Pharmacological Studies on the Ca < sup > 2+ < /sup > Influx Pathways in Platelet-Activating Factor (PAF)-Induced Mouse Urinary Bladder Smooth Muscle Contraction
In this study, we examined the Ca2+ influx pathways involved in PAF-induced BTI and OC in the mouse UBSM. PAF (10-6 M) induced BTI and OC in mouse UBSM. However, the PAF-induced BTI and OC were completely suppressed by extracellular Ca2+ removal. PAF-induced BTI and OC frequencies were markedly suppressed by voltage-dependent Ca2+ channel (VDCC) inhibitors (verapamil (10-5 M), diltiazem (10-5 M), and nifedipine (10-7 M)). However, these VDCC inhibitors had a minor effect on the PAF-induced OC amplitude. The PAF-induced OC amplitude in the presence of verapamil (10-5 M) was strongly suppressed by SKF-96365 (3 × 10-5 M), an...
Source: Biological and Pharmaceutical Bulletin - July 2, 2023 Category: Drugs & Pharmacology Authors: Ge Liu Keisuke Obara Kento Yoshioka Yoshio Tanaka Source Type: research
Continuous Monitoring of the Hydration Behavior of Hydrophilic Matrix Tablets Using Time-Domain NMR
Chem Pharm Bull (Tokyo). 2023;71(7):576-583. doi: 10.1248/cpb.c23-00214.ABSTRACTTime-domain NMR (TD-NMR) was used for continuous monitoring of the hydration behavior of hydrophilic matrix tablets. The model matrix tablets comprised high molecular weight polyethylene oxide (PEO), hydroxypropyl methylcellulose (HPMC), and polyethylene glycol (PEG). The model tablets were immersed in water. Their T2 relaxation curves were acquired by TD-NMR with solid-echo sequence. A curve-fitting analysis was conducted on the acquired T2 relaxation curves to identify the NMR signals corresponding to the nongelated core remaining in the samp...
Source: Chemical and Pharmaceutical Bulletin - July 2, 2023 Category: Drugs & Pharmacology Authors: Takahiro Tsuji Takashi Ono Hiromu Taguchi Kok Hoong Leong Yoshihiro Hayashi Shungo Kumada Kotaro Okada Yoshinori Onuki Source Type: research
Pharmacological Studies on the Ca < sup > 2+ < /sup > Influx Pathways in Platelet-Activating Factor (PAF)-Induced Mouse Urinary Bladder Smooth Muscle Contraction
In this study, we examined the Ca2+ influx pathways involved in PAF-induced BTI and OC in the mouse UBSM. PAF (10-6 M) induced BTI and OC in mouse UBSM. However, the PAF-induced BTI and OC were completely suppressed by extracellular Ca2+ removal. PAF-induced BTI and OC frequencies were markedly suppressed by voltage-dependent Ca2+ channel (VDCC) inhibitors (verapamil (10-5 M), diltiazem (10-5 M), and nifedipine (10-7 M)). However, these VDCC inhibitors had a minor effect on the PAF-induced OC amplitude. The PAF-induced OC amplitude in the presence of verapamil (10-5 M) was strongly suppressed by SKF-96365 (3 × 10-5 M), an...
Source: Biological and Pharmaceutical Bulletin - July 2, 2023 Category: Drugs & Pharmacology Authors: Ge Liu Keisuke Obara Kento Yoshioka Yoshio Tanaka Source Type: research
Continuous Monitoring of the Hydration Behavior of Hydrophilic Matrix Tablets Using Time-Domain NMR
Chem Pharm Bull (Tokyo). 2023;71(7):576-583. doi: 10.1248/cpb.c23-00214.ABSTRACTTime-domain NMR (TD-NMR) was used for continuous monitoring of the hydration behavior of hydrophilic matrix tablets. The model matrix tablets comprised high molecular weight polyethylene oxide (PEO), hydroxypropyl methylcellulose (HPMC), and polyethylene glycol (PEG). The model tablets were immersed in water. Their T2 relaxation curves were acquired by TD-NMR with solid-echo sequence. A curve-fitting analysis was conducted on the acquired T2 relaxation curves to identify the NMR signals corresponding to the nongelated core remaining in the samp...
