Flanker Task-Elicited Event-Related Potential Sources Reflect Human Recombinant Erythropoietin Differential Effects on Parkinson's Patients.
Authors: Bringas Vega ML, Liu S, Zhang M, Pedroso Ibañez I, Morales Chacon LM, Galan Garcia L, Perez Bocourt V, Jahanshahi M, Valdes-Sosa PA Abstract We used EEG source analysis to identify which cortical areas were involved in the automatic and controlled processes of inhibitory control on a flanker task and compared the potential efficacy of recombinant-human erythropoietin (rHuEPO) on the performance of Parkinson's Disease patients. The samples were 18 medicated PD patients (nine of them received rHuEPO in addition to their usual anti-PD medication through random allocation and the other nine patients wer...
Source: Parkinsons Disease - June 24, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Evidence of Rehabilitative Impact of Progressive Resistance Training (PRT) Programs in Parkinson Disease: An Umbrella Review.
Authors: Paolucci T, Sbardella S, La Russa C, Agostini F, Mangone M, Tramontana L, Bernetti A, Paoloni M, Pezzi L, Bellomo RG, Santilli V, Saggini R Abstract Parkinson disease (PD) is a chronic neurodegenerative condition that leads to progressive disability. PD-related reductions in muscle strength have been reported to be associated with lower functional performance and balance confidence with an increased risk of falls. Progressive resistance training (PRT) improves strength, balance, and functional abilities. This umbrella review examines the efficacy of PRT regarding muscular strength in PD patients. The PubMe...
Source: Parkinsons Disease - June 24, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Intestinal Levodopa/Carbidopa Infusion as a Therapeutic Option for Unresponsive Freezing of Gait after Deep Brain Stimulation in Parkinson's Disease.
Conclusions: Intestinal levodopa infusion may be a valuable therapeutic option for unresponsive-FOG developed after subthalamic nucleus deep brain stimulation. PMID: 32509261 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - June 10, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Direct Cost of Parkinson's Disease: A Real-World Data Study of Second-Line Therapies.
Authors: Gomez-Inhiesto E, Acaiturri-Ayesta MT, Ustarroz-Aguirre I, Camahuali D, Urtaran-Laresgoiti M, Basabe-Aldecoa M, Nuño-Solinís R, Urizar E Abstract Parkinson's disease is one of the main reasons for neurological consultation in Spain. Due to the nature of the disease, it impacts patients, families, and caregivers. Parkinson's disease is a degenerative disease with no cure, although second-line therapies have recently improved the quality of life of patients in advanced stages. The aim of this study was to analyse the costs of the following therapies: deep brain stimulation (DBS), continuous duo...
Source: Parkinsons Disease - May 28, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Psychosocial Adjustment of In-Home Caregivers of Family Members with Dementia and Parkinson's Disease: A Comparative Study.
This study compares the psychosocial adjustment of family members who care for people with dementia and Parkinson's disease and identifies the main sociodemographic variables that affect the processes of adjustment to both conditions. To this end, the Psychosocial Adjustment to Illness Scale (PAIS-SR) and a sociodemographic form were administered to 157 family caregivers in Navarre, Spain. The results show that adjustment to the disease in family caregivers of people with Parkinson's disease and dementia is, in general, satisfactory and related to variables such as place of residence, income, and employment status. The ill...
Source: Parkinsons Disease - May 15, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Long-Term Use of Antibiotics and Risk of Parkinson's Disease in the Nurses' Health Study.
Conclusion: In this cohort study, we did not observe a significant association between antibiotic use and incidence PD. A major limitation of our study is assessment of exposure, which required many participants to recall their antibiotic use decades in the past. Thus, although the results of this study do not support an effect of antibiotic use on PD risk, larger investigations relying on records of antibiotic prescriptions would provide more definitive evidence. PMID: 32399169 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - May 15, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Freezing More than Gait: A Case Report of Freezing of Urination (FOU) in Parkinson's Disease.
