Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life
Parkinsons Dis. 2021 May 13;2021:8871549. doi: 10.1155/2021/8871549. eCollection 2021.ABSTRACTINTRODUCTION: In a degenerative disorder such as Parkinson's disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr's motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the disability and the patient's quality of life (QoL) with regard to a defined clinical stage.MATERIALS AND METHODS: Cross-sectional study in which 603 PD patients f...
Source: Parkinsons Disease - June 7, 2021 Category: Neurology Authors: D Santos Garc ía T De Deus Fonticoba J M Paz Gonz ález C Cores Bartolom é L Vald és Aymerich J G Mu ñoz Enríquez E Su árez S Jes ús M Aguilar P Pastor L L Planellas M Cosgaya J Garc ía Caldentey N Caballol I Legarda J Hern ández Vara I Cabo L L Source Type: research

Validation of the Parkinson's Disease Caregiver Burden Questionnaire in Progressive Supranuclear Palsy
This study aims to validate the Parkinson's disease caregiver burden questionnaire (PDCB) as a specific measure of caregiver burden in PSP. PSP patients were assessed by the PSP rating scale, PSP quality-of-life questionnaire (PSP-QoL), Montreal cognitive assessment test (MoCA), and geriatric depression scale (GDS-15). Caregivers filled out the short form 36-health survey, GDS-15, PDCB, and the caregiver burden inventory (CBI). 22 patient caregiver pairs completed the study. PDCB showed a highly significant correlation with the CBI (r 0.911; p
Source: Parkinsons Disease - May 28, 2021 Category: Neurology Authors: Martin Klietz Hannah V Eichel Selma Staege Anna Kutschenko Gesine Respondek Meret K Huber Stephan Greten G ünter U Höglinger Florian Wegner Source Type: research

Transcranial Sonography of the Substantia Nigra for the Differential Diagnosis of Parkinson's Disease and Other Movement Disorders: A Meta-Analysis
Parkinsons Dis. 2021 Apr 30;2021:8891874. doi: 10.1155/2021/8891874. eCollection 2021.ABSTRACTThis meta-analysis aimed to evaluate the accuracy of hyperechogenicity of the substantia nigra (SN) for the differential diagnosis of Parkinson's disease (PD) and other movement disorders. We systematically searched the PubMed, EMBASE, Cochrane Library, and China National Knowledge Infrastructure databases for relevant studies published between January 2015 and May 2020. Eligible articles comparing the echogenicity of the SN between patients with PD and those with other movement disorders were screened, and two independent reviewe...
Source: Parkinsons Disease - May 19, 2021 Category: Neurology Authors: Yan-Liang Mei Jing Yang Zheng-Rong Wu Ying Yang Yu-Ming Xu Source Type: research

Impact of Progression of Parkinson's Disease on Swallowing Ability and Oral Environment
This study investigated the impact of the severity and treatment of Parkinson's disease (PD) on the swallowing ability and oral environment of patients. Swallowing dysfunction increases the aspiration risk and may lead to poor oral health among patients with PD. We investigated the influences of PD progression and drug treatment on the swallowing ability and oral environment using simple noninvasive screening measurements. We recruited 87 patients with PD (mean age, 71.9 ± 8.0 years; mean Hoehn and Yahr score, 2.9 ± 0.9). The PD condition was assessed in each patient using the unified Parkinson's disease rati...
Source: Parkinsons Disease - May 13, 2021 Category: Neurology Authors: George Umemoto Shinsuke Fujioka Yasuyuki Iwasa Yoshie Ozaki Kayoko Koga Kazumi Nishimura Yoshio Tsuboi Source Type: research

