was to investigate the neuroprotective effects of 7,8-DHF on the rotenone-induced motor deficit of Parkinson's disease. Nine-month-old rats were treated with rotenone (2 mg/kg/day, i.h.) for 5 weeks to establish the animal model of Parkinson's disease (PD), and 7,8-DHF (5 mg/kg, i.p.) was administrated daily throughout the whole period of rotenone injection. Five w...
Source: Parkinsons Disease - April 6, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Relationship between Lower Urinary Tract Dysfunction and Clinical Features in Chinese Parkinson's Disease Patients.
Conclusions: The FAB score, H-Y stage, and RBD are accompanying factors for OAB. A higher OABSS in PD patients was related to a lower FAB score for frontal lobe executive dysfunction, a higher H-Y stage for severity of motor disorders, RBD, and an older age. PMID: 30949327 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - April 6, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Effects of Tai Chi Exercise on Reducing Falls and Improving Balance Performance in Parkinson's Disease: A Meta-Analysis.
Authors: Liu HH, Yeh NC, Wu YF, Yang YR, Wang RY, Cheng FY Abstract Introduction: Parkinson's disease (PD) is a common neurodegenerative disorder that may increase the risk of falls, functional limitation, and balance deficits. Tai Chi was used as an option for improving balance in people with PD. The aim of this meta-analysis was to evaluate the effects of Tai Chi on falls, balance, and functional mobility in individuals with PD. Method: The literature search was conducted in PubMed, the Cochrane Library, CINAHL, PEDro, Medline, Embase, sportDISCUS, Trip, and the National Digital Library of Theses and Disserta...
Source: Parkinsons Disease - March 30, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Bone Mineral Density, TBS, and Body Composition Indexes in Ukrainian Men with Parkinson's Disease.
Conclusion: Due to low BMD values, changes in BC are present in PD males, and appropriate screening and preventive strategies should be instigated to maintain bone health in PD subjects. PMID: 30881687 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - March 20, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Identification of Differentially Expressed Genes and Long Noncoding RNAs Associated with Parkinson's Disease.
Conclusions: IGF1R, PRKACA, and lncRNA-XIST could be potentially involved in PD, and these diverse molecular mechanisms could support the development of the similar treatment for PD. PMID: 30867898 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - March 16, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

The Lived Experiences of Deep Brain Stimulation in Parkinson's Disease: An Interpretative Phenomenological Analysis.
In this study, we used an interpretative phenomenological analysis to explore how 10 male people with PD experienced life after STN-DBS surgery. Two themes emerged. The first, "Healed and relieved: all that glitters is not gold," highlights the benefits and the personal "costs" of surgery. The second, "The change within: new interpretations of the present and future unfold," explores how patients reinterpreted their lives as individuals and members of society in the present and as they face their future. Relief, gratitude, disappointment, and the need for social support are expressed as well a...
Source: Parkinsons Disease - March 13, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Driving with Parkinson's Disease: Exploring Lived Experience.
This study lays the foundation for the development of client-centred and evidence-informed driving interventions for individuals with PD, as well as the development of driving retirement programs. PMID: 30854186 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - March 13, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Cortical Visual Performance Test Setup for Parkinson's Disease Based on Motion Blur Orientation.
Authors: Isenkul ME Abstract Studies on Parkinson's disease (PD) are becoming very popular on multidisciplinary platforms. The development of predictable telemonitored early detection models has become closely related to many different research areas. The aim of this article is to develop a visual performance test that can examine the effects of Parkinson's disease on the visual cortex, which can be a subtitle scoring test in UPDRS. However, instead of showing random images and asking for discrepancies between them, it is expected that the questions to be asked to patients should be provable in the existing cortex ...
Source: Parkinsons Disease - March 13, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Automated Subfield Volumetric Analysis of Hippocampus in Patients with Drug-Na ïve Nondementia Parkinson's Disease.
In this study, we investigated the hippocampal subfield volume of patients with early-stage nondementia PD compared with normal healthy subjects using the ASHS method. A total of 32 subjects were enrolled in this study (sixteen patients with drug naive nondementia PD and sixteen healthy controls). All subjects were scanned with a 1.5 tesla MRI. The volumes of the seven subfields were calculated separately, and then, the whole hippocampal volume was calculated by the summing of CA1, CA2-3, CA4-DG, subiculum, presubiculum, and fimbria, excluding the hippocampal fissure. There were significant diagnosis-by-hemisphere i...
Source: Parkinsons Disease - March 13, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Five-Year Clinical Outcomes of Local versus General Anesthesia Deep Brain Stimulation for Parkinson's Disease.