Authors: Xu M, Chen T, Yang C, Meng X, Peng Q, Lei X Abstract Freezing of gait (FOG) is a disabling phenomenon that is described by patients with Parkinson's disease (PD). Not only gait may be involved in the freezing phenomenon, but also some nonmotor symptoms, such as freezing of urination (FOU) in this case. The characters of urinary dysfunctions in this case resemble "off" freezing: (1) abrupt difficulty in starting or continuing in urination; (2) the urinary dysfunctions fluctuated with medication state; and (3) the urinary dysfunctions could be alleviated dramatically by an external cueing. Urinary ...
Source: Parkinsons Disease - May 15, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Self-Management Education for Persons with Parkinson's Disease and Their Care Partners: A Quasi-Experimental Case-Control Study in Clinical Practice.
Conclusion: The findings indicate that the Swedish National Parkinson School may improve health status and self-management among persons with Parkinson's disease, but further studies are needed to better understand the effects of the programme. PMID: 32399171 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - May 15, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Nonmotor-Related Quality of Life in Parkinson's Patients with Subjective Memory Complaints: Comparison with PDQ-39.
Authors: Jenny AL, Meyer A, Handabaka I, Calabrese P, Fuhr P, Gschwandtner U Abstract Background: Parkinson's disease (PD) is associated with cognitive decline, progressing from subjective memory complaints (SMC) via mild cognitive impairment (MCI) to dementia. SMC are only measurable by an interview and thus rely on individuals reporting a subjectively perceived worsening of cognitive functioning. Cognitive decline is accompanied by a reduction in quality of life (QoL); however, the extent to which SMC manifest a reduction of QoL remains unclear. Objective: To determine the association between SMC and deterior...
Source: Parkinsons Disease - May 8, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Genetic Analysis of EGLN1 C127S Variant in Taiwanese Parkinson's Disease.
Authors: Chiang HL, Chen CM, Chen YC, Chao CY, Wu YR, Lee-Chen GJ Abstract Parkinson's disease (PD) is a neurodegenerative disorder related to nigrostriatal dopaminergic neuron degeneration and iron accumulation. As a cellular oxygen sensor, prolyl hydroxylase domain containing protein 2 (PHD2, encoded by egl-9 family hypoxia inducible factor 1, EGLN1) modifies hypoxia-inducible factor alpha (HIF-α) protein for proteasomal destruction under normoxic condition. In addition, 2-oxoglutarate- (OG-) dependent dioxygenase activity of PHD2 is involved in the oxygen and iron regulation of iron-responsive element bind...
Source: Parkinsons Disease - May 8, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Wearable Sensors Measure Ankle Joint Changes of Patients with Parkinson's Disease before and after Acute Levodopa Challenge.
Authors: Wu Z, Jiang X, Zhong M, Shen B, Zhu J, Pan Y, Dong J, Xu P, Zhang W, Zhang L Abstract Background: Previous studies found levodopa could improve the activity of the ankle joints of patients with Parkinson's disease (PD). But ankle joint movement is composed of four motion ranges. The specific changes of four motion ranges in PD remain unknown. Objective: The purpose of this study was to decompose the complex ankle joint movement, measure ankle joint changes before and after the acute levodopa challenge test (ALCT), and investigate the effects of these parameters on gait performance. Methods: 29 PD p...
Source: Parkinsons Disease - May 1, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Taking Time: A Mixed Methods Study of Parkinson's Disease Caregiver Participation in Activities in Relation to Their Wellbeing.
Conclusion: This study suggests that caregivers of people with PD can find a healthy balance in terms of their own wellbeing by jointly participating in two-thirds of activities while ensuring the remaining third is time reserved for themselves. PMID: 32351682 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - May 1, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Combining a Cognitive Concurrent Task with a Motor or Motor-Cognitive Task: Which Is Better to Differentiate Levels of Affectation in Parkinson's Disease?
Conclusion: The hybrid of motor-cognitive task combining with a cognitive task (i. e., fluency) successfully differentiated between mild and moderate PD patients in the context of dual and triple multitask sets even when the cognitive status was statistically controlled. Our results highlight the importance of jointly measuring the complex interplay between motor and cognitive skills in PD. PMID: 32322384 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - April 25, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

The Beneficial Effects of Conventional Visual Cues Are Retained When Augmented Reality Glasses Are Worn.