Quantitative Analysis of Postural Instability in Patients with Parkinson's Disease
This study trial was registered with the Chinese Clinical Trial Registry (no. ChiCTR1900022715).RESULTS: All participants were able to complete the limit of stability tasks without any complications. Patients in stages II to IV exhibited smaller end point excursion and slower time to complete than controls, suggesting an impaired limit of stability. The patients in stage II exhibited a remarkable decline in most directions compared to controls, except for right and left, and forward and backward decline occurred the earliest. For patients in stage III, right was the only direction with no significant difference from contro...
Source: Parkinsons Disease - May 3, 2021 Category: Neurology Authors: Yang Yu Siquan Liang Yue Wang Yanan Zhao Jiaojiao Zhao Haitao Li Jingchao Wu Yuanyuan Cheng Fan Wu Jialing Wu Source Type: research

Use of a Smartphone to Gather Parkinson's Disease Neurological Vital Signs during the COVID-19 Pandemic
Parkinsons Dis. 2021 Apr 8;2021:5534282. doi: 10.1155/2021/5534282. eCollection 2021.ABSTRACTINTRODUCTION: To overcome travel restrictions during the COVID-19 pandemic, consumer-based technology was rapidly deployed to the smartphones of individuals with Parkinson's disease (PD) participating in a 12-month exercise trial. The aim of the project was to determine the feasibility of utilizing a combined synchronous and asynchronous self-administered smartphone application to characterize PD symptoms.METHODS: A synchronous video virtual visit was completed for the administration of virtual Movement Disorder Society-Unified Par...
Source: Parkinsons Disease - April 19, 2021 Category: Neurology Authors: Jay L Alberts Mandy Miller Koop Marisa P McGinley Amanda L Penko Hubert H Fernandez Steven Shook Robert A Bermel Andr é Machado Anson B Rosenfeldt Source Type: research

Progression of Nonmotor Symptoms in Parkinson's Disease by Sex and Motor Laterality
In conclusion, males experienced increased NMS burden in Parkinson's disease. Laterality of motor symptoms did not significantly influence NMS progression, except anxious mood. We analyzed NMS in a large cohort of PD patients, and these data are valuable to improve PD patients' quality of life by therapeutically alleviating nonmotor symptoms.PMID:33868631 | PMC:PMC8035033 | DOI:10.1155/2021/8898887 (Source: Parkinsons Disease)
Source: Parkinsons Disease - April 19, 2021 Category: Neurology Authors: Zimple Kurlawala Paul H Shadowen Joseph D McMillan Levi J Beverly Robert P Friedland Source Type: research

Use of a Smartphone to Gather Parkinson's Disease Neurological Vital Signs during the COVID-19 Pandemic
Parkinsons Dis. 2021 Apr 8;2021:5534282. doi: 10.1155/2021/5534282. eCollection 2021.ABSTRACTINTRODUCTION: To overcome travel restrictions during the COVID-19 pandemic, consumer-based technology was rapidly deployed to the smartphones of individuals with Parkinson's disease (PD) participating in a 12-month exercise trial. The aim of the project was to determine the feasibility of utilizing a combined synchronous and asynchronous self-administered smartphone application to characterize PD symptoms.METHODS: A synchronous video virtual visit was completed for the administration of virtual Movement Disorder Society-Unified Par...
Source: Parkinsons Disease - April 19, 2021 Category: Neurology Authors: Jay L Alberts Mandy Miller Koop Marisa P McGinley Amanda L Penko Hubert H Fernandez Steven Shook Robert A Bermel Andr é Machado Anson B Rosenfeldt Source Type: research

Progression of Nonmotor Symptoms in Parkinson's Disease by Sex and Motor Laterality
In conclusion, males experienced increased NMS burden in Parkinson's disease. Laterality of motor symptoms did not significantly influence NMS progression, except anxious mood. We analyzed NMS in a large cohort of PD patients, and these data are valuable to improve PD patients' quality of life by therapeutically alleviating nonmotor symptoms.PMID:33868631 | PMC:PMC8035033 | DOI:10.1155/2021/8898887 (Source: Parkinsons Disease)
Source: Parkinsons Disease - April 19, 2021 Category: Neurology Authors: Zimple Kurlawala Paul H Shadowen Joseph D McMillan Levi J Beverly Robert P Friedland Source Type: research