Conclusions: Our study confirmed that STN localization with microelectrode recording and patient comfort could be achieved based on equal effectiveness and safety of STN-DBS under GA compared with LA. PMID: 30800263 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - February 27, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson's Disease.
Authors: Liu JB, Leng JL, Wang YG, Zhang Y, Tang TY, Tao LH, Zhang XJ, Liu CF Abstract Background: Nonmotor symptoms (NMS) are prodromal characteristics of Parkinson's disease (PD). The first-degree relatives (FDR) of PD patients had a higher risk of PD and also had more NMS. Objective: To delineate NMS in FDR of patients with different clinical types of PD. Methods: A total of 98 PD probands were recruited; 256 siblings of them were enrolled in the FDR group. Various scales were used to assess NMS, including depression, anxiety, cognitive impairment, insomnia, constipation, excessive daytime sleepiness, ra...
Source: Parkinsons Disease - February 7, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Polymorphisms of ACMSD-TMEM163, MCCC1, and BCKDK-STX1B Are Not Associated with Parkinson's Disease in Taiwan.
Authors: Chang KH, Chen CM, Chen YC, Fung HC, Wu YR Abstract Previous genome-wide association studies in Caucasian populations suggest that genetic loci in amino acid catabolism may be associated with Parkinson's disease (PD). However, these genetic disease associations were limitedly reported in Asian populations. Herein, we investigated the effect of top three PD-associated genetic variants related to amino acid catabolism in Caucasians listed on the top risk loci identified by meta-analysis of genome-wide association studies in PDGene database, including aminocarboxymuconate-semialdehyde decarboxylase- (ACMSD-) ...
Source: Parkinsons Disease - February 7, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Enhanced Motivational Modulation of Motor Behaviour with Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease.
Discussion: The effect of monetary incentive on movement speed in PD patients is more pronounced with STN-DBS than dopaminergic medications, suggesting that motivational modulation of movement speed may be enhanced as a direct consequence of STN stimulation. PMID: 30719276 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - February 7, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Reliability and Validity of Fall Efficacy Scale-International in People with Parkinson's Disease during On- and Off-Drug Phases.
Conclusion: This study verified that FES-I is unidimensional, reliable, and valid to measure the Fear of Falling during On- and Off-drug phases in people with PD. PMID: 30719277 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - February 7, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Evaluating Dose- and Time-Dependent Effects of Vitamin C Treatment on a Parkinson's Disease Fly Model.
Authors: Man Anh H, Linh DM, My Dung V, Thi Phuong Thao D Abstract Parkinson's disease (PD) is a common neurodegenerative disorder and characterized by progressive locomotive defects and loss of dopaminergic neurons (DA neuron). Currently, there is no potent therapy to cure PD, and the medications merely support to control the symptoms. It is difficult to develop an effective treatment, since the PD onset mechanism of PD is still unclear. Oxidative stress is considered as a major cause of neurodegenerative diseases, and there is increasing evidence for the association between PD and oxidative stress. Therefore, ant...
Source: Parkinsons Disease - February 7, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

A Randomized Crossover Pilot Study of Telemedicine Delivered via iPads in Parkinson's Disease.
Conclusions: We observed that a telemedicine system delivered via a tablet could successfully be used by patients as a part of their care. Further studies investigating the use of telemedicine to replace in-person visits are warranted. This trial is registered with UMIN000015536. PMID: 30723541 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - February 7, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Comparing Balance Performance on Force Platform Measures in Individuals with Parkinson's Disease and Healthy Adults.
Conclusion: These findings suggest FP measures provide clinically meaningful, diagnostic information in the examination of balance impairments in individuals with PD. FP measures may inform clinicians regarding intrinsic balance deficits and guide them in designing targeted balance interventions to reduce fall risk in persons with PD. PMID: 30687494 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - January 30, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Dietary Variations in a Multiethnic Parkinson's Disease Cohort and Possible Influences on Nonmotor Aspects: A Cross-Sectional Multicentre Study.
Authors: Sauerbier A, Schrag A, Martinez-Martin P, Hall LJ, Parry M, Mischley LK, Zis P, Chaudhuri KR Abstract Dietary habits may differ between Parkinson's disease (PD) patients of different ethnicities. The primary aim of this cross-sectional analysis was to compare dietary habits in a multiethnic PD population and investigate potential nonmotor differences. All patients completed a dietary habits questionnaire. Besides basic demographics, patients' motor involvement (Hoehn and Yahr (HY)) and nonmotor symptoms (Nonmotor Symptoms Scale; Hospital Anxiety and Depression Scale) were assessed. 139 PD patients were inc...