We present a single-patient study in which a patient with Parkinson's disease traversed a doorway under different cueing conditions. Wearing augmented reality (AR) glasses did not deteriorate FOG nor affect the beneficial effects of cues. The AR visual cues did not improve FOG. This single-patient study implies that the current design of AR glasses does not stand in the way of the development of augmented reality visual cues. However, the effectivity of augmented reality visual cues remains to be proven. PMID: 32322385 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - April 25, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Ultrasonography of the Vagus Nerve in the Diagnosis of Parkinson's Disease.
Conclusions: To conclude, no differences were found in VN diameter between the PD and control groups. Therefore, our data do not support the hypothesis that PD could be associated with a smaller diameter of the VN. PMID: 32318257 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - April 24, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Patients' Perspective of Comprehensive Parkinson Care in Rural Victoria.
Authors: Iansek R, Danoudis M Abstract Methods: This descriptive study used a survey to explore health-care experiences. Questionnaires were mailed to participants living in rural Victoria. Eligibility criteria included having a diagnosis of PD or Parkinsonism and sufficient English to respond to the survey. The validated Patient-Centred Questionnaire for PD was used to measure health-care experiences. The questions are grouped accordingly under one of the 6 subscales or domains. Outcomes from the questionnaire included summary experience scores (SES) for 6 subscales; overall patient-centeredness score (OPS); and q...
Source: Parkinsons Disease - April 24, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Event-Related Potentials Elicited by Face and Face Pareidolia in Parkinson's Disease.
Conclusion: The results of our study showed that ERPs associated with face and also face-pareidolia stimuli processing are changed in early-stage neurophysiological activity in the temporoparietal cortex of Parkinson's patients. PMID: 32318259 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - April 24, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Evolution of Initial Pharmacologic Treatment of Newly Diagnosed Parkinson's Disease Patients over a Decade in Singapore.
Authors: Neo S, Wong SYA, Ng HL, Li W, Tay KY, Au WL, Tan LCS Abstract Objective: The aim of this study is to compare Parkinson's disease (PD) treatment practices by movement disorder (MD) specialists across a decade, and to determine the factors that influence drug choice for the motor symptoms of PD in newly diagnosed drug-naïve patients. Methods: This prospective temporal analysis included patients seen at the National Neuroscience Institute in Singapore and diagnosed with PD by MD specialists in the years 2007 and 2017. Primary outcomes were use of specific PD drugs and changes in drug-prescribing patt...
Source: Parkinsons Disease - April 24, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Proactive and Integrated Management and Empowerment in Parkinson's Disease: Designing a New Model of Care.
Authors: Tenison E, Smink A, Redwood S, Darweesh S, Cottle H, van Halteren A, van den Haak P, Hamlin R, Ypinga J, Bloem BR, Ben-Shlomo Y, Munneke M, Henderson E Abstract Parkinson's disease is the second most common neurodegenerative condition after Alzheimer's disease. The number of patients will rise dramatically due to ageing of the population and possibly also due to environmental issues. It is widely recognised that the current models of care for people with Parkinson's disease or a form of atypical parkinsonism lack continuity, are reactive to problems rather than proactive, and do not adequately support indi...
Source: Parkinsons Disease - April 24, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Feasibility Aspects of Exploring Exercise-Induced Neuroplasticity in Parkinson's Disease: A Pilot Randomized Controlled Trial.
Conclusions: The overall trial design proved feasible to perform, but further strengthening ahead of the definitive RCT is recommended, specifically with respect to MRI setup, cognitive dual-tasks during gait, and blinding procedures. This trial is registered with NCT03213873. PMID: 32300475 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - April 18, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Update on the Management of Parkinson's Disease for General Neurologists.