Use of a Smartphone to Gather Parkinson's Disease Neurological Vital Signs during the COVID-19 Pandemic
Parkinsons Dis. 2021 Apr 8;2021:5534282. doi: 10.1155/2021/5534282. eCollection 2021.ABSTRACTINTRODUCTION: To overcome travel restrictions during the COVID-19 pandemic, consumer-based technology was rapidly deployed to the smartphones of individuals with Parkinson's disease (PD) participating in a 12-month exercise trial. The aim of the project was to determine the feasibility of utilizing a combined synchronous and asynchronous self-administered smartphone application to characterize PD symptoms.METHODS: A synchronous video virtual visit was completed for the administration of virtual Movement Disorder Society-Unified Par...
Source: Parkinsons Disease - April 19, 2021 Category: Neurology Authors: Jay L Alberts Mandy Miller Koop Marisa P McGinley Amanda L Penko Hubert H Fernandez Steven Shook Robert A Bermel Andr é Machado Anson B Rosenfeldt Source Type: research

Progression of Nonmotor Symptoms in Parkinson's Disease by Sex and Motor Laterality
In conclusion, males experienced increased NMS burden in Parkinson's disease. Laterality of motor symptoms did not significantly influence NMS progression, except anxious mood. We analyzed NMS in a large cohort of PD patients, and these data are valuable to improve PD patients' quality of life by therapeutically alleviating nonmotor symptoms.PMID:33868631 | PMC:PMC8035033 | DOI:10.1155/2021/8898887 (Source: Parkinsons Disease)
Source: Parkinsons Disease - April 19, 2021 Category: Neurology Authors: Zimple Kurlawala Paul H Shadowen Joseph D McMillan Levi J Beverly Robert P Friedland Source Type: research

Use of a Smartphone to Gather Parkinson's Disease Neurological Vital Signs during the COVID-19 Pandemic
Parkinsons Dis. 2021 Apr 8;2021:5534282. doi: 10.1155/2021/5534282. eCollection 2021.ABSTRACTINTRODUCTION: To overcome travel restrictions during the COVID-19 pandemic, consumer-based technology was rapidly deployed to the smartphones of individuals with Parkinson's disease (PD) participating in a 12-month exercise trial. The aim of the project was to determine the feasibility of utilizing a combined synchronous and asynchronous self-administered smartphone application to characterize PD symptoms.METHODS: A synchronous video virtual visit was completed for the administration of virtual Movement Disorder Society-Unified Par...
Source: Parkinsons Disease - April 19, 2021 Category: Neurology Authors: Jay L Alberts Mandy Miller Koop Marisa P McGinley Amanda L Penko Hubert H Fernandez Steven Shook Robert A Bermel Andr é Machado Anson B Rosenfeldt Source Type: research

Progression of Nonmotor Symptoms in Parkinson's Disease by Sex and Motor Laterality
In conclusion, males experienced increased NMS burden in Parkinson's disease. Laterality of motor symptoms did not significantly influence NMS progression, except anxious mood. We analyzed NMS in a large cohort of PD patients, and these data are valuable to improve PD patients' quality of life by therapeutically alleviating nonmotor symptoms.PMID:33868631 | PMC:PMC8035033 | DOI:10.1155/2021/8898887 (Source: Parkinsons Disease)
Source: Parkinsons Disease - April 19, 2021 Category: Neurology Authors: Zimple Kurlawala Paul H Shadowen Joseph D McMillan Levi J Beverly Robert P Friedland Source Type: research

Use of a Smartphone to Gather Parkinson's Disease Neurological Vital Signs during the COVID-19 Pandemic
Parkinsons Dis. 2021 Apr 8;2021:5534282. doi: 10.1155/2021/5534282. eCollection 2021.ABSTRACTINTRODUCTION: To overcome travel restrictions during the COVID-19 pandemic, consumer-based technology was rapidly deployed to the smartphones of individuals with Parkinson's disease (PD) participating in a 12-month exercise trial. The aim of the project was to determine the feasibility of utilizing a combined synchronous and asynchronous self-administered smartphone application to characterize PD symptoms.METHODS: A synchronous video virtual visit was completed for the administration of virtual Movement Disorder Society-Unified Par...
Source: Parkinsons Disease - April 19, 2021 Category: Neurology Authors: Jay L Alberts Mandy Miller Koop Marisa P McGinley Amanda L Penko Hubert H Fernandez Steven Shook Robert A Bermel Andr é Machado Anson B Rosenfeldt Source Type: research