Source: Chemical and Pharmaceutical Bulletin - July 2, 2023 Category: Drugs & Pharmacology Authors: Takahiro Tsuji Takashi Ono Hiromu Taguchi Kok Hoong Leong Yoshihiro Hayashi Shungo Kumada Kotaro Okada Yoshinori Onuki Source Type: research
Pharmacological Studies on the Ca < sup > 2+ < /sup > Influx Pathways in Platelet-Activating Factor (PAF)-Induced Mouse Urinary Bladder Smooth Muscle Contraction
In this study, we examined the Ca2+ influx pathways involved in PAF-induced BTI and OC in the mouse UBSM. PAF (10-6 M) induced BTI and OC in mouse UBSM. However, the PAF-induced BTI and OC were completely suppressed by extracellular Ca2+ removal. PAF-induced BTI and OC frequencies were markedly suppressed by voltage-dependent Ca2+ channel (VDCC) inhibitors (verapamil (10-5 M), diltiazem (10-5 M), and nifedipine (10-7 M)). However, these VDCC inhibitors had a minor effect on the PAF-induced OC amplitude. The PAF-induced OC amplitude in the presence of verapamil (10-5 M) was strongly suppressed by SKF-96365 (3 × 10-5 M), an...
Source: Biological and Pharmaceutical Bulletin - July 2, 2023 Category: Drugs & Pharmacology Authors: Ge Liu Keisuke Obara Kento Yoshioka Yoshio Tanaka Source Type: research
Continuous Monitoring of the Hydration Behavior of Hydrophilic Matrix Tablets Using Time-Domain NMR
Chem Pharm Bull (Tokyo). 2023;71(7):576-583. doi: 10.1248/cpb.c23-00214.ABSTRACTTime-domain NMR (TD-NMR) was used for continuous monitoring of the hydration behavior of hydrophilic matrix tablets. The model matrix tablets comprised high molecular weight polyethylene oxide (PEO), hydroxypropyl methylcellulose (HPMC), and polyethylene glycol (PEG). The model tablets were immersed in water. Their T2 relaxation curves were acquired by TD-NMR with solid-echo sequence. A curve-fitting analysis was conducted on the acquired T2 relaxation curves to identify the NMR signals corresponding to the nongelated core remaining in the samp...
Source: Chemical and Pharmaceutical Bulletin - July 2, 2023 Category: Drugs & Pharmacology Authors: Takahiro Tsuji Takashi Ono Hiromu Taguchi Kok Hoong Leong Yoshihiro Hayashi Shungo Kumada Kotaro Okada Yoshinori Onuki Source Type: research
Continuous Monitoring of the Hydration Behavior of Hydrophilic Matrix Tablets Using Time-Domain NMR
Chem Pharm Bull (Tokyo). 2023;71(7):576-583. doi: 10.1248/cpb.c23-00214.ABSTRACTTime-domain NMR (TD-NMR) was used for continuous monitoring of the hydration behavior of hydrophilic matrix tablets. The model matrix tablets comprised high molecular weight polyethylene oxide (PEO), hydroxypropyl methylcellulose (HPMC), and polyethylene glycol (PEG). The model tablets were immersed in water. Their T2 relaxation curves were acquired by TD-NMR with solid-echo sequence. A curve-fitting analysis was conducted on the acquired T2 relaxation curves to identify the NMR signals corresponding to the nongelated core remaining in the samp...
Source: Chemical and Pharmaceutical Bulletin - July 2, 2023 Category: Drugs & Pharmacology Authors: Takahiro Tsuji Takashi Ono Hiromu Taguchi Kok Hoong Leong Yoshihiro Hayashi Shungo Kumada Kotaro Okada Yoshinori Onuki Source Type: research
Continuous Monitoring of the Hydration Behavior of Hydrophilic Matrix Tablets Using Time-Domain NMR
Chem Pharm Bull (Tokyo). 2023;71(7):576-583. doi: 10.1248/cpb.c23-00214.ABSTRACTTime-domain NMR (TD-NMR) was used for continuous monitoring of the hydration behavior of hydrophilic matrix tablets. The model matrix tablets comprised high molecular weight polyethylene oxide (PEO), hydroxypropyl methylcellulose (HPMC), and polyethylene glycol (PEG). The model tablets were immersed in water. Their T2 relaxation curves were acquired by TD-NMR with solid-echo sequence. A curve-fitting analysis was conducted on the acquired T2 relaxation curves to identify the NMR signals corresponding to the nongelated core remaining in the samp...