Authors: Pirtošek Z, Bajenaru O, Kovács N, Milanov I, Relja M, Skorvanek M Abstract Management of Parkinson's disease (PD) is complicated due to its progressive nature, the individual patient heterogeneity, and the wide range of signs, symptoms, and daily activities that are increasingly affected over its course. The last 10-15 years have seen great progress in the identification, evaluation, and management of PD, particularly in the advanced stages. Highly specialized information can be found in the scientific literature, but updates do not always reach general neurologists in a practical and useful ...
Source: Parkinsons Disease - April 18, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Cognition Deficits in Parkinson's Disease: Mechanisms and Treatment.
Authors: Fang C, Lv L, Mao S, Dong H, Liu B Abstract Parkinson's disease (PD) is the second most common progressive neurodegenerative disorder mainly in middle-elderly population, which represents diverse nonmotor symptoms (NMS) besides such well-documented motor symptoms as bradykinesia, resting tremor, rigidity, and postural instability. With the advancement of aging trend worldwide, the global prevalence of PD is mounting up year after year. Nowadays, accumulating lines of studies have given a comprehensive and thorough coverage of motor symptoms in PD. Yet much less attention as compared has been paid to the no...
Source: Parkinsons Disease - April 11, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

5-2-1 Criteria: A Simple Screening Tool for Identifying Advanced PD Patients Who Need an Optimization of Parkinson's Treatment.
Authors: Santos-García D, de Deus Fonticoba T, Suárez Castro E, Aneiros Díaz A, McAfee D Abstract Objective: 5- (5 times oral levodopa tablet taken/day) 2- (2 hours of OFF time/day) 1- (1 hour/day of troublesome dyskinesia) criteria have been proposed by a Delphi expert consensus panel for diagnosing advanced Parkinson's disease (PD). The aim of the present study is to compare quality of life (QoL) in PD patients with "5-2-1 positive criteria" vs QoL in PD patients without "5-2-1 positive criteria" (defined as meeting ≥1 of the criteria). Methods: This is a cross-sect...
Source: Parkinsons Disease - April 11, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Effect of Intestinal Levodopa-Carbidopa Infusion on Pharyngeal Dysphagia: Results from a Retrospective Pilot Study in Patients with Parkinson's Disease.
Conclusions: LCIG may affect PDrPD and reduce premature bolus spillage and pharyngeal bradykinesia. Future studies with larger sample sizes are required to follow-up on these pilot results and identify which factors predict a good response of PDrPD to LCIG treatment. PMID: 32257098 [PubMed - as supplied by publisher] (Source: Parkinsons Disease)
Source: Parkinsons Disease - April 8, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Altered Body Composition and Increased Resting Metabolic Rate Associated with the Postural Instability/Gait Difficulty Parkinson's Disease Subtype.
Authors: Femat-Roldán G, Gaitán Palau MA, Castilla-Cortázar I, Elizondo Ochoa G, Moreno NG, Martín-Estal I, Jiménez Yarza M Abstract Background: Weight loss in Parkinson's disease (PD) patients is a common but poorly understood manifestation. Several studies have reported that weight changes could be related to motor symptoms, drug side effects, dysphagia, depression, and/or dementia. Weight loss in PD is not a benign phenomenon and it has several clinical and prognostic implications with increased morbidity and mortality. Thus, it is crucial to determine nutritional changes in PD...
Source: Parkinsons Disease - April 8, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Atomoxetine Does Not Improve Complex Attention in Idiopathic Parkinson's Disease Patients with Cognitive Deficits: A Meta-Analysis.
Conclusion: In idiopathic PD with MCI, atomoxetine does not improve complex attention. Also, a deteriorative trend in the executive function was noted. PMID: 32211146 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - March 28, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Association of Motor and Cognitive Symptoms with Health-Related Quality of Life and Caregiver Burden in a German Cohort of Advanced Parkinson's Disease Patients.