Progression of Nonmotor Symptoms in Parkinson's Disease by Sex and Motor Laterality
In conclusion, males experienced increased NMS burden in Parkinson's disease. Laterality of motor symptoms did not significantly influence NMS progression, except anxious mood. We analyzed NMS in a large cohort of PD patients, and these data are valuable to improve PD patients' quality of life by therapeutically alleviating nonmotor symptoms.PMID:33868631 | PMC:PMC8035033 | DOI:10.1155/2021/8898887 (Source: Parkinsons Disease)
Source: Parkinsons Disease - April 19, 2021 Category: Neurology Authors: Zimple Kurlawala Paul H Shadowen Joseph D McMillan Levi J Beverly Robert P Friedland Source Type: research

Use of a Smartphone to Gather Parkinson's Disease Neurological Vital Signs during the COVID-19 Pandemic
Parkinsons Dis. 2021 Apr 8;2021:5534282. doi: 10.1155/2021/5534282. eCollection 2021.ABSTRACTINTRODUCTION: To overcome travel restrictions during the COVID-19 pandemic, consumer-based technology was rapidly deployed to the smartphones of individuals with Parkinson's disease (PD) participating in a 12-month exercise trial. The aim of the project was to determine the feasibility of utilizing a combined synchronous and asynchronous self-administered smartphone application to characterize PD symptoms.METHODS: A synchronous video virtual visit was completed for the administration of virtual Movement Disorder Society-Unified Par...
Source: Parkinsons Disease - April 19, 2021 Category: Neurology Authors: Jay L Alberts Mandy Miller Koop Marisa P McGinley Amanda L Penko Hubert H Fernandez Steven Shook Robert A Bermel Andr é Machado Anson B Rosenfeldt Source Type: research

Progression of Nonmotor Symptoms in Parkinson's Disease by Sex and Motor Laterality
In conclusion, males experienced increased NMS burden in Parkinson's disease. Laterality of motor symptoms did not significantly influence NMS progression, except anxious mood. We analyzed NMS in a large cohort of PD patients, and these data are valuable to improve PD patients' quality of life by therapeutically alleviating nonmotor symptoms.PMID:33868631 | PMC:PMC8035033 | DOI:10.1155/2021/8898887 (Source: Parkinsons Disease)
Source: Parkinsons Disease - April 19, 2021 Category: Neurology Authors: Zimple Kurlawala Paul H Shadowen Joseph D McMillan Levi J Beverly Robert P Friedland Source Type: research

Use of a Smartphone to Gather Parkinson's Disease Neurological Vital Signs during the COVID-19 Pandemic
Parkinsons Dis. 2021 Apr 8;2021:5534282. doi: 10.1155/2021/5534282. eCollection 2021.ABSTRACTINTRODUCTION: To overcome travel restrictions during the COVID-19 pandemic, consumer-based technology was rapidly deployed to the smartphones of individuals with Parkinson's disease (PD) participating in a 12-month exercise trial. The aim of the project was to determine the feasibility of utilizing a combined synchronous and asynchronous self-administered smartphone application to characterize PD symptoms.METHODS: A synchronous video virtual visit was completed for the administration of virtual Movement Disorder Society-Unified Par...
Source: Parkinsons Disease - April 19, 2021 Category: Neurology Authors: Jay L Alberts Mandy Miller Koop Marisa P McGinley Amanda L Penko Hubert H Fernandez Steven Shook Robert A Bermel Andr é Machado Anson B Rosenfeldt Source Type: research

