Relaxant Effects of Piperine and Piperlongumine from Piper longum Linn. Fruits on Porcine Coronary Artery
Biol Pharm Bull. 2023 Nov 21. doi: 10.1248/bpb.b23-00694. Online ahead of print.ABSTRACTSince ancient times, Piper longum Linn. fruits have been recognized for exhibiting various effects, including the diaphoretic effects linked to enhanced blood flow. Piperine and piperlongumine coexist in Piper longum Linn. fruits, although the cardiovascular effects of both compounds remain elusive. We investigated their action of piperine and piperlongumine in porcine coronary arteries, comparing them to the Ca2+ channel antagonist diltiazem. Piperlongumine, unlike piperine or diltiazem, concentration-dependently inhibited basal contra...
Source: Biological and Pharmaceutical Bulletin - November 21, 2023 Category: Drugs & Pharmacology Authors: Kazuo Noguchi Moka Teramura Ayano Kitagawa Miyuki Ejima Chinami Ueda Haruna Kanae Source Type: research
Drug-induced hyperglycemia and diabetes
CONCLUSIONS: The risks of induced hyperglycemia vary from one drug to another, and the underlying mechanisms are multiple and potentially complex. Clinicians need to be vigilant when using at-risk drugs in order to detect and manage these adverse drug reactions. However, it is to emphasize that the benefits of appropriately prescribed treatments most often outweigh their metabolic risks.PMID:37985310 | DOI:10.1016/j.therap.2023.09.010 (Source: Therapie)
Source: Therapie - November 20, 2023 Category: Psychiatry & Psychology Authors: Marie-Anne Heurtebize Jean-Luc Faillie Source Type: research
Drug-induced hyperglycemia and diabetes
CONCLUSIONS: The risks of induced hyperglycemia vary from one drug to another, and the underlying mechanisms are multiple and potentially complex. Clinicians need to be vigilant when using at-risk drugs in order to detect and manage these adverse drug reactions. However, it is to emphasize that the benefits of appropriately prescribed treatments most often outweigh their metabolic risks.PMID:37985310 | DOI:10.1016/j.therap.2023.09.010 (Source: Therapie)
Source: Therapie - November 20, 2023 Category: Psychiatry & Psychology Authors: Marie-Anne Heurtebize Jean-Luc Faillie Source Type: research
Structural basis of properties, mechanisms, and channelopathy of cyclic nucleotide-gated channels
This article summarizes recent advances in CNG channel structural biology, describes key structural features and elements, and illuminates a detailed conformational landscape of activation by cyclic nucleotides. The review also correlates structures with findings and properties delineated in functional studies, including nonselective monovalent cation selectivity, Ca2+ permeation and block, block by L-cis-diltiazem, location of the activation gate, lack of voltage-dependent gating, and modulation by lipids and calmodulin. A perspective on future research is also offered.PMID:37905307 | DOI:10.1080/19336950.2023.2273165 (Source: Channels)
Source: Channels - October 31, 2023 Category: Molecular Biology Authors: Zhengshan Hu Jian Yang Source Type: research
Role of magnesium alone or in combination with diltiazem and/or amiodarone in prevention of atrial fibrillation following off-pump coronary artery bypass grafting
CONCLUSIONS: It is concluded that the use of amiodarone and/or diltiazem in addition to magnesium did not result in additional benefit of lowering the incidence of AF.PMID:37861573 | DOI:10.4103/aca.aca_35_23 (Source: Annals of Cardiac Anaesthesia)
Source: Annals of Cardiac Anaesthesia - October 20, 2023 Category: Anesthesiology Authors: Deepak K Tempe Ankit Maheshwari Nirmeen Fatima Priyanka Khurana Muhammad A Geelani Harpreet S Minhas Source Type: research
Role of magnesium alone or in combination with diltiazem and/or amiodarone in prevention of atrial fibrillation following off-pump coronary artery bypass grafting
CONCLUSIONS: It is concluded that the use of amiodarone and/or diltiazem in addition to magnesium did not result in additional benefit of lowering the incidence of AF.PMID:37861573 | DOI:10.4103/aca.aca_35_23 (Source: Annals of Cardiac Anaesthesia)
Source: Annals of Cardiac Anaesthesia - October 20, 2023 Category: Anesthesiology Authors: Deepak K Tempe Ankit Maheshwari Nirmeen Fatima Priyanka Khurana Muhammad A Geelani Harpreet S Minhas Source Type: research
Role of magnesium alone or in combination with diltiazem and/or amiodarone in prevention of atrial fibrillation following off-pump coronary artery bypass grafting
CONCLUSIONS: It is concluded that the use of amiodarone and/or diltiazem in addition to magnesium did not result in additional benefit of lowering the incidence of AF.PMID:37861573 | DOI:10.4103/aca.aca_35_23 (Source: Annals of Cardiac Anaesthesia)
Source: Annals of Cardiac Anaesthesia - October 20, 2023 Category: Anesthesiology Authors: Deepak K Tempe Ankit Maheshwari Nirmeen Fatima Priyanka Khurana Muhammad A Geelani Harpreet S Minhas Source Type: research
Role of magnesium alone or in combination with diltiazem and/or amiodarone in prevention of atrial fibrillation following off-pump coronary artery bypass grafting
CONCLUSIONS: It is concluded that the use of amiodarone and/or diltiazem in addition to magnesium did not result in additional benefit of lowering the incidence of AF.PMID:37861573 | DOI:10.4103/aca.aca_35_23 (Source: Annals of Cardiac Anaesthesia)
Source: Annals of Cardiac Anaesthesia - October 20, 2023 Category: Anesthesiology Authors: Deepak K Tempe Ankit Maheshwari Nirmeen Fatima Priyanka Khurana Muhammad A Geelani Harpreet S Minhas Source Type: research
Role of magnesium alone or in combination with diltiazem and/or amiodarone in prevention of atrial fibrillation following off-pump coronary artery bypass grafting
CONCLUSIONS: It is concluded that the use of amiodarone and/or diltiazem in addition to magnesium did not result in additional benefit of lowering the incidence of AF.PMID:37861573 | DOI:10.4103/aca.aca_35_23 (Source: Annals of Cardiac Anaesthesia)
Source: Annals of Cardiac Anaesthesia - October 20, 2023 Category: Anesthesiology Authors: Deepak K Tempe Ankit Maheshwari Nirmeen Fatima Priyanka Khurana Muhammad A Geelani Harpreet S Minhas Source Type: research
Role of magnesium alone or in combination with diltiazem and/or amiodarone in prevention of atrial fibrillation following off-pump coronary artery bypass grafting
CONCLUSIONS: It is concluded that the use of amiodarone and/or diltiazem in addition to magnesium did not result in additional benefit of lowering the incidence of AF.PMID:37861573 | DOI:10.4103/aca.aca_35_23 (Source: Annals of Cardiac Anaesthesia)
Source: Annals of Cardiac Anaesthesia - October 20, 2023 Category: Anesthesiology Authors: Deepak K Tempe Ankit Maheshwari Nirmeen Fatima Priyanka Khurana Muhammad A Geelani Harpreet S Minhas Source Type: research