Authors: Klietz M, Schnur T, Drexel S, Lange F, Tulke A, Rippena L, Paracka L, Dressler D, Höglinger GU, Wegner F Abstract Parkinson's disease (PD) is a chronic progressive movement disorder with severe reduction in patients' health-related quality of life (HR-QoL). Motor and cognitive symptoms are especially linked with decreased PD patients' HR-QoL. However, the relationship of these symptoms to caregiver burden is relatively unclear. Influence of the Montreal Cognitive Assessment scale (MoCA) as a cognitive screening tool and Movement Disorders Society Unified Parkinson's disease Rating Scale MDS-UPDRS symp...
Source: Parkinsons Disease - March 19, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Attitude of Asian Parkinson Patients towards Clinical Research and Tissue Donation.
Conclusion: The attitude of Singaporean Parkinson patients toward clinical research and tissue donation is encouraging with about half of the participants willing to support clinical research. Three-quarters of patients would support tissue donations. Participation in research may be further increased with greater patient and public education to overcome misconceptions and also by limiting the demands of studies. PMID: 32148750 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - March 11, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Improvement of Blood Plasmalogens and Clinical Symptoms in Parkinson's Disease by Oral Administration of Ether Phospholipids: A Preliminary Report.
Conclusion: 1 mg/day of oral administration of purified ether phospholipids derived from scallop can increase ether phospholipids in peripheral blood and concomitantly improve some clinical symptoms of PD. PMID: 32148751 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - March 11, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

LRRK2 Mutations and Asian Disease-Associated Variants in the First Parkinson's Disease Cohort from Kazakhstan.
Conclusions: We showed that East Asian LRRK variants could be found in Central Asian populations but their pathogenicity remains to be elucidated in larger PD cohorts. PMID: 32148752 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - March 11, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Validation of a Parkinson Disease Predictive Model in a Population-Based Study.
Authors: Faust IM, Racette BA, Searles Nielsen S Abstract Parkinson disease (PD) has a relatively long prodromal period that may permit early identification to reduce diagnostic testing for other conditions when patients are simply presenting with early PD symptoms, as well as to reduce morbidity from fall-related trauma. Earlier identification also could prove critical to the development of neuroprotective therapies. We previously developed a PD predictive model using demographic and Medicare claims data in a population-based case-control study. The area under the receiver-operating characteristic curve (AUC) indi...
Source: Parkinsons Disease - March 11, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Validation of Revised Chinese Version of PD-CRS in Parkinson's Disease Patients.
Authors: Tan Y, Liu W, Du J, Hou M, Yu C, Liu Y, Cui S, Yan L, Lu Y, Lv H, Han L, Wang X, Zha S, Luo X, Tang H, Chen S Abstract There is a high prevalence of mild cognitive impairment (MCI) and dementia in Parkinson's disease (PD) patients, but a Chinese version of cognitive rating scale that is specific and sensitive to PD patients is still lacking. The aims of this study are to test the reliability and validity of a Chinese version of Parkinson's disease-cognitive rating scale (PD-CRS), establish cutoff scores for diagnosis of Parkinson's disease dementia (PDD) and PD with mild cognitive impairment (PD-MCI), expl...
Source: Parkinsons Disease - March 11, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Can the Executive Control Network be Used to Diagnose Parkinson's Disease and as an Efficacy Indicator of Deep Brain Stimulation?
Conclusions: The FC of ECN in PD patients was different from that in normal controls, but the FC of the ECN in patients with PD may not be altered by DBS. This suggests that the ECN may be considered an imaging biomarker for the identification of PD but may not be a good imaging biomarker for the evaluation of DBS efficacy. PMID: 32148755 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - March 11, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Sicca Symptoms in Parkinson's Disease: Association with Other Nonmotor Symptoms and Health-Related Quality of Life.
Conclusion: Sicca symptoms are common in PD and negatively influence QoL. The observed association between sicca symptoms and other nonmotor symptoms provides further preliminary evidence for the growing recognition of different nonmotor clusters in PD. PMID: 32104559 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - February 28, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Safety of Levodopa-Carbidopa Intestinal Gel Treatment in Patients with Advanced Parkinson's Disease Receiving ≥2000 mg Daily Dose of Levodopa.