Progression of Nonmotor Symptoms in Parkinson's Disease by Sex and Motor Laterality
In conclusion, males experienced increased NMS burden in Parkinson's disease. Laterality of motor symptoms did not significantly influence NMS progression, except anxious mood. We analyzed NMS in a large cohort of PD patients, and these data are valuable to improve PD patients' quality of life by therapeutically alleviating nonmotor symptoms.PMID:33868631 | PMC:PMC8035033 | DOI:10.1155/2021/8898887 (Source: Parkinsons Disease)
Source: Parkinsons Disease - April 19, 2021 Category: Neurology Authors: Zimple Kurlawala Paul H Shadowen Joseph D McMillan Levi J Beverly Robert P Friedland Source Type: research

Use of a Smartphone to Gather Parkinson's Disease Neurological Vital Signs during the COVID-19 Pandemic
Parkinsons Dis. 2021 Apr 8;2021:5534282. doi: 10.1155/2021/5534282. eCollection 2021.ABSTRACTINTRODUCTION: To overcome travel restrictions during the COVID-19 pandemic, consumer-based technology was rapidly deployed to the smartphones of individuals with Parkinson's disease (PD) participating in a 12-month exercise trial. The aim of the project was to determine the feasibility of utilizing a combined synchronous and asynchronous self-administered smartphone application to characterize PD symptoms.METHODS: A synchronous video virtual visit was completed for the administration of virtual Movement Disorder Society-Unified Par...
Source: Parkinsons Disease - April 19, 2021 Category: Neurology Authors: Jay L Alberts Mandy Miller Koop Marisa P McGinley Amanda L Penko Hubert H Fernandez Steven Shook Robert A Bermel Andr é Machado Anson B Rosenfeldt Source Type: research

Progression of Nonmotor Symptoms in Parkinson's Disease by Sex and Motor Laterality
In conclusion, males experienced increased NMS burden in Parkinson's disease. Laterality of motor symptoms did not significantly influence NMS progression, except anxious mood. We analyzed NMS in a large cohort of PD patients, and these data are valuable to improve PD patients' quality of life by therapeutically alleviating nonmotor symptoms.PMID:33868631 | PMC:PMC8035033 | DOI:10.1155/2021/8898887 (Source: Parkinsons Disease)
Source: Parkinsons Disease - April 19, 2021 Category: Neurology Authors: Zimple Kurlawala Paul H Shadowen Joseph D McMillan Levi J Beverly Robert P Friedland Source Type: research

Use of a Smartphone to Gather Parkinson's Disease Neurological Vital Signs during the COVID-19 Pandemic
Parkinsons Dis. 2021 Apr 8;2021:5534282. doi: 10.1155/2021/5534282. eCollection 2021.ABSTRACTINTRODUCTION: To overcome travel restrictions during the COVID-19 pandemic, consumer-based technology was rapidly deployed to the smartphones of individuals with Parkinson's disease (PD) participating in a 12-month exercise trial. The aim of the project was to determine the feasibility of utilizing a combined synchronous and asynchronous self-administered smartphone application to characterize PD symptoms.METHODS: A synchronous video virtual visit was completed for the administration of virtual Movement Disorder Society-Unified Par...
Source: Parkinsons Disease - April 19, 2021 Category: Neurology Authors: Jay L Alberts Mandy Miller Koop Marisa P McGinley Amanda L Penko Hubert H Fernandez Steven Shook Robert A Bermel Andr é Machado Anson B Rosenfeldt Source Type: research

Progression of Nonmotor Symptoms in Parkinson's Disease by Sex and Motor Laterality
In conclusion, males experienced increased NMS burden in Parkinson's disease. Laterality of motor symptoms did not significantly influence NMS progression, except anxious mood. We analyzed NMS in a large cohort of PD patients, and these data are valuable to improve PD patients' quality of life by therapeutically alleviating nonmotor symptoms.PMID:33868631 | PMC:PMC8035033 | DOI:10.1155/2021/8898887 (Source: Parkinsons Disease)
Source: Parkinsons Disease - April 19, 2021 Category: Neurology Authors: Zimple Kurlawala Paul H Shadowen Joseph D McMillan Levi J Beverly Robert P Friedland Source Type: research