Source: Parkinsons Disease - January 22, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Zonisamide Enhances Motor Effects of Levodopa, Not of Apomorphine, in a Rat Model of Parkinson's Disease.
In conclusion, zonisamide appears to generate its antiparkinsonian effects by modulating levodopa-dopamine metabolism in the parkinsonian striatum. PMID: 30662707 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - January 22, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Genetic Impact on Clinical Features in Parkinson's Disease: A Study on SNCA-rs11931074.
Authors: Shu L, Liang D, Pan H, Xu Q, Guo J, Sun Q, Tang B, Yan X Abstract SNCA-rs11931074 had been demonstrated to be strongly correlated with PD risk. However, there was lack of comprehensive analysis of SNCA-rs11931074-related clinical features which may help explain clinical heterogeneity of PD. In our study, we performed association analyses on the relationship between SNCA-rs11931074 and motor symptoms, nonmotor symptoms, and comorbidities in PD. 611 rs11931074 carriers and 113 rs11931074 noncarriers were enrolled. In the clinical phenotype analyses, the Unified Parkinson's Disease Rating Scale part II (UPDRS...
Source: Parkinsons Disease - January 12, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Gastrointestinal Dysfunctions Are Associated with IL-10 Variants in Parkinson's Disease.
In conclusion, we found less severe gastrointestinal dysfunctions of both IL-10 rs1800871 and rs1800872 carriers than noncarriers in PD. PMID: 30631418 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - January 12, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Factor Structure of the Ways of Coping Questionnaire in Parkinson's Disease.
Authors: Corti EJ, Johnson AR, Gasson N, Bucks RS, Thomas MG, Loftus AM Abstract The Ways of Coping Questionnaire (WCQ) is used extensively in health research, but the measurement properties and suitability of the WCQ for people with Parkinson's disease (PD) have not been psychometrically assessed. If the WCQ does not align with its original 8-factor structure in a PD population, the use of the WCQ subscales may not be appropriate. The present study used confirmatory factor analysis (CFA), exploratory factor analysis (EFA), and multiple-group EFA to determine the ideal factor structure of the WCQ in a PD sample. Th...
Source: Parkinsons Disease - January 12, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Cognitive Stimulation for Individuals with Parkinson's Disease Dementia Living in Long-Term Care: Preliminary Data from a Randomized Crossover Pilot Study.
Conclusions: Although our data are preliminary due to the small sample size, this study shows that CS is feasible and potentially effective for cognitive and noncognitive outcomes in PDD patients. Randomized controlled trials with larger sample sizes are needed to confirm these promising results. PMID: 30631420 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - January 12, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Motor and Nonmotor Symptoms of Parkinson's Disease: Antagonistic Pleiotropy Phenomena Derived from α-Synuclein Evolvability?
Motor and Nonmotor Symptoms of Parkinson's Disease: Antagonistic Pleiotropy Phenomena Derived from α-Synuclein Evolvability? Parkinsons Dis. 2018;2018:5789424 Authors: Takamatsu Y, Fujita M, Ho GJ, Wada R, Sugama S, Takenouchi T, Waragai M, Masliah E, Hashimoto M Abstract Lewy body diseases, such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), are associated with a wide range of nonmotor symptoms (NMS), including cognitive impairment, depression and anxiety, sleep disorders, gastrointestinal symptoms, and autonomic failure. The reason why such dive...
Source: Parkinsons Disease - January 1, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Problems with Facial Mimicry Might Contribute to Emotion Recognition Impairment in Parkinson's Disease.
Authors: Prenger MTM, MacDonald PA Abstract Difficulty with emotion recognition is increasingly being recognized as a symptom of Parkinson's disease. Most research into this area contends that progressive cognitive decline accompanying the disease is to be blamed. However, facial mimicry (i.e., the involuntary congruent activation of facial expression muscles upon viewing a particular facial expression) might also play a role and has been relatively understudied in this clinical population. In healthy participants, facial mimicry has been shown to improve recognition of observed emotions, a phenomenon described by ...
Source: Parkinsons Disease - December 14, 2018 Category: Neurology Tags: Parkinsons Dis Source Type: research

Rehabilitation Therapy Utilization in Patients with Parkinson's Disease in Korea.
Conclusion: This study demonstrated that the rate of rehabilitation therapy utilization did not change remarkably in patients with PD from 2004 to 2015 in Korea although the number of physiatrist visits increased dramatically. The present evidence and guidelines may have not been adequately integrated into clinical practice during the period of study. Additional efforts may be warranted to provide adequate rehabilitation therapies in clinical practice for patients with PD. PMID: 30538812 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - December 14, 2018 Category: Neurology Tags: Parkinsons Dis Source Type: research