This report evaluates long-term safety and efficacy of high-dose LCIG in PD patients. Methods: Data were collected from several prospective, phase III clinical studies and an observational registry. The phase III program (N = 412) included four multicenter studies: a 12-week, randomized, double-blind study and three open-label studies extending ≥12 months. GLORIA (N = 412) included four multicenter studies: a 12-week, randomized, double-blind study and three open-label studies extending ≥12 months. GLORIA (. Results: A total of 72 of 412 (17.5%) patients required dosages ≥2000&t...
Source: Parkinsons Disease - February 28, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

The Therapeutic Effect of Nordic Walking on Freezing of Gait in Parkinson's Disease: A Pilot Study.
Conclusions: The present study showed that NW training had a beneficial effect on FOG in PD and that the achieved improvement is long-lasting. Future research should clarify whether the observed improvement limited to FoG triggered by only some circumstances reflects different pathomechanisms of FoG subtypes. PMID: 32089815 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - February 25, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Assessing the Relationship between the Enhanced Gait Variability Index and Falls in Individuals with Parkinson's Disease.
Authors: Schmitt AC, Baudendistel ST, Fallon MS, Roper JA, Hass CJ Abstract Gait impairment and increased gait variability are common among individuals with Parkinson's disease (PD) and have been associated with increased risk for falls. The development of composite scores has gained interest to aggregate multiple aspects of gait into a single metric. The Enhanced Gait Variability Index (EGVI) was developed to compare an individual's gait variability to the amount of variability in a healthy population, yet the EGVI's individual parts may also provide important information that may be lost in this conversion. We so...
Source: Parkinsons Disease - February 25, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Phosphorylated Alpha-Synuclein in Red Blood Cells as a Potential Diagnostic Biomarker for Multiple System Atrophy: A Pilot Study.
In this study, levels of serine 129-phosphorylated α-syn (pS-α-syn), a major pathologic form of α-syn, in red blood cells (RBCs), were measured using ELISA in a Chinese cohort consisting of 107 MSA patients and 220 healthy controls. A significant increase in the levels of pS-α-syn in RBCs (pS-α-syn-RBC) was observed in MSA patients than in healthy controls (14.02 ± 4.02 ng/mg versus 11.89 ± 3.57 ng/mg; p
Source: Parkinsons Disease - February 25, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Novel Compound Heterozygous PRKN Variants in a Han-Chinese Family with Early-Onset Parkinson's Disease.
This study identified novel compound heterozygous variants (p.T240K and p.L272R) of the PRKN gene in a Han-Chinese family with early-onset PD. This finding is helpful in the genetic diagnosis of PD and also the functional research of the PRKN gene. PMID: 31929871 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - January 15, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Predictive Factors of Concerns about Falling in People with Parkinson's Disease: A 3-Year Longitudinal Study.
This study aimed to identify predictive factors of FOF (conceptualized as concerns about falling) after three years, with and without adjusting for concerns about falling at baseline, in people with PD. Methods: This study included 151 participants (35% women) with PD. At baseline, their mean (SD) age and PD duration were 68 (±9.0) and 9 (±6.1) years, respectively. The Falls Efficacy Scale-International (FES-I) was used as the dependent variable in multivariable linear regression analyses. Results: The mean (SD) FES-I score increased from 28.1 (11.9) to 33.1 (14.0) three years later (p
Source: Parkinsons Disease - January 11, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Analysis of the Relationship between Type II Diabetes Mellitus and Parkinson's Disease: A Systematic Review.
In conclusion, the available evidence on the interaction between T2DM and PD justifies more robust clinical trials exploring this interaction especially the clinical management of patients with both conditions. PMID: 31871617 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - December 26, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Corrigendum to "Five-Year Clinical Outcomes of Local versus General Anesthesia Deep Brain Stimulation for Parkinson's Disease".