Source: Chemical and Pharmaceutical Bulletin - July 2, 2023 Category: Drugs & Pharmacology Authors: Takahiro Tsuji Takashi Ono Hiromu Taguchi Kok Hoong Leong Yoshihiro Hayashi Shungo Kumada Kotaro Okada Yoshinori Onuki Source Type: research
Atrial fibrillation induced by gabapentin: a case report
ConclusionWith rapidly increasing usage of gabapentin for approved and off-label indications, it is important to identify unintended adverse effects of this drug as they are considered safe alternatives to opioids. New-onset atrial fibrillation could be induced by gabapentin in young individuals. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - June 9, 2023 Category: General Medicine Source Type: research
Prevalence and bleeding risk associated with the concomitant use of direct oral anticoagulants and antiarrhythmic drugs in patients with atrial fibrillation, based on the French healthcare insurance database
ConclusionExposure to antiarrhythmic drugs was not associated with an increased risk of hospitalization for bleeding in patients with AF under rivaroxaban or apixaban. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - May 15, 2023 Category: Drugs & Pharmacology Source Type: research
Association of Nondihydropyridine Calcium Channel Blockers Versus β-Adrenergic Receptor Blockers With Risk of Heart Failure Hospitalization
Heart failure (HF) with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) are interrelated and often coexisting conditions in older adults. Although equally recommended, nondihydropyridine calcium channel blockers (non-DHP CCBs), such as diltiazem and verapamil, are less often used than β blockers. Because recent studies suggested that β-blocker use in both HFpEF and AF may increase the risk for HF, we tested whether non-DHP CCBs were associated with lower HF hospitalization risk than β blockers. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 5, 2023 Category: Cardiology Authors: Markus Meyer, James B. Wetmore, Eric D. Weinhandl, Nicholas S. Roetker Source Type: research
Assessment of wastewater-borne pharmaceuticals in tissues and body fluids from riverine fish
Environ Pollut. 2023 Feb 27:121374. doi: 10.1016/j.envpol.2023.121374. Online ahead of print.ABSTRACTRiverine fish in densely populated areas is constantly exposed to wastewater-borne contaminants from effluent discharges. These can enter the organism through the skin, gills or by ingestion. Whereas most studies assessing the contaminant burden in exposed fish have focused either on muscle or a limited set of tissues. Here we set out to generate a more comprehensive overview of the distribution of pollutants across tissues by analyzing a panel of matrices including liver, kidney, skin, brain, muscle, heart, plasma and bile...
Source: Environmental Pollution - March 1, 2023 Category: Environmental Health Authors: D P Manjarr és-López J M Pe ña-Herrera L Benejam N Montemurro S P érez Source Type: research
[ASAP] Structural Dynamics-Driven Discovery of Anticancer and Antimetastatic Effects of Diltiazem and Glibenclamide Targeting Urokinase Receptor
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c01663 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - February 28, 2023 Category: Chemistry Authors: Yang Zhou, Meiru Song, Daoqing Xie, Shufeng Yan, Shujuan Yu, Song Xie, Meiqin Cai, Hanlin Li, Le Shang, Longguang Jiang, Cai Yuan, Mingdong Huang, Jinyu Li, and Peng Xu Source Type: research
Sensors, Vol. 23, Pages 2527: Different Ventricular Fibrillation Types in Low-Dimensional Latent Spaces
This study confirms that latent variables are better VF descriptors than conventional time or domain features, making this technique useful in current VF research on elucidation of the underlying VF mechanisms. (Source: Sensors)
Source: Sensors - February 24, 2023 Category: Biotechnology Authors: Carlos Pa úl Bernal Oñate Francisco-Manuel Melgarejo Meseguer Enrique V. Carrera Juan Jos é Sánchez Muñoz Arcadi Garc ía Alberola Jos é Luis Rojo Álvarez Tags: Article Source Type: research
Pharmaceutical active compounds in a heavily industrialized and urbanized bay, Eastern China
Environ Sci Pollut Res Int. 2023 Feb 22. doi: 10.1007/s11356-023-26019-z. Online ahead of print.ABSTRACTBays are transition zones connecting freshwater ecosystems and marine ecosystems, and they are strongly influenced by intensive human activities. Pharmaceuticals are of concern in bay aquatic environments because of their potential threat to marine food web. We studied the occurrence, spatial distribution, and ecological risks of 34 pharmaceutical active compounds (PhACs) in Xiangshan Bay, a heavily industrialized and urbanized area in Zhejiang Province, Eastern China. PhACs were ubiquitously detected in the coastal wate...
Source: Environmental Science and Pollution Research International - February 22, 2023 Category: Environmental Health Authors: Jing Sun Ziyan Ke Yujie Zhang Qin Wu Yihua Chen Jianfeng Tang Source Type: research
