Recurrent syncope due to ischemia with non-obstructive coronary artery disease: a case report
ConclusionThis study highlights the importance of considering ischemia with non-obstructive coronary artery disease as a potential cause of syncope in the differential diagnosis. It emphasizes the need for early diagnosis of ischemia with non-obstructive coronary artery disease to facilitate more effective management strategies. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 12, 2024 Category: General Medicine Source Type: research
Efficacy and Safety of Prehospital Diltiazem
Conclusions: Prehospital diltiazem is effective and safe for most patients. Adverse events are more likely in patients with baseline SBP less than 140 mmHg, HR less than 120 beats per minute, and concurrent nitroglycerin administration. Future opportunities for research include examining the relationship between adverse events and underlying etiology as well as investigating downstream outcomes.PMID:38436598 | DOI:10.1080/10903127.2024.2326598 (Source: Prehospital Emergency Care)
Source: Prehospital Emergency Care - March 4, 2024 Category: Endocrinology Authors: Ellen Pil Matthew Levy Timothy Chizmar Ruben Troncoso Eric Garfinkel Asa Margolis Source Type: research
SERCA-1 conformational change exerted by the Ca < sup > 2+ < /sup > -channel blocker diltiazem affects mammalian skeletal muscle function
Cell Calcium. 2024 Feb 8;119:102852. doi: 10.1016/j.ceca.2024.102852. Online ahead of print.ABSTRACTIn skeletal muscle (SM), inward Ca2+-currents have no apparent role in excitation-contraction coupling (e-c coupling), however the Ca2+-channel blocker can affect twitch and tetanic muscle in mammalian SM. Experiments were conducted to study how diltiazem (DLZ) facilitates e-c coupling and inhibits contraction. 1) In complete Extensor Digitorum Longus (EDL) muscle and single intact fibres, 0.03 mM DLZ causes twitch potentiation and decreases force during tetanic activity, with increased fatigue. 2) In split open fibres isola...
Source: Cell Calcium - February 27, 2024 Category: Cytology Authors: Aura Jim énez-Garduño Ibrahim Ramirez-Soto Ileana Miranda-Rodr íguez Sof ía Gitler Alicia Ortega Source Type: research
SERCA-1 conformational change exerted by the Ca < sup > 2+ < /sup > -channel blocker diltiazem affects mammalian skeletal muscle function
Cell Calcium. 2024 Feb 8;119:102852. doi: 10.1016/j.ceca.2024.102852. Online ahead of print.ABSTRACTIn skeletal muscle (SM), inward Ca2+-currents have no apparent role in excitation-contraction coupling (e-c coupling), however the Ca2+-channel blocker can affect twitch and tetanic muscle in mammalian SM. Experiments were conducted to study how diltiazem (DLZ) facilitates e-c coupling and inhibits contraction. 1) In complete Extensor Digitorum Longus (EDL) muscle and single intact fibres, 0.03 mM DLZ causes twitch potentiation and decreases force during tetanic activity, with increased fatigue. 2) In split open fibres isola...
Source: Cell Calcium - February 27, 2024 Category: Cytology Authors: Aura Jim énez-Garduño Ibrahim Ramirez-Soto Ileana Miranda-Rodr íguez Sof ía Gitler Alicia Ortega Source Type: research
SERCA-1 conformational change exerted by the Ca < sup > 2+ < /sup > -channel blocker diltiazem affects mammalian skeletal muscle function
Cell Calcium. 2024 Feb 8;119:102852. doi: 10.1016/j.ceca.2024.102852. Online ahead of print.ABSTRACTIn skeletal muscle (SM), inward Ca2+-currents have no apparent role in excitation-contraction coupling (e-c coupling), however the Ca2+-channel blocker can affect twitch and tetanic muscle in mammalian SM. Experiments were conducted to study how diltiazem (DLZ) facilitates e-c coupling and inhibits contraction. 1) In complete Extensor Digitorum Longus (EDL) muscle and single intact fibres, 0.03 mM DLZ causes twitch potentiation and decreases force during tetanic activity, with increased fatigue. 2) In split open fibres isola...
Source: Cell Calcium - February 27, 2024 Category: Cytology Authors: Aura Jim énez-Garduño Ibrahim Ramirez-Soto Ileana Miranda-Rodr íguez Sof ía Gitler Alicia Ortega Source Type: research
Evaluation of the drug –drug interaction potential of brigatinib using a physiologically‐based pharmacokinetic modeling approach
AbstractBrigatinib is an oral anaplastic lymphoma kinase (ALK) inhibitor approved for the treatment ofALK-positive metastatic non-small cell lung cancer. In vitro studies indicated that brigatinib is primarily metabolized by CYP2C8 and CYP3A4 and inhibits P-gp, BCRP, OCT1, MATE1, and MATE2K. Clinical drug–drug interaction (DDI) studies with the strong CYP3A inhibitor itraconazole or the strong CYP3A inducer rifampin demonstrated that CYP3A-mediated metabolism was the primary contributor to overall brigatinib clearance in humans. A physiologically-based pharmacokinetic (PBPK) model for brigatinib was developed to predic...
Source: CPT: Pharmacometrics and Systems Pharmacology - January 31, 2024 Category: Drugs & Pharmacology Authors: Michael J. Hanley,
Karen Rowland Yeo,
Meera Tugnait,
Shinji Iwasaki,
Narayana Narasimhan,
Pingkuan Zhang,
Karthik Venkatakrishnan,
Neeraj Gupta Tags: ARTICLE Source Type: research
The combination of doxazosin and metyrosine as a preoperative treatment for pheochromocytomas and paragangliomas
ConclusionThe combination of metyrosine and doxazosin as a preoperative treatment for PPGLs affects intraoperative circulatory hemodynamics, such as a reduced occurrence of blood pressure elevation during surgery. Further research is necessary to identify patients who will benefit most from this combination treatment. (Source: Endocrine)
Source: Endocrine - January 11, 2024 Category: Endocrinology Source Type: research
Acute Management Of Atrial Fibrillation: Comparison Of Metoprolol And Diltiazem In Early Rate Control
This study analyzed the outcomes of patients who received IV CCB or BB for acute rate control of AF in the emergency department (ED). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Kaitlyn Withers, Wesley Parker, Adam Schertz, Jonathan Mayl, Drake Scott, Abigail Thomas, Stephanie Ira, Patrick Whalen, Ghanshyam Shantha, Prashant Bhave, Barbara Pisani Tags: 442 Source Type: research
Risk factors for anticoagulant-associated gastrointestinal hemorrhage: a systematic review and meta-analysis
CONCLUSIONS: The study found that anemia, co-administration of gemfibrozil, co-administration of verapamil or diltiazem, INR, heart failure, myocardial infarction et al. were associated with anticoagulation-related GIB, and these factors were not in the existing prediction models. This study informs risk prediction for anticoagulant-associated GIB, it also informs guidelines for GIB prevention and future research.PMID:38062723 | DOI:10.3904/kjim.2023.098 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - December 8, 2023 Category: Internal Medicine Authors: Fuxin Ma Shuyi Wu Shiqi Li Zhiwei Zeng Jinhua Zhang Source Type: research