Corrigendum to "Five-Year Clinical Outcomes of Local versus General Anesthesia Deep Brain Stimulation for Parkinson's Disease". Parkinsons Dis. 2019;2019:2654204 Authors: Tsai ST, Chen TY, Lin SH, Chen SY Abstract [This corrects the article DOI: 10.1155/2019/5676345.]. PMID: 31827761 [PubMed - in process] (Source: Parkinsons Disease)
Source: Parkinsons Disease - December 13, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Knowing Your Beans in Parkinson's Disease: A Critical Assessment of Current Knowledge about Different Beans and Their Compounds in the Treatment of Parkinson's Disease and in Animal Models.
Authors: Rijntjes M Abstract This review contains a critical appraisal of current knowledge about the use of beans in both animal models and patients with Parkinson's disease (PD). The potential beneficial effects of beans in PD are increasingly being touted, not only in scientific journals but also by the lay media. While there is a long tradition in Ayurvedic medicine of prescribing extracts from Mucuna pruriens (MP), whose seeds contain 5% L-3,4-dihydroxyphenylalanin (L-DOPA), many other beans also contain L-DOPA (broad beans, common beans, and soybeans) or have other ingredients (coffee and cocoa) that may bene...
Source: Parkinsons Disease - November 30, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Occupational Therapy for Parkinsonian Patients: A Retrospective Study.
Authors: Franciotta M, Maestri R, Ortelli P, Ferrazzoli D, Mastalli F, Frazzitta G Abstract Background: Hand functionality and finger dexterity are impaired in patients with Parkinson's disease (PD). These disturbances lead to a dependency in activities of daily living (ADL) and poor quality of life (QoL). Objective: We aimed to evaluate whether a specific occupational therapy (OT) program is effective in improving finger and hand dexterity and its impact on ADL in PD patients. Methods: We retrospectively studied PD patients, hospitalized for a 4-week multidisciplinary intensive rehabilitation treatment (MI...
Source: Parkinsons Disease - November 30, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Patterns and Determinants of Prescribing for Parkinson's Disease: A Systematic Literature Review.
In conclusion, L-dopa is now the most commonly prescribed medication for cases of PD but there is large variation in the prescribing rates of catechol-O-methyltransferase (COMT) inhibitors, monoamine oxidase B (MAO-B) inhibitors, amantadine, and anticholinergics between countries. New studies examining the effects of recent clinical trials and measuring the prescribing rates of newly approved medications are warranted. PMID: 31781365 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - November 30, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Gait in Parkinson's Disease.
Authors: Martinez-Ramirez D, Rodriguez-Violante M, Ramirez-Zamora A PMID: 31772732 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - November 29, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Early Postural Instability in Parkinson's Disease: A Biomechanical Analysis of the Pull Test.
In conclusion, patients in the early stages of PD already exhibit a degree of postural instability due to inefficient postural adjustments, and they can more easily be destabilized by small perturbations than healthy subjects. This balance impairment becomes more pronounced in more advanced PD. In the pull test, pull force to step back should be a variable to consider when testing balance in clinical practice. PMID: 31772733 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - November 29, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Improvement of Subthalamic Nucleus Deep Brain Stimulation in Sleeping Symptoms in Parkinson's Disease: A Meta-Analysis.
Conclusions: STN DBS is a powerful method in the management of sleep quality and restless leg symptoms in PD patients, but its long-term effects with larger populations must be thoroughly assessed. PMID: 31687125 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - November 8, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Subthalamic Nucleus Stimulation Does Not Have Any Acute Effects on Verbal Fluency or on Speed of Word Generation in Parkinson's Disease.
Conclusion: In conclusion, (i) acute STN-DBS manipulation did not alter either verbal fluency performance or the time pattern of word generation and (ii) external cueing significantly improved verbal fluency performance both with STN-DBS On and Off. PMID: 31687126 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - November 8, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research

Trait Impulsivity Is Independent of Mild Cognitive Impairment in a Parkinson's Disease Cohort.
Conclusions: These findings suggest that impulsive traits and behaviors are independent of changes in cognitive state and are not altered in PD patients with mild cognitive impairment. PMID: 31662842 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - October 31, 2019 Category: Neurology Tags: Parkinsons Dis Source Type